{"id":"https://openalex.org/W200591355","doi":"https://doi.org/10.4049/jimmunol.178.supp.91.8","title":"CD45RB expression refines delineation of memory CD4 T cells and aids in understanding their development (91.8)","display_name":"CD45RB expression refines delineation of memory CD4 T cells and aids in understanding their development (91.8)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W200591355","doi":"https://doi.org/10.4049/jimmunol.178.supp.91.8","mag":"200591355"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.91.8","doi":"https://doi.org/10.4049/jimmunol.178.supp.91.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.91.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057287837","display_name":"Stephan M. Caucheteux","orcid":"https://orcid.org/0000-0002-2831-5579","observed_orcids":["https://orcid.org/0000-0002-2831-5579"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan M Caucheteux","raw_affiliation_strings":["NIAID, NIH, Building 10, Room 11N314, 10 Center Drive, Bethesda, MD, 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH, Building 10, Room 11N314, 10 Center Drive, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000024507","display_name":"Souheil\u2010Antoine Younes","orcid":"https://orcid.org/0000-0003-2186-7140","observed_orcids":["https://orcid.org/0000-0003-2186-7140"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Souheil A Younes","raw_affiliation_strings":["NIAID, NIH, Building 10, Room 11N314, 10 Center Drive, Bethesda, MD, 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH, Building 10, Room 11N314, 10 Center Drive, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110180932","display_name":"William E. Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E Paul","raw_affiliation_strings":["NIAID, NIH, Building 10, Room 11N314, 10 Center Drive, Bethesda, MD, 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, NIH, Building 10, Room 11N314, 10 Center Drive, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"S161","last_page":"S161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd45rb","display_name":"CD45RB","score":0.9950000047683716},{"id":"https://openalex.org/keywords/memory-cd4-t-cells","display_name":"memory CD4+ T cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/central-memory-t-cells","display_name":"central memory T cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/effector-memory-t-cells","display_name":"effector memory T cells","score":1.0},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9629999995231628},{"id":"https://openalex.org/keywords/l-selectin","display_name":"L-selectin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/thymectomy","display_name":"thymectomy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6060000061988831},{"id":"https://openalex.org/keywords/t-cell-receptor-transgenic-mice","display_name":"T cell receptor transgenic mice","score":0.675000011920929},{"id":"https://openalex.org/keywords/t-cell-fate","display_name":"T cell fate","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.841535747051239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6399320960044861},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5344146490097046},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46710529923439026},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44419604539871216},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4151563346385956},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3516734540462494},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20495349168777466},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12224400043487549},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12191957235336304}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.91.8","doi":"https://doi.org/10.4049/jimmunol.178.supp.91.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.91.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072616902","https://openalex.org/W2335055374","https://openalex.org/W4313366316","https://openalex.org/W4313344723","https://openalex.org/W1971526898","https://openalex.org/W2155059804","https://openalex.org/W2405119222","https://openalex.org/W1550274701","https://openalex.org/W1982976321","https://openalex.org/W2125671909"],"abstract_inverted_index":{"Abstract":[0],"Upon":[1],"immunization,":[2,154],"CD4":[3,84,96],"T":[4,85,97,140,192],"cell":[5,141],"stimulation":[6],"leads":[7],"to":[8,235],"the":[9,27,114,117,123,126,134,150,157,161,189,199,210,213,254,259],"development":[10],"of":[11,15,19,35,73,116,125,136,198,202,258],"effectors":[12,49],"cells":[13,46,60,98,159,176,193,205,243],"and":[14,23,37,81,109,122,128,206,212,229,237,241,246],"2":[16,65],"major":[17],"subsets":[18,118],"memory":[20,25,45,83,95,130,168,185,204,242],"cells:":[21],"central":[22,44,80,94,127,184],"effector":[24,82,129,165,167,191,240],"cells,":[26,144,186],"latter":[28],"often":[29],"defined":[30,119],"by":[31,120,253],"their":[32,70,207],"differential":[33],"expression":[34,71],"CD62L":[36],"CD44.":[38],"It":[39],"is":[40,216],"still":[41,195],"unclear":[42],"whether":[43],"derive":[47],"from":[48],"or":[50,166],"are":[51,99,105,194],"directly":[52],"induced.":[53],"Our":[54],"results":[55],"have":[56],"shown":[57],"that":[58,92,224],"CD44hi":[59],"can":[61],"be":[62],"divided":[63],"into":[64],"different":[66],"subtypes":[67],"depending":[68],"on":[69],"level":[72],"CD45RB,":[74,225],"providing":[75],"a":[76,171,232],"precise":[77],"distinction":[78],"among":[79],"cells.":[86,169],"Using":[87],"these":[88,203,221],"markers,":[89],"we":[90,132],"show":[91],"while":[93,187],"absent":[100],"in":[101,107,177,188,244],"young":[102],"mice,":[103],"they":[104],"enriched":[106],"old":[108],"thymectomized":[110],"animals":[111],"To":[112],"understand":[113],"properties":[115],"CD45RB":[121],"establishment":[124],"pools,":[131],"followed":[133],"fate":[135],"transferred":[137,158],"nai\u0308ve":[138],"5C.C7":[139,175],"receptor":[142],"transgenic":[143],"specific":[145],"for":[146],"pigeon":[147],"cytochrome.":[148],"During":[149],"first":[151],"days":[152],"following":[153],"virtually":[155],"all":[156,174],"adopt":[160],"phenotype":[162],"associated":[163,182],"with":[164,183,227],"After":[170],"month,":[172],"essentially":[173],"lymphoid":[178,211,245],"organs":[179,215],"express":[180],"phenotypes":[181],"lung":[190],"found.":[196],"Analysis":[197],"mean":[200],"\u201clife\u201d":[201],"cycling":[208],"within":[209],"non-lymphoid":[214,247],"under":[217],"investigation.":[218],"Taken":[219],"together,":[220],"observations":[222],"suggest":[223],"together":[226],"CD44":[228],"CD62L,":[230],"provides":[231],"powerful":[233],"tool":[234],"identify":[236],"quantitate":[238],"nai\u0308ve,":[239],"organs.":[248],"This":[249],"work":[250],"was":[251],"supported":[252],"Intramural":[255],"Research":[256],"Program":[257],"NIAID.":[260]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}