{"id":"https://openalex.org/W2005681064","doi":"https://doi.org/10.1146/annurev.pa.24.040184.002315","title":"Cyanide Intoxication and its Mechanism of Antagonism","display_name":"Cyanide Intoxication and its Mechanism of Antagonism","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2005681064","doi":"https://doi.org/10.1146/annurev.pa.24.040184.002315","mag":"2005681064","pmid":"https://pubmed.ncbi.nlm.nih.gov/6428300"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.pa.24.040184.002315","doi":"https://doi.org/10.1146/annurev.pa.24.040184.002315","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.pa.24.040184.002315","pdf_url":null,"source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005681064"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103732226","display_name":"James L. Way","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J L Way","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103732226"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3701,"has_fulltext":false,"cited_by_count":491,"citation_normalized_percentile":{"value":0.95476407,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"24","issue":"1","first_page":"451","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyanide-poisoning","display_name":"cyanide poisoning","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cyanide-metabolism","display_name":"cyanide metabolism","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.8762655258178711},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6874662637710571},{"id":"https://openalex.org/C2778455166","wikidata":"https://www.wikidata.org/wiki/Q55076544","display_name":"Cyanide","level":2,"score":0.6083729863166809},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49416592717170715},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48180311918258667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31981638073921204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19395342469215393},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08324676752090454},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.07483503222465515},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.04907533526420593},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003486","descriptor_name":"Cyanides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003486","descriptor_name":"Cyanides","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008706","descriptor_name":"Methemoglobin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.pa.24.040184.002315","doi":"https://doi.org/10.1146/annurev.pa.24.040184.002315","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.pa.24.040184.002315","pdf_url":null,"source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},{"id":"doi:10.1146/annurev.pharmtox.24.1.451","doi":"https://doi.org/10.1146/annurev.pharmtox.24.1.451","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.pharmtox.24.1.451","pdf_url":null,"source":{"id":"https://openalex.org/S163849586","display_name":"The Annual Review of Pharmacology and Toxicology","issn_l":"0362-1642","issn":["0362-1642","1545-4304"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Pharmacology and Toxicology","raw_type":"journal-article"},{"id":"pmid:6428300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6428300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of pharmacology and toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7045894641","https://openalex.org/W4389938549","https://openalex.org/W2618517920","https://openalex.org/W4241373212","https://openalex.org/W1940923144","https://openalex.org/W2400750975","https://openalex.org/W7061064301","https://openalex.org/W2211620348","https://openalex.org/W2420378442","https://openalex.org/W4244682549"],"abstract_inverted_index":{"The":[0,18,61],"biological":[1],"studies":[2],"on":[3,22,55,183],"cyanide":[4,29,56,70,85,157,180,229],"are":[5,195],"unique":[6],"in":[7,40,48,179,219,225,237,244],"that":[8],"they":[9],"preceded":[10],"the":[11,15,23,82,153,176],"chemical":[12,128],"preparation":[13],"of":[14,28,69,81,84,90,156,175],"substance":[16],"(1).":[17],"last":[19],"comprehensive":[20],"review":[21,45,63],"pharma\u00ad":[24],"cology":[25],"and":[26,53,71,78,87,100,130,146,204,222,235,240],"toxicology":[27],"was":[30,46,223],"written":[31,47],"by":[32,214,232],"Dr.":[33],"Reid":[34],"Hunt":[35],"at":[36],"Johns":[37],"Hopkins":[38],"University":[39],"1923":[41],"(2);":[42],"however,":[43,188],"this":[44],"German.":[49],"Recently,":[50],"other":[51],"books":[52],"monographs":[54],"have":[57,104,139,150],"appeared":[58],"(3,":[59],"4).":[60],"present":[62],"is":[64,72,133,208,230],"restricted":[65],"to":[66,117,197],"selected":[67],"aspects":[68],"primarily":[73],"concerned":[74],"with":[75,142,169],"a":[76,125,211,242],"descriptive":[77],"interpretive":[79],"appraisal":[80],"status":[83],"intoxication":[86],"its":[88,184,189,198],"mechanism":[89],"antagonism.":[91],"Cyanide":[92,207],"bas":[93],"created":[94,164],"complex":[95],"problems":[96,120,165,194],"for":[97],"modem":[98],"society":[99],"these":[101],"prob\u00ad":[102,137],"lems":[103,138],"evolved":[105],"not":[106,209],"only":[107],"from":[108,113,201],"industrial":[109,154],"pollution":[110,119],"but,":[111],"paradoxically,":[112],"an":[114],"inadvertent":[115],"attempt":[116],"resolve":[118],"(5).":[121],"Its":[122],"use":[123,155],"as":[124,152,216],"suicidal,":[126],"homicidal,":[127],"warfare,":[129],"genocidal":[131],"agent":[132],"well":[134],"known.":[135],"Toxic":[136],"been":[140],"associated":[141],"ingesting":[143],"cyanide-containing":[144],"foods,":[145],"occu\u00ad":[147],"pational":[148],"hazards":[149],"arisen":[151],"has":[158,163,181,241],"increased.":[159],"In":[160,227],"medicine,":[161],"it":[162,217],"because":[166],"some":[167],"drugs":[168],"nitrile":[170],"moieties":[171],"liberate":[172],"cyanide.":[173],"Much":[174],"toxicological":[177],"interest":[178],"focused":[182],"rapid":[185],"lethal":[186],"action;":[187],"most":[190],"widely":[191],"distributed":[192],"toxicologic":[193],"due":[196],"chronic":[199],"toxicity":[200],"dietary,":[202],"industrial,":[203],"environmental":[205],"factors.":[206],"wholly":[210],"toxin":[212],"synthesized":[213],"civilization,":[215],"existed":[218],"prebiotic":[220],"times":[221],"involved":[224],"biogenesis.":[226],"addition,":[228],"produced":[231],"various":[233],"organisms":[234],"plants":[236],"our":[238],"environment":[239],"role":[243],"normal":[245],"metabolism.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":36},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}