{"id":"https://openalex.org/W2005833069","doi":"https://doi.org/10.1159/000221847","title":"In vitro Study on the Effects of Silver Sulfadiazine on Bilirubin Binding","display_name":"In vitro Study on the Effects of Silver Sulfadiazine on Bilirubin Binding","publication_year":2009,"publication_date":"2009-05-25","ids":{"openalex":"https://openalex.org/W2005833069","doi":"https://doi.org/10.1159/000221847","mag":"2005833069","pmid":"https://pubmed.ncbi.nlm.nih.gov/1157569"},"language":"en","primary_location":{"id":"doi:10.1159/000221847","doi":"https://doi.org/10.1159/000221847","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000221847","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112243187","display_name":"William T. Speck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William T. Speck","raw_affiliation_strings":["Departments of Pediatrics and Microbiology, College of Physicians and Surgeons, Babies Hospital, Columbia University, New York, N.Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Microbiology, College of Physicians and Surgeons, Babies Hospital, Columbia University, New York, N.Y","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073709590","display_name":"Herbert S. Rosenkranz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert S. Rosenkranz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112243187"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.1341,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.50075089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"2","first_page":"61","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silver-sulfadiazine","display_name":"silver sulfadiazine","score":1.0},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/jaundice","display_name":"jaundice","score":0.6430000066757202},{"id":"https://openalex.org/keywords/topical-antimicrobials","display_name":"topical antimicrobial agents","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2776532303","wikidata":"https://www.wikidata.org/wiki/Q420984","display_name":"Silver sulfadiazine","level":3,"score":0.8389924168586731},{"id":"https://openalex.org/C2778269047","wikidata":"https://www.wikidata.org/wiki/Q2555060","display_name":"Sulfadiazine","level":3,"score":0.819273829460144},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7030973434448242},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5939591526985168},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.5848677754402161},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5641887784004211},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5567871928215027},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5156751871109009},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.47688084840774536},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3593483567237854},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32477957010269165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31241363286972046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26839932799339294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24358341097831726},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14020341634750366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12876757979393005},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.06180006265640259},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.060317039489746094}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007565","descriptor_name":"Jaundice","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013411","descriptor_name":"Sulfadiazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000221847","doi":"https://doi.org/10.1159/000221847","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000221847","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},{"id":"pmid:1157569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1157569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988987714","https://openalex.org/W4245005263","https://openalex.org/W2061651826","https://openalex.org/W4291947907","https://openalex.org/W2024358593","https://openalex.org/W4250077757","https://openalex.org/W2061151325","https://openalex.org/W2943856043","https://openalex.org/W2394652414","https://openalex.org/W2069159572"],"abstract_inverted_index":{"Silver":[0],"sulfadiazine":[1],"is":[2],"a":[3,9,63,89],"new":[4],"topical":[5],"antimicrobial":[6],"agent":[7,61],"with":[8],"broad":[10,26],"spectrum":[11,27],"of":[12,28,44,59,85,92],"activity":[13,29],"against":[14],"most":[15],"bacterial":[16,46],"(both":[17],"gram-positive":[18],"and":[19,21,73],"gram-negative)":[20],"many":[22],"fungal":[23,48],"species.":[24],"This":[25],"suggests":[30],"that":[31],"silver":[32,93],"sulfiazine":[33],"may":[34],"be":[35],"useful":[36],"in":[37],"clinical":[38],"situations":[39],"which":[40],"require":[41],"the":[42,57],"inhibition":[43],"cutaneous":[45],"and/or":[47],"colonization.":[49],"The":[50],"present":[51],"study":[52],"was":[53],"undertaken":[54],"to":[55,81],"determine":[56],"effect":[58],"this":[60],"on":[62,69],"bilirubin-protein":[64],"binding.":[65],"Using":[66],"chromatographic":[67],"procedures":[68],"artificially":[70],"jaundiced":[71],"sera":[72],"human":[74],"serum":[75],"albumin":[76],"solutions,":[77],"we":[78],"were":[79],"unable":[80],"detect":[82],"any":[83],"releast":[84],"protein-bound":[86],"bilirubin":[87],"by":[88],"saturated":[90],"suspension":[91],"sulfadiazine.":[94]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}