{"id":"https://openalex.org/W2005683602","doi":"https://doi.org/10.9734/ejmp/2015/16058","title":"Hypoglycemic and Hypolipidemic Potentials of Extract of Vernonia calvoana on Alloxan-Induced Diabetic Albino Wistar Rats","display_name":"Hypoglycemic and Hypolipidemic Potentials of Extract of Vernonia calvoana on Alloxan-Induced Diabetic Albino Wistar Rats","publication_year":2015,"publication_date":"2015-01-10","ids":{"openalex":"https://openalex.org/W2005683602","doi":"https://doi.org/10.9734/ejmp/2015/16058","mag":"2005683602"},"language":"en","primary_location":{"id":"doi:10.9734/ejmp/2015/16058","doi":"https://doi.org/10.9734/ejmp/2015/16058","is_oa":false,"landing_page_url":"https://doi.org/10.9734/ejmp/2015/16058","pdf_url":null,"source":{"id":"https://openalex.org/S2765025883","display_name":"European Journal of Medicinal Plants","issn_l":"2231-0894","issn":["2231-0894"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Plants","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://journalejmp.com/index.php/EJMP/article/view/403","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040527697","display_name":"I. A. Iwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3970730","display_name":"University of Calabar","ror":"https://ror.org/05qderh61","country_code":"NG","type":"education","lineage":["https://openalex.org/I3970730"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"I. Iwara","raw_affiliation_strings":["Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria","institution_ids":["https://openalex.org/I3970730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071469254","display_name":"Godwin Oju Igile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3970730","display_name":"University of Calabar","ror":"https://ror.org/05qderh61","country_code":"NG","type":"education","lineage":["https://openalex.org/I3970730"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"G. Igile","raw_affiliation_strings":["Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria","institution_ids":["https://openalex.org/I3970730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035502059","display_name":"F.E. Uboh","orcid":"https://orcid.org/0000-0002-9546-4363","observed_orcids":["https://orcid.org/0000-0002-9546-4363"]},"institutions":[{"id":"https://openalex.org/I3970730","display_name":"University of Calabar","ror":"https://ror.org/05qderh61","country_code":"NG","type":"education","lineage":["https://openalex.org/I3970730"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"F. Uboh","raw_affiliation_strings":["Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria","institution_ids":["https://openalex.org/I3970730"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Eyong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3970730","display_name":"University of Calabar","ror":"https://ror.org/05qderh61","country_code":"NG","type":"education","lineage":["https://openalex.org/I3970730"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"E. Eyong","raw_affiliation_strings":["Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria","institution_ids":["https://openalex.org/I3970730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112229400","display_name":"Patrick Ekong Ebong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3970730","display_name":"University of Calabar","ror":"https://ror.org/05qderh61","country_code":"NG","type":"education","lineage":["https://openalex.org/I3970730"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"P. Ebong","raw_affiliation_strings":["Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar,  Calabar, Nigeria","institution_ids":["https://openalex.org/I3970730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3970730"],"apc_list":null,"apc_paid":null,"fwci":2.8988,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.91152773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"2","first_page":"78","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoglycemic-activity","display_name":"hypoglycemic activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hypolipidemic-activity","display_name":"hypolipidemic activity","score":1.0},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9879999756813049},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7590000033378601},{"id":"https://openalex.org/keywords/serum-glucose","display_name":"serum glucose","score":0.6650000214576721},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5289999842643738},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9490000009536743},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.8389999866485596},{"id":"https://openalex.org/keywords/antidiabetic-plants","display_name":"antidiabetic plants","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.8553022146224976},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6592149138450623},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.5971523523330688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5384827256202698},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.5292474627494812},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4707380533218384},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.45219430327415466},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4419430196285248},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42451566457748413},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4106253981590271},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4102799594402313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2579169273376465}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.9734/ejmp/2015/16058","doi":"https://doi.org/10.9734/ejmp/2015/16058","is_oa":false,"landing_page_url":"https://doi.org/10.9734/ejmp/2015/16058","pdf_url":null,"source":{"id":"https://openalex.org/S2765025883","display_name":"European Journal of Medicinal Plants","issn_l":"2231-0894","issn":["2231-0894"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Plants","raw_type":"journal-article"},{"id":"pmh:oai:journalejmp.com:article/403","doi":null,"is_oa":true,"landing_page_url":"https://journalejmp.com/index.php/EJMP/article/view/403","pdf_url":null,"source":{"id":"https://openalex.org/S2765025883","display_name":"European Journal of Medicinal Plants","issn_l":"2231-0894","issn":["2231-0894"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2231-0894","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05439074v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05439074","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Medicinal Plants, 2015, 8 (2), pp.78-86","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:journalejmp.com:article/403","doi":null,"is_oa":true,"landing_page_url":"https://journalejmp.com/index.php/EJMP/article/view/403","pdf_url":null,"source":{"id":"https://openalex.org/S2765025883","display_name":"European Journal of Medicinal Plants","issn_l":"2231-0894","issn":["2231-0894"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2231-0894","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1497084215","https://openalex.org/W1976191764","https://openalex.org/W1986281144","https://openalex.org/W2029388483","https://openalex.org/W2039515473","https://openalex.org/W2042464457","https://openalex.org/W2059027410","https://openalex.org/W2086374760","https://openalex.org/W2089563981","https://openalex.org/W2109514669","https://openalex.org/W2122256127","https://openalex.org/W2146357747","https://openalex.org/W2501562952"],"related_works":["https://openalex.org/W3011038164","https://openalex.org/W1621602360","https://openalex.org/W2035639260","https://openalex.org/W2901597947","https://openalex.org/W2050761047","https://openalex.org/W86646240","https://openalex.org/W1965773571","https://openalex.org/W2116852198","https://openalex.org/W2992414444","https://openalex.org/W7214077285"],"abstract_inverted_index":{"Objective:":[0],"Investigations":[1],"were":[2,58,85],"carried":[3],"out":[4],"to":[5],"evaluate":[6],"the":[7,21,89,119],"therapeutic":[8],"potentials":[9,25],"of":[10,12,26,28,43,97,108],"extract":[11,27,96],"Vernonia":[13,29,98,109],"calvoana":[14,30,99,110],"as":[15],"herbal":[16],"medicines.Methods:":[17],"In":[18],"this":[19],"study,":[20],"hypoglycemic":[22,102,113],"and":[23,36,55,64,80,103,114],"hypolipidemic":[24,104,115],"was":[31,93],"evaluated":[32],"by":[33],"using":[34],"normal":[35],"alloxan-induced":[37],"diabetic":[38],"rats":[39],"at":[40,60],"a":[41],"dose":[42],"400":[44],"mg/kg":[45],"b.w.":[46],"daily":[47],"for":[48,122],"14":[49],"days.":[50],"Fasting":[51],"Blood":[52],"glucose":[53],"levels":[54],"body":[56],"weight":[57],"monitored":[59],"7":[61],"days":[62],"intervals,":[63],"different":[65],"biochemical":[66],"parameters,":[67],"serum":[68,70,72],"glucose,":[69],"cholesterol,":[71],"triacylglycerol,":[73],"high":[74],"density":[75,78,83],"lipoprotein,":[76],"low":[77,82],"lipoprotein":[79,84],"very":[81],"also":[86],"assessed":[87],"in":[88],"experimental":[90],"animals.Results:":[91],"It":[92],"found":[94],"that":[95],"showed":[100,111],"significant":[101,112],"activity":[105],"(P<0.01).Conclusion:":[106],"Extracts":[107],"activity,":[116],"which":[117],"provides":[118],"scientific":[120],"proof":[121],"their":[123],"traditional":[124],"claims.":[125]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2016-06-24T00:00:00"}