{"id":"https://openalex.org/W2005709390","doi":"https://doi.org/10.1016/j.bbrc.2012.12.029","title":"Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice","display_name":"Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice","publication_year":2012,"publication_date":"2012-12-19","ids":{"openalex":"https://openalex.org/W2005709390","doi":"https://doi.org/10.1016/j.bbrc.2012.12.029","mag":"2005709390","pmid":"https://pubmed.ncbi.nlm.nih.gov/23261432"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2012.12.029","doi":"https://doi.org/10.1016/j.bbrc.2012.12.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2012.12.029","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005709390"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088042829","display_name":"Jee-Hyung Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jee-Hyung Lee","raw_affiliation_strings":["Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016925586","display_name":"Jiaping Gao","orcid":"https://orcid.org/0000-0001-9526-8648","observed_orcids":["https://orcid.org/0000-0001-9526-8648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaping Gao","raw_affiliation_strings":["Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053330274","display_name":"Penelope A. Kosinski","orcid":"https://orcid.org/0000-0002-4465-0924","observed_orcids":["https://orcid.org/0000-0002-4465-0924"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Penelope A. Kosinski","raw_affiliation_strings":["Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091419246","display_name":"Stephen J. Elliman","orcid":"https://orcid.org/0000-0003-2121-8407","observed_orcids":["https://orcid.org/0000-0003-2121-8407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen J. Elliman","raw_affiliation_strings":["Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061359578","display_name":"Thomas E. Hughes","orcid":"https://orcid.org/0000-0002-2930-0088","observed_orcids":["https://orcid.org/0000-0002-2930-0088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas E. Hughes","raw_affiliation_strings":["Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008058230","display_name":"Jesper Gromada","orcid":"https://orcid.org/0000-0002-0278-3454","observed_orcids":["https://orcid.org/0000-0002-0278-3454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jesper Gromada","raw_affiliation_strings":["Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108356463","display_name":"Daniel M. Kemp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel M. Kemp","raw_affiliation_strings":["Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolism Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108356463"],"corresponding_institution_ids":[],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.7168,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.6337087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"430","issue":"3","first_page":"1109","last_page":"1113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9649999737739563},{"id":"https://openalex.org/keywords/auy922","display_name":"AUY922","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hsf1","display_name":"HSF1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9779999852180481},{"id":"https://openalex.org/keywords/jnk1-phosphorylation","display_name":"JNK1 phosphorylation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8330000042915344},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.984000027179718},{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2776667301","wikidata":"https://www.wikidata.org/wiki/Q18027324","display_name":"HSF1","level":5,"score":0.9238293170928955},{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.7654442191123962},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.7009849548339844},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.632019579410553},{"id":"https://openalex.org/C52981337","wikidata":"https://www.wikidata.org/wiki/Q24782817","display_name":"Heat shock factor","level":5,"score":0.6215628385543823},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.611832320690155},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5820249915122986},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48785400390625},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.42960113286972046},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42800039052963257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42536604404449463},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4169909358024597},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.414380818605423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3611416220664978},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35425418615341187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3486025035381317},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28971874713897705},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.21379780769348145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1506420075893402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076249","descriptor_name":"Heat Shock Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012118","descriptor_name":"Resorcinols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012118","descriptor_name":"Resorcinols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047029","descriptor_name":"Lactams, Macrocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2012.12.029","doi":"https://doi.org/10.1016/j.bbrc.2012.12.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2012.12.029","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:23261432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23261432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1590102610","https://openalex.org/W1984382435","https://openalex.org/W2003578093","https://openalex.org/W2012248291","https://openalex.org/W2022420894","https://openalex.org/W2028978816","https://openalex.org/W2038018821","https://openalex.org/W2049129605","https://openalex.org/W2053593111","https://openalex.org/W2057123776","https://openalex.org/W2059524588","https://openalex.org/W2066982679","https://openalex.org/W2093155745","https://openalex.org/W2102683312","https://openalex.org/W2110671157","https://openalex.org/W2130091960","https://openalex.org/W2131914005","https://openalex.org/W2139745857","https://openalex.org/W2144995506","https://openalex.org/W2157386619","https://openalex.org/W2158563216","https://openalex.org/W2166999544","https://openalex.org/W2413825624"],"related_works":["https://openalex.org/W2278878505","https://openalex.org/W2126201508","https://openalex.org/W2037153563","https://openalex.org/W2786964269","https://openalex.org/W2402590212","https://openalex.org/W2587679685","https://openalex.org/W2307669865","https://openalex.org/W2530008360","https://openalex.org/W2989799842","https://openalex.org/W3006720835"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}