{"id":"https://openalex.org/W2005708590","doi":"https://doi.org/10.1016/0006-2952(91)90208-m","title":"Effect of amiodarone on the phospholipid and lamellar body content of lymphoblasts in vitro and peripheral blood lymphocytes in vivo","display_name":"Effect of amiodarone on the phospholipid and lamellar body content of lymphoblasts in vitro and peripheral blood lymphocytes in vivo","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2005708590","doi":"https://doi.org/10.1016/0006-2952(91)90208-m","mag":"2005708590","pmid":"https://pubmed.ncbi.nlm.nih.gov/1848974"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(91)90208-m","doi":"https://doi.org/10.1016/0006-2952(91)90208-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(91)90208-m","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009097053","display_name":"Karl Y. Hostetler","orcid":"https://orcid.org/0000-0002-1155-2885","observed_orcids":["https://orcid.org/0000-0002-1155-2885"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karl Y. Hostetler","raw_affiliation_strings":["Department of Medicine, University of California, San Diego 92093","Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093, U.S.A","Veterans Administration Medical Center, San Diego, CA 92161, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego 92093","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Administration Medical Center, San Diego, CA 92161, U.S.A","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112374928","display_name":"Jerry S. Vande Berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Vande Berg","raw_affiliation_strings":["Department of Surgery, Division of Plastic Surgery, University of California, San Diego, San Diego, CA 92093, U.S.A","Veterans Administration Medical Center, San Diego, CA 92161, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Plastic Surgery, University of California, San Diego, San Diego, CA 92093, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Administration Medical Center, San Diego, CA 92161, U.S.A","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038674105","display_name":"Kathy A. Aldern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathy A. Aldern","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093, U.S.A","Veterans Administration Medical Center, San Diego, CA 92161, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, San Diego, CA 92093, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Administration Medical Center, San Diego, CA 92161, U.S.A","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050871976","display_name":"Gregory T. Brophy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory T. Brophy","raw_affiliation_strings":["The Lilly Research Laboratories, Greenfield, IN 46140, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lilly Research Laboratories, Greenfield, IN 46140, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009097053"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I36258959"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.4213,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.58808933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"41","issue":"6-7","first_page":"1007","last_page":"1013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.513700008392334,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.16760000586509705,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amiodarone","display_name":"amiodarone","score":0.9869999885559082},{"id":"https://openalex.org/keywords/amiodarone-toxicity","display_name":"amiodarone toxicity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/phospholipid-accumulation","display_name":"phospholipid accumulation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/multilamellar-bodies","display_name":"multilamellar bodies","score":0.906000018119812},{"id":"https://openalex.org/keywords/lymphoblasts","display_name":"lymphoblasts","score":0.8399999737739563},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/desethylamiodarone","display_name":"desethylamiodarone","score":0.8679999709129333},{"id":"https://openalex.org/keywords/drug-induced-lung-injury","display_name":"drug-induced lung injury","score":0.4970000088214874},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.8884243369102478},{"id":"https://openalex.org/C2779934242","wikidata":"https://www.wikidata.org/wiki/Q7187520","display_name":"Phospholipidosis","level":4,"score":0.8242731690406799},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7754848003387451},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6910784840583801},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6636395454406738},{"id":"https://openalex.org/C113842279","wikidata":"https://www.wikidata.org/wiki/Q1873857","display_name":"Lymphoblast","level":3,"score":0.6069863438606262},{"id":"https://openalex.org/C145156650","wikidata":"https://www.wikidata.org/wiki/Q4253549","display_name":"Lamellar granule","level":3,"score":0.5735428929328918},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.53094881772995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4992375373840332},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47903457283973694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47092241048812866},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4683529734611511},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4276033043861389},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.42444509267807007},{"id":"https://openalex.org/C203750385","wikidata":"https://www.wikidata.org/wiki/Q1308970","display_name":"Inclusion bodies","level":4,"score":0.41402170062065125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3289757966995239},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.27902260422706604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27507343888282776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2483324408531189},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.15023273229599},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11527997255325317},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(91)90208-m","doi":"https://doi.org/10.1016/0006-2952(91)90208-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(91)90208-m","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:1848974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1848974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G606171320","display_name":null,"funder_award_id":"GM24979","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7397776078","display_name":"ANTIVIRAL LIPID PRODRUGS IN AIDS AND HEPATITIS B","funder_award_id":"5r01gm024979-20","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1966383754","https://openalex.org/W1970639801","https://openalex.org/W1975956882","https://openalex.org/W1976921391","https://openalex.org/W2003709444","https://openalex.org/W2010724836","https://openalex.org/W2029952223","https://openalex.org/W2031305613","https://openalex.org/W2050071623","https://openalex.org/W2065732506","https://openalex.org/W2078677365","https://openalex.org/W2088600176","https://openalex.org/W2095530693","https://openalex.org/W2112021306","https://openalex.org/W2168526937","https://openalex.org/W2409565603","https://openalex.org/W2415165777","https://openalex.org/W4213205077"],"related_works":["https://openalex.org/W1970639801","https://openalex.org/W2101965284","https://openalex.org/W2029952223","https://openalex.org/W2031305613","https://openalex.org/W2401116956","https://openalex.org/W2461823873","https://openalex.org/W1888455958","https://openalex.org/W4235591792","https://openalex.org/W2031134295","https://openalex.org/W2062485163"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}