{"id":"https://openalex.org/W200604181","doi":"https://doi.org/10.1007/978-1-60761-322-0_17","title":"Dynamics of Adipose Tissue Development by 2H2O Labeling","display_name":"Dynamics of Adipose Tissue Development by 2H2O Labeling","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W200604181","doi":"https://doi.org/10.1007/978-1-60761-322-0_17","mag":"200604181","pmid":"https://pubmed.ncbi.nlm.nih.gov/19763484"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-322-0_17","doi":"https://doi.org/10.1007/978-1-60761-322-0_17","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-322-0_17","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4229668220","display_name":"Lipidomics"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033151398","display_name":"Etienne B. Pouteau","orcid":"https://orcid.org/0000-0002-8254-1892","observed_orcids":["https://orcid.org/0000-0002-8254-1892"]},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Etienne Pouteau","raw_affiliation_strings":["Nutrition and Health Department, Nestle Research Center, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Health Department, Nestle Research Center, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035102402","display_name":"Carine Beysen","orcid":"https://orcid.org/0000-0002-2259-0932","observed_orcids":["https://orcid.org/0000-0002-2259-0932"]},"institutions":[{"id":"https://openalex.org/I4210144499","display_name":"KineMed (United States)","ror":"https://ror.org/04b05q786","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144499"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carine Beysen","raw_affiliation_strings":["KineMed, Inc., Emeryville, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KineMed, Inc., Emeryville, CA, USA","institution_ids":["https://openalex.org/I4210144499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034498341","display_name":"Nabil M. R. Saad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144499","display_name":"KineMed (United States)","ror":"https://ror.org/04b05q786","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144499"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabil Saad","raw_affiliation_strings":["KineMed, Inc., Emeryville, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KineMed, Inc., Emeryville, CA, USA","institution_ids":["https://openalex.org/I4210144499"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014393890","display_name":"Scott Turner","orcid":"https://orcid.org/0000-0002-6618-6405","observed_orcids":["https://orcid.org/0000-0002-6618-6405"]},"institutions":[{"id":"https://openalex.org/I4210144499","display_name":"KineMed (United States)","ror":"https://ror.org/04b05q786","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144499"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Turner","raw_affiliation_strings":["KineMed, Inc., Emeryville, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KineMed, Inc., Emeryville, CA, USA","institution_ids":["https://openalex.org/I4210144499"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.948,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.92378049,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"579","issue":null,"first_page":"337","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.1459999978542328,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-tissue-development","display_name":"adipose tissue development","score":0.9350000023841858},{"id":"https://openalex.org/keywords/adipose-tissue-remodeling","display_name":"adipose tissue remodeling","score":0.6959999799728394},{"id":"https://openalex.org/keywords/adipocyte-hypertrophy","display_name":"adipocyte hypertrophy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/adipocyte-hyperplasia","display_name":"adipocyte hyperplasia","score":0.9419999718666077},{"id":"https://openalex.org/keywords/triacylglycerol-biosynthesis","display_name":"triglyceride synthesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/de-novo-lipogenesis","display_name":"de novo lipogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.609000027179718},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/zucker-rats","display_name":"Zucker rats","score":0.875},{"id":"https://openalex.org/keywords/deuterium-enrichment","display_name":"deuterium enrichment","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7740898132324219},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5636894702911377},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36447885632514954},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3551428020000458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29687798023223877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2517883777618408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21952667832374573},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08559152483940125},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.05350136756896973}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017666","descriptor_name":"Deuterium Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-60761-322-0_17","doi":"https://doi.org/10.1007/978-1-60761-322-0_17","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-322-0_17","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:19763484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19763484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1509269909","https://openalex.org/W1911396260","https://openalex.org/W1931900695","https://openalex.org/W1972515638","https://openalex.org/W1975339033","https://openalex.org/W2069547975","https://openalex.org/W2073774893","https://openalex.org/W2074789422","https://openalex.org/W2075727603","https://openalex.org/W2107000838","https://openalex.org/W2108436796","https://openalex.org/W2129460636","https://openalex.org/W2132978340","https://openalex.org/W2133305838","https://openalex.org/W2162242212","https://openalex.org/W2283126371"],"related_works":["https://openalex.org/W2107000838","https://openalex.org/W4384942642","https://openalex.org/W2085237586","https://openalex.org/W2013627907","https://openalex.org/W2073774893","https://openalex.org/W2162242212","https://openalex.org/W2106807391","https://openalex.org/W4400760287","https://openalex.org/W2097404139","https://openalex.org/W1953103451"],"abstract_inverted_index":{"Adipose":[0],"tissue":[1,54,75,235],"development":[2],"undergoes":[3],"remodeling":[4],"in":[5,18,45,93,107,136,139,210,227,238],"terms":[6],"of":[7,25,52,97,100,152,182,202,204,207,233],"newly":[8,13],"synthesized":[9,14],"cells":[10,27],"(hyperplasia)":[11],"and":[12,28,33,59,85,145,163,170,173,198,206,221,240],"lipids":[15,29],"that":[16],"accumulate":[17],"adipocytes":[19],"(hypertrophy).":[20],"Synthesis":[21],"and/or":[22,134],"breakdown":[23],"rates":[24,201],"adipose":[26,53,74,166,212,234],"follow":[30],"a":[31,43,68,142],"continuous":[32],"dynamic":[34],"pattern,":[35],"e.g.,":[36],"during":[37],"obesity":[38],"development.":[39],"This":[40],"chapter":[41],"describes":[42],"unique":[44],"vivo":[46,228],"method":[47,215],"to":[48,71,160,177,194],"measure":[49],"the":[50,73,79,82,86,94,121,150,153,158,165,174,179,196,211,231],"dynamics":[51,237],"growth":[55,236],"using":[56],"2H2O":[57,66,91],"labeling":[58,154],"mass":[60],"spectrometry":[61],"analyses.":[62],"The":[63,127,189,214],"approach":[64],"uses":[65],"as":[67,78,104,106],"metabolic":[69],"tracer":[70],"label":[72],"components":[76,167,184],"such":[77],"triglycerides":[80],"(TG),":[81],"fatty":[83],"acids,":[84],"genomic":[87,171],"DNA.":[88],"Deuterium":[89,115],"from":[90],"incorporates":[92,117],"C-H":[95],"bonds":[96],"glycerol":[98],"moiety":[99,109],"TG":[101],"through":[102,110,120],"glyceroneogenesis":[103],"well":[105],"palmitate":[108],"de":[111,122],"novo":[112,123],"lipogenesis":[113],"(DNL).":[114],"also":[116],"into":[118],"DNA":[119,208],"nucleoside":[124],"synthesis":[125,200],"pathway.":[126],"labeled":[128],"water,":[129],"2H2O,":[130],"is":[131,216],"administrated":[132],"intraperitoneally":[133],"orally":[135],"rodents":[137],"or":[138],"humans":[140],"for":[141],"defined":[143],"duration":[144],"biopsies":[146],"are":[147,192],"collected":[148],"at":[149],"end":[151],"period.":[155],"We":[156,224],"describe":[157],"procedure":[159,176],"extract,":[161],"isolate,":[162],"purify":[164],"(TG-glycerol,":[168],"TG-palmitate,":[169],"DNA)":[172],"derivation":[175],"analyze":[178],"isotopic":[180],"2H-enrichment":[181],"these":[183],"by":[185],"gas":[186],"chromatography/mass":[187],"spectrometry.":[188],"calculation":[190],"principles":[191],"described":[193],"obtain":[195],"fractional":[197],"absolute":[199],"TG,":[203],"DNL,":[205],"measured":[209],"tissues.":[213],"nonradioactive,":[217],"nonhazardous,":[218],"accurate,":[219],"reproducible,":[220],"very":[222],"sensitive.":[223],"present":[225],"recent":[226],"data":[229],"on":[230],"ontogeny":[232],"young":[239],"adult":[241],"obese":[242],"Zucker":[243,248],"rats":[244],"compared":[245],"with":[246],"lean":[247],"rats.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
