{"id":"https://openalex.org/W2006040668","doi":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","title":"The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment","display_name":"The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment","publication_year":2007,"publication_date":"2007-07-17","ids":{"openalex":"https://openalex.org/W2006040668","doi":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","mag":"2006040668","pmid":"https://pubmed.ncbi.nlm.nih.gov/17635499","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2198787"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.2007.02979.x","doi":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2007.02979.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2007.02979.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085998748","display_name":"Neeraj Dhaun","orcid":"https://orcid.org/0000-0001-9128-6603","observed_orcids":["https://orcid.org/0000-0001-9128-6603"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Neeraj Dhaun","raw_affiliation_strings":["Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Unit, Edinburgh, UK. bean.dhaun@ed.ac.uk","Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Unit, Edinburgh, UK. bean.dhaun@ed.ac.uk","institution_ids":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046897692","display_name":"Vanessa Melville","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vanessa Melville","raw_affiliation_strings":["Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075818401","display_name":"William G. Kramer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Kramer","raw_affiliation_strings":["Encysive Pharmaceuticals Inc, Houston, TX and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encysive Pharmaceuticals Inc, Houston, TX and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000572967","display_name":"Fiona D. Stavros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fiona Stavros","raw_affiliation_strings":["Encysive Pharmaceuticals Inc, Houston, TX and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encysive Pharmaceuticals Inc, Houston, TX and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060410193","display_name":"TERRANCE C. COYNE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terrance Coyne","raw_affiliation_strings":["Encysive Pharmaceuticals Inc, Houston, TX and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encysive Pharmaceuticals Inc, Houston, TX and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060132287","display_name":"Suzanne K. Swan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148841","display_name":"DaVita Clinical Research (United States)","ror":"https://ror.org/04m8yw794","country_code":"US","type":"education","lineage":["https://openalex.org/I4210148841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Swan","raw_affiliation_strings":["DaVita Clinical Research, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DaVita Clinical Research, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I4210148841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113653074","display_name":"Jane G. Goddard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Goddard","raw_affiliation_strings":["Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081449769","display_name":"David John Webb","orcid":"https://orcid.org/0000-0003-0755-1756","observed_orcids":["https://orcid.org/0000-0003-0755-1756","https://orcid.org/0000-0002-8109-1877","https://orcid.org/0000-0002-3932-3339"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Webb","raw_affiliation_strings":["Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, University of Edinburgh, Queen's Medical Research Institute and Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK,","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5085998748"],"corresponding_institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I4210164624","https://openalex.org/I98677209"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.6498,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84210056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"64","issue":"6","first_page":"733","last_page":"737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sitaxsentan","display_name":"sitaxsentan","score":0.996999979019165},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":0.7450000047683716},{"id":"https://openalex.org/keywords/endothelin-a-receptor","display_name":"ETA receptor","score":0.8339999914169312},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8420000076293945},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9300000071525574},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.843999981880188},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.8130000233650208},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5139999985694885},{"id":"https://openalex.org/keywords/oral-clearance","display_name":"oral clearance","score":0.6669999957084656},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7924385070800781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7527768611907959},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7502807378768921},{"id":"https://openalex.org/C2908822073","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Impaired renal function","level":3,"score":0.6063787341117859},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5727860331535339},{"id":"https://openalex.org/C2776345702","wikidata":"https://www.wikidata.org/wiki/Q390709","display_name":"Endothelin receptor antagonist","level":4,"score":0.5420805215835571},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4980638027191162},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.45694881677627563},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.4559318721294403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4412137567996979},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4356813430786133},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4316330850124359},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4172608256340027},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16634872555732727}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D044022","descriptor_name":"Receptor, Endothelin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065130","descriptor_name":"Endothelin A Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.2007.02979.x","doi":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2007.02979.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2198787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2198787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:17635499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17635499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.2007.02979.x","doi":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2007.02979.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2007.02979.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006040668.pdf","grobid_xml":"https://content.openalex.org/works/W2006040668.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1550111394","https://openalex.org/W1955970211","https://openalex.org/W1977343715","https://openalex.org/W1994059773","https://openalex.org/W2021160040","https://openalex.org/W2023453199","https://openalex.org/W2024322045","https://openalex.org/W2076644187","https://openalex.org/W2115537569","https://openalex.org/W2159819952","https://openalex.org/W2163370089","https://openalex.org/W2298101895"],"related_works":["https://openalex.org/W1976743350","https://openalex.org/W2332902004","https://openalex.org/W2013583236","https://openalex.org/W2171108647","https://openalex.org/W2280985989","https://openalex.org/W2460103661","https://openalex.org/W2137701513","https://openalex.org/W2060902067","https://openalex.org/W1984235853","https://openalex.org/W2906245407"],"abstract_inverted_index":{"What":[0,65],"is":[1,23,39,78,101],"already":[2],"known":[3],"about":[4],"this":[5,66,89,115],"subject":[6,285],"\u2022":[7,37,69,95,111],"The":[8,96,112,231],"initial":[9],"indication":[10],"for":[11,80,246,287],"endothelin":[12,74,148],"(ET)":[13],"receptor":[14,76,151],"antagonism":[15],"as":[16,241],"a":[17,139,146,209,303],"treatment":[18,82],"strategy,":[19],"primary":[20],"pulmonary":[21,33,84],"hypertension,":[22,85],"now":[24],"expanding":[25],"to":[26,41,55],"include":[27],"scleroderma,":[28],"which":[29],"can":[30],"cause":[31],"both":[32],"and":[34,86,128,157,182,226,268,289,291,299],"renal":[35,47,63,109,126,159,184,187,228,323],"disease.":[36],"It":[38],"important":[40],"understand":[42],"the":[43,50,81,135,224,239,243,279,283],"effects":[44],"of":[45,52,83,88,99,108,114,121,138,144,211,223,263,296,308],"impaired":[46,62,158,183,322],"function":[48,185],"on":[49],"pharmacokinetics":[51,316],"these":[53,297],"drugs":[54],"allow":[56,118],"appropriate":[57],"dosing":[58,120],"in":[59,91,103,123,153,171,221,282,314],"individuals":[60,124],"with":[61,105,125,155,173,319],"function.":[64,160,324],"study":[67,116,170],"adds":[68],"Sitaxsentan,":[70],"an":[71,164],"oral":[72,142,168,256,306],"selective":[73,147],"A":[75,150],"antagonist,":[77,152],"licensed":[79],"studies":[87],"drug":[90],"CKD":[92],"are":[93],"planned.":[94],"pharmacokinetic":[97,136],"profile":[98,137],"sitaxsentan":[100,122,234,309],"unchanged":[102],"subjects":[104,154,172,207,217,318],"varying":[106],"degrees":[107],"impairment.":[110],"results":[113],"will":[117],"confident":[119],"impairment,":[127],"inform":[129],"future":[130],"studies.":[131],"Aim":[132],"To":[133],"investigate":[134],"single":[140,167,304],"100\u2010mg":[141,305],"dose":[143,169,210,307],"sitaxsentan,":[145],"type":[149],"normal":[156,174,225,320],"Methods":[161],"This":[162],"was":[163,275],"open":[165],"label,":[166],"[creatinine":[175],"clearance":[176,257],"(CrCL)":[177],"\u2265":[178],"80":[179],"ml":[180,191,197,204,260],"min\u22121]":[181],"(mild":[186],"impairment":[188,194,200,229],"CrCL":[189,195,201],"51\u201380":[190],"min\u22121,":[192,198],"moderate":[193],"31\u201350":[196],"severe":[199],"\u2264":[202],"30":[203],"min\u22121).":[205],"All":[206],"received":[208],"100":[212],"mg":[213],"sitaxsentan.":[214],"Results":[215],"Twenty\u2010four":[216],"were":[218,236,242,311],"enrolled,":[219],"six":[220],"each":[222],"three":[227],"groups.":[230],"mean":[232,244],"plasma":[233],"concentrations":[235],"comparable":[237],"across":[238],"groups,":[240],"values":[245,286],"Cmax":[247],"(10.3\u201313.9":[248],"\u00b5g":[249],"ml\u22121),":[250,255],"AUC\u221e":[251],"(18.7\u201322.5":[252],"h":[253],"\u00b5g\u22121":[254],"(CL/F,":[258],"82.3\u201394.9":[259],"min\u22121),":[261],"volume":[262],"distribution":[264],"(Vz/F,":[265],"64.8\u201369.6":[266],"l)":[267],"elimination":[269],"half\u2010life":[270],"(t1/2,":[271],"8.6\u20139.6":[272],"h).":[273],"There":[274],"substantial":[276],"overlap":[277],"among":[278,317],"four":[280],"groups":[281],"individual":[284],"CL/F":[288],"Vz/F":[290],"no":[292,312],"relationship":[293],"between":[294],"either":[295],"parameters":[298],"CrCL.":[300],"Conclusion":[301],"After":[302],"there":[310],"differences":[313],"its":[315],"or":[321]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
