{"id":"https://openalex.org/W2006102747","doi":"https://doi.org/10.1182/blood-2003-12-4296","title":"Substitution of the \u03b3-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking","display_name":"Substitution of the \u03b3-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking","publication_year":2004,"publication_date":"2004-02-10","ids":{"openalex":"https://openalex.org/W2006102747","doi":"https://doi.org/10.1182/blood-2003-12-4296","mag":"2006102747","pmid":"https://pubmed.ncbi.nlm.nih.gov/14764520"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2003-12-4296","doi":"https://doi.org/10.1182/blood-2003-12-4296","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2003-12-4296","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://soar-ir.repo.nii.ac.jp/record/3988/files/r308Variant(BLOOD)+Fig.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055376136","display_name":"Nobuo Okumura","orcid":"https://orcid.org/0000-0003-4269-1279","observed_orcids":["https://orcid.org/0000-0003-4269-1279"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Nobuo Okumura","raw_affiliation_strings":["From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105358046","display_name":"Oleg V. Gorkun","orcid":"https://orcid.org/0000-0002-3068-3389","observed_orcids":["https://orcid.org/0000-0002-3068-3389"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Oleg V. Gorkun","raw_affiliation_strings":["From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080104308","display_name":"Fumiko Terasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Fumiko Terasawa","raw_affiliation_strings":["From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137975476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112869963","display_name":"Susan T. Lord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Susan T. Lord","raw_affiliation_strings":["From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Clinical Chemistry, Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan; and the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I137975476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.0664,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76921256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"103","issue":"11","first_page":"4157","last_page":"4163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrinogen-gamma-chain","display_name":"fibrinogen gamma chain","score":0.7929999828338623},{"id":"https://openalex.org/keywords/d-d-interaction","display_name":"d-d interaction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/fibrin-polymerization","display_name":"fibrin polymerization","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dysfibrinogenemia","display_name":"dysfibrinogenemia","score":0.7990000247955322},{"id":"https://openalex.org/keywords/calcium-dependence","display_name":"calcium dependence","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fibrin-protofibrils","display_name":"fibrin protofibrils","score":0.7850000262260437},{"id":"https://openalex.org/keywords/lysine-substitution","display_name":"lysine substitution","score":0.6169999837875366},{"id":"https://openalex.org/keywords/isoleucine-substitution","display_name":"isoleucine substitution","score":0.7789999842643738},{"id":"https://openalex.org/keywords/alanine-substitution","display_name":"alanine substitution","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.799174427986145},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.743245005607605},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.7051606178283691},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5031179785728455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5029987692832947},{"id":"https://openalex.org/C2911038020","wikidata":"https://www.wikidata.org/wiki/Q423712","display_name":"Factor XIIIa","level":3,"score":0.5029897093772888},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.48145216703414917},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43373411893844604},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.39890986680984497},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3237011432647705},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2554611563682556},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.20856037735939026},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17309114336967468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09268641471862793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07099676132202148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005345","descriptor_name":"Fibrinopeptide B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026122","descriptor_name":"Factor XIIIa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood-2003-12-4296","doi":"https://doi.org/10.1182/blood-2003-12-4296","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2003-12-4296","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:14764520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14764520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:soar-ir.repo.nii.ac.jp:00003988","doi":null,"is_oa":true,"landing_page_url":"https://soar-ir.repo.nii.ac.jp/record/3988/files/r308Variant(BLOOD)+Fig.pdf","pdf_url":"https://soar-ir.repo.nii.ac.jp/record/3988/files/r308Variant(BLOOD)+Fig.pdf","source":{"id":"https://openalex.org/S4306402150","display_name":"SOAR (Shinshu University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137975476","host_organization_name":"Shinshu University","host_organization_lineage":["https://openalex.org/I137975476"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:irdb.nii.ac.jp:00990:0001368377","doi":null,"is_oa":true,"landing_page_url":"https://soar-ir.repo.nii.ac.jp/records/3988","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BLOOD","raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:soar-ir.repo.nii.ac.jp:00003988","doi":null,"is_oa":true,"landing_page_url":"https://soar-ir.repo.nii.ac.jp/record/3988/files/r308Variant(BLOOD)+Fig.pdf","pdf_url":"https://soar-ir.repo.nii.ac.jp/record/3988/files/r308Variant(BLOOD)+Fig.pdf","source":{"id":"https://openalex.org/S4306402150","display_name":"SOAR (Shinshu University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137975476","host_organization_name":"Shinshu University","host_organization_lineage":["https://openalex.org/I137975476"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3722891963","display_name":null,"funder_award_id":"HL-31048","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006102747.pdf","grobid_xml":"https://content.openalex.org/works/W2006102747.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W83307249","https://openalex.org/W83420435","https://openalex.org/W119707112","https://openalex.org/W280022368","https://openalex.org/W1008040401","https://openalex.org/W1067939983","https://openalex.org/W1146534089","https://openalex.org/W1250426746","https://openalex.org/W1487236423","https://openalex.org/W1589960479","https://openalex.org/W1604635179","https://openalex.org/W1638131725","https://openalex.org/W1862150195","https://openalex.org/W1873059451","https://openalex.org/W1907444416","https://openalex.org/W1927300831","https://openalex.org/W1963857259","https://openalex.org/W1970973011","https://openalex.org/W1977946969","https://openalex.org/W1980346550","https://openalex.org/W1981438065","https://openalex.org/W1984005393","https://openalex.org/W1989144240","https://openalex.org/W1991257779","https://openalex.org/W1995171177","https://openalex.org/W1996711965","https://openalex.org/W1999504108","https://openalex.org/W2027141031","https://openalex.org/W2038236709","https://openalex.org/W2056387032","https://openalex.org/W2060363641","https://openalex.org/W2066217822","https://openalex.org/W2089819981","https://openalex.org/W2093913003","https://openalex.org/W2101570493","https://openalex.org/W2106782261","https://openalex.org/W2113773848","https://openalex.org/W2114907461","https://openalex.org/W2120487268","https://openalex.org/W2123183798","https://openalex.org/W2129089609","https://openalex.org/W2131347378","https://openalex.org/W2135846300","https://openalex.org/W2146172466","https://openalex.org/W2153011820","https://openalex.org/W2154775342","https://openalex.org/W2167223080","https://openalex.org/W2241911783","https://openalex.org/W2344655412","https://openalex.org/W2473572525","https://openalex.org/W4296275883"],"related_works":["https://openalex.org/W7098713906","https://openalex.org/W1991257779","https://openalex.org/W2344655412","https://openalex.org/W2086099682","https://openalex.org/W1998419415","https://openalex.org/W2017467971","https://openalex.org/W2969909334","https://openalex.org/W1980346550","https://openalex.org/W2295124736","https://openalex.org/W2417735377"],"abstract_inverted_index":{"Crystallographic":[0],"structures":[1],"indicate":[2],"that":[3],"gamma-chain":[4],"residue":[5,187],"Asn308":[6,33,183],"participates":[7],"in":[8,23,34,109],"D:D":[9],"interactions":[10],"and":[11,48,63,163],"indeed":[12],"substitutions":[13],"of":[14,32,76,95,102,112,137,144,149,175,182],"gammaAsn308":[15,41],"with":[16,25,83,124,133,140,184,201],"lysine":[17,44,202],"or":[18],"isoleucine":[19,46],"have":[20],"been":[21],"identified":[22],"dysfibrinogens":[24],"impaired":[26,82],"polymerization.":[27,164],"To":[28],"probe":[29],"the":[30,74,110,157,173],"role":[31],"polymerization,":[35],"we":[36],"synthesized":[37],"3":[38,85],"variant":[39],"fibrinogens:":[40],"changed":[42],"to":[43],"(gammaN308K),":[45],"(gammaN308I),":[47],"alanine":[49],"(gammaN308A).":[50],"We":[51],"measured":[52],"thrombin-catalyzed":[53,103],"polymerization":[54,79,94],"by":[55,59,67],"turbidity,":[56],"fibrinopeptide":[57,104],"release":[58,101,120,162],"high-performance":[60],"liquid":[61],"chromatography,":[62],"factor":[64],"XIIIa-catalyzed":[65,127],"cross-linking":[66],"sodium":[68],"dodecyl":[69],"sulfate-polyacrylamide":[70],"gel":[71],"electrophoresis.":[72],"In":[73,87],"absence":[75,111,136],"added":[77],"calcium,":[78,92,113],"was":[80,107,121,131,152],"clearly":[81],"all":[84],"variants.":[86],"contrast,":[88],"at":[89,115,195],"0.1":[90],"mM":[91,117],"only":[93,123,150],"gammaN308K":[96,151],"remained":[97],"markedly":[98],"abnormal.":[99],"The":[100],"B":[105],"(FpB)":[106],"delayed":[108,122,132],"whereas":[114,139,199],"1":[116],"calcium":[118,197],"FpB":[119,161],"gammaN308K.":[125],"Factor":[126],"gamma-gamma":[128,146],"dimer":[129,147],"formation":[130,148,169,191],"fibrinogen":[134],"(in":[135,142],"thrombin),":[138],"fibrin":[141,167],"presence":[143],"thrombin)":[145],"delayed.":[153],"These":[154],"data":[155],"corroborate":[156],"recognized":[158],"link":[159],"between":[160],"They":[165],"show":[166,180],"cross-link":[168],"likely":[170],"depends":[171],"on":[172],"structure":[174,194],"protofibrils.":[176],"Together,":[177],"our":[178],"results":[179],"substitution":[181,200],"a":[185],"hydrophobic":[186],"altered":[188,203],"neither":[189],"polymer":[190,193],"nor":[192],"physiologic":[196],"concentrations,":[198],"both.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}