{"id":"https://openalex.org/W2005961440","doi":"https://doi.org/10.1111/j.1526-4610.2007.00719.x","title":"Insulin Metabolism is Altered in Migraineurs: A New Pathogenic Mechanism for Migraine?","display_name":"Insulin Metabolism is Altered in Migraineurs: A New Pathogenic Mechanism for Migraine?","publication_year":2007,"publication_date":"2007-02-22","ids":{"openalex":"https://openalex.org/W2005961440","doi":"https://doi.org/10.1111/j.1526-4610.2007.00719.x","mag":"2005961440","pmid":"https://pubmed.ncbi.nlm.nih.gov/18052953"},"language":"en","primary_location":{"id":"doi:10.1111/j.1526-4610.2007.00719.x","doi":"https://doi.org/10.1111/j.1526-4610.2007.00719.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1526-4610.2007.00719.x","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007748007","display_name":"Cinzia Cavestro","orcid":"https://orcid.org/0000-0003-1172-1009","observed_orcids":["https://orcid.org/0000-0003-1172-1009"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Cavestro","raw_affiliation_strings":["Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","institution_ids":[]},{"raw_affiliation_string":"From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035681074","display_name":"Annalisa Rosatello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Rosatello","raw_affiliation_strings":["Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","institution_ids":[]},{"raw_affiliation_string":"From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067394281","display_name":"Gianmatteo Micca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"GianMatteo Micca","raw_affiliation_strings":["Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","institution_ids":[]},{"raw_affiliation_string":"From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070077527","display_name":"Marisa Ravotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marisa Ravotto","raw_affiliation_strings":["Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","institution_ids":[]},{"raw_affiliation_string":"From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101863031","display_name":"Maria Marino","orcid":"https://orcid.org/0000-0001-8063-6743","observed_orcids":["https://orcid.org/0000-0001-8063-6743"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Pia Marino","raw_affiliation_strings":["Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","institution_ids":[]},{"raw_affiliation_string":"From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012374595","display_name":"G. Asteggiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Asteggiano","raw_affiliation_strings":["Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","institution_ids":[]},{"raw_affiliation_string":"From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080587787","display_name":"Ettore Beghi","orcid":"https://orcid.org/0000-0003-2542-0469","observed_orcids":["https://orcid.org/0000-0003-2542-0469"]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ettore Beghi","raw_affiliation_strings":["Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Rosatello)","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Marino)","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Asteggiano)","institution_ids":[]},{"raw_affiliation_string":"From the Headache Center, Department of Neurology, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Cavestro)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Biochemistry, \"San Lazzaro\" Hospital, Alba, Italy (Dr. Micca and Mrs. Ravotto)","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurological Disorders, Istituto di Ricerche Farmacologiche \"Mario Negri,\" Milan, Italy (Dr. Beghi)","institution_ids":["https://openalex.org/I19630809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19630809"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.5309,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.92099172,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"0","issue":"0","first_page":"070222151332009","last_page":"1442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11929","display_name":"Cerebral Venous Sinus Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/insulin-metabolism","display_name":"insulin metabolism","score":0.8809999823570251},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9089999794960022},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7419999837875366},{"id":"https://openalex.org/keywords/insulin-levels","display_name":"insulin levels","score":0.8529999852180481},{"id":"https://openalex.org/keywords/migraine-pathogenesis","display_name":"migraine pathogenesis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/oral-glucose-tolerance-test","display_name":"oral glucose tolerance test","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.9106113910675049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8139629364013672},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7783339023590088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7579245567321777},{"id":"https://openalex.org/C2780966972","wikidata":"https://www.wikidata.org/wiki/Q86","display_name":"Headaches","level":2,"score":0.7147565484046936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6104813814163208},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4902854263782501},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.46280235052108765},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10328933596611023}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006261","descriptor_name":"Headache","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1526-4610.2007.00719.x","doi":"https://doi.org/10.1111/j.1526-4610.2007.00719.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1526-4610.2007.00719.x","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},{"id":"doi:10.1111/j.1526-4610.2006.00719.x","doi":"https://doi.org/10.1111/j.1526-4610.2006.00719.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1526-4610.2006.00719.x","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},{"id":"pmid:18052953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18052953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W48858401","https://openalex.org/W172206944","https://openalex.org/W202612886","https://openalex.org/W824745094","https://openalex.org/W1578931571","https://openalex.org/W1605899467","https://openalex.org/W1963748811","https://openalex.org/W1966773831","https://openalex.org/W1971466761","https://openalex.org/W1971911315","https://openalex.org/W1996498907","https://openalex.org/W1997131808","https://openalex.org/W2008180402","https://openalex.org/W2014074875","https://openalex.org/W2030893161","https://openalex.org/W2035832718","https://openalex.org/W2038218097","https://openalex.org/W2041014915","https://openalex.org/W2045567183","https://openalex.org/W2062284311","https://openalex.org/W2070989337","https://openalex.org/W2074082327","https://openalex.org/W2075321850","https://openalex.org/W2075668179","https://openalex.org/W2082095188","https://openalex.org/W2089807279","https://openalex.org/W2096884778","https://openalex.org/W2110210537","https://openalex.org/W2114706736","https://openalex.org/W2114978780","https://openalex.org/W2123431738","https://openalex.org/W2132802847","https://openalex.org/W2155916559","https://openalex.org/W2178492210","https://openalex.org/W4246003883"],"related_works":["https://openalex.org/W2737201081","https://openalex.org/W4412844310","https://openalex.org/W2010722900","https://openalex.org/W2134310649","https://openalex.org/W2077306997","https://openalex.org/W4220811154","https://openalex.org/W1972930600","https://openalex.org/W2796331606","https://openalex.org/W4309074173","https://openalex.org/W2315665620"],"abstract_inverted_index":{"BACKGROUND:":[0],"Migraine":[1],"is":[2,270],"a":[3,9,87,94,105,136,166,192],"complex":[4],"biochemical":[5],"dysfunction":[6],"attributed":[7],"to":[8,37,165,203,229,232,243,265],"disorder":[10],"of":[11,18,43,257,275],"the":[12,44,255,266,273],"trigeminal":[13],"and":[14,30,46,56,58,62,76,86,97,99,125,158,164,172,209,240,262],"hypothalamic":[15],"pathways.":[16],"Impairment":[17],"glucose":[19,45,55,90,98,142,217],"metabolism":[20],"has":[21],"been":[22],"reported":[23],"in":[24,222,238,249,272],"migraine,":[25,75],"but":[26,147,225],"data":[27],"are":[28,248],"scanty":[29],"inconsistent.":[31],"OBJECTIVE:":[32],"The":[33,152,196],"main":[34],"aim":[35],"was":[36,183,198],"verify":[38],"whether":[39],"migraineurs":[40,111],"have":[41],"abnormalities":[42],"insulin":[47,57,60,100,187,258,269],"metabolism.":[48],"We":[49],"also":[50,184],"studied":[51],"correlations":[52],"between":[53,59,139,156,169,181],"blood":[54,84],"levels":[61,143,218,235],"migraine":[63,70,157,201],"severity.":[64],"PATIENTS":[65],"AND":[66],"METHODS:":[67],"Patients":[68],"with":[69,118,191,251],"or":[71],"headache":[72,120,223],"other":[73,170,204],"than":[74],"healthy":[77,127,159,173,210],"volunteers":[78],"were":[79,101,154,236],"included.":[80],"All":[81],"had":[82],"general":[83],"tests":[85],"standard":[88],"oral":[89],"tolerance":[91],"test":[92],"after":[93],"12-hour":[95],"fast,":[96],"measured.":[102],"RESULTS:":[103],"Over":[104],"6-month":[106],"period,":[107],"we":[108],"recruited":[109],"84":[110],"(73":[112],"women,":[113,122,130],"11":[114],"men),":[115,124],"25":[116],"patients":[117],"nonmigraine":[119],"(20":[121],"5":[123],"26":[126],"controls":[128,160,174,211],"(24":[129],"2":[131],"men).":[132],"Multivariate":[133],"analysis":[134],"confirmed":[135,199],"significant":[137,149,179,193],"difference":[138,180,197],"groups":[140,182],"for":[141,186,200],"(P":[144,161,175,188,206,212],"<":[145,162,176,189,207,213],".0001),":[146,190],"no":[148],"time":[150,194],"interaction.":[151,195],"differences":[153],"mostly":[155],".0001)":[163,208],"lesser":[167],"extent":[168],"headaches":[171,205],".05).":[177],"A":[178],"found":[185],"compared":[202],".0001).":[214],"CONCLUSIONS:":[215],"Blood":[216],"may":[219],"be":[220,230],"high":[221],"patients,":[224],"do":[226],"not":[227],"seem":[228],"specific":[231,242],"migraineurs.":[233],"Insulin":[234],"higher":[237],"migraineurs,":[239],"seemed":[241],"this":[244],"group.":[245],"These":[246],"findings":[247],"keeping":[250],"recent":[252],"reports":[253],"on":[254,259],"effects":[256],"brain":[260],"functions":[261],"lend":[263],"support":[264],"possibility":[267],"that":[268],"involved":[271],"pathogenesis":[274],"migraine.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}