{"id":"https://openalex.org/W2005755609","doi":"https://doi.org/10.1007/s00262-008-0634-y","title":"Anti-ganglioside anti-idiotypic monoclonal antibody-based cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma","display_name":"Anti-ganglioside anti-idiotypic monoclonal antibody-based cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma","publication_year":2008,"publication_date":"2008-12-09","ids":{"openalex":"https://openalex.org/W2005755609","doi":"https://doi.org/10.1007/s00262-008-0634-y","mag":"2005755609","pmid":"https://pubmed.ncbi.nlm.nih.gov/19066887","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030083"},"language":"en","primary_location":{"id":"doi:10.1007/s00262-008-0634-y","doi":"https://doi.org/10.1007/s00262-008-0634-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00262-008-0634-y","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Y. Diaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Y. Diaz","raw_affiliation_strings":["Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba","Center of Molecular Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]},{"raw_affiliation_string":"Center of Molecular Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111725963","display_name":"A. Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"A. Gonzalez","raw_affiliation_strings":["Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","Center of Molecular Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]},{"raw_affiliation_string":"Center of Molecular Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Lopez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"A. Lopez","raw_affiliation_strings":["Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","Center of Molecular Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]},{"raw_affiliation_string":"Center of Molecular Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103117328","display_name":"Rolando P\u00e9rez","orcid":"https://orcid.org/0000-0002-9498-886X","observed_orcids":["https://orcid.org/0000-0002-9498-886X"]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"R. Perez","raw_affiliation_strings":["Research and Development, Center of Molecular Immunology, Havana, Cuba","Center of Molecular Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Center of Molecular Immunology, Havana, Cuba","institution_ids":["https://openalex.org/I2355400"]},{"raw_affiliation_string":"Center of Molecular Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101936588","display_name":"Ana Mar\u00eda V\u00e1zquez","orcid":"https://orcid.org/0000-0003-1265-5066","observed_orcids":["https://orcid.org/0000-0003-1265-5066"]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"A. M. Vazquez","raw_affiliation_strings":["Antibody Engineering Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","Center of Molecular Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antibody Engineering Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]},{"raw_affiliation_string":"Center of Molecular Immunology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030297062","display_name":"Enrique Montero","orcid":"https://orcid.org/0000-0002-7127-6675","observed_orcids":["https://orcid.org/0000-0002-7127-6675"]},"institutions":[{"id":"https://openalex.org/I2355400","display_name":"Center of Molecular Immunology (Cuba)","ror":"https://ror.org/01gh7yb82","country_code":"CU","type":"company","lineage":["https://openalex.org/I2355400"]}],"countries":["CU"],"is_corresponding":true,"raw_author_name":"E. Montero","raw_affiliation_strings":["Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","Center of Molecular Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Immunotherapy Department, Center of Molecular Immunology, P.O. Box 16040, Havana, 11600, Cuba","institution_ids":["https://openalex.org/I2355400"]},{"raw_affiliation_string":"Center of Molecular Immunology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030297062"],"corresponding_institution_ids":["https://openalex.org/I2355400"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.8033,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.70086293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"58","issue":"7","first_page":"1117","last_page":"1128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.7210000157356262},{"id":"https://openalex.org/keywords/lewis-lung-carcinoma","display_name":"Lewis lung carcinoma","score":0.7839999794960022},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.847000002861023},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.7450000047683716},{"id":"https://openalex.org/keywords/aluminum-hydroxide-adjuvant","display_name":"aluminum hydroxide adjuvant","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.5580000281333923},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7063227891921997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6168118715286255},{"id":"https://openalex.org/C2777847059","wikidata":"https://www.wikidata.org/wiki/Q6537255","display_name":"Lewis lung carcinoma","level":4,"score":0.5981045365333557},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5401069521903992},{"id":"https://openalex.org/C2777331542","wikidata":"https://www.wikidata.org/wiki/Q419287","display_name":"Ganglioside","level":2,"score":0.5374736189842224},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5137585401535034},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.49356234073638916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4785750210285187},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.47245481610298157},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46648409962654114},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4626997113227844},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4544050097465515},{"id":"https://openalex.org/C2779975986","wikidata":"https://www.wikidata.org/wiki/Q6823250","display_name":"Metastatic carcinoma","level":3,"score":0.4307674169540405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4058458209037781},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.405692458152771},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.39593541622161865},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.27951112389564514},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2694414258003235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2631727457046509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2609347701072693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11451664566993713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018827","descriptor_name":"Carcinoma, Lewis Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00262-008-0634-y","doi":"https://doi.org/10.1007/s00262-008-0634-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00262-008-0634-y","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11030083","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030083","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunol Immunother","raw_type":"Text"},{"id":"pmid:19066887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19066887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology, immunotherapy : CII","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11030083","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11030083","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunol Immunother","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W65839805","https://openalex.org/W198761891","https://openalex.org/W1499321737","https://openalex.org/W1545986396","https://openalex.org/W1566766802","https://openalex.org/W1601227390","https://openalex.org/W1906135384","https://openalex.org/W1966035396","https://openalex.org/W1971656718","https://openalex.org/W1972085567","https://openalex.org/W1980013575","https://openalex.org/W1981305742","https://openalex.org/W2000174284","https://openalex.org/W2001281410","https://openalex.org/W2002581939","https://openalex.org/W2007854174","https://openalex.org/W2008581828","https://openalex.org/W2009066451","https://openalex.org/W2015615249","https://openalex.org/W2033195789","https://openalex.org/W2034269086","https://openalex.org/W2034624445","https://openalex.org/W2035446451","https://openalex.org/W2041182099","https://openalex.org/W2044896527","https://openalex.org/W2049370546","https://openalex.org/W2049766468","https://openalex.org/W2054873994","https://openalex.org/W2056733813","https://openalex.org/W2059860479","https://openalex.org/W2063856952","https://openalex.org/W2066735040","https://openalex.org/W2067844377","https://openalex.org/W2080267208","https://openalex.org/W2088028339","https://openalex.org/W2096319621","https://openalex.org/W2098176107","https://openalex.org/W2102895446","https://openalex.org/W2108572537","https://openalex.org/W2109043551","https://openalex.org/W2115951816","https://openalex.org/W2121753159","https://openalex.org/W2129268236","https://openalex.org/W2130528643","https://openalex.org/W2134403422","https://openalex.org/W2135505001","https://openalex.org/W2141157173","https://openalex.org/W2145299145","https://openalex.org/W2150048971","https://openalex.org/W2154027407","https://openalex.org/W2164352638","https://openalex.org/W2165677345","https://openalex.org/W2166573361","https://openalex.org/W2168152078","https://openalex.org/W2207393693","https://openalex.org/W2406769462"],"related_works":["https://openalex.org/W2002581939","https://openalex.org/W2033195789","https://openalex.org/W1930259341","https://openalex.org/W4313351427","https://openalex.org/W2054873994","https://openalex.org/W2164374194","https://openalex.org/W2249564639","https://openalex.org/W2129268236","https://openalex.org/W2035446451","https://openalex.org/W2075808338"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}