{"id":"https://openalex.org/W2005773834","doi":"https://doi.org/10.1136/thx.42.7.520","title":"Thyroid function and endocrine abnormalities in elderly patients with severe chronic obstructive lung disease.","display_name":"Thyroid function and endocrine abnormalities in elderly patients with severe chronic obstructive lung disease.","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W2005773834","doi":"https://doi.org/10.1136/thx.42.7.520","mag":"2005773834","pmid":"https://pubmed.ncbi.nlm.nih.gov/3125626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/460817"},"language":"en","primary_location":{"id":"doi:10.1136/thx.42.7.520","doi":"https://doi.org/10.1136/thx.42.7.520","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.42.7.520","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/42/7/520.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/42/7/520.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008739652","display_name":"Sean Gow","orcid":"https://orcid.org/0009-0006-9106-2048","observed_orcids":["https://orcid.org/0009-0006-9106-2048"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S M Gow","raw_affiliation_strings":["Department of Clinical Chemistry, Royal Infirmary, Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Royal Infirmary, Edinburgh","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113770256","display_name":"J. Seth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Seth","raw_affiliation_strings":["Department of Clinical Chemistry, Royal Infirmary, Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Royal Infirmary, Edinburgh","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110026366","display_name":"Geoffrey J. Beckett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G J Beckett","raw_affiliation_strings":["Department of Clinical Chemistry, Royal Infirmary, Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Royal Infirmary, Edinburgh","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"last","author":{"id":null,"display_name":"G Douglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Douglas","raw_affiliation_strings":["Department of Clinical Chemistry, Royal Infirmary, Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Royal Infirmary, Edinburgh","institution_ids":["https://openalex.org/I2802789809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802789809"],"apc_list":null,"apc_paid":null,"fwci":0.2996,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.5617341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"7","first_page":"520","last_page":"525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7599999904632568},{"id":"https://openalex.org/keywords/thyroid-function","display_name":"thyroid function","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-function","display_name":"hypothalamic-pituitary function","score":0.8349999785423279},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.7900000214576721},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.8949999809265137},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.7710000276565552},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.8130000233650208},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9900000095367432},{"id":"https://openalex.org/keywords/endocrine-disorders","display_name":"endocrine disorders","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7480000257492065},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9236443638801575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7294507026672363},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7243139743804932},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6089183688163757},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.5835614800453186},{"id":"https://openalex.org/C2777104659","wikidata":"https://www.wikidata.org/wiki/Q3508797","display_name":"Obstructive lung disease","level":3,"score":0.548265814781189},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5454299449920654},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5211079716682434},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5063201189041138},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.441481351852417},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.43755993247032166},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.4131917953491211},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.12196257710456848},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.07196640968322754}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010907","descriptor_name":"Pituitary Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/thx.42.7.520","doi":"https://doi.org/10.1136/thx.42.7.520","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.42.7.520","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/42/7/520.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:460817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/460817","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Text"},{"id":"pmid:3125626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3125626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/thx.42.7.520","doi":"https://doi.org/10.1136/thx.42.7.520","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.42.7.520","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/42/7/520.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005773834.pdf","grobid_xml":"https://content.openalex.org/works/W2005773834.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W139388767","https://openalex.org/W1682043670","https://openalex.org/W1792035729","https://openalex.org/W1971029030","https://openalex.org/W1975746562","https://openalex.org/W1984041946","https://openalex.org/W1993342638","https://openalex.org/W2003565987","https://openalex.org/W2005018999","https://openalex.org/W2005063633","https://openalex.org/W2015861946","https://openalex.org/W2029799151","https://openalex.org/W2033013744","https://openalex.org/W2035681024","https://openalex.org/W2037889332","https://openalex.org/W2040309622","https://openalex.org/W2052598407","https://openalex.org/W2057696664","https://openalex.org/W2060631523","https://openalex.org/W2070398372","https://openalex.org/W2093238278","https://openalex.org/W2118966087","https://openalex.org/W2133776966","https://openalex.org/W2160893704","https://openalex.org/W2329315405","https://openalex.org/W2411200131","https://openalex.org/W2964776980"],"related_works":["https://openalex.org/W1993118540","https://openalex.org/W2371782343","https://openalex.org/W2005063633","https://openalex.org/W4382180914","https://openalex.org/W100888021","https://openalex.org/W2364997080","https://openalex.org/W2009739634","https://openalex.org/W1982341272","https://openalex.org/W2082669946","https://openalex.org/W2368983946"],"abstract_inverted_index":{"Serum":[0],"pituitary":[1,10],"and":[2,6,33,57,62,69,71,89,123,166,174],"thyroid":[3,59],"hormones,":[4],"testosterone,":[5],"the":[7,149],"response":[8],"of":[9,65,76,144,172,183],"hormones":[11],"to":[12,104],"thyrotrophin":[13,77,102,105],"releasing":[14,78,106],"hormone":[15,60,79,127,147,168],"were":[16,53,80,113,129,152],"measured":[17],"in":[18,34,55,82,116,124,131,148,185,189],"20":[19],"inpatients":[20,38],"(mean":[21,39],"age":[22,40,173],"68,":[23],"range":[24,42],"42-81":[25],"years)":[26,44],"with":[27,84,94,118,133,192],"severe":[28],"chronic":[29,85,95,119,134,193],"obstructive":[30,86,96,120,135,194],"lung":[31,87,97,121,136,195],"disease":[32,122,137],"15":[35],"control":[36,90],"convalescent":[37],"73,":[41],"57-83":[43],"who":[45],"had":[46,100],"normal":[47],"respiratory":[48],"function.":[49],"No":[50],"significant":[51,159],"differences":[52],"found":[54,114],"total":[56],"free":[58],"concentrations":[61,64,112,128,143],"basal":[63],"thyrotrophin,":[66],"growth":[67],"hormone,":[68],"prolactin;":[70],"their":[72],"increments":[73],"after":[74],"injection":[75],"similar":[81],"patients":[83,93,117,191],"disease,":[88,98],"patients.":[91],"Three":[92],"however,":[99],"no":[101,158],"responses":[103],"hormone.":[107],"In":[108],"men,":[109],"low":[110],"testosterone":[111],"both":[115],"controls.":[125],"Luteinising":[126],"higher":[130],"men":[132],"(p":[138],"less":[139],"than":[140,180],"0.02),":[141],"whereas":[142],"follicle":[145],"stimulating":[146],"two":[150],"groups":[151],"not":[153],"significantly":[154],"different.":[155],"There":[156],"was":[157],"correlation":[160],"between":[161],"arterial":[162],"blood":[163],"gas":[164],"tensions":[165],"these":[167],"measurements.":[169],"General":[170],"effects":[171,182],"illness":[175],"may":[176],"be":[177],"more":[178],"important":[179],"direct":[181],"hypoxia":[184],"determining":[186],"hypothalamic-pituitary":[187],"function":[188],"elderly":[190],"disease.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}