{"id":"https://openalex.org/W2005929965","doi":"https://doi.org/10.1083/jcb.97.1.92","title":"Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cells.","display_name":"Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cells.","publication_year":1983,"publication_date":"1983-07-01","ids":{"openalex":"https://openalex.org/W2005929965","doi":"https://doi.org/10.1083/jcb.97.1.92","mag":"2005929965","pmid":"https://pubmed.ncbi.nlm.nih.gov/6306015","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112476"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.97.1.92","doi":"https://doi.org/10.1083/jcb.97.1.92","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.97.1.92","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112476","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103390419","display_name":"Johannes Boonstra","orcid":"https://orcid.org/0009-0006-5957-7244","observed_orcids":["https://orcid.org/0009-0006-5957-7244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Boonstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061490638","display_name":"Wouter H. Moolenaar","orcid":"https://orcid.org/0000-0001-7545-198X","observed_orcids":["https://orcid.org/0000-0001-7545-198X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W H Moolenaar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103522402","display_name":"Paul H. M. Harrison","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P H Harrison","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068114766","display_name":"P.J. Moed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Moed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108367804","display_name":"Paul T. van der Saag","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P T van der Saag","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111393836","display_name":"Siegfried W. de Laat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S W de Laat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8078,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.96649281,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"97","issue":"1","first_page":"92","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.2937000095844269,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.06960000097751617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.984000027179718},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/pheochromocytoma-cells","display_name":"pheochromocytoma cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/na-h-exchange","display_name":"Na+/H+ exchange","score":0.8759999871253967},{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sodium-influx","display_name":"sodium influx","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cell-growth-stimulation","display_name":"cell growth stimulation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9940000176429749},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.8109999895095825},{"id":"https://openalex.org/keywords/h-efflux","display_name":"H+ efflux","score":0.875}],"concepts":[{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.920154333114624},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.8451724052429199},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.7880569100379944},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.7279062867164612},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6324018836021423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5788576602935791},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5623525381088257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5518044233322144},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.417807936668396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34467411041259766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2582883834838867},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25246864557266235},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23326891660690308},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.17888721823692322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1443423628807068},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10798278450965881},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.97.1.92","doi":"https://doi.org/10.1083/jcb.97.1.92","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.97.1.92","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:914545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2112476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:6306015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6306015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.3638","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.3638","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d6/47/J_Cell_Biol_1983_Jul_1_97(1)_92-98.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:914545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W169930070","https://openalex.org/W1510058062","https://openalex.org/W1533674371","https://openalex.org/W1570821412","https://openalex.org/W1748249604","https://openalex.org/W1967530659","https://openalex.org/W1970494123","https://openalex.org/W1970587959","https://openalex.org/W1975384687","https://openalex.org/W1977187673","https://openalex.org/W1999835375","https://openalex.org/W2001040193","https://openalex.org/W2001163784","https://openalex.org/W2005773860","https://openalex.org/W2014297207","https://openalex.org/W2017172209","https://openalex.org/W2022107846","https://openalex.org/W2022360237","https://openalex.org/W2031888868","https://openalex.org/W2040796522","https://openalex.org/W2041327494","https://openalex.org/W2055186781","https://openalex.org/W2059811943","https://openalex.org/W2060656493","https://openalex.org/W2065094901","https://openalex.org/W2068736074","https://openalex.org/W2072388933","https://openalex.org/W2079515940","https://openalex.org/W2080669192","https://openalex.org/W2081386962","https://openalex.org/W2081887194","https://openalex.org/W2082192837","https://openalex.org/W2083778777","https://openalex.org/W2083945298","https://openalex.org/W2088808067","https://openalex.org/W2088818868","https://openalex.org/W2095088339","https://openalex.org/W2108746469","https://openalex.org/W2123698545","https://openalex.org/W2128722618","https://openalex.org/W2132032118","https://openalex.org/W2139661225","https://openalex.org/W2140018115","https://openalex.org/W2148127814","https://openalex.org/W2169930352","https://openalex.org/W3105898142"],"related_works":["https://openalex.org/W7097843108","https://openalex.org/W2041327494","https://openalex.org/W2018518469","https://openalex.org/W2062850394","https://openalex.org/W2132032118","https://openalex.org/W2007667427","https://openalex.org/W2143242955","https://openalex.org/W1748249604","https://openalex.org/W2319587333","https://openalex.org/W2058599624"],"abstract_inverted_index":{"Rat":[0],"pheochromocytoma":[1],"cells":[2,53,112],"(clone":[3],"PC12)":[4],"respond":[5],"to":[6,51,76,86,177,184],"nerve":[7],"growth":[8,48,163,166,179,193,227,242],"factor":[9,49],"(NGF)":[10],"by":[11,37,70,115,194,244],"the":[12,120,153,187],"acquirement":[13],"of":[14,46,58,66,90,103,122,152,158,180,189,209,235],"a":[15,56],"phenotype":[16],"resembling":[17],"neuronal":[18],"cells.":[19,145,211],"In":[20,186,200],"an":[21,29,88,137,225],"earlier":[22],"study":[23],"we":[24,42],"showed":[25],"that":[26,44,131,218],"NGF":[27,71,104,133,159,174,195,223,245],"causes":[28],"increase":[30,65],"in":[31,55,96,110,143,150,219],"Na+,K+":[32,59,67],"pump":[33,60,68],"activity,":[34],"as":[35,62],"monitored":[36],"ouabain-sensitive":[38],"Rb+":[39],"influx.":[40,79,127,254],"Here":[41],"show":[43],"addition":[45,102],"epidermal":[47],"(EGF)":[50],"PC12":[52,111,144,181,210,220],"resulted":[54],"stimulation":[57,243],"activity":[61,69],"well.":[63],"The":[64],"or":[72,105],"EGF":[73,135,197,247],"was":[74,84,113,175,198],"due":[75],"increased":[77,81,236,251],"Na+":[78,82,126,238,253],"This":[80],"influx":[83],"sensitive":[85],"amiloride,":[87,190],"inhibitor":[89],"Na+,H+":[91,108,140],"exchange.":[92],"Furthermore,":[93],"no":[94],"changes":[95],"membrane":[97],"potential":[98],"were":[99,148],"observed":[100],"upon":[101],"EGF.":[106,185],"Amiloride-sensitive":[107],"exchange":[109,141],"demonstrated":[114],"H+":[116],"efflux":[117],"measurements":[118],"and":[119,134,160,196,240,246],"effects":[121,157],"weak":[123],"acids":[124],"on":[125],"These":[128,146],"observations":[129,214],"suggest":[130],"both":[132],"activate":[136],"amiloride-sensitive,":[138],"electroneutral":[139],"mechanism":[142],"findings":[147],"surprising":[149],"view":[151],"opposite":[154],"ultimate":[155],"biological":[156],"EGF,":[161],"e.g.,":[162],"arrest":[164],"vs.":[165],"stimulation.":[167],"However,":[168],"within":[169],"24":[170],"h":[171],"after":[172],"addition,":[173],"found":[176],"stimulate":[178],"cells,":[182],"comparable":[183],"presence":[188],"this":[191],"stimulated":[192],"abolished.":[199],"contrast,":[201],"amiloride":[202],"did":[203],"not":[204],"affect":[205],"NGF-induced":[206],"neurite":[207,231],"outgrowth":[208,232],"From":[212],"these":[213],"it":[215],"is":[216,233,248],"concluded":[217],"cells:":[221],"(a)":[222],"has":[224],"initial":[226],"stimulating":[228],"effect;":[229],"(b)":[230],"independent":[234],"amiloride-sensitive":[237,252],"influx;":[239],"(c)":[241],"associated":[249],"with":[250]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
