{"id":"https://openalex.org/W2006034098","doi":"https://doi.org/10.2174/187152208783790723","title":"Dynamins, Spermatogenesis and Contraceptive Development","display_name":"Dynamins, Spermatogenesis and Contraceptive Development","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2006034098","doi":"https://doi.org/10.2174/187152208783790723","mag":"2006034098"},"language":"en","primary_location":{"id":"doi:10.2174/187152208783790723","doi":"https://doi.org/10.2174/187152208783790723","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152208783790723","pdf_url":null,"source":{"id":"https://openalex.org/S4210228866","display_name":"Immunology Endocrine & Metabolic Agents - Medicinal Chemistry","issn_l":"1871-5222","issn":["1871-5222","1875-6115"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology\u201a Endocrine & Metabolic Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072413923","display_name":"C. Yan Cheng","orcid":"https://orcid.org/0000-0003-3117-3791","observed_orcids":["https://orcid.org/0000-0003-3117-3791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000133136","display_name":"Pearl P.Y. Lie","orcid":"https://orcid.org/0000-0001-5838-958X","observed_orcids":["https://orcid.org/0000-0001-5838-958X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pearl Lie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041273456","display_name":"Dolores D. Mruk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dolores Mruk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3859,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.71367969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"1","first_page":"51","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamin","display_name":"dynamin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dynamin-ii","display_name":"dynamin II","score":0.8500000238418579},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/blood-testis-barrier","display_name":"blood-testis barrier","score":0.9620000123977661},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/clathrin-independent-endocytosis","display_name":"clathrin-independent endocytosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8730000257492065},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.9620000123977661},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ectoplasmic-specialization","display_name":"ectoplasmic specialization","score":0.953000009059906},{"id":"https://openalex.org/keywords/tubulobulbar-complexes","display_name":"tubulobulbar complexes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/male-contraception","display_name":"male contraception","score":0.7419999837875366},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.6990000009536743},{"id":"https://openalex.org/keywords/seminiferous-epithelium","display_name":"seminiferous epithelium","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.8640053272247314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7367743253707886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6829063296318054},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.6314562559127808},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6007131934165955},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.5366994738578796},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4634179174900055},{"id":"https://openalex.org/C2636012","wikidata":"https://www.wikidata.org/wiki/Q489842","display_name":"Blood\u2013testis barrier","level":4,"score":0.45747897028923035},{"id":"https://openalex.org/C156407911","wikidata":"https://www.wikidata.org/wiki/Q420160","display_name":"Dynamin","level":4,"score":0.4314047694206238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17520955204963684},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1561855673789978},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1473616659641266},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.08818435668945312}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/187152208783790723","doi":"https://doi.org/10.2174/187152208783790723","is_oa":false,"landing_page_url":"https://doi.org/10.2174/187152208783790723","pdf_url":null,"source":{"id":"https://openalex.org/S4210228866","display_name":"Immunology Endocrine & Metabolic Agents - Medicinal Chemistry","issn_l":"1871-5222","issn":["1871-5222","1875-6115"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology\u201a Endocrine & Metabolic Agents in Medicinal Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2126065054","https://openalex.org/W2082741761","https://openalex.org/W2145562458","https://openalex.org/W2075229853","https://openalex.org/W2409928594","https://openalex.org/W2039795039","https://openalex.org/W1995616568","https://openalex.org/W7000516301","https://openalex.org/W2147965409","https://openalex.org/W2093187124"],"abstract_inverted_index":{"Dynamins":[0],"are":[1],"large":[2],"GTPases":[3],"of":[4,35,70,112,124,151],"\u223c100":[5],"kDa":[6],"known":[7],"to":[8,94,141,147,175,179],"participate":[9],"in":[10,19,32,66,106,130,153],"endocytosis":[11],"and":[12,60,84,97,133],"interact":[13],"with":[14,54],"the":[15,33,63,67,113,125,131,144,149,185],"actin-based":[16],"cytoskeletal":[17],"network":[18],"multiple":[20],"tissues.":[21],"Recent":[22],"studies":[23,47,146],"have":[24,48],"shown":[25,49],"that":[26,50,158],"dynamins":[27,129,152,159],"play":[28],"a":[29,103,169],"critical":[30,104],"role":[31,150],"internalization":[34],"integral":[36],"membrane":[37],"proteins":[38],"via":[39],"either":[40],"clathrin-mediated":[41],"or":[42,162],"clathrin-independent":[43],"endocytosis.":[44],"Furthermore,":[45],"recent":[46],"dynamin":[51],"II":[52],"interacts":[53],"junctional":[55],"complex":[56],"adaptors,":[57],"namely":[58],"ZO-1":[59],"\u03b2-catenin,":[61],"at":[62,109],"blood-testis":[64,91,192],"barrier":[65,92],"seminiferous":[68,114],"epithelium":[69],"adult":[71],"rat":[72],"testes.":[73],"This":[74],"interaction":[75],"may":[76],"be":[77,139],"responsible":[78],"for":[79,171],"pulling":[80],"away":[81],"tight":[82],"junction-":[83],"adherens":[85,198],"junction-based":[86],"protein":[87,165],"complexes,":[88],"thereby":[89],"facilitating":[90],"opening":[93],"permit":[95],"preleptotene":[96],"leptotene":[98],"spermatocyte":[99],"migration,":[100],"which":[101],"is":[102,156],"event":[105],"spermatogenesis":[107],"occurring":[108],"stage":[110],"VIII":[111],"epithelial":[115],"cycle.":[116],"In":[117],"this":[118,136],"short":[119],"review,":[120],"we":[121],"highlight":[122],"some":[123],"latest":[126],"findings":[127],"on":[128],"field,":[132],"discuss":[134],"how":[135],"information":[137],"can":[138,167],"used":[140],"further":[142],"expand":[143],"functional":[145],"tackle":[148],"spermatogenesis.":[154],"It":[155],"likely":[157],"per":[160],"se":[161],"their":[163],"interacting":[164],"partners":[166],"become":[168],"target":[170],"male":[172,181],"contraceptive":[173],"research":[174],"compromise":[176],"spermatogenesis,":[177],"leading":[178],"transient":[180],"infertility":[182],"without":[183],"perturbing":[184],"hypothalamic-pituitary-testicular":[186],"axis.":[187],"Keywords:":[188],"Testis,":[189],"GTPases,":[190],"dynamins,":[191],"barrier,":[193],"ectoplasmic":[194],"specialization,":[195],"tubulobulbar":[196],"complex,":[197],"junction,":[199,201],"anchoring":[200],"Sertoli":[202],"cells":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2016-06-24T00:00:00"}