{"id":"https://openalex.org/W2005681088","doi":"https://doi.org/10.1136/gut.41.5.636","title":"Enhanced mucosal permeability and nitric oxide synthase activity in jejunum of mast cell deficient mice","display_name":"Enhanced mucosal permeability and nitric oxide synthase activity in jejunum of mast cell deficient mice","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2005681088","doi":"https://doi.org/10.1136/gut.41.5.636","mag":"2005681088","pmid":"https://pubmed.ncbi.nlm.nih.gov/9414970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1891569"},"language":"en","primary_location":{"id":"doi:10.1136/gut.41.5.636","doi":"https://doi.org/10.1136/gut.41.5.636","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.41.5.636","pdf_url":"https://gut.bmj.com/content/gutjnl/41/5/636.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/41/5/636.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S Komatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Komatsu","raw_affiliation_strings":["Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014512255","display_name":"Matthew B. Grisham","orcid":"https://orcid.org/0000-0001-9090-721X","observed_orcids":["https://orcid.org/0000-0001-9090-721X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M B Grisham","raw_affiliation_strings":["Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111402167","display_name":"Janice M. Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Russell","raw_affiliation_strings":["Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055112840","display_name":"D. Neil Granger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D N Granger","raw_affiliation_strings":["Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, LSU Medical Center, 1501 Kings Highway, Shreveport, Louisiana 71130\u20133932, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055112840"],"corresponding_institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"],"apc_list":null,"apc_paid":null,"fwci":0.8722,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.73142208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"41","issue":"5","first_page":"636","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.13899999856948853,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8130000233650208},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9399999976158142},{"id":"https://openalex.org/keywords/jejunum","display_name":"jejunum","score":0.8080000281333923},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.7799999713897705},{"id":"https://openalex.org/keywords/w-wv-mice","display_name":"W/Wv mice","score":0.9129999876022339},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.8259999752044678},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8840000033378601},{"id":"https://openalex.org/keywords/aminoguanidine","display_name":"aminoguanidine","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lodoxamide","display_name":"lodoxamide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitrate-nitrite","display_name":"nitrite/nitrate","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7293050289154053},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.7087469100952148},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.6280432343482971},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5734330415725708},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5614127516746521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5492862462997437},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5382101535797119},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.48300135135650635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44445881247520447},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.41044771671295166},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3368406593799591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32861483097076416},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.328345388174057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31640535593032837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29092323780059814},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002860","descriptor_name":"Chromium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009566","descriptor_name":"Nitrates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010072","descriptor_name":"Oxamic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010072","descriptor_name":"Oxamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/gut.41.5.636","doi":"https://doi.org/10.1136/gut.41.5.636","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.41.5.636","pdf_url":"https://gut.bmj.com/content/gutjnl/41/5/636.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1891569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1891569","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmid:9414970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9414970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:gutjnl:41/5/636","doi":null,"is_oa":false,"landing_page_url":"http://gut.bmj.com/cgi/content/short/41/5/636","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/gut.41.5.636","doi":"https://doi.org/10.1136/gut.41.5.636","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.41.5.636","pdf_url":"https://gut.bmj.com/content/gutjnl/41/5/636.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4733363870","display_name":"Role of the Microcirculation in Intestinal Inflammation","funder_award_id":"P01DK043785","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005681088.pdf","grobid_xml":"https://content.openalex.org/works/W2005681088.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1512958442","https://openalex.org/W1596698400","https://openalex.org/W1597600237","https://openalex.org/W1636878974","https://openalex.org/W1770775371","https://openalex.org/W1951931529","https://openalex.org/W1965396438","https://openalex.org/W1988469124","https://openalex.org/W1988530903","https://openalex.org/W1994109486","https://openalex.org/W1998483474","https://openalex.org/W2026779790","https://openalex.org/W2029491963","https://openalex.org/W2037597903","https://openalex.org/W2045846314","https://openalex.org/W2046615921","https://openalex.org/W2047230911","https://openalex.org/W2062083637","https://openalex.org/W2063436204","https://openalex.org/W2069808501","https://openalex.org/W2071660979","https://openalex.org/W2077824574","https://openalex.org/W2088355754","https://openalex.org/W2112811492","https://openalex.org/W2113580903","https://openalex.org/W2125076307","https://openalex.org/W2157532432","https://openalex.org/W2164872793","https://openalex.org/W2180152260","https://openalex.org/W2188572482","https://openalex.org/W2258953297","https://openalex.org/W2273708733","https://openalex.org/W2313326603","https://openalex.org/W2345586391","https://openalex.org/W2402495332","https://openalex.org/W2413662182","https://openalex.org/W2417254274","https://openalex.org/W4285719527","https://openalex.org/W6668085317"],"related_works":["https://openalex.org/W2258953297","https://openalex.org/W2025833444","https://openalex.org/W2069728546","https://openalex.org/W3103861079","https://openalex.org/W2180152260","https://openalex.org/W2208022181","https://openalex.org/W2084750391","https://openalex.org/W1606925436","https://openalex.org/W2415805250","https://openalex.org/W2092713847"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"reports":[2],"have":[3,17],"described":[4],"a":[5,19,228],"modulating":[6],"influence":[7,236],"of":[8,35,182,196,225],"nitric":[9],"oxide":[10],"(NO)":[11],"on":[12],"intestinal":[13],"mucosal":[14,40],"permeability":[15,41,230],"and":[16,58,75,79,133,222],"implicated":[18],"role":[20],"for":[21],"mast":[22,36,54,59,138,209,240],"cells":[23,37,184,210],"in":[24,94,105,113,150,153,161,165,174,193,219],"this":[25,233],"NO":[26,46],"mediated":[27],"process.":[28],"AIMS:":[29],"To":[30],"assess":[31],"further":[32],"the":[33,39,45,102,126,137,170,180,186,194,220],"contribution":[34],"to":[38,70,213],"changes":[42],"elicited":[43,90],"by":[44,91,119,136,201,239],"synthase":[47],"(NOS)":[48],"inhibitor":[49],"NG-nitro-L-arginine":[50],"methylester":[51],"(L-NAME),":[52],"using":[53],"cell":[55,60,139,241],"deficient":[56],"(W/Wv)":[57],"replete":[61],"mice":[62,96,108,115,163],"(+/+).":[63],"METHODS:":[64],"Chromium-51":[65],"EDTA":[66,88],"clearance":[67,89],"(from":[68],"blood":[69],"jejunal":[71,73,157],"lumen),":[72],"NOS":[74,129,145,173,191,216,226],"myeloperoxidase":[76],"(MPO)":[77],"activities,":[78],"plasma":[80],"nitrate/nitrite":[81],"levels":[82],"were":[83],"monitored.":[84],"RESULTS:":[85],"The":[86,110,188],"increased":[87],"intraluminal":[92],"L-NAME":[93],"W/Wv":[95,114,151,162,175,197],"(4.4-fold)":[97],"was":[98,116,147,159,198],"significantly":[99,148,199],"greater":[100],"than":[101,152,164],"response":[103,112,231],"observed":[104],"control":[106],"(+/+)":[107],"(1.8-fold).":[109],"exacerbated":[111],"greatly":[117],"attenuated":[118,135],"pretreatment":[120],"with":[121],"either":[122],"dexamethasone":[123,202],"(1.3-fold)":[124],"or":[125],"selective":[127],"inducible":[128,144,172,190,215],"inhibitor,":[130],"aminoguanidine":[131],"(1.4-fold),":[132],"partially":[134],"stabiliser,":[140],"lodoxamide":[141],"(2.9-fold).":[142],"Jejunal":[143],"activity":[146,192,217],"higher":[149,171,189],"+/+":[154,166],"mice,":[155,167],"while":[156],"MPO":[158],"lower":[160],"suggesting":[168],"that":[169,208,223],"does":[176],"not":[177],"result":[178],"from":[179],"recruitment":[181],"inflammatory":[183],"into":[185],"gut.":[187],"jejunum":[195],"reduced":[200],"treatment.":[203],"CONCLUSIONS:":[204],"Our":[205],"results":[206],"suggest":[207],"normally":[211],"serve":[212],"inhibit":[214],"tonically":[218],"gut":[221],"inhibitors":[224],"elicit":[227],"larger":[229],"when":[232],"tonic":[234],"inhibitory":[235],"is":[237],"released":[238],"depletion.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}