{"id":"https://openalex.org/W2006023434","doi":"https://doi.org/10.1111/apt.12336","title":"Letter: assessment of safety and efficacy of mesalazine in Indian patients with ulcerative colitis","display_name":"Letter: assessment of safety and efficacy of mesalazine in Indian patients with ulcerative colitis","publication_year":2013,"publication_date":"2013-06-06","ids":{"openalex":"https://openalex.org/W2006023434","doi":"https://doi.org/10.1111/apt.12336","mag":"2006023434","pmid":"https://pubmed.ncbi.nlm.nih.gov/23738791"},"language":"en","primary_location":{"id":"doi:10.1111/apt.12336","doi":"https://doi.org/10.1111/apt.12336","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.12336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.12336","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.12336","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052681520","display_name":"Jacob B Jayan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802466914","display_name":"T. D. Medical College","ror":"https://ror.org/039k9pj72","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802466914"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. B. Jayan","raw_affiliation_strings":["Govt. Medical College, Alappuzha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Govt. Medical College, Alappuzha, India","institution_ids":["https://openalex.org/I2802466914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113930456","display_name":"M.A. Habeeb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. A. Habeeb","raw_affiliation_strings":["Owaisi Hospital Hyderabad India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Owaisi Hospital Hyderabad India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046991799","display_name":"Bailuru Vishwanath Tantry","orcid":"https://orcid.org/0000-0003-3039-6862","observed_orcids":["https://orcid.org/0000-0003-3039-6862"]},"institutions":[{"id":"https://openalex.org/I4387153400","display_name":"Kasturba Medical College, Mangalore","ror":"https://ror.org/048vk1h54","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I4387153400"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V. B. Tantry","raw_affiliation_strings":["KMC Hospital Mangalore India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KMC Hospital Mangalore India","institution_ids":["https://openalex.org/I4387153400"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Yarlagadda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145498","display_name":"MaxCure Hospitals","ror":"https://ror.org/055cmzr24","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210145498"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N. Yarlagadda","raw_affiliation_strings":["Mediciti Hospitals Hyderabad India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mediciti Hospitals Hyderabad India","institution_ids":["https://openalex.org/I4210145498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076057471","display_name":"Abraham Koshy","orcid":"https://orcid.org/0000-0002-9997-6569","observed_orcids":["https://orcid.org/0000-0002-9997-6569"]},"institutions":[{"id":"https://openalex.org/I2799617311","display_name":"Lakeshore Hospital","ror":"https://ror.org/01dm18990","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2799617311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. Koshy","raw_affiliation_strings":["Lakeshore Hospital; Kochi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lakeshore Hospital; Kochi India","institution_ids":["https://openalex.org/I2799617311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066914737","display_name":"Ubal Dhus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327930874","display_name":"Apollo Hospitals","ror":"https://ror.org/02ew45630","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1327930874"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"U. Dhus","raw_affiliation_strings":["Apollo Hospitals Chennai India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apollo Hospitals Chennai India","institution_ids":["https://openalex.org/I1327930874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078495176","display_name":"Binny Krishnankutty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117495","display_name":"Dr. Reddy's Laboratories (India)","ror":"https://ror.org/01rkxa860","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210117495"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B. Krishnankutty","raw_affiliation_strings":["Dr. Reddy's Laboratories Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Reddy's Laboratories Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210117495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109978812","display_name":"LathaSubramanya Moodahadu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117495","display_name":"Dr. Reddy's Laboratories (India)","ror":"https://ror.org/01rkxa860","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210117495"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"L. S. Moodahadu","raw_affiliation_strings":["Dr. Reddy's Laboratories Ltd, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Reddy's Laboratories Ltd, Hyderabad, India","institution_ids":["https://openalex.org/I4210117495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5109978812"],"corresponding_institution_ids":["https://openalex.org/I4210117495"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"1","first_page":"74","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/indian-patients","display_name":"Indian patients","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.8519999980926514},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.6959999799728394},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6179999709129333},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8519999980926514},{"id":"https://openalex.org/keywords/low-haemoglobin","display_name":"low haemoglobin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5609999895095825},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5149999856948853},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.48899999260902405},{"id":"https://openalex.org/keywords/open-label-extension-studies","display_name":"open-label extension studies","score":0.42800000309944153},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.45100000500679016},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9390302300453186},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8157559633255005},{"id":"https://openalex.org/C2779174533","wikidata":"https://www.wikidata.org/wiki/Q412479","display_name":"Mesalazine","level":4,"score":0.6985674500465393},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6948280930519104},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6917210817337036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6197524666786194},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5499550104141235},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4582066535949707},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1807418167591095}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/apt.12336","doi":"https://doi.org/10.1111/apt.12336","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.12336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.12336","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:23738791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23738791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1111/apt.12336","doi":"https://doi.org/10.1111/apt.12336","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apt.12336","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apt.12336","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006023434.pdf","grobid_xml":"https://content.openalex.org/works/W2006023434.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2081888431"],"related_works":["https://openalex.org/W3031938560","https://openalex.org/W2018842389","https://openalex.org/W3206030161","https://openalex.org/W2600014798","https://openalex.org/W7223400048","https://openalex.org/W2928271814","https://openalex.org/W4382599827","https://openalex.org/W4303422244","https://openalex.org/W2369616795","https://openalex.org/W7037541407"],"abstract_inverted_index":{"With":[0],"reference":[1],"to":[2,12,117,275,285,288,305],"the":[3,17,76,86,92,108,113,143,291,333],"recent":[4],"article":[5],"by":[6,81,393],"Flourie":[7],"et":[8],"al.,1":[9],"we":[10],"wish":[11],"convey":[13],"our":[14,306],"findings":[15],"on":[16],"efficacy,":[18],"safety":[19,303],"and":[20,59,138,165,173,184,233,269,328,339,357],"tolerability":[21],"of":[22,104,136,145,309,345,354,363,370,383,386],"mesalazine":[23],"extended":[24,296],"release":[25,297],"(MER)":[26],"in":[27,107,155,182,201,219,253,266,361],"Indian":[28],"patients":[29,268],"with":[30,51,163,170,192,246,301],"mild-to-moderate":[31],"ulcerative":[32],"colitis":[33],"(UC)":[34],"assessed":[35],"through":[36],"an":[37,352],"8-week,":[38],"prospective,":[39],"open":[40],"label,":[41],"noncomparative":[42],"study.":[43],"Patients":[44],"(n":[45],"=":[46,49],"62,":[47],"men":[48],"47)":[50],"UC":[52],"disease":[53],"activity":[54],"index":[55],"(UCDAI)":[56],"score":[57,78,110,158],"\u22653":[58],"\u22648":[60],"were":[61,142,186,264],"administered":[62],"2.4":[63],"g":[64],"MER":[65],"once":[66,119],"daily,":[67],"for":[68,91,121],"4":[69,94,124,161,172,194],"weeks":[70],"initially.":[71],"At":[72],"week":[73,160,167,171,189,193,260],"4,":[74],"if":[75],"UCDAI":[77,109,126,157,220],"was":[79,89,98,115,148,199,223,240,272,283,290,391],"reduced":[80],"\u22652":[82],"points":[83],"from":[84,111],"baseline,":[85,112,164],"same":[87],"dose":[88,114,209,258],"continued":[90],"next":[93],"weeks.":[95,125],"If":[96],"there":[97],"no":[99],"reduction":[100,103,154,215,252],"or":[101],"a":[102,122,149,212,224,247,256,359],"1":[105],"point":[106],"increased":[116],"4.8g/day":[118],"daily":[120],"further":[123],"score,":[127],"investigator's":[128],"global":[129,133],"assessment":[130,134],"(IGA),":[131],"patient's":[132],"(PGA)":[135],"efficacy":[137],"adverse":[139],"events":[140],"(AE)":[141],"outcomes":[144],"interest.":[146,346,384],"There":[147,222],"significant":[150,225,248],"(P":[151,178,216,249],"<":[152,179,217,229,250],"0.001)":[153,180,218,230,251],"mean":[156],"at":[159,166,188,259],"compared":[162,169,191],"8":[168,190],"baseline":[174],"(Table":[175],"1).":[176,196],"Significant":[177],"increases":[181],"remission":[183],"improvement":[185],"observed":[187],"(Fig":[195],"Dose":[197],"up-titration":[198,210],"required":[200],"28":[202],"patients.":[203,307],"Those":[204],"who":[205,335],"did":[206],"not":[207,341,379],"require":[208],"showed":[211],"significantly":[213],"greater":[214],"score.":[221],"agreement":[226],"(71%,":[227],"P":[228],"between":[231],"IGA":[232],"PGA":[234],"(kappa":[235],"statistic":[236],"0.58).":[237],"Overall":[238],"compliance":[239],"96%":[241],"(standard":[242],"deviation":[243],"\u00b1":[244],"2.8%)":[245],"those":[254],"receiving":[255],"higher":[257],"4.":[261],"Eleven":[262],"AEs":[263],"reported":[265],"10":[267],"one":[270],"AE":[271],"\u2018probably\u2019":[273],"related":[274],"mesalazine.":[276],"Low":[277],"haemoglobin":[278],"[4":[279],"(6.5%)":[280],"patients],":[281],"which":[282],"unlikely":[284],"be":[286],"due":[287],"mesalazine,":[289],"most":[292],"common":[293],"AE.":[294],"Mesalazine":[295],"offered":[298],"therapeutic":[299],"benefit":[300],"good":[302],"profile":[304],"Declaration":[308,385],"personal":[310],"interests:":[311,388],"Dr":[312,315,319,324,329,347,365,371,394],"Abraham":[313],"Koshy,":[314],"Jacob":[316],"Jayan":[317],"B,":[318],"Mohammed":[320],"Aejaz":[321],"Habeeb,":[322],"Dr.NagarjunaYarlagadda,":[323],"Tantry":[325],"B":[326],"Vishwanath":[327],"Ubal":[330],"Dhus":[331],"are":[332],"investigators":[334],"conducted":[336],"this":[337],"study":[338,390],"do":[340],"have":[342,380],"any":[343,381],"conflict":[344,382],"L.":[348],"S.":[349],"Moodahadu":[350],"is":[351],"employee":[353,369],"Sponsor":[355],"Company":[356],"has":[358],"stake":[360],"terms":[362],"salary.":[364],"B.":[366],"Krishnankutty,":[367],"former":[368],"Reddy's":[372,395],"Laboratories":[373,396],"Ltd.,":[374,397],"Hyderabad,":[375,398],"India":[376],"currently":[377],"does":[378],"funding":[387],"This":[389],"sponsored":[392],"India.":[399]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}