{"id":"https://openalex.org/W2005723593","doi":"https://doi.org/10.1194/jlr.m800112-jlr200","title":"Ceramide accelerates ultraviolet-induced MMP-1 expression through JAK1/STAT-1 pathway in cultured human dermal fibroblasts","display_name":"Ceramide accelerates ultraviolet-induced MMP-1 expression through JAK1/STAT-1 pathway in cultured human dermal fibroblasts","publication_year":2008,"publication_date":"2008-07-30","ids":{"openalex":"https://openalex.org/W2005723593","doi":"https://doi.org/10.1194/jlr.m800112-jlr200","mag":"2005723593","pmid":"https://pubmed.ncbi.nlm.nih.gov/18664717"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m800112-jlr200","doi":"https://doi.org/10.1194/jlr.m800112-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m800112-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1194/jlr.m800112-jlr200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100704241","display_name":"Sang\u2010Min Kim","orcid":"https://orcid.org/0000-0001-6172-6954","observed_orcids":["https://orcid.org/0000-0001-6172-6954"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sangmin Kim","raw_affiliation_strings":["Department of Dermatology, Seoul National University College of Medicine, Korea","Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Seoul National University College of Medicine, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063729455","display_name":"Yoonkyung Kim","orcid":"https://orcid.org/0000-0001-5535-164X","observed_orcids":["https://orcid.org/0000-0001-5535-164X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoonkyung Kim","raw_affiliation_strings":["Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101440786","display_name":"Youngae Lee","orcid":"https://orcid.org/0000-0003-2167-6205","observed_orcids":["https://orcid.org/0000-0003-2167-6205"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngae Lee","raw_affiliation_strings":["Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056846121","display_name":"Jin Ho Chung","orcid":"https://orcid.org/0000-0002-0582-6392","observed_orcids":["https://orcid.org/0000-0002-0582-6392"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin Ho Chung","raw_affiliation_strings":["Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Seoul National University College of Medicine, and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056846121"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.896,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.6910997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"49","issue":"12","first_page":"2571","last_page":"2581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.4207000136375427,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/uv-irradiation","display_name":"UV irradiation","score":0.906000018119812},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/human-dermal-fibroblasts","display_name":"human dermal fibroblasts","score":0.9089999794960022},{"id":"https://openalex.org/keywords/acid-sphingomyelinase","display_name":"acid sphingomyelinase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ceramidase","display_name":"ceramidase","score":0.6129999756813049},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.7149999737739563},{"id":"https://openalex.org/keywords/piceatannol","display_name":"piceatannol","score":0.9150000214576721},{"id":"https://openalex.org/keywords/jak3-inhibition","display_name":"JAK3 inhibition","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7100054025650024},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5848744511604309},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5526670217514038},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5435559153556824},{"id":"https://openalex.org/C3018555722","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet b","level":2,"score":0.5049074292182922},{"id":"https://openalex.org/C3017420807","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet a","level":2,"score":0.4656558632850647},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.4557265341281891},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3867516815662384},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34567561745643616},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33516955375671387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29962727427482605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27699393033981323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15129882097244263},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1501466929912567},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.11042821407318115},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.10538294911384583}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013108","descriptor_name":"Sphingomyelin Phosphodiesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053616","descriptor_name":"Janus Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053616","descriptor_name":"Janus Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055572","descriptor_name":"Ceramidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D055572","descriptor_name":"Ceramidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.m800112-jlr200","doi":"https://doi.org/10.1194/jlr.m800112-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m800112-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:18664717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18664717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aea5705c175548e2a3bd6d00f1292731","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aea5705c175548e2a3bd6d00f1292731","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 49, Iss 12, Pp 2571-2581 (2008)","raw_type":"article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/67536","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/67536","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m800112-jlr200","doi":"https://doi.org/10.1194/jlr.m800112-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m800112-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W10200443","https://openalex.org/W128536076","https://openalex.org/W171737858","https://openalex.org/W1497283905","https://openalex.org/W1536767595","https://openalex.org/W1557945185","https://openalex.org/W1566441785","https://openalex.org/W1585296580","https://openalex.org/W1894541755","https://openalex.org/W1945253873","https://openalex.org/W1969117799","https://openalex.org/W1970352919","https://openalex.org/W1972917887","https://openalex.org/W1973645860","https://openalex.org/W1981397830","https://openalex.org/W1981707898","https://openalex.org/W1984142578","https://openalex.org/W1986010238","https://openalex.org/W1987141787","https://openalex.org/W2015333209","https://openalex.org/W2017240991","https://openalex.org/W2017517432","https://openalex.org/W2031951021","https://openalex.org/W2036351012","https://openalex.org/W2037209759","https://openalex.org/W2039506763","https://openalex.org/W2047453411","https://openalex.org/W2065352517","https://openalex.org/W2065766712","https://openalex.org/W2067454860","https://openalex.org/W2069747363","https://openalex.org/W2073642026","https://openalex.org/W2077073821","https://openalex.org/W2081173396","https://openalex.org/W2086025404","https://openalex.org/W2096012158","https://openalex.org/W2126544407","https://openalex.org/W2135687585","https://openalex.org/W2136238444","https://openalex.org/W2139257034","https://openalex.org/W2162007544","https://openalex.org/W2184363469","https://openalex.org/W2418741078"],"related_works":["https://openalex.org/W571792643","https://openalex.org/W4321258662","https://openalex.org/W263696313","https://openalex.org/W2287382274","https://openalex.org/W2065079609","https://openalex.org/W1992969009","https://openalex.org/W2606089703","https://openalex.org/W2045233234","https://openalex.org/W2345051496","https://openalex.org/W1534612631"],"abstract_inverted_index":{"Ultraviolet":[0],"(UV)":[1],"irradiation":[2],"accelerates":[3],"formation":[4],"of":[5,9,20,48,55,74,100,107,112,133,154,172,191,211],"ceramide":[6,21,76,101,174,193],"through":[7,72],"hydrolysis":[8],"sphingomyelin":[10],"and":[11,38,57,66,110,128,156],"de":[12],"novo":[13],"synthesis.":[14],"Here,":[15],"we":[16,168,186],"investigated":[17],"the":[18,53,62,152,192],"effects":[19],"on":[22],"UV-induced":[23,58,67,157],"matrix":[24],"metalloproteinase-1":[25],"(MMP-1)":[26],"expression":[27,41,69,89,118,159,181],"in":[28,142],"human":[29,143],"dermal":[30,144],"fibroblasts.":[31,145],"Our":[32,82],"results":[33,83],"showed":[34,85],"that":[35,86,149,170,188],"acidic-sphingomyelinase":[36],"(aSMase)":[37],"MMP-1":[39,59,68,87,117,158,179,204],"mRNA":[40],"were":[42],"increased":[43,71,92],"by":[44,77,93,103,122,137,163,175],"UV":[45,150,176],"irradiation.":[46],"Treatment":[47],"D609":[49],"(aSMase":[50],"inhibitor)":[51],"decreased":[52,162],"level":[54],"basal":[56,65],"expression.":[60],"On":[61],"other":[63],"hand,":[64],"was":[70,90,119,160],"induction":[73,171],"intracellular":[75,173],"D-MAPP,":[78],"a":[79,130,198,208],"ceramidase":[80],"inhibitor.":[81],"also":[84,147],"protein":[88],"dose-dependently":[91],"C(2)-ceramide":[94,104],"or":[95],"SMase":[96],"treatment.":[97],"The":[98],"activation":[99],"pathway":[102,195],"enhanced":[105],"phosphorylation":[106,153],"signal":[108],"transducer":[109],"activators":[111],"transcription-1":[113],"(STAT-1),":[114],"whereas":[115],"ceramide-induced":[116],"potently":[120],"prevented":[121],"piceatannol;":[123],"Janus":[124],"kinase":[125],"(JAK1)":[126],"inhibtor;":[127],"WHI-P131,":[129],"specific":[131],"inhibitor":[132],"JAK3;":[134],"but":[135],"not":[136],"AG490,":[138],"JAK":[139],"2":[140],"inhbitor,":[141],"We":[146],"found":[148],"induced":[151],"STAT-1,":[155],"significantly":[161],"JAK1":[164],"inhibitor,":[165],"piceatannol.":[166],"Overall,":[167],"demonstrate":[169],"may":[177,196],"activate":[178],"gene":[180,210],"via":[182],"JAK1/STAT-1":[183],"pathway.":[184],"Therefore,":[185],"suggest":[187],"targeted":[189],"modulation":[190],"signaling":[194],"offer":[197],"novel":[199],"therapeutic":[200],"approach":[201],"for":[202],"inhibiting":[203],"expression,":[205],"which":[206],"is":[207],"causing":[209],"skin":[212],"aging.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
