{"id":"https://openalex.org/W2006023485","doi":"https://doi.org/10.1016/j.bpj.2012.11.2972","title":"Probing the Structural Origins of Unusually Strong Target Membrane Affinity of Synaptotagmin 7 C2A and C2Ab Domains","display_name":"Probing the Structural Origins of Unusually Strong Target Membrane Affinity of Synaptotagmin 7 C2A and C2Ab Domains","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2006023485","doi":"https://doi.org/10.1016/j.bpj.2012.11.2972","mag":"2006023485"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2012.11.2972","doi":"https://doi.org/10.1016/j.bpj.2012.11.2972","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2012.11.2972","pdf_url":"http://www.cell.com/article/S000634951204218X/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S000634951204218X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072618329","display_name":"Beatriz Salazar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatriz Salazar","raw_affiliation_strings":["University of Colorado, Denver, DENVER, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Denver, DENVER, CO, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065135605","display_name":"Devin S. Brandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin S. Brandt","raw_affiliation_strings":["University of Colorado Denver, Denver, CO, USA","University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver, Denver, CO, USA","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037954668","display_name":"Matthew D. Coffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Coffman","raw_affiliation_strings":["University of Colorado, Denver, DENVER, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Denver, DENVER, CO, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008303385","display_name":"J. Ryan Osterberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Ryan Osterberg","raw_affiliation_strings":["University of Colorado, Denver, DENVER, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Denver, DENVER, CO, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082355606","display_name":"Kan Chantranuvatana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kan Chantranuvatana","raw_affiliation_strings":["University of Colorado, Denver, DENVER, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Denver, DENVER, CO, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052976771","display_name":"Joseph J. Falke","orcid":"https://orcid.org/0000-0002-3704-4694","observed_orcids":["https://orcid.org/0000-0002-3704-4694"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph J. Falke","raw_affiliation_strings":["University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046226962","display_name":"Jefferson D. Knight","orcid":"https://orcid.org/0000-0003-2208-4420","observed_orcids":["https://orcid.org/0000-0003-2208-4420"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jefferson Knight","raw_affiliation_strings":["University of Colorado, Denver, DENVER, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado, Denver, DENVER, CO, USA","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08127664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"2","first_page":"537a","last_page":"537a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptotagmin-7","display_name":"synaptotagmin 7","score":0.9789999723434448},{"id":"https://openalex.org/keywords/c2a-domain","display_name":"C2A domain","score":0.9629999995231628},{"id":"https://openalex.org/keywords/membrane-docking","display_name":"membrane docking","score":0.47699999809265137},{"id":"https://openalex.org/keywords/calcium-sensitivity","display_name":"calcium sensitivity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/vesicle-fusion","display_name":"vesicle fusion","score":0.7269999980926514},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/protein-membrane-interactions","display_name":"protein-membrane interactions","score":0.5929999947547913},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.44600000977516174},{"id":"https://openalex.org/keywords/protein-protein-contacts","display_name":"protein-protein contacts","score":0.6269999742507935},{"id":"https://openalex.org/keywords/synaptotagmin-1","display_name":"synaptotagmin-1","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C86473631","wikidata":"https://www.wikidata.org/wiki/Q18031809","display_name":"Synaptotagmin 1","level":5,"score":0.847506046295166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6899436712265015},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.607471227645874},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5661925673484802},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.5340486764907837},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.510749340057373},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.5018870830535889},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.41893231868743896},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.3709794878959656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34040379524230957},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.23346972465515137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1670183539390564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2012.11.2972","doi":"https://doi.org/10.1016/j.bpj.2012.11.2972","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2012.11.2972","pdf_url":"http://www.cell.com/article/S000634951204218X/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2012.11.2972","doi":"https://doi.org/10.1016/j.bpj.2012.11.2972","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2012.11.2972","pdf_url":"http://www.cell.com/article/S000634951204218X/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2006023485.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995952267","https://openalex.org/W1418660035","https://openalex.org/W1988516903","https://openalex.org/W2463635772","https://openalex.org/W1224729583","https://openalex.org/W2560738186","https://openalex.org/W2058033043","https://openalex.org/W2326261425","https://openalex.org/W2886589052","https://openalex.org/W2793316565"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}