{"id":"https://openalex.org/W2005805356","doi":"https://doi.org/10.1371/journal.pone.0100394","title":"Mangiferin Attenuates Th1/Th2 Cytokine Imbalance in an Ovalbumin-Induced Asthmatic Mouse Model","display_name":"Mangiferin Attenuates Th1/Th2 Cytokine Imbalance in an Ovalbumin-Induced Asthmatic Mouse Model","publication_year":2014,"publication_date":"2014-06-23","ids":{"openalex":"https://openalex.org/W2005805356","doi":"https://doi.org/10.1371/journal.pone.0100394","mag":"2005805356","pmid":"https://pubmed.ncbi.nlm.nih.gov/24955743"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0100394","doi":"https://doi.org/10.1371/journal.pone.0100394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100394","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100394&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100394&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hong-Wei Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Wei Guo","raw_affiliation_strings":["Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China; Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China","Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China","Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China; Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078236403","display_name":"Chenxia Yun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen-Xia Yun","raw_affiliation_strings":["School of Basic Medical Sciences, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046605176","display_name":"Guang-Han Hou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-Han Hou","raw_affiliation_strings":["Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112647145","display_name":"Jun Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Du","raw_affiliation_strings":["Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040831062","display_name":"Xin Huang","orcid":"https://orcid.org/0000-0001-6778-8849","observed_orcids":["https://orcid.org/0000-0001-6778-8849"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Huang","raw_affiliation_strings":["Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015327473","display_name":"Yi Lu","orcid":"https://orcid.org/0000-0002-6423-8582","observed_orcids":["https://orcid.org/0000-0002-6423-8582"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Lu","raw_affiliation_strings":["Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056820426","display_name":"Evan T. Keller","orcid":"https://orcid.org/0000-0002-7592-7535","observed_orcids":["https://orcid.org/0000-0002-7592-7535"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan T. Keller","raw_affiliation_strings":["Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409987","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-6558-791X","observed_orcids":["https://orcid.org/0000-0002-6558-791X"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"Key Laboratory of Longevity and Aging-related Disease, Chinese Ministry of Education, Nanning, Guangxi, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029697163","display_name":"Jiagang Deng","orcid":"https://orcid.org/0000-0003-2079-981X","observed_orcids":["https://orcid.org/0000-0003-2079-981X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jia-Gang Deng","raw_affiliation_strings":["Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Pharmacodynamic Studies of Traditional Chinese Medicine, Nanning, Guangxi, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029697163","https://openalex.org/A5100409987"],"corresponding_institution_ids":["https://openalex.org/I160354086"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":15.0658,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.99009935,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"e100394","last_page":"e100394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13846","display_name":"Mangiferin and Mango Extracts","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13846","display_name":"Mangiferin and Mango Extracts","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mangiferin","display_name":"mangiferin","score":1.0},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.7919999957084656},{"id":"https://openalex.org/keywords/th1-th2-imbalance","display_name":"Th1/Th2 imbalance","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ovalbumin-induced-asthma","display_name":"ovalbumin-induced asthma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mango","display_name":"mango","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antiasthmatic-effect","display_name":"antiasthmatic effect","score":0.8669999837875366},{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.9440000057220459},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.6790000200271606},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.8960000276565552},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8899999856948853},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.847000002861023},{"id":"https://openalex.org/keywords/eosinophil-infiltration","display_name":"eosinophil infiltration","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.6650000214576721},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2777781930","wikidata":"https://www.wikidata.org/wiki/Q1074417","display_name":"Mangiferin","level":2,"score":0.9786698818206787},{"id":"https://openalex.org/C2777716647","wikidata":"https://www.wikidata.org/wiki/Q5381961","display_name":"Eotaxin","level":4,"score":0.7711198329925537},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.7524169683456421},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6635016202926636},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5777170658111572},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5381624698638916},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.5263417959213257},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.45631489157676697},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4500121474266052},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4480401575565338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4321654438972473},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.42139697074890137},{"id":"https://openalex.org/C32046619","wikidata":"https://www.wikidata.org/wiki/Q14878303","display_name":"Interleukin 13","level":4,"score":0.41869205236434937},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.32733309268951416},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2844207286834717},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2053508162498474},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1802515983581543}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0100394","doi":"https://doi.org/10.1371/journal.pone.0100394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100394","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100394&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:24955743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24955743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4067356","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4067356","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.812.8521","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.812.8521","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/60/5a/pone.0100394.PMC4067356.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:89fb09dbd67c45c1b1e35cf6b8220c20","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/89fb09dbd67c45c1b1e35cf6b8220c20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 6, p e100394 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0100394","doi":"https://doi.org/10.1371/journal.pone.0100394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100394","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100394&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2400729759","display_name":null,"funder_award_id":"30973916","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G49856488","display_name":"\u8292\u679c\u82f7\u8c03\u63a7\u6162\u6027\u652f\u6c14\u7ba1\u708e\u75c7\u53ca\u708e\u75c7\u7ec6\u80de\u6d3b\u5316\u5173\u952e\u57fa\u56e0\u4e0e\u86cb\u767d\u8868\u8fbe\u7684\u7814\u7a76","funder_award_id":"81260666","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005805356.pdf","grobid_xml":"https://content.openalex.org/works/W2005805356.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W186485608","https://openalex.org/W300336612","https://openalex.org/W974479914","https://openalex.org/W1494153940","https://openalex.org/W1541540076","https://openalex.org/W1565847282","https://openalex.org/W1604192110","https://openalex.org/W1967261754","https://openalex.org/W1967456106","https://openalex.org/W1972484309","https://openalex.org/W1976476555","https://openalex.org/W1983187303","https://openalex.org/W1992396801","https://openalex.org/W1998429989","https://openalex.org/W1999065889","https://openalex.org/W2011754426","https://openalex.org/W2018485248","https://openalex.org/W2019348905","https://openalex.org/W2019638998","https://openalex.org/W2023488690","https://openalex.org/W2029146247","https://openalex.org/W2029555805","https://openalex.org/W2030499733","https://openalex.org/W2031986590","https://openalex.org/W2038271225","https://openalex.org/W2045223699","https://openalex.org/W2045877360","https://openalex.org/W2048151370","https://openalex.org/W2050237494","https://openalex.org/W2052121459","https://openalex.org/W2056367946","https://openalex.org/W2056743382","https://openalex.org/W2062384175","https://openalex.org/W2066027253","https://openalex.org/W2066210562","https://openalex.org/W2075147772","https://openalex.org/W2075603878","https://openalex.org/W2083370876","https://openalex.org/W2085270777","https://openalex.org/W2087274636","https://openalex.org/W2090745121","https://openalex.org/W2090831287","https://openalex.org/W2109032237","https://openalex.org/W2126208157","https://openalex.org/W2134496342","https://openalex.org/W2141262645","https://openalex.org/W2169303799","https://openalex.org/W2171449633","https://openalex.org/W2315018741","https://openalex.org/W2318902947","https://openalex.org/W2322180497","https://openalex.org/W2325644377","https://openalex.org/W2336319013","https://openalex.org/W2364190891","https://openalex.org/W2396462863","https://openalex.org/W2469911195","https://openalex.org/W2626246102","https://openalex.org/W4251519441","https://openalex.org/W4254570903"],"related_works":["https://openalex.org/W2038477076","https://openalex.org/W1922154875","https://openalex.org/W2157340183","https://openalex.org/W2956356077","https://openalex.org/W2037532083","https://openalex.org/W2024425458","https://openalex.org/W2104964526","https://openalex.org/W2074798704","https://openalex.org/W1835748585","https://openalex.org/W2335627284"],"abstract_inverted_index":{"Mangiferin":[0,72],"is":[1],"a":[2],"major":[3],"bioactive":[4],"ingredient":[5],"in":[6,31,66,89,93,133,175],"Mangifera":[7],"indica":[8],"Linn.":[9],"(Anacardiaceae)":[10],"leaves.":[11],"Aqueous":[12],"extract":[13],"of":[14,39,54,69,86,105,108,140,150,171,196],"such":[15],"leaves":[16],"have":[17],"been":[18],"used":[19],"as":[20],"an":[21],"indigenous":[22],"remedy":[23],"for":[24],"respiratory":[25],"diseases":[26],"like":[27],"asthma":[28],"and":[29,60,80,91,115,128,130,154,156,161,169,173],"coughing":[30],"traditional":[32],"Chinese":[33],"medicine.":[34],"However,":[35],"underlying":[36,63,189],"molecular":[37],"mechanisms":[38],"mangiferin":[40,55,101,164,183],"on":[41,56],"anti-asthma":[42],"remain":[43],"unclear.":[44],"In":[45],"our":[46],"present":[47],"study,":[48],"we":[49],"investigated":[50],"the":[51,75,84,103,138,146,167,194,202],"anti-asthmatic":[52,186],"effect":[53],"Th1/Th2":[57,141,197],"cytokine":[58,198],"profiles":[59],"explored":[61],"its":[62],"immunoregulatory":[64],"mechanism":[65,190],"mouse":[67],"model":[68],"allergic":[70],"asthma.":[71],"significantly":[73],"reduced":[74],"total":[76],"inflammatory":[77],"cell":[78],"counts":[79],"eosinophil":[81],"infiltration,":[82],"decreased":[83],"production":[85],"ovalbumin-specific":[87],"IgE":[88],"serum":[90],"PGD2":[92],"BALF.":[94],"The":[95,188],"antibody":[96],"array":[97],"analysis":[98],"showed":[99],"that":[100,182],"down-regulated":[102],"levels":[104,149],"one":[106],"group":[107],"cytokines/chemokines":[109],"including":[110],"Th2-related":[111],"IL-4,":[112],"IL-5,":[113],"IL-13,":[114],"others":[116],"IL-3,":[117],"IL-9,":[118],"IL-17,":[119],"RANTES,":[120],"TNF-\u03b1,":[121],"but":[122],"simultaneously":[123],"up-regulated":[124],"Th1-related":[125],"IFN-\u03b3,":[126],"IL-2":[127],"IL-10":[129],"IL-12":[131],"expression":[132,170],"serum.":[134],"Thus":[135],"it":[136],"attenuates":[137],"imbalance":[139,199],"cells":[142],"ratio":[143],"by":[144],"diminishing":[145],"abnormal":[147],"mRNA":[148],"Th1":[151],"cytokines":[152,158],"(IFN-\u03b3":[153],"IL-12)":[155],"Th2":[157],"(IL-4,":[159],"IL-5":[160],"IL-13).":[162],"Finally,":[163],"substantially":[165],"inhibited":[166],"activation":[168],"STAT-6":[172],"GATA-3":[174],"excised":[176],"lung":[177],"tissues.":[178],"Our":[179],"results":[180],"suggest":[181],"can":[184],"exert":[185],"effect.":[187],"may":[191],"attribute":[192],"to":[193],"modulation":[195],"via":[200],"inhibiting":[201],"STAT6":[203],"signaling":[204],"pathway.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
