{"id":"https://openalex.org/W2006097435","doi":"https://doi.org/10.1196/annals.1369.018","title":"Human Immunodeficiency Virus\u20101 Protein Tat and Methamphetamine Interactions","display_name":"Human Immunodeficiency Virus\u20101 Protein Tat and Methamphetamine Interactions","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2006097435","doi":"https://doi.org/10.1196/annals.1369.018","mag":"2006097435","pmid":"https://pubmed.ncbi.nlm.nih.gov/17105916"},"language":"en","primary_location":{"id":"doi:10.1196/annals.1369.018","doi":"https://doi.org/10.1196/annals.1369.018","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1369.018","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103418869","display_name":"Shaji Theodore","orcid":"https://orcid.org/0000-0003-2961-7285","observed_orcids":["https://orcid.org/0000-0003-2961-7285"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHAJI THEODORE","raw_affiliation_strings":["Department of Neurology, University of Kentucky, 260 Health Science Research Building, 1095 V.A. Drive, Lexington, KY 40536-0305, USA","Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Kentucky, 260 Health Science Research Building, 1095 V.A. Drive, Lexington, KY 40536-0305, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536,USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088520124","display_name":"Stephanie Stolberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEPHANIE STOLBERG","raw_affiliation_strings":["Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536,USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070181972","display_name":"Wayne A. Cass","orcid":"https://orcid.org/0009-0006-2153-3262","observed_orcids":["https://orcid.org/0009-0006-2153-3262"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WAYNE A. CASS","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087514982","display_name":"William F. Maragos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"WILLIAM F. MARAGOS","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536, USA","Department of Neurology, University of Kentucky, Lexington, Kentucky 40536, USA","Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536,USA","Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Neurology, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536,USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087514982"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.8088,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.66402455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1074","issue":"1","first_page":"178","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.8669999837875366},{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5920000076293945},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8379999995231628},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.6079999804496765},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6904453635215759},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.6417363882064819},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6251650452613831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3353816866874695},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.154312402009964}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008694","descriptor_name":"Methamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015696","descriptor_name":"Gene Products, tat","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016622","descriptor_name":"Silver Staining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1196/annals.1369.018","doi":"https://doi.org/10.1196/annals.1369.018","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1369.018","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:17105916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17105916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1412983295","display_name":null,"funder_award_id":"DA13144","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G1890816925","display_name":"AGING AND 6 HYDROXYDOPAMINE NEUROTOXICITY","funder_award_id":"R01AG017963","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3538202583","display_name":"METHAMPHETAMINE AND HIV PROTEIN-INDUCED NEUROTOXICITY","funder_award_id":"R01DA013144","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6950377491","display_name":null,"funder_award_id":"AG17963","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W304081","https://openalex.org/W154250135","https://openalex.org/W1524845305","https://openalex.org/W1544120675","https://openalex.org/W1574896709","https://openalex.org/W1597436532","https://openalex.org/W1969249644","https://openalex.org/W1984215166","https://openalex.org/W1995777463","https://openalex.org/W2005807968","https://openalex.org/W2007383758","https://openalex.org/W2012547110","https://openalex.org/W2021557865","https://openalex.org/W2024476573","https://openalex.org/W2035516686","https://openalex.org/W2044360533","https://openalex.org/W2062200627","https://openalex.org/W2089232076","https://openalex.org/W2091073665","https://openalex.org/W2096599172","https://openalex.org/W2115375118","https://openalex.org/W2125202557","https://openalex.org/W2146904216","https://openalex.org/W2153835317","https://openalex.org/W2160588949","https://openalex.org/W2167447199","https://openalex.org/W2169211575","https://openalex.org/W2317192882"],"related_works":["https://openalex.org/W1574896709","https://openalex.org/W1983015010","https://openalex.org/W2101021124","https://openalex.org/W2076357732","https://openalex.org/W2047963679","https://openalex.org/W1994556577","https://openalex.org/W4389023268","https://openalex.org/W2044365995","https://openalex.org/W2016831512","https://openalex.org/W2030657267"],"abstract_inverted_index":{"The":[0,26,41],"human":[1],"immunodeficiency":[2],"virus-1":[3],"(HIV-1)":[4],"affects":[5,54],"the":[6,55,84,95,126,151,157,160,174,181,195],"central":[7],"nervous":[8],"system":[9],"(CNS)":[10],"in":[11,37,165],"approximately":[12],"30%":[13],"of":[14,43,60,78,91,97,134,142,153,177,183,194,197],"infected":[15],"individuals":[16],"and":[17,81,99,114,137],"basal":[18,56],"ganglia":[19],"structures":[20],"seem":[21],"to":[22,33,70,83,117,149],"be":[23,34],"most":[24],"affected.":[25],"HIV-1-transactivating":[27],"protein,":[28],"Tat,":[29],"has":[30],"been":[31],"suggested":[32],"pathogenically":[35],"relevant":[36],"HIV-1-induced":[38],"neuronal":[39],"injury.":[40],"abuse":[42],"methamphetamine":[44],"(METH),":[45],"which":[46],"is":[47,179,189],"great":[48],"among":[49],"this":[50,120],"patient":[51],"population,":[52],"also":[53,124],"ganglia,":[57],"causing":[58],"degeneration":[59],"dopaminergic":[61],"terminals.":[62,93],"In":[63],"previous":[64],"studies,":[65],"we":[66,109,146],"demonstrated":[67],"that":[68,159,173],"coexposure":[69],"these":[71],"two":[72],"toxins":[73],"caused":[74],"a":[75,89,132,140,191],"synergistic":[76,175],"loss":[77,90,96,176],"striatal":[79],"dopamine":[80,85,92,98,106,178,184],"binding":[82],"transporter":[86],"(DAT),":[87],"suggesting":[88],"Because":[94],"DAT,":[100],"however,":[101],"do":[102],"not":[103,190],"necessarily":[104],"reflect":[105],"terminal":[107,185],"degeneration,":[108],"have":[110,123,147],"used":[111],"silver":[112],"staining":[113],"TH":[115],"immunohistochemistry":[116],"further":[118],"examine":[119],"issue.":[121],"We":[122],"examined":[125],"glial":[127],"reaction":[128],"using":[129],"GFAP":[130],"as":[131,139],"marker":[133,141],"astrocyte":[135],"activation":[136],"OX-42":[138],"activated":[143,198],"microglia.":[144],"Lastly,":[145],"begun":[148],"explore":[150],"mechanism":[152],"synergy":[154],"by":[155],"investigating":[156],"role":[158],"cytokine":[161],"TNF-alpha":[162],"might":[163],"play":[164],"Tat":[166],"+":[167],"METH":[168],"synergy.":[169],"Our":[170],"data":[171],"indicate":[172],"likely":[180],"result":[182,193],"degeneration.":[186],"This":[187],"injury":[188],"direct":[192],"number":[196],"glia":[199],"but":[200],"does":[201],"involve":[202],"TNF-alpha.":[203]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}