{"id":"https://openalex.org/W2005808472","doi":"https://doi.org/10.1002/jgm.1189","title":"Gene transfer into guinea pig cochlea using adeno\u2010associated virus vectors","display_name":"Gene transfer into guinea pig cochlea using adeno\u2010associated virus vectors","publication_year":2008,"publication_date":"2008-03-14","ids":{"openalex":"https://openalex.org/W2005808472","doi":"https://doi.org/10.1002/jgm.1189","mag":"2005808472","pmid":"https://pubmed.ncbi.nlm.nih.gov/18338819"},"language":"en","primary_location":{"id":"doi:10.1002/jgm.1189","doi":"https://doi.org/10.1002/jgm.1189","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jgm.1189","pdf_url":null,"source":{"id":"https://openalex.org/S91057606","display_name":"The Journal of Gene Medicine","issn_l":"1099-498X","issn":["1099-498X","1521-2254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Gene Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103709120","display_name":"Masaya Konishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaya Konishi","raw_affiliation_strings":["Departments of Otolaryngology and Head-Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan. konishim@takii.kmu.ac.jp","Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology and Head-Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan. konishim@takii.kmu.ac.jp","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009416830","display_name":"Kohei Kawamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Kawamoto","raw_affiliation_strings":["Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035693174","display_name":"Masahiko Izumikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Izumikawa","raw_affiliation_strings":["Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109500173","display_name":"Hiromichi Kuriyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromichi Kuriyama","raw_affiliation_strings":["Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105234243","display_name":"Toshio Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Yamashita","raw_affiliation_strings":["Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology and Head\u2013Neck Surgery, Kansai Medical University, Moriguchi, Osaka, Japan","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103709120"],"corresponding_institution_ids":["https://openalex.org/I126884977"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.6642,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.83728668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"6","first_page":"610","last_page":"618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cochlea","display_name":"cochlea","score":0.8119999766349792},{"id":"https://openalex.org/keywords/inner-hair-cells","display_name":"inner hair cells","score":0.6629999876022339},{"id":"https://openalex.org/keywords/aav-serotypes","display_name":"AAV serotypes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.75},{"id":"https://openalex.org/keywords/cochlear-implantation","display_name":"cochlear implantation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tissue-tropism","display_name":"tissue tropism","score":0.753000020980835},{"id":"https://openalex.org/keywords/aav-receptor","display_name":"AAV receptor","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mesothelial-cells","display_name":"mesothelial cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hearing-preservation","display_name":"hearing preservation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.859618067741394},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.7872111201286316},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.7767238616943359},{"id":"https://openalex.org/C2778317342","wikidata":"https://www.wikidata.org/wiki/Q2070958","display_name":"Perilymph","level":3,"score":0.7513659000396729},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.749208390712738},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5261811017990112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5184628367424011},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.467888742685318},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.4660654366016388},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.4237898588180542},{"id":"https://openalex.org/C2780659331","wikidata":"https://www.wikidata.org/wiki/Q1128309","display_name":"Organ of Corti","level":3,"score":0.41311711072921753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3863973319530487},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.3057914972305298},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2988389730453491},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.29125720262527466},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2399638295173645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13018697500228882},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.04513096809387207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006199","descriptor_name":"Hair Cells, Auditory, Inner","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006199","descriptor_name":"Hair Cells, Auditory, Inner","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015834","descriptor_name":"Cochlear Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016057","descriptor_name":"Evoked Potentials, Auditory, Brain Stem","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jgm.1189","doi":"https://doi.org/10.1002/jgm.1189","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jgm.1189","pdf_url":null,"source":{"id":"https://openalex.org/S91057606","display_name":"The Journal of Gene Medicine","issn_l":"1099-498X","issn":["1099-498X","1521-2254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Gene Medicine","raw_type":"journal-article"},{"id":"pmid:18338819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18338819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of gene medicine","raw_type":"Journal Article"},{"id":"mag:2259442663","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000514484","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1501115822","https://openalex.org/W1504723104","https://openalex.org/W1643195787","https://openalex.org/W1763501725","https://openalex.org/W1912028323","https://openalex.org/W1922255142","https://openalex.org/W1963623233","https://openalex.org/W1968382713","https://openalex.org/W1968625045","https://openalex.org/W1971436726","https://openalex.org/W1971973958","https://openalex.org/W1975949784","https://openalex.org/W1984568759","https://openalex.org/W1986127962","https://openalex.org/W1988568788","https://openalex.org/W1989377502","https://openalex.org/W1991406404","https://openalex.org/W1999126478","https://openalex.org/W2003456064","https://openalex.org/W2006402322","https://openalex.org/W2011132034","https://openalex.org/W2014144089","https://openalex.org/W2022977561","https://openalex.org/W2023572143","https://openalex.org/W2035924524","https://openalex.org/W2046488302","https://openalex.org/W2047608515","https://openalex.org/W2054771268","https://openalex.org/W2058532244","https://openalex.org/W2060516472","https://openalex.org/W2061820614","https://openalex.org/W2065280914","https://openalex.org/W2067180101","https://openalex.org/W2081831000","https://openalex.org/W2086666355","https://openalex.org/W2089837341","https://openalex.org/W2095274746","https://openalex.org/W2098414451","https://openalex.org/W2105493567","https://openalex.org/W2111790428","https://openalex.org/W2113637218","https://openalex.org/W2140348457","https://openalex.org/W2141569557","https://openalex.org/W2151176501","https://openalex.org/W2154329712","https://openalex.org/W2154330857","https://openalex.org/W2156092213","https://openalex.org/W2168841004","https://openalex.org/W2170490863","https://openalex.org/W2176417291","https://openalex.org/W2176800073","https://openalex.org/W2245959075","https://openalex.org/W2322177492","https://openalex.org/W2334644780","https://openalex.org/W2411688463","https://openalex.org/W4206826545"],"related_works":["https://openalex.org/W1991406404","https://openalex.org/W2010600673","https://openalex.org/W2151176501","https://openalex.org/W2086666355","https://openalex.org/W2014144089","https://openalex.org/W2245959075","https://openalex.org/W2087549058","https://openalex.org/W2563204780","https://openalex.org/W2502831104","https://openalex.org/W2035924524"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"genes":[2],"are":[3,20],"candidates":[4],"for":[5,191],"treating":[6],"inner":[7,18,39,137,183,199],"ear":[8,19,184,200],"diseases.":[9],"For":[10],"clinical":[11],"applications,":[12],"minimally":[13],"invasive":[14],"approaches":[15],"to":[16,89,119,136,146,181],"the":[17,36,56,104,112,123,159,182,198],"desirable":[21],"along":[22],"with":[23,140],"minimal":[24],"side-effects.":[25],"METHODS:":[26],"Adeno-associated":[27],"virus":[28],"(AAV)":[29],"was":[30,86,106],"used":[31,65,88],"as":[32],"a":[33,188],"vector":[34,85,176],"into":[35,53,194],"guinea":[37],"pig":[38],"ear.":[40],"Six":[41],"AAV-cytomegalovirus":[42],"hybrids":[43],"(AAV-2/1,":[44],"-2/2,":[45],"-2/5,":[46],"-2/7,":[47],"-2/8":[48],"and":[49,80,165,185],"-2/9)":[50],"were":[51,82,167],"infused":[52],"perilymph":[54],"of":[55,76,92,97,101,152,161,197],"cochlea":[57,105],"basal":[58],"turn,":[59],"an":[60],"approach":[61],"that":[62,174],"could":[63,116,154],"be":[64,117,156,178],"in":[66,103],"cochlear":[67],"implant":[68],"surgery.":[69],"At":[70],"7":[71],"days":[72],"after":[73],"injection,":[74],"distribution":[75,96,160],"gene":[77,93],"expression,":[78],"hearing":[79],"morphology":[81,166],"evaluated.":[83],"Adenoviral":[84],"also":[87],"compare":[90],"distributions":[91],"expression.":[94],"Moreover,":[95],"cell":[98],"surface":[99],"receptors":[100],"AAV":[102,131,153,162,175],"examined":[107],"using":[108],"immunohistochemistry.":[109],"RESULTS:":[110],"Using":[111],"perilymphatic":[113],"approach,":[114],"adenovirus":[115],"transferred":[118],"mesothelial":[120],"cells":[121,196],"lining":[122],"perilymph,":[124],"but":[125],"not":[126,155],"sensory":[127,147,195],"cells.":[128,148],"Conversely,":[129],"all":[130],"serotypes":[132],"displayed":[133],"tissue":[134,150],"tropism":[135,151],"hair":[138],"cells,":[139],"AAV-2/2":[141,186],"showing":[142],"particularly":[143],"efficient":[144],"transfer":[145],"This":[149],"explained":[157],"by":[158],"receptors.":[163],"Hearing":[164],"largely":[168],"unaffected.":[169],"CONCLUSIONS:":[170],"Our":[171],"results":[172],"indicate":[173],"can":[177],"safely":[179],"applied":[180],"offers":[187],"good":[189],"tool":[190],"transferring":[192],"transgenes":[193],"efficiently":[201],"without":[202],"toxicity.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}