{"id":"https://openalex.org/W2006043706","doi":"https://doi.org/10.1016/j.bcp.2009.02.001","title":"Synthetic regulators of the 2-oxoglutarate oxidative decarboxylation alleviate the glutamate excitotoxicity in cerebellar granule neurons","display_name":"Synthetic regulators of the 2-oxoglutarate oxidative decarboxylation alleviate the glutamate excitotoxicity in cerebellar granule neurons","publication_year":2009,"publication_date":"2009-02-14","ids":{"openalex":"https://openalex.org/W2006043706","doi":"https://doi.org/10.1016/j.bcp.2009.02.001","mag":"2006043706","pmid":"https://pubmed.ncbi.nlm.nih.gov/19426691"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcp.2009.02.001","doi":"https://doi.org/10.1016/j.bcp.2009.02.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2009.02.001","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087948864","display_name":"Maria S. Kabysheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria S. Kabysheva","raw_affiliation_strings":["Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russian Federation","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109940476","display_name":"Tatiana P. Storozhevykh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158655","display_name":"Scientific Center of Children's Health","ror":"https://ror.org/049317064","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210117042","https://openalex.org/I4210158655"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana P. Storozhevykh","raw_affiliation_strings":["Research Center for Children's Health, Russian Academy of Medical Sciences, 119991 Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Children's Health, Russian Academy of Medical Sciences, 119991 Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210158655"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035248679","display_name":"Vsevolod G. Pinelis","orcid":"https://orcid.org/0000-0001-8579-605X","observed_orcids":["https://orcid.org/0000-0001-8579-605X"]},"institutions":[{"id":"https://openalex.org/I4210158655","display_name":"Scientific Center of Children's Health","ror":"https://ror.org/049317064","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210117042","https://openalex.org/I4210158655"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vsevolod G. Pinelis","raw_affiliation_strings":["Research Center for Children's Health, Russian Academy of Medical Sciences, 119991 Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Children's Health, Russian Academy of Medical Sciences, 119991 Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210158655"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058544171","display_name":"Victoria I. Bunik","orcid":"https://orcid.org/0000-0002-2552-8560","observed_orcids":["https://orcid.org/0000-0002-2552-8560"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Victoria I. Bunik","raw_affiliation_strings":["Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russian Federation","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058544171"],"corresponding_institution_ids":["https://openalex.org/I19880235"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.5267,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.77340545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"77","issue":"9","first_page":"1531","last_page":"1540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-oxoglutarate-dehydrogenase","display_name":"2-oxoglutarate dehydrogenase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.875},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7900000214576721},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.5709999799728394},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.68694007396698},{"id":"https://openalex.org/C2777626080","wikidata":"https://www.wikidata.org/wiki/Q422733","display_name":"Phosphonate","level":2,"score":0.684463620185852},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5826789140701294},{"id":"https://openalex.org/C2779634684","wikidata":"https://www.wikidata.org/wiki/Q3818578","display_name":"Oxidative decarboxylation","level":3,"score":0.5292914509773254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5230209231376648},{"id":"https://openalex.org/C2780595602","wikidata":"https://www.wikidata.org/wiki/Q898436","display_name":"Decarboxylation","level":3,"score":0.5223361253738403},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.4769001007080078},{"id":"https://openalex.org/C2777202666","wikidata":"https://www.wikidata.org/wiki/Q417383","display_name":"Glutamate dehydrogenase","level":4,"score":0.4448031187057495},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.424574613571167},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.42037349939346313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34431275725364685},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3411710262298584},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15704402327537537},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.14071404933929443},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05343756079673767}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007655","descriptor_name":"Ketoglutarate Dehydrogenase Complex","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bcp.2009.02.001","doi":"https://doi.org/10.1016/j.bcp.2009.02.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2009.02.001","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:19426691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19426691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329591","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W251883897","https://openalex.org/W1488079166","https://openalex.org/W1560978813","https://openalex.org/W1590010999","https://openalex.org/W1963857149","https://openalex.org/W1965417094","https://openalex.org/W1970230937","https://openalex.org/W1970883608","https://openalex.org/W1975700762","https://openalex.org/W1991614275","https://openalex.org/W2005944335","https://openalex.org/W2016166660","https://openalex.org/W2023454927","https://openalex.org/W2023535483","https://openalex.org/W2026572950","https://openalex.org/W2032779002","https://openalex.org/W2034259981","https://openalex.org/W2036791676","https://openalex.org/W2039133868","https://openalex.org/W2045584818","https://openalex.org/W2048506674","https://openalex.org/W2051400760","https://openalex.org/W2057466509","https://openalex.org/W2058693910","https://openalex.org/W2067844277","https://openalex.org/W2069852546","https://openalex.org/W2071389866","https://openalex.org/W2081350198","https://openalex.org/W2081877505","https://openalex.org/W2088848201","https://openalex.org/W2091160232","https://openalex.org/W2093094905","https://openalex.org/W2094247127","https://openalex.org/W2098324936","https://openalex.org/W2103297428","https://openalex.org/W2112696881","https://openalex.org/W2116409317","https://openalex.org/W2124271890","https://openalex.org/W2124567863","https://openalex.org/W2132318672","https://openalex.org/W2138114813","https://openalex.org/W2141260882","https://openalex.org/W2143967813","https://openalex.org/W2280141619","https://openalex.org/W2401763442","https://openalex.org/W2411082310","https://openalex.org/W2785544473","https://openalex.org/W2808327857","https://openalex.org/W6609499112"],"related_works":["https://openalex.org/W2026073739","https://openalex.org/W4210783586","https://openalex.org/W4388364397","https://openalex.org/W2080944779","https://openalex.org/W4323928491","https://openalex.org/W2081877505","https://openalex.org/W2019513832","https://openalex.org/W1972122272","https://openalex.org/W2075354592","https://openalex.org/W2062388126"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
