{"id":"https://openalex.org/W2005807520","doi":"https://doi.org/10.1038/npp.1994.11","title":"Age-Related Effects of the Nicotinic Antagonist Mecamylamine on Cognition and Behavior","display_name":"Age-Related Effects of the Nicotinic Antagonist Mecamylamine on Cognition and Behavior","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W2005807520","doi":"https://doi.org/10.1038/npp.1994.11","mag":"2005807520","pmid":"https://pubmed.ncbi.nlm.nih.gov/8024677"},"language":"en","primary_location":{"id":"doi:10.1038/npp.1994.11","doi":"https://doi.org/10.1038/npp.1994.11","is_oa":false,"landing_page_url":"https://doi.org/10.1038/npp.1994.11","pdf_url":null,"source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053733868","display_name":"PAUL A. NEWHOUSE","orcid":"https://orcid.org/0000-0002-9298-7185","observed_orcids":["https://orcid.org/0000-0002-9298-7185"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Newhouse","raw_affiliation_strings":["Department of Psychiatry, University of Vermont College of Medicine, Burlington 05401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Vermont College of Medicine, Burlington 05401","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076987503","display_name":"Alexandra Potter","orcid":"https://orcid.org/0000-0001-5813-6259","observed_orcids":["https://orcid.org/0000-0001-5813-6259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Potter","raw_affiliation_strings":["From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington, Vennont","From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington, Vennont","institution_ids":[]},{"raw_affiliation_string":"From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113584667","display_name":"June Corwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June Corwin","raw_affiliation_strings":["Department of Psychiatry, NYU School of Medicine and Department of Veteran's Affairs Medical Center, New York, New York","Department of Psychiatry, NYU School of Medicine and Department of Veteran's Affairs Medical Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, NYU School of Medicine and Department of Veteran's Affairs Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Psychiatry, NYU School of Medicine and Department of Veteran's Affairs Medical Center, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108474121","display_name":"Robert H. Lenox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Lenox","raw_affiliation_strings":["From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington, Vennont","From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington, Vennont","institution_ids":[]},{"raw_affiliation_string":"From the Department of Psychiatry, Clinical Neuroscience Research Unit, University of Vennont College of Medicine, Burlington","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":null,"fwci":2.1508,"has_fulltext":true,"cited_by_count":136,"citation_normalized_percentile":{"value":0.88127355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"93","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mecamylamine","display_name":"mecamylamine","score":1.0},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/age-related-cognitive-impairment","display_name":"age-related cognitive impairment","score":0.7020000219345093},{"id":"https://openalex.org/keywords/learning-disabilities","display_name":"learning disabilities","score":0.5289999842643738},{"id":"https://openalex.org/keywords/recognition-memory","display_name":"recognition memory","score":0.8949999809265137},{"id":"https://openalex.org/keywords/response-bias","display_name":"response bias","score":0.8629999756813049},{"id":"https://openalex.org/keywords/reaction-time","display_name":"reaction time","score":0.871999979019165},{"id":"https://openalex.org/keywords/ganglionic-blockade","display_name":"ganglionic blockade","score":0.8659999966621399},{"id":"https://openalex.org/keywords/elderly-subjects","display_name":"elderly subjects","score":0.42100000381469727},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6570000052452087},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2776880047","wikidata":"https://www.wikidata.org/wiki/Q3332124","display_name":"Mecamylamine","level":4,"score":0.9819469451904297},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.8358190059661865},{"id":"https://openalex.org/C2779338893","wikidata":"https://www.wikidata.org/wiki/Q5025484","display_name":"Cambridge Neuropsychological Test Automated Battery","level":5,"score":0.6176932454109192},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.5522543787956238},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5449290871620178},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5346376895904541},{"id":"https://openalex.org/C2909754679","wikidata":"https://www.wikidata.org/wiki/Q2080426","display_name":"Nicotinic Antagonist","level":4,"score":0.5205884575843811},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4257183074951172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4084182381629944},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3837074041366577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3039948344230652},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.23189407587051392},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20894649624824524},{"id":"https://openalex.org/C43729271","wikidata":"https://www.wikidata.org/wiki/Q3560550","display_name":"Spatial memory","level":4,"score":0.13211438059806824}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008464","descriptor_name":"Mecamylamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011939","descriptor_name":"Mental Recall","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/npp.1994.11","doi":"https://doi.org/10.1038/npp.1994.11","is_oa":false,"landing_page_url":"https://doi.org/10.1038/npp.1994.11","pdf_url":null,"source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},{"id":"pmid:8024677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8024677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1617731935","display_name":null,"funder_award_id":"NIMA R29-46625","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G2500516749","display_name":null,"funder_award_id":"M01-00109","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320312462","display_name":"University of Vermont","ror":"https://ror.org/0155zta11"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1090862","https://openalex.org/W12462625","https://openalex.org/W1924882872","https://openalex.org/W1963949960","https://openalex.org/W1970701059","https://openalex.org/W1972370700","https://openalex.org/W1979313849","https://openalex.org/W1979910403","https://openalex.org/W1984696272","https://openalex.org/W1985151137","https://openalex.org/W1985313812","https://openalex.org/W1985815443","https://openalex.org/W1993786161","https://openalex.org/W1994067502","https://openalex.org/W1998658132","https://openalex.org/W1999504727","https://openalex.org/W2005274709","https://openalex.org/W2006065683","https://openalex.org/W2008275284","https://openalex.org/W2014671682","https://openalex.org/W2019108324","https://openalex.org/W2020844317","https://openalex.org/W2022212313","https://openalex.org/W2027107708","https://openalex.org/W2028884770","https://openalex.org/W2033177247","https://openalex.org/W2033802694","https://openalex.org/W2040340862","https://openalex.org/W2044381447","https://openalex.org/W2045122897","https://openalex.org/W2048537897","https://openalex.org/W2049324264","https://openalex.org/W2058393573","https://openalex.org/W2061664301","https://openalex.org/W2062453566","https://openalex.org/W2063055630","https://openalex.org/W2067140003","https://openalex.org/W2068987805","https://openalex.org/W2069317157","https://openalex.org/W2072037824","https://openalex.org/W2075954880","https://openalex.org/W2076425653","https://openalex.org/W2079402537","https://openalex.org/W2080919332","https://openalex.org/W2087628505","https://openalex.org/W2090773271","https://openalex.org/W2092722747","https://openalex.org/W2093374391","https://openalex.org/W2095477109","https://openalex.org/W2110103662","https://openalex.org/W2111916837","https://openalex.org/W2119530373","https://openalex.org/W2131607277","https://openalex.org/W2156810782","https://openalex.org/W2265672234","https://openalex.org/W2297177542","https://openalex.org/W2330539884","https://openalex.org/W4232343248","https://openalex.org/W4251508433","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1979910403","https://openalex.org/W2026350032","https://openalex.org/W2784251215","https://openalex.org/W2050726047","https://openalex.org/W2008563383","https://openalex.org/W2158968819","https://openalex.org/W2016865092","https://openalex.org/W2069894189","https://openalex.org/W2026053038","https://openalex.org/W2084576994"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}