{"id":"https://openalex.org/W2005759213","doi":"https://doi.org/10.1371/journal.pone.0019148","title":"Identification of a Novel Marine Fish Virus, Singapore Grouper Iridovirus-Encoded MicroRNAs Expressed in Grouper Cells by Solexa Sequencing","display_name":"Identification of a Novel Marine Fish Virus, Singapore Grouper Iridovirus-Encoded MicroRNAs Expressed in Grouper Cells by Solexa Sequencing","publication_year":2011,"publication_date":"2011-04-29","ids":{"openalex":"https://openalex.org/W2005759213","doi":"https://doi.org/10.1371/journal.pone.0019148","mag":"2005759213","pmid":"https://pubmed.ncbi.nlm.nih.gov/21559453"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0019148","doi":"https://doi.org/10.1371/journal.pone.0019148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0019148","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019148&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019148&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101958334","display_name":"Yan Yang","orcid":"https://orcid.org/0000-0001-7075-3428","observed_orcids":["https://orcid.org/0000-0001-7075-3428"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yan","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108405323","display_name":"Huachun Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huachun Cui","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101658532","display_name":"Songshan Jiang","orcid":"https://orcid.org/0000-0003-4170-5042","observed_orcids":["https://orcid.org/0000-0003-4170-5042"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songshan Jiang","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108330868","display_name":"Youhua Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youhua Huang","raw_affiliation_strings":["Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"raw_affiliation_string":"Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019162911","display_name":"Xiaohong Huang","orcid":"https://orcid.org/0000-0003-3617-8911","observed_orcids":["https://orcid.org/0000-0003-3617-8911"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohong Huang","raw_affiliation_strings":["Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"raw_affiliation_string":"Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103842495","display_name":"Shina Wei","orcid":"https://orcid.org/0009-0005-8687-9873","observed_orcids":["https://orcid.org/0009-0005-8687-9873"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shina Wei","raw_affiliation_strings":["Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"raw_affiliation_string":"Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051750846","display_name":"Weiyi Xu","orcid":"https://orcid.org/0000-0003-2365-1183","observed_orcids":["https://orcid.org/0000-0003-2365-1183"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyi Xu","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"State Key Laboratory of Biocontrol; School of Life Sciences; Sun Yat-sen University; Guangzhou; China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102724962","display_name":"Qiwei Qin","orcid":"https://orcid.org/0000-0001-6768-2569","observed_orcids":["https://orcid.org/0000-0001-6768-2569"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103685","display_name":"South China Sea Institute Of Oceanology","ror":"https://ror.org/0192yj155","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiwei Qin","raw_affiliation_strings":["Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]},{"raw_affiliation_string":"Key\u00a0Laboratory\u00a0of\u00a0Marine\u00a0Bio-resources\u00a0Sustainable\u00a0Utilization, South\u00a0China\u00a0Sea\u00a0Institute\u00a0of\u00a0Oceanology,\u00a0Chinese Academy of Sciences,\u00a0Guangzhou, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102724962"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210103685"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.5862,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.89495798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"e19148","last_page":"e19148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/singapore-grouper-iridovirus","display_name":"Singapore grouper iridovirus","score":0.996999979019165},{"id":"https://openalex.org/keywords/viral-micrornas","display_name":"viral microRNAs","score":0.9120000004768372},{"id":"https://openalex.org/keywords/iridovirus","display_name":"iridovirus","score":0.8450000286102295},{"id":"https://openalex.org/keywords/grouper","display_name":"grouper","score":0.6539999842643738},{"id":"https://openalex.org/keywords/epinephelus-awoara","display_name":"Epinephelus awoara","score":0.9409999847412109},{"id":"https://openalex.org/keywords/small-rna","display_name":"small RNA","score":0.5389999747276306},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"viral pathogenesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/aquaculture-disease","display_name":"aquaculture disease","score":0.6650000214576721},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8700940608978271},{"id":"https://openalex.org/C2778967481","wikidata":"https://www.wikidata.org/wiki/Q5559352","display_name":"Grouper","level":3,"score":0.8592159748077393},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.6607149243354797},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6272240877151489},{"id":"https://openalex.org/C2909396630","wikidata":"https://www.wikidata.org/wiki/Q18819341","display_name":"Iridovirus","level":3,"score":0.5467145442962646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4529423415660858},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44537946581840515},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40701597929000854},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.354580819606781},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3441564440727234},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.084795743227005},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017994","descriptor_name":"Iridovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017994","descriptor_name":"Iridovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017994","descriptor_name":"Iridovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0019148","doi":"https://doi.org/10.1371/journal.pone.0019148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0019148","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019148&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:21559453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21559453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2100244","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084752","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3084752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bfad42d6552847f3b34f915bf77f8ba3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bfad42d6552847f3b34f915bf77f8ba3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 4, p e19148 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0019148","doi":"https://doi.org/10.1371/journal.pone.0019148","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0019148","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019148&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.8899999856948853}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2913615539","display_name":null,"funder_award_id":"2006CB101802","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5144931251","display_name":null,"funder_award_id":"KZCX2-EW-Q213","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G6018784918","display_name":null,"funder_award_id":"30725027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G902984598","display_name":"\u77f3\u6591\u9c7c\u5bbf\u4e3b\u7ec6\u80de\u611f\u67d3\u8679\u5f69\u75c5\u6bd2\uff08SGIV\uff09\u540e\u7684\u7ec6\u80de\u51cb\u4ea1\u673a\u5236","funder_award_id":"30930070","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005759213.pdf","grobid_xml":"https://content.openalex.org/works/W2005759213.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1507566062","https://openalex.org/W1542925727","https://openalex.org/W1963958969","https://openalex.org/W1965893507","https://openalex.org/W1978693569","https://openalex.org/W1989915939","https://openalex.org/W2001514368","https://openalex.org/W2006372543","https://openalex.org/W2007461233","https://openalex.org/W2032399160","https://openalex.org/W2035265635","https://openalex.org/W2041018885","https://openalex.org/W2045756360","https://openalex.org/W2046195371","https://openalex.org/W2050223484","https://openalex.org/W2053276356","https://openalex.org/W2060468039","https://openalex.org/W2063329578","https://openalex.org/W2067880695","https://openalex.org/W2068118422","https://openalex.org/W2083766597","https://openalex.org/W2083778040","https://openalex.org/W2086700085","https://openalex.org/W2087462807","https://openalex.org/W2090975474","https://openalex.org/W2098402449","https://openalex.org/W2099935683","https://openalex.org/W2100085836","https://openalex.org/W2103282388","https://openalex.org/W2107277218","https://openalex.org/W2108896844","https://openalex.org/W2112171859","https://openalex.org/W2115503551","https://openalex.org/W2117124710","https://openalex.org/W2119979880","https://openalex.org/W2120210602","https://openalex.org/W2124938530","https://openalex.org/W2127011605","https://openalex.org/W2129038927","https://openalex.org/W2139760555","https://openalex.org/W2140726238","https://openalex.org/W2141157874","https://openalex.org/W2145021085","https://openalex.org/W2149472465","https://openalex.org/W2152736091","https://openalex.org/W2153854777","https://openalex.org/W2158201646","https://openalex.org/W2161222316","https://openalex.org/W2162647435","https://openalex.org/W2171115570","https://openalex.org/W2172245644","https://openalex.org/W4237011200"],"related_works":["https://openalex.org/W2083766597","https://openalex.org/W2922528021","https://openalex.org/W2943448754","https://openalex.org/W2972417544","https://openalex.org/W2399546217","https://openalex.org/W3082912130","https://openalex.org/W2060053284","https://openalex.org/W3025516652","https://openalex.org/W2033845816","https://openalex.org/W2162506288"],"abstract_inverted_index":{"BACKGROUND:":[0],"MicroRNAs":[1],"(miRNAs)":[2],"are":[3,29,154,164,172],"ubiquitous":[4],"non-coding":[5],"RNAs":[6],"that":[7,22,56,142,193],"regulate":[8],"gene":[9],"expression":[10],"at":[11,187],"the":[12,70,80,83,167,175,252,259],"post-transcriptional":[13],"level.":[14],"An":[15],"increasing":[16],"number":[17],"of":[18,119,204,221,240,254,263],"studies":[19,279],"has":[20,57],"revealed":[21],"viruses":[23],"can":[24],"also":[25],"encode":[26],"miRNAs,":[27],"which":[28,120,151],"proposed":[30],"to":[31,147],"be":[32],"involved":[33],"in":[34,62,156,229],"viral":[35,206,223,249],"replication":[36],"and":[37,44,64,82,108,184,200,214,219,227,245,283],"persistence,":[38],"cell-mediated":[39],"antiviral":[40],"immune":[41],"response,":[42],"angiogenesis,":[43],"cell":[45],"cycle":[46],"regulation.":[47],"Singapore":[48],"grouper":[49,60,103],"iridovirus":[50,55,284],"(SGIV)":[51],"is":[52,76,258],"a":[53,96,136,140,144,237,273],"pathogenic":[54,84],"severely":[58],"affected":[59],"aquaculture":[61],"China":[63],"Southeast":[65],"Asia.":[66],"Comprehensive":[67],"knowledge":[68],"about":[69],"related":[71,158],"miRNAs":[72,93,132,153,163,180,207,224,264],"during":[73,94],"SGIV":[74,91,168,281],"infection":[75,81,282],"helpful":[77],"for":[78,243,276],"understanding":[79],"mechanisms.":[85],"METHODOLOGY/PRINCIPAL":[86],"FINDINGS:":[87],"To":[88,251],"determine":[89],"whether":[90],"encoded":[92,126,265],"infection,":[95],"small":[97,123],"RNA":[98,124],"library":[99],"derived":[100],"from":[101],"SGIV-infected":[102,230],"(GP)":[104],"cells":[105],"was":[106],"constructed":[107],"sequenced":[109],"by":[110,127,135,210,266],"Illumina/Solexa":[111],"deep-sequencing":[112],"technology.":[113],"We":[114],"recovered":[115],"6,802,977":[116],"usable":[117],"reads,":[118],"34,400":[121],"represented":[122],"sequences":[125],"SGIV.":[128],"Sixteen":[129],"novel":[130,248],"SGIV-encoded":[131,179],"were":[133,208,225],"identified":[134,246],"computational":[137],"pipeline,":[138],"including":[139],"miRNA":[141,149,241],"shared":[143],"similar":[145],"sequence":[146,183],"herpesvirus":[148],"HSV2-miR-H4-5p,":[150],"suggests":[152],"conserved":[155],"far":[157],"viruses.":[159,269],"Generally,":[160],"these":[161,205,222],"16":[162,247],"dispersed":[165],"throughout":[166],"genome,":[169],"whereas":[170],"three":[171],"located":[173],"within":[174],"ORF057L":[176],"region.":[177],"Some":[178],"showed":[181],"marked":[182],"length":[185],"heterogeneity":[186],"their":[188,196],"3'":[189],"and/or":[190],"5'":[191],"end":[192],"could":[194],"modulate":[195],"functions.":[197],"Expression":[198],"levels":[199],"potential":[201],"biological":[202],"activities":[203],"examined":[209],"stem-loop":[211],"quantitative":[212],"RT-PCR":[213],"luciferase":[215],"reporter":[216],"assay,":[217],"respectively,":[218],"11":[220],"present":[226],"functional":[228],"GP":[231],"cells.":[232],"CONCLUSIONS:":[233],"Our":[234],"study":[235],"provided":[236],"genome-wide":[238],"view":[239],"production":[242],"iridoviruses":[244],"miRNAs.":[250],"best":[253],"our":[255],"knowledge,":[256],"this":[257],"first":[260],"experimental":[261],"demonstration":[262],"aquatic":[267],"animal":[268],"The":[270],"results":[271],"provide":[272],"useful":[274],"resource":[275],"further":[277],"in-depth":[278],"on":[280],"pathogenesis.":[285]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}