{"id":"https://openalex.org/W2005999591","doi":"https://doi.org/10.3109/08830189509056700","title":"V\u03b2 Gene Repertoire in the Aging Mouse: A Developmental Perspective","display_name":"V\u03b2 Gene Repertoire in the Aging Mouse: A Developmental Perspective","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2005999591","doi":"https://doi.org/10.3109/08830189509056700","mag":"2005999591","pmid":"https://pubmed.ncbi.nlm.nih.gov/7595012"},"language":"en","primary_location":{"id":"doi:10.3109/08830189509056700","doi":"https://doi.org/10.3109/08830189509056700","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08830189509056700","pdf_url":null,"source":{"id":"https://openalex.org/S19733918","display_name":"International Reviews of Immunology","issn_l":"0883-0185","issn":["0883-0185","1026-8006","1563-5244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Reviews of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020312110","display_name":"Rosana Gonz\u00e1lez\u2010Quintial","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosana Gonz\u00e1lez-Quintial","raw_affiliation_strings":["Scripps Research Institute, Department of Immunology, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Department of Immunology, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088597500","display_name":"Roberto Baccal\u00e0","orcid":"https://orcid.org/0000-0002-3159-8469","observed_orcids":["https://orcid.org/0000-0002-3159-8469"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Baccal\u00e0","raw_affiliation_strings":["The Scripps Research Institute, Department of Immunology, La Jolla, CaliforniaUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, Department of Immunology, La Jolla, CaliforniaUSA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072501858","display_name":"ROBERT S. BALDERAS","orcid":"https://orcid.org/0000-0002-8734-8629","observed_orcids":["https://orcid.org/0000-0002-8734-8629"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Balderas","raw_affiliation_strings":["The Scripps Research Institute, Department of Immunology, La Jolla, CaliforniaUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, Department of Immunology, La Jolla, CaliforniaUSA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108420436","display_name":"Argyrios N. Theofilopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Argyrios N. Theofilopoulos","raw_affiliation_strings":["The Scripps Research Institute, Department of Immunology, La Jolla, CaliforniaUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, Department of Immunology, La Jolla, CaliforniaUSA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":0.2193,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.27150538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":"27","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8109999895095825},{"id":"https://openalex.org/keywords/aging-immune-system","display_name":"aging immune system","score":0.7620000243186951},{"id":"https://openalex.org/keywords/thymic-involution","display_name":"thymic involution","score":0.843999981880188},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.5730000138282776},{"id":"https://openalex.org/keywords/positive-and-negative-selection","display_name":"positive and negative selection","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lupus","display_name":"lupus","score":0.6940000057220459},{"id":"https://openalex.org/keywords/fas-gene","display_name":"FAS gene","score":0.871999979019165},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/fetal-and-neonatal-development","display_name":"fetal and neonatal development","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7835954427719116},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6448159217834473},{"id":"https://openalex.org/C2777314012","wikidata":"https://www.wikidata.org/wiki/Q7799617","display_name":"Thymic involution","level":4,"score":0.6033643484115601},{"id":"https://openalex.org/C36333154","wikidata":"https://www.wikidata.org/wiki/Q772950","display_name":"Superantigen","level":4,"score":0.5427485108375549},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5410008430480957},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5378308892250061},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5315717458724976},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4814683496952057},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4720505177974701},{"id":"https://openalex.org/C2781409172","wikidata":"https://www.wikidata.org/wiki/Q17056802","display_name":"Involution (esoterism)","level":3,"score":0.4690896272659302},{"id":"https://openalex.org/C2777868816","wikidata":"https://www.wikidata.org/wiki/Q5134952","display_name":"Clonal deletion","level":5,"score":0.4172288179397583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38764098286628723},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3293142020702362},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.29134243726730347},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13905936479568481},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08830189509056700","doi":"https://doi.org/10.3109/08830189509056700","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08830189509056700","pdf_url":null,"source":{"id":"https://openalex.org/S19733918","display_name":"International Reviews of Immunology","issn_l":"0883-0185","issn":["0883-0185","1026-8006","1563-5244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Reviews of Immunology","raw_type":"journal-article"},{"id":"pmid:7595012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7595012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International reviews of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6800000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1696621559","display_name":"T CELL RECEPTOR GENE REPERTOIRE IN AGING","funder_award_id":"7r01ag009430-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1870729294","display_name":null,"funder_award_id":"AG-09430","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G273090450","display_name":null,"funder_award_id":"AR31203","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5272301047","display_name":"T Cell Homeostasis in Systemic Autoimmunity","funder_award_id":"R01AR031203","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320312826","display_name":"Massachusetts Life Sciences Center","ror":"https://ror.org/033km2469"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W216228190","https://openalex.org/W1215373674","https://openalex.org/W1430328160","https://openalex.org/W1479707669","https://openalex.org/W1481979720","https://openalex.org/W1505469822","https://openalex.org/W1531134742","https://openalex.org/W1548380108","https://openalex.org/W1559705382","https://openalex.org/W1563796887","https://openalex.org/W1584796166","https://openalex.org/W1588093675","https://openalex.org/W1599176230","https://openalex.org/W1671694443","https://openalex.org/W1674251039","https://openalex.org/W1679376704","https://openalex.org/W1680049018","https://openalex.org/W1834649693","https://openalex.org/W1834783482","https://openalex.org/W1928409557","https://openalex.org/W1934463538","https://openalex.org/W1965322366","https://openalex.org/W1972354503","https://openalex.org/W1975868741","https://openalex.org/W1977546470","https://openalex.org/W1979836429","https://openalex.org/W1990159938","https://openalex.org/W1995179449","https://openalex.org/W1995833795","https://openalex.org/W1996822762","https://openalex.org/W1997208169","https://openalex.org/W1997251774","https://openalex.org/W1999952681","https://openalex.org/W2016471634","https://openalex.org/W2018416540","https://openalex.org/W2019638830","https://openalex.org/W2022847127","https://openalex.org/W2025036070","https://openalex.org/W2028111124","https://openalex.org/W2030568053","https://openalex.org/W2031011895","https://openalex.org/W2035339960","https://openalex.org/W2036109455","https://openalex.org/W2037367542","https://openalex.org/W2042371846","https://openalex.org/W2044512941","https://openalex.org/W2046848558","https://openalex.org/W2048232849","https://openalex.org/W2068804204","https://openalex.org/W2087526889","https://openalex.org/W2090121937","https://openalex.org/W2090896399","https://openalex.org/W2091080603","https://openalex.org/W2099127242","https://openalex.org/W2120409395","https://openalex.org/W2123787609","https://openalex.org/W2133908456","https://openalex.org/W2140489687","https://openalex.org/W2142490832","https://openalex.org/W2145520919","https://openalex.org/W2148406205","https://openalex.org/W2150288775","https://openalex.org/W2152508168","https://openalex.org/W2154503489","https://openalex.org/W2162032607","https://openalex.org/W2164432743","https://openalex.org/W2165748470","https://openalex.org/W2172466148","https://openalex.org/W2227157639","https://openalex.org/W2416387514","https://openalex.org/W2423620718","https://openalex.org/W4211183850","https://openalex.org/W4232753482"],"related_works":["https://openalex.org/W1588093675","https://openalex.org/W2039913670","https://openalex.org/W2074350902","https://openalex.org/W2101087277","https://openalex.org/W1676343675","https://openalex.org/W1525884246","https://openalex.org/W2030731868","https://openalex.org/W2021265202","https://openalex.org/W1680560833","https://openalex.org/W2409769693"],"abstract_inverted_index":{"To":[0],"define":[1],"age-associated":[2,197],"alterations":[3,198],"in":[4,87,127,173,180,199,209],"the":[5,9,22,58,62,67,138,174,210],"immune":[6,200],"system":[7],"at":[8,21,61],"molecular":[10],"level,":[11],"we":[12],"have":[13],"analyzed":[14],"TCR":[15,212],"V":[16,34,39,117,132,162],"beta":[17,40,118,163],"gene":[18,177],"expression":[19,128],"patterns":[20],"fetal,":[23],"neonatal,":[24],"adult,":[25],"and":[26,36,94,112,141,151,165],"advanced":[27,124],"ages":[28],"of":[29,71,158],"mice.":[30],"In":[31],"contrast":[32],"to":[33,47,105],"gamma":[35],"VH":[37],"genes,":[38],"genes":[41],"rearranged":[42],"without":[43],"any":[44,206],"preference":[45],"related":[46],"their":[48],"chromosomal":[49],"organization.":[50],"Endogenous":[51],"superantigen-mediated":[52],"clonal":[53,191],"deletions":[54],"were":[55,78,146,155,178],"registered":[56],"for":[57,130],"first":[59],"time":[60],"neonatal":[63],"stage,":[64],"presumably":[65,142],"reflecting":[66,143],"late":[68],"developmental":[69],"appearance":[70],"these":[72],"molecules.":[73],"Such":[74],"deletions,":[75],"once":[76],"established,":[77],"maintained":[79,102],"throughout":[80],"life":[81],"with":[82,123,137,149,169],"little,":[83],"if":[84],"any,":[85],"leakage":[86],"this":[88,181],"process.":[89],"Furthermore,":[90],"bone":[91],"marrow":[92],"transplantation":[93],"other":[95],"studies":[96],"indicated":[97],"that":[98],"an":[99],"involuted":[100],"thymus":[101],"its":[103,108],"capacity":[104],"perform":[106],"both":[107],"functions,":[109],"i.e.":[110],"positive":[111],"negative":[113],"selection.":[114],"Although":[115],"overall":[116,211],"repertoires":[119],"showed":[120],"remarkable":[121],"stability":[122],"age,":[125],"modifications":[126],"levels":[129],"some":[131,189],"beta,":[133],"particularly":[134],"those":[135],"associated":[136],"CD8":[139],"subset":[140],"antigenic":[144,195],"stimulation,":[145,196],"recorded.":[147],"Mice":[148],"lupus":[150,167],"early-life":[152],"thymic":[153],"involution":[154],"fully":[156],"capable":[157],"deleting":[159],"endogenous":[160],"superantigen-reactive":[161],"clones,":[164],"even":[166],"mice":[168],"a":[170],"genetic":[171],"defect":[172],"apoptosis-promoting":[175],"Fas":[176],"normal":[179],"regard.":[182],"The":[183],"results":[184],"indicate":[185],"that,":[186],"aside":[187],"from":[188],"anticipated":[190],"expansions":[192],"induced":[193],"by":[194,205],"functions":[201],"are":[202],"not":[203],"caused":[204],"profound":[207],"changes":[208],"repertoire.":[213]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}