{"id":"https://openalex.org/W2005676198","doi":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","title":"Antagonism by \u03b2\u2010adrenoceptor blocking agents of the antianaphylactic effect of isoprenaline","display_name":"Antagonism by \u03b2\u2010adrenoceptor blocking agents of the antianaphylactic effect of isoprenaline","publication_year":1971,"publication_date":"1971-08-01","ids":{"openalex":"https://openalex.org/W2005676198","doi":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","mag":"2005676198","pmid":"https://pubmed.ncbi.nlm.nih.gov/4107257","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1665737"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1971.tb07146.x","doi":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1971.tb07146.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1971.tb07146.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063839160","display_name":"E. S. K. Assem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. S. K. ASSEM","raw_affiliation_strings":["Department of Pharmacology, University College London, Gower Street, WC1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, Gower Street, WC1","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046257898","display_name":"H. O. Schild","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. O. SCHILD","raw_affiliation_strings":["Department of Pharmacology, University College London, Gower Street, WC1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, Gower Street, WC1","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.7187,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.89579127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"4","first_page":"620","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.09790000319480896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.7929999828338623},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9589999914169312},{"id":"https://openalex.org/keywords/practolol","display_name":"practolol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/butoxamine","display_name":"butoxamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2776663762","wikidata":"https://www.wikidata.org/wiki/Q7237376","display_name":"Practolol","level":3,"score":0.9823511838912964},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.8855699300765991},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.7661776542663574},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.7095968723297119},{"id":"https://openalex.org/C2908894505","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Beta adrenoceptor","level":4,"score":0.5984137058258057},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5309398174285889},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5212728977203369},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5087054371833801},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.4668954610824585},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.4229426383972168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3590155839920044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35231539607048035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2984624207019806},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2692224383354187},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.10090750455856323},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000083","descriptor_name":"Acetanilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000707","descriptor_name":"Anaphylaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011437","descriptor_name":"Propylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013565","descriptor_name":"Sympatholytics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1971.tb07146.x","doi":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1971.tb07146.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1665737","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1665737","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:4107257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4107257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1971.tb07146.x","doi":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1971.tb07146.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1971.tb07146.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005676198.pdf","grobid_xml":"https://content.openalex.org/works/W2005676198.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1555189702","https://openalex.org/W1667851067","https://openalex.org/W1873095075","https://openalex.org/W1968586463","https://openalex.org/W1977041027","https://openalex.org/W1977503509","https://openalex.org/W1995803479","https://openalex.org/W2000292004","https://openalex.org/W2005503022","https://openalex.org/W2018699052","https://openalex.org/W2022090382","https://openalex.org/W2057971042","https://openalex.org/W2064088278","https://openalex.org/W2065174822","https://openalex.org/W2083225590","https://openalex.org/W2091780008","https://openalex.org/W2117833280","https://openalex.org/W2142828966","https://openalex.org/W2436587621","https://openalex.org/W2443150403","https://openalex.org/W4313309031","https://openalex.org/W4407023093"],"related_works":["https://openalex.org/W1978947001","https://openalex.org/W2047537471","https://openalex.org/W2396380920","https://openalex.org/W2158343698","https://openalex.org/W1969867173","https://openalex.org/W2243791841","https://openalex.org/W2007509274","https://openalex.org/W1967190058","https://openalex.org/W195872762","https://openalex.org/W2049698008"],"abstract_inverted_index":{"1.":[0],"beta-Adrenoceptor":[1],"blocking":[2,61],"agents":[3],"antagonized":[4,50],"the":[5,28,39,58],"inhibitory":[6],"(antianaphylactic)":[7],"effect":[8,29,46],"of":[9,47,68],"isoprenaline":[10,48],"on":[11],"antigen-induced":[12],"histamine":[13],"release":[14],"in":[15],"isolated,":[16],"passively":[17],"sensitized,":[18],"human":[19,40],"lung":[20,25],"and":[21,64,76],"actively":[22],"sensitized":[23],"guinea-pig":[24],"suggesting":[26],"that":[27],"is":[30,70],"exerted":[31],"through":[32],"beta-adrenoceptors.":[33],"No":[34],"antagonism":[35],"was":[36,49],"obtained":[37],"with":[38],"allergic":[41],"leucocyte":[42],"preparation.2.":[43],"The":[44,66],"antianaphylactic":[45,75],"not":[51],"only":[52],"by":[53,57],"propranolol":[54],"but":[55],"also":[56],";selective'":[59],"beta-adrenoceptor":[60],"agents,":[62],"practolol":[63],"butoxamine.3.":[65],"classification":[67],"beta-adrenoceptors":[69,78],"discussed.":[71],"Certain":[72],"similarities":[73],"between":[74],"lipolytic":[77],"are":[79],"noted.":[80]},"counts_by_year":[{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
