{"id":"https://openalex.org/W2006062243","doi":"https://doi.org/10.1074/jbc.m511013200","title":"LIM Mineralization Protein-1 Potentiates Bone Morphogenetic Protein Responsiveness via a Novel Interaction with Smurf1 Resulting in Decreased Ubiquitination of Smads","display_name":"LIM Mineralization Protein-1 Potentiates Bone Morphogenetic Protein Responsiveness via a Novel Interaction with Smurf1 Resulting in Decreased Ubiquitination of Smads","publication_year":2006,"publication_date":"2006-04-13","ids":{"openalex":"https://openalex.org/W2006062243","doi":"https://doi.org/10.1074/jbc.m511013200","mag":"2006062243","pmid":"https://pubmed.ncbi.nlm.nih.gov/16611643"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m511013200","doi":"https://doi.org/10.1074/jbc.m511013200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m511013200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m511013200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061268455","display_name":"Sreedhara Sangadala","orcid":"https://orcid.org/0000-0003-4042-1187","observed_orcids":["https://orcid.org/0000-0003-4042-1187"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreedhara Sangadala","raw_affiliation_strings":["Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002847881","display_name":"Scott D. Boden","orcid":"https://orcid.org/0000-0002-6210-5487","observed_orcids":["https://orcid.org/0000-0002-6210-5487"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott D. Boden","raw_affiliation_strings":["Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329. Electronic address: Scott_boden@emory.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329. Electronic address: Scott_boden@emory.org","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055151607","display_name":"Manjula Viggeswarapu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manjula Viggeswarapu","raw_affiliation_strings":["Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100562528","display_name":"Yunshan Liu","orcid":"https://orcid.org/0009-0007-2254-2600","observed_orcids":["https://orcid.org/0009-0007-2254-2600"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunshan Liu","raw_affiliation_strings":["Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113554421","display_name":"Louisa Titus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louisa Titus","raw_affiliation_strings":["Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Veterans Affairs Medical Center and the Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30329","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002847881"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3357,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.87486284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"281","issue":"25","first_page":"17212","last_page":"17219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12960","display_name":"Heterotopic Ossification and Related Conditions","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smurf1","display_name":"Smurf1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.7170000076293945},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/smad1","display_name":"Smad1","score":0.7409999966621399},{"id":"https://openalex.org/keywords/smad5","display_name":"Smad5","score":1.0},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8220000267028809},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.8638712167739868},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.8589599132537842},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7006626129150391},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.5495131015777588},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5202276110649109},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5120266079902649},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.5036877989768982},{"id":"https://openalex.org/C73834784","wikidata":"https://www.wikidata.org/wiki/Q17849752","display_name":"BMPR2","level":4,"score":0.4497423768043518},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.419811487197876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3808223605155945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1777125895023346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05194813013076782},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D060588","descriptor_name":"LIM Domain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060588","descriptor_name":"LIM Domain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060588","descriptor_name":"LIM Domain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m511013200","doi":"https://doi.org/10.1074/jbc.m511013200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m511013200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16611643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16611643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m511013200","doi":"https://doi.org/10.1074/jbc.m511013200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m511013200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W129492009","https://openalex.org/W1485894565","https://openalex.org/W1519258930","https://openalex.org/W1519370577","https://openalex.org/W1962351050","https://openalex.org/W1966639987","https://openalex.org/W1968590981","https://openalex.org/W1971157583","https://openalex.org/W1979518793","https://openalex.org/W1981089517","https://openalex.org/W1988810849","https://openalex.org/W2007444505","https://openalex.org/W2007576341","https://openalex.org/W2012448313","https://openalex.org/W2016311922","https://openalex.org/W2025927453","https://openalex.org/W2026296040","https://openalex.org/W2029930661","https://openalex.org/W2034596514","https://openalex.org/W2036906183","https://openalex.org/W2042658249","https://openalex.org/W2058138869","https://openalex.org/W2058733924","https://openalex.org/W2063090066","https://openalex.org/W2066612343","https://openalex.org/W2090905598","https://openalex.org/W2093417867","https://openalex.org/W2104752640","https://openalex.org/W2108595411","https://openalex.org/W2111063080","https://openalex.org/W2139540060","https://openalex.org/W2145456538","https://openalex.org/W2148676064","https://openalex.org/W2169012342","https://openalex.org/W2260043331","https://openalex.org/W4211027922","https://openalex.org/W4255781844"],"related_works":["https://openalex.org/W1994324715","https://openalex.org/W4230801422","https://openalex.org/W2031572777","https://openalex.org/W1991156103","https://openalex.org/W1976571581","https://openalex.org/W3026637588","https://openalex.org/W2800624143","https://openalex.org/W2165658291","https://openalex.org/W4242486335","https://openalex.org/W2119100530"],"abstract_inverted_index":{"Development":[0],"and":[1,7,23,104,130,136,182],"repair":[2],"of":[3,16,33,48,52,67,90,107,112,162,168],"the":[4,46,110,126,151,165,189],"skeletal":[5],"system":[6],"other":[8],"organs":[9],"is":[10,72,78,119],"highly":[11],"dependent":[12],"on":[13],"precise":[14],"regulation":[15],"bone":[17,38,94,116],"morphogenetic":[18],"proteins":[19,27,54],"(BMPs),":[20],"their":[21,24],"receptors,":[22],"intracellular":[25],"signaling":[26,191],"known":[28],"as":[29],"Smads.":[30,108,158],"The":[31],"use":[32],"BMPs":[34,71],"clinically":[35],"to":[36,70,153,170,179],"induce":[37],"formation":[39],"has":[40],"been":[41],"limited":[42],"in":[43,55,60,175],"part":[44],"by":[45],"requirement":[47],"much":[49],"higher":[50],"doses":[51],"recombinant":[53],"primates":[56],"than":[57],"were":[58],"needed":[59],"cell":[61],"culture":[62],"or":[63],"rodents.":[64],"Therefore,":[65],"control":[66],"cellular":[68,177],"responsiveness":[69,178],"now":[73],"a":[74,85,120,184],"critical":[75],"area":[76],"that":[77,83,122,143],"poorly":[79],"understood.":[80],"We":[81,140],"determined":[82],"LMP-1,":[84],"LIM":[86],"domain":[87,129,167],"protein":[88],"capable":[89],"inducing":[91],"de":[92],"novo":[93],"formation,":[95,117],"interacts":[96,124],"with":[97,125,134,164],"Smurf1":[98,127,155,169],"(Smad":[99],"ubiquitin":[100],"regulatory":[101,186],"factor":[102],"1)":[103],"prevents":[105],"ubiquitination":[106],"In":[109],"region":[111],"LMP":[113],"responsible":[114],"for":[115,138,188],"there":[118],"motif":[121,148],"directly":[123],"WW2":[128,166],"can":[131,149],"effectively":[132],"compete":[133],"Smad1":[135],"Smad5":[137],"binding.":[139],"have":[141],"shown":[142],"small":[144],"peptides":[145],"containing":[146],"this":[147],"mimic":[150],"ability":[152],"block":[154,171],"from":[156],"binding":[157,173],"This":[159],"novel":[160,185],"interaction":[161],"LMP-1":[163],"Smad":[172],"results":[174],"increased":[176],"exogenous":[180],"BMP":[181,190],"demonstrates":[183],"mechanism":[187],"pathway.":[192]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
