{"id":"https://openalex.org/W2006016855","doi":"https://doi.org/10.1016/0005-2736(82)90595-8","title":"Na+ channels and amiloride-induced noise in the mammalian colon epithelium","display_name":"Na+ channels and amiloride-induced noise in the mammalian colon epithelium","publication_year":1982,"publication_date":"1982-05-01","ids":{"openalex":"https://openalex.org/W2006016855","doi":"https://doi.org/10.1016/0005-2736(82)90595-8","mag":"2006016855","pmid":"https://pubmed.ncbi.nlm.nih.gov/6284228"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2736(82)90595-8","doi":"https://doi.org/10.1016/0005-2736(82)90595-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2736(82)90595-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113527752","display_name":"Wolfgang Zeiske","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Zeiske","raw_affiliation_strings":["Laboratorium voor Fysiologie, Campus Gasthuisberg, B-3000 Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorium voor Fysiologie, Campus Gasthuisberg, B-3000 Leuven Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001975548","display_name":"Nancy K. Wills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy K. Wills","raw_affiliation_strings":["Department of Physiology, Yale University, 333 Cedar Street, New Haven, CT U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Yale University, 333 Cedar Street, New Haven, CT U.S.A","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104475109","display_name":"Willy Van Driessche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Willy Van Driessche","raw_affiliation_strings":["Laboratorium voor Fysiologie, Campus Gasthuisberg, B-3000 Leuven Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorium voor Fysiologie, Campus Gasthuisberg, B-3000 Leuven Belgium","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":3.4007,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.93258783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"688","issue":"1","first_page":"201","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.08959999680519104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-channels","display_name":"sodium channels","score":0.8410000205039978},{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":0.9980000257492065},{"id":"https://openalex.org/keywords/colonic-epithelium","display_name":"colonic epithelium","score":0.8100000023841858},{"id":"https://openalex.org/keywords/short-circuit-current","display_name":"short-circuit current","score":0.8420000076293945},{"id":"https://openalex.org/keywords/single-channel-currents","display_name":"single-channel currents","score":0.6439999938011169},{"id":"https://openalex.org/keywords/channel-density","display_name":"channel density","score":0.6690000295639038},{"id":"https://openalex.org/keywords/activation-energy","display_name":"activation energy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tight-epithelia","display_name":"tight epithelia","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.9358434081077576},{"id":"https://openalex.org/C6507245","wikidata":"https://www.wikidata.org/wiki/Q424948","display_name":"Epithelial sodium channel","level":3,"score":0.5802747011184692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.569958508014679},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4878501892089844},{"id":"https://openalex.org/C153461711","wikidata":"https://www.wikidata.org/wiki/Q5072487","display_name":"Channel blocker","level":3,"score":0.4805929362773895},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3470827043056488},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.23173615336418152},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.06112945079803467},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.05914309620857239},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2736(82)90595-8","doi":"https://doi.org/10.1016/0005-2736(82)90595-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2736(82)90595-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},{"id":"pmid:6284228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6284228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1971849369","https://openalex.org/W1998333223","https://openalex.org/W2004406632","https://openalex.org/W2010422198","https://openalex.org/W2021462079","https://openalex.org/W2022449248","https://openalex.org/W2033970084","https://openalex.org/W2040801479","https://openalex.org/W2043717585","https://openalex.org/W2051381705","https://openalex.org/W2057579989","https://openalex.org/W2062392489","https://openalex.org/W2063855102","https://openalex.org/W2064359124","https://openalex.org/W2067823823","https://openalex.org/W2093134815","https://openalex.org/W2112924546","https://openalex.org/W2120003464","https://openalex.org/W2150922838","https://openalex.org/W2920633646"],"related_works":["https://openalex.org/W2280264547","https://openalex.org/W2333786349","https://openalex.org/W2062209168","https://openalex.org/W2009327273","https://openalex.org/W2010643621","https://openalex.org/W2052465981","https://openalex.org/W2035640265","https://openalex.org/W2055765138","https://openalex.org/W2057547581","https://openalex.org/W1979790452"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}