{"id":"https://openalex.org/W2005694161","doi":"https://doi.org/10.1016/s0306-9877(98)90054-8","title":"An immunological model connecting the pathogenesis of stress, depression and carcinoma","display_name":"An immunological model connecting the pathogenesis of stress, depression and carcinoma","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2005694161","doi":"https://doi.org/10.1016/s0306-9877(98)90054-8","mag":"2005694161","pmid":"https://pubmed.ncbi.nlm.nih.gov/9824837"},"language":"en","primary_location":{"id":"doi:10.1016/s0306-9877(98)90054-8","doi":"https://doi.org/10.1016/s0306-9877(98)90054-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0306-9877(98)90054-8","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/An_immunological_model_connecting_the_pathogenesis_of_stress_depression_and_carcinoma/22834697","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108531431","display_name":"R.J. Holden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"R.J. Holden","raw_affiliation_strings":["Medical Research Unit, University of Wollongong, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Unit, University of Wollongong, NSW, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080656438","display_name":"I.S. Pakula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I2801592211","display_name":"Shellharbour Hospital","ror":"https://ror.org/01dvjey82","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801592211"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"I.S. Pakula","raw_affiliation_strings":["Associate Professor and Director, Psychiatric Services, lllawarra Area Health Service, Shellharbour Hospital, P.O. Box 52, Shellharbour Square, NSW 2529, Australia","Associate Professor, Medical Research Unit, University of Wollongong, Northfields Ave., Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor and Director, Psychiatric Services, lllawarra Area Health Service, Shellharbour Hospital, P.O. Box 52, Shellharbour Square, NSW 2529, Australia","institution_ids":["https://openalex.org/I2801592211"]},{"raw_affiliation_string":"Associate Professor, Medical Research Unit, University of Wollongong, Northfields Ave., Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113560670","display_name":"P.A. Mooney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]},{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P.A. Mooney","raw_affiliation_strings":["Associate Professor, Medical Research Unit, University of Wollongong, Northfields Ave., Wollongong, NSW 2522, Australia","Senior Lecturer, Dept of Biomedical Science, University of Tasmania at Launceston, P.O. Box 1214, Launceston 7250, Tasmania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Medical Research Unit, University of Wollongong, Northfields Ave., Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Senior Lecturer, Dept of Biomedical Science, University of Tasmania at Launceston, P.O. Box 1214, Launceston 7250, Tasmania USA","institution_ids":["https://openalex.org/I129801699"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108531431"],"corresponding_institution_ids":["https://openalex.org/I204824540"],"apc_list":{"value":2820,"currency":"USD","value_usd":2820},"apc_paid":null,"fwci":1.4917,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.8118156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"51","issue":"4","first_page":"309","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.06350000202655792,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychological-stress","display_name":"psychological stress","score":0.9290000200271606},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.621999979019165},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6869999766349792},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9950000047683716},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.9240000247955322},{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"immune surveillance","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8360000252723694},{"id":"https://openalex.org/keywords/bereavement","display_name":"bereavement","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.671863853931427},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6165345907211304},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.5968409776687622},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49137869477272034},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.46474000811576843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.405266672372818},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3725633919239044},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36009451746940613},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001615","descriptor_name":"beta-Endorphin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0306-9877(98)90054-8","doi":"https://doi.org/10.1016/s0306-9877(98)90054-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0306-9877(98)90054-8","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},{"id":"pmid:9824837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9824837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical hypotheses","raw_type":"Journal Article"},{"id":"pmh:oai:ecite.utas.edu.au:13021","doi":null,"is_oa":false,"landing_page_url":"http://ecite.utas.edu.au/13021","pdf_url":null,"source":{"id":"https://openalex.org/S4306401569","display_name":"eCite Digital Repository (University of Tasmania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129801699","host_organization_name":"University of Tasmania","host_organization_lineage":["https://openalex.org/I129801699"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Refereed Article"},{"id":"pmh:oai:figshare.com:article/22834697","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/An_immunological_model_connecting_the_pathogenesis_of_stress_depression_and_carcinoma/22834697","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/22834697","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/An_immunological_model_connecting_the_pathogenesis_of_stress_depression_and_carcinoma/22834697","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W151019400","https://openalex.org/W1488330478","https://openalex.org/W1497715963","https://openalex.org/W1865315112","https://openalex.org/W1891172846","https://openalex.org/W1953976277","https://openalex.org/W1968806460","https://openalex.org/W1984123902","https://openalex.org/W1985017497","https://openalex.org/W1985598702","https://openalex.org/W1989497964","https://openalex.org/W1991516626","https://openalex.org/W1995905499","https://openalex.org/W1997486491","https://openalex.org/W2002008252","https://openalex.org/W2005764829","https://openalex.org/W2008946516","https://openalex.org/W2009015174","https://openalex.org/W2014649622","https://openalex.org/W2015723942","https://openalex.org/W2017786018","https://openalex.org/W2019324493","https://openalex.org/W2019327238","https://openalex.org/W2023111652","https://openalex.org/W2029755823","https://openalex.org/W2034472258","https://openalex.org/W2036974395","https://openalex.org/W2039086573","https://openalex.org/W2043342443","https://openalex.org/W2045139088","https://openalex.org/W2051397541","https://openalex.org/W2055258442","https://openalex.org/W2060345189","https://openalex.org/W2071923667","https://openalex.org/W2073520179","https://openalex.org/W2077756813","https://openalex.org/W2078702667","https://openalex.org/W2080001677","https://openalex.org/W2082617556","https://openalex.org/W2085867358","https://openalex.org/W2090804691","https://openalex.org/W2093144764","https://openalex.org/W2093568058","https://openalex.org/W2114405576","https://openalex.org/W2121167131","https://openalex.org/W2135808990","https://openalex.org/W2150004057","https://openalex.org/W2153077969","https://openalex.org/W2157038569","https://openalex.org/W2163992925","https://openalex.org/W2208092455","https://openalex.org/W2402199320","https://openalex.org/W2402519141","https://openalex.org/W2408079125","https://openalex.org/W2409140847","https://openalex.org/W2412346301","https://openalex.org/W2412646788","https://openalex.org/W2413880302","https://openalex.org/W2416324400","https://openalex.org/W2471374224","https://openalex.org/W4320801142","https://openalex.org/W6639729924","https://openalex.org/W6713341182","https://openalex.org/W6714263452"],"related_works":["https://openalex.org/W1969507374","https://openalex.org/W2506339301","https://openalex.org/W2151313580","https://openalex.org/W4414086507","https://openalex.org/W2077856275","https://openalex.org/W2118233432","https://openalex.org/W2353701824","https://openalex.org/W2789988309","https://openalex.org/W2417103331","https://openalex.org/W4212985022"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}