{"id":"https://openalex.org/W2005779371","doi":"https://doi.org/10.1016/s0168-8227(00)81361-3","title":"First degree relatives of albuminuric, young-onset Chinese type 2 diabetic patients have impaired insulin secretion and increased risks of microalbuminuria","display_name":"First degree relatives of albuminuric, young-onset Chinese type 2 diabetic patients have impaired insulin secretion and increased risks of microalbuminuria","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2005779371","doi":"https://doi.org/10.1016/s0168-8227(00)81361-3","mag":"2005779371"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8227(00)81361-3","doi":"https://doi.org/10.1016/s0168-8227(00)81361-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8227(00)81361-3","pdf_url":null,"source":{"id":"https://openalex.org/S171311646","display_name":"Diabetes Research and Clinical Practice","issn_l":"0168-8227","issn":["0168-8227","1872-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Research and Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087793653","display_name":"J.K.Y. Li","orcid":"https://orcid.org/0000-0002-6211-5239","observed_orcids":["https://orcid.org/0000-0002-6211-5239"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"J.K.Y Li","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034303175","display_name":"Maggie C.Y. Ng","orcid":"https://orcid.org/0000-0002-4133-2007","observed_orcids":["https://orcid.org/0000-0002-4133-2007"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"M.C.Y Ng","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012506828","display_name":"S.C Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"S.C Lee","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012926832","display_name":"Cherry K P Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"C.K.P Chiu","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055568348","display_name":"Gang-Jee Ko","orcid":"https://orcid.org/0000-0001-8355-1083","observed_orcids":["https://orcid.org/0000-0001-8355-1083"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"G.T.C Ko","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103963544","display_name":"Wing\u2010Yee So","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"W.Y So","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103823881","display_name":"C. C. Chow","orcid":"https://orcid.org/0009-0006-8305-8671","observed_orcids":["https://orcid.org/0009-0006-8305-8671"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"C.C Chow","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101762","display_name":"Peter C.Y. Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"P.C.Y Tong","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102707381","display_name":"Ming Wai Yeung","orcid":"https://orcid.org/0000-0001-9794-3109","observed_orcids":["https://orcid.org/0000-0001-9794-3109"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"V.T.F Yeung","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036805172","display_name":"Julia Critchley","orcid":"https://orcid.org/0000-0002-5248-4188","observed_orcids":["https://orcid.org/0000-0002-5248-4188"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"J.A.J.H Critchley","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109928518","display_name":"Clive Stewart Cockram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"C.S Cockram","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091832416","display_name":"Juliana C.N. Chan","orcid":"https://orcid.org/0000-0003-1325-1194","observed_orcids":["https://orcid.org/0000-0003-1325-1194"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I4210114914","display_name":"Prince of Wales Hospital","ror":"https://ror.org/02827ca86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I4210114914"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"J.C.N Chan","raw_affiliation_strings":["Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","institution_ids":["https://openalex.org/I177725633","https://openalex.org/I4210114914"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12171487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":null,"first_page":"399","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.45899999141693115,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.45899999141693115,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.3537999987602234,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.7139999866485596},{"id":"https://openalex.org/keywords/familial-aggregation","display_name":"familial aggregation","score":0.492000013589859},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.7480000257492065},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.890999972820282},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8149999976158142},{"id":"https://openalex.org/keywords/young-onset-diabetes","display_name":"young-onset diabetes","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2781203188","wikidata":"https://www.wikidata.org/wiki/Q1676817","display_name":"Microalbuminuria","level":3,"score":0.9710443615913391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9322243928909302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7218399047851562},{"id":"https://openalex.org/C2779862289","wikidata":"https://www.wikidata.org/wiki/Q25098571","display_name":"First-degree relatives","level":3,"score":0.6308947801589966},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6010903120040894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5603428483009338},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5136739611625671},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.45742595195770264},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.12625008821487427}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0168-8227(00)81361-3","doi":"https://doi.org/10.1016/s0168-8227(00)81361-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8227(00)81361-3","pdf_url":null,"source":{"id":"https://openalex.org/S171311646","display_name":"Diabetes Research and Clinical Practice","issn_l":"0168-8227","issn":["0168-8227","1872-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Research and Clinical Practice","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1583119082","https://openalex.org/W2017666780","https://openalex.org/W7067518688","https://openalex.org/W7073589362","https://openalex.org/W2027221421","https://openalex.org/W3030341968","https://openalex.org/W2119586817","https://openalex.org/W4252081406","https://openalex.org/W1992159509","https://openalex.org/W2320222158"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}