{"id":"https://openalex.org/W2005688973","doi":"https://doi.org/10.1118/1.4820534","title":"Use of dMLC for implementation of dynamic respiratory\u2010gated radiation therapy","display_name":"Use of dMLC for implementation of dynamic respiratory\u2010gated radiation therapy","publication_year":2013,"publication_date":"2013-09-13","ids":{"openalex":"https://openalex.org/W2005688973","doi":"https://doi.org/10.1118/1.4820534","mag":"2005688973","pmid":"https://pubmed.ncbi.nlm.nih.gov/24089898","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785535"},"language":"en","primary_location":{"id":"doi:10.1118/1.4820534","doi":"https://doi.org/10.1118/1.4820534","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4820534","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785535","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072763706","display_name":"Eric W. Pepin","orcid":"https://orcid.org/0000-0002-1185-9764","observed_orcids":["https://orcid.org/0000-0002-1185-9764"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric W. Pepin","raw_affiliation_strings":["Purdue School of Engineering Technology, IUPUI, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue School of Engineering Technology, IUPUI, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011747432","display_name":"Huanmei Wu","orcid":"https://orcid.org/0000-0003-0346-6044","observed_orcids":["https://orcid.org/0000-0003-0346-6044"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huanmei Wu","raw_affiliation_strings":["Purdue School of Engineering Technology, IUPUI, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue School of Engineering Technology, IUPUI, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020774876","display_name":"Hiroki Shirato","orcid":"https://orcid.org/0000-0003-3699-6439","observed_orcids":["https://orcid.org/0000-0003-3699-6439"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Shirato","raw_affiliation_strings":["Hokkaido University School of Medicine, Sapporo 060-8638, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hokkaido University School of Medicine, Sapporo 060-8638, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072763706"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I55769427"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.3305,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61000742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"40","issue":"10","first_page":"101708","last_page":"101708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamic-multileaf-collimator","display_name":"dynamic multileaf collimator","score":0.9810000061988831},{"id":"https://openalex.org/keywords/respiratory-gating","display_name":"respiratory gating","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.5979999899864197},{"id":"https://openalex.org/keywords/baseline-drift","display_name":"baseline drift","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tumor-motion-tracking","display_name":"tumor motion tracking","score":0.8040000200271606},{"id":"https://openalex.org/keywords/finite-state-models","display_name":"finite-state models","score":0.9779999852180481},{"id":"https://openalex.org/keywords/duty-cycle","display_name":"duty cycle","score":0.7829999923706055},{"id":"https://openalex.org/keywords/fluence-map","display_name":"fluence map","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-obstruction","display_name":"tumor obstruction","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.9405450820922852},{"id":"https://openalex.org/C199822604","wikidata":"https://www.wikidata.org/wiki/Q557120","display_name":"Duty cycle","level":3,"score":0.6771821975708008},{"id":"https://openalex.org/C161471255","wikidata":"https://www.wikidata.org/wiki/Q374703","display_name":"Multileaf collimator","level":4,"score":0.6419569253921509},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40039879083633423},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.3403254747390747},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3252685070037842},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.31287333369255066},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.20833304524421692},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19332802295684814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19303235411643982},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12117674946784973},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011881","descriptor_name":"Radiotherapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011881","descriptor_name":"Radiotherapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011881","descriptor_name":"Radiotherapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1118/1.4820534","doi":"https://doi.org/10.1118/1.4820534","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.4820534","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3785535","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785535","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Phys","raw_type":"Text"},{"id":"pmid:24089898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24089898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical physics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3785535","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785535","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Phys","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5199999809265137,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2530892357","display_name":null,"funder_award_id":"R21 CA130849","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4692667752","display_name":"Lung Tumor Motion Behavior Analysis Using 4DCT","funder_award_id":"5r21ca130849-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8829695835","display_name":null,"funder_award_id":"1R21CA130849-01A","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000003880","display_name":null,"funder_award_id":"1R21CA130849-01A","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1965847111","https://openalex.org/W1972479925","https://openalex.org/W1973093899","https://openalex.org/W1975262667","https://openalex.org/W1983592049","https://openalex.org/W1983934388","https://openalex.org/W1988158291","https://openalex.org/W1990105063","https://openalex.org/W1993643279","https://openalex.org/W1994600962","https://openalex.org/W1994914401","https://openalex.org/W1999208323","https://openalex.org/W2000278090","https://openalex.org/W2001595923","https://openalex.org/W2002305212","https://openalex.org/W2013889193","https://openalex.org/W2016811299","https://openalex.org/W2020671330","https://openalex.org/W2024047234","https://openalex.org/W2025553206","https://openalex.org/W2041850109","https://openalex.org/W2045208074","https://openalex.org/W2049736486","https://openalex.org/W2051988933","https://openalex.org/W2059122531","https://openalex.org/W2060484971","https://openalex.org/W2060640319","https://openalex.org/W2067918107","https://openalex.org/W2077291026","https://openalex.org/W2078148714","https://openalex.org/W2080298337","https://openalex.org/W2080343265","https://openalex.org/W2084077062","https://openalex.org/W2084822925","https://openalex.org/W2119594372","https://openalex.org/W2121420238","https://openalex.org/W2123488884","https://openalex.org/W2158994833","https://openalex.org/W2167583425","https://openalex.org/W2226420951"],"related_works":["https://openalex.org/W2051425291","https://openalex.org/W1994914401","https://openalex.org/W2013782864","https://openalex.org/W1543166530","https://openalex.org/W2069692960","https://openalex.org/W7061537270","https://openalex.org/W3024855804","https://openalex.org/W1991148066","https://openalex.org/W6966575147","https://openalex.org/W1602938056"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"simulate":[2],"and":[3,61,128,139,163],"evaluate":[4],"the":[5,36,51,55,63,164],"use":[6,153],"of":[7,70,96,154,167],"dynamic":[8,41,83,119,133,155,178],"multileaf":[9],"collimators":[10],"(dMLC)":[11],"in":[12,47,82],"respiratory":[13,42],"gating":[14,43,84,120,123,134,156,162],"to":[15,91,172,177],"compensate":[16],"for":[17,99,107],"baseline":[18],"drift.":[19],"METHODS:":[20],"Tumor":[21],"motion":[22,78],"tracking":[23],"data":[24],"from":[25],"30":[26],"lung":[27],"tumors":[28],"over":[29],"322":[30],"treatment":[31,85],"fractions":[32],"was":[33,45,80,104,115,143],"analyzed":[34],"with":[35,76,148],"finite":[37],"state":[38],"model.":[39],"A":[40,73],"window":[44],"established":[46],"real-time":[48],"by":[49],"determining":[50],"average":[52,69,112,146],"positions":[53],"during":[54],"previous":[56],"two":[57],"end-of-expiration":[58],"breathing":[59],"phases":[60],"centering":[62],"dMLC":[64,75,169],"aperture":[65],"on":[66,145],"a":[67,93,168],"weighted":[68],"these":[71],"positions.":[72],"simulated":[74],"physical":[77,165],"constraints":[79,166],"used":[81],"simulations.":[86],"Fluence":[87],"maps":[88],"were":[89,170],"created":[90],"provide":[92],"statistical":[94],"description":[95],"radiation":[97],"delivery":[98,141],"each":[100,108,140],"fraction.":[101,109],"Duty":[102],"cycle":[103,114],"also":[105,124],"calculated":[106],"RESULTS:":[110],"The":[111,152],"duty":[113],"2.3%":[116],"greater":[117],"under":[118],"conditions.":[121],"Dynamic":[122],"showed":[125,157],"higher":[126],"fluences":[127],"less":[129],"tumor":[130],"obstruction.":[131],"Additionally,":[132],"required":[135],"fewer":[136],"beam":[137],"toggles":[138],"period":[142],"longer":[144],"than":[147,160],"static":[149,161],"gating.":[150,179],"CONCLUSIONS:":[151],"better":[158],"performance":[159],"shown":[171],"not":[173],"be":[174],"an":[175],"impediment":[176]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}