{"id":"https://openalex.org/W2005683431","doi":"https://doi.org/10.1021/op9002328","title":"Comparison of Large-Scale Routes to Manufacture Chiral exo-2-Norbornyl Thiourea","display_name":"Comparison of Large-Scale Routes to Manufacture Chiral exo-2-Norbornyl Thiourea","publication_year":2009,"publication_date":"2009-12-08","ids":{"openalex":"https://openalex.org/W2005683431","doi":"https://doi.org/10.1021/op9002328","mag":"2005683431"},"language":"en","primary_location":{"id":"doi:10.1021/op9002328","doi":"https://doi.org/10.1021/op9002328","is_oa":false,"landing_page_url":"https://doi.org/10.1021/op9002328","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research &amp; Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077941304","display_name":"Seb Caille","orcid":"https://orcid.org/0000-0001-5434-5483","observed_orcids":["https://orcid.org/0000-0001-5434-5483"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seb Caille","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031319725","display_name":"Jerome Boni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome Boni","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112783678","display_name":"Geoffrey B. Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey B. Cox","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077542724","display_name":"Margaret M. Faul","orcid":"https://orcid.org/0009-0008-3709-3462","observed_orcids":["https://orcid.org/0009-0008-3709-3462"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret M. Faul","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064921533","display_name":"Pilar Franco","orcid":"https://orcid.org/0000-0001-7488-3932","observed_orcids":["https://orcid.org/0000-0001-7488-3932"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pilar Franco","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037439941","display_name":"Saab Khattabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saab Khattabi","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010949745","display_name":"Liane M. Klingensmith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liane M. Klingensmith","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055954213","display_name":"Jay F. Larrow","orcid":"https://orcid.org/0000-0003-4756-3874","observed_orcids":["https://orcid.org/0000-0003-4756-3874"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay F. Larrow","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081001948","display_name":"James K. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James K. Lee","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063361991","display_name":"Michael J. Martinelli","orcid":"https://orcid.org/0009-0007-4647-3064","observed_orcids":["https://orcid.org/0009-0007-4647-3064"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Martinelli","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073671304","display_name":"Larry M. Miller","orcid":"https://orcid.org/0000-0002-2085-1844","observed_orcids":["https://orcid.org/0000-0002-2085-1844"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry M. Miller","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043461259","display_name":"George A. Moniz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George A. Moniz","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085982278","display_name":"Kenichi Sakai","orcid":"https://orcid.org/0000-0003-4038-8954","observed_orcids":["https://orcid.org/0000-0003-4038-8954","https://orcid.org/0009-0001-8111-7969"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenichi Sakai","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060803368","display_name":"Jason S. Tedrow","orcid":"https://orcid.org/0000-0002-5663-2360","observed_orcids":["https://orcid.org/0000-0002-5663-2360"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason S. Tedrow","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103631458","display_name":"Karl B. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I4405286566","display_name":"Daicel Chiral Technologies (United States)","ror":"https://ror.org/02h076f86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120603","https://openalex.org/I4405286566"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karl B. Hansen","raw_affiliation_strings":["Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d\u2019Innovation, Gonthier d\u2019Andernach Boulevard, 67400 Illkrich-Cedex, France","institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077941304","https://openalex.org/A5103631458"],"corresponding_institution_ids":["https://openalex.org/I1320553840","https://openalex.org/I4405286566"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.5696,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.59331271,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"133","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12527","display_name":"Chemistry and Stereochemistry Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.718999981880188},{"id":"https://openalex.org/keywords/large-scale-synthesis","display_name":"large-scale synthesis","score":0.5529999732971191},{"id":"https://openalex.org/keywords/diastereomeric-salt-formation","display_name":"diastereomeric salt formation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/chemical-resolution","display_name":"chemical resolution","score":0.6570000052452087},{"id":"https://openalex.org/keywords/chiral-chromatography","display_name":"chiral chromatography","score":0.953000009059906},{"id":"https://openalex.org/keywords/chiral-stationary-phase","display_name":"chiral stationary phase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/enantiomeric-separation","display_name":"enantiomer separation","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2780538656","wikidata":"https://www.wikidata.org/wiki/Q528995","display_name":"Thiourea","level":2,"score":0.8607330918312073},{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.7302077412605286},{"id":"https://openalex.org/C180827041","wikidata":"https://www.wikidata.org/wiki/Q7048865","display_name":"2-Norbornyl cation","level":2,"score":0.6685647964477539},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.6159439086914062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6015787124633789},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.556671679019928},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.43179967999458313},{"id":"https://openalex.org/C2993377673","wikidata":"https://www.wikidata.org/wiki/Q5101828","display_name":"Chiral stationary phase","level":3,"score":0.41925132274627686},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.4174630641937256},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.403216153383255},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.39086973667144775},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.3537179231643677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17898401618003845},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/op9002328","doi":"https://doi.org/10.1021/op9002328","is_oa":false,"landing_page_url":"https://doi.org/10.1021/op9002328","pdf_url":null,"source":{"id":"https://openalex.org/S107255770","display_name":"Organic Process Research & Development","issn_l":"1083-6160","issn":["1083-6160","1520-586X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Process Research &amp; Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1512177901","https://openalex.org/W1972051918","https://openalex.org/W1976979083","https://openalex.org/W1996422038","https://openalex.org/W2036715876","https://openalex.org/W2060881282","https://openalex.org/W2095144285","https://openalex.org/W2136064817","https://openalex.org/W2487641208","https://openalex.org/W2953321239"],"related_works":["https://openalex.org/W2073067388","https://openalex.org/W1981422414","https://openalex.org/W4414163151","https://openalex.org/W1969547388","https://openalex.org/W2952236480","https://openalex.org/W2023779054","https://openalex.org/W2314530807","https://openalex.org/W1966793982","https://openalex.org/W7007859531","https://openalex.org/W2619643456"],"abstract_inverted_index":{"Two":[0],"routes":[1],"aimed":[2],"at":[3],"the":[4,42,61,68,74,77,84,88],"manufacture":[5],"of":[6,56,83],"chiral":[7,54,69],"exo":[8],"-2-norbornyl":[9],"thiourea":[10],"(":[11],"1":[12,58],")":[13],"on":[14,28],"large":[15],"scale":[16],"are":[17],"described.":[18],"The":[19,36,45],"first":[20],"approach":[21,47],"involves":[22],"five":[23],"chemical":[24,50],"steps":[25,51],"and":[26,52,81],"hinges":[27],"a":[29,53,91],"classical":[30],"resolution":[31,43],"via":[32],"diastereomeric":[33],"salt":[34],"formation.":[35],"synthesis":[37],"utilizes":[38],"amine":[39],"2":[40],"as":[41],"handle.":[44],"second":[46,89],"includes":[48],"two":[49],"chromatography":[55],"(\u00b1)-":[57],".":[59],"Despite":[60],"larger":[62],"initial":[63],"investment":[64],"necessary":[65],"to":[66],"acquire":[67],"stationary":[70],"phase":[71],"used":[72],"in":[73],"chromatographic":[75,85],"approach,":[76],"shorter":[78],"reaction":[79],"sequence":[80],"efficiency":[82],"separation":[86],"make":[87],"route":[90],"more":[92],"attractive":[93],"option":[94],"for":[95],"long-term":[96],"applications.":[97]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2016-06-24T00:00:00"}
