{"id":"https://openalex.org/W2005673682","doi":"https://doi.org/10.1002/jcp.1041470304","title":"Effects of a putative prostaglandlin E2 antagonist, AH6809, on chondrogenesis in serum\u2010free cultures of chick limb mesenchyme","display_name":"Effects of a putative prostaglandlin E2 antagonist, AH6809, on chondrogenesis in serum\u2010free cultures of chick limb mesenchyme","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W2005673682","doi":"https://doi.org/10.1002/jcp.1041470304","mag":"2005673682","pmid":"https://pubmed.ncbi.nlm.nih.gov/1648563"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1041470304","doi":"https://doi.org/10.1002/jcp.1041470304","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041470304","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111808041","display_name":"Anthony A. Capehart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony A. Capehart","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103","Department of Neurobiology and Anatomy, Bowman Cray School of Medicine, Wake Forest University, Winston\u2010Salem, North Carolina 27103"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Bowman Cray School of Medicine, Wake Forest University, Winston\u2010Salem, North Carolina 27103","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086565656","display_name":"David M. Biddulph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Biddulph","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Bowman Cray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Bowman Cray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086565656"],"corresponding_institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I47251452"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.11188294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"147","issue":"3","first_page":"403","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ah6809","display_name":"AH6809","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/limb-mesenchyme","display_name":"limb mesenchyme","score":0.7630000114440918},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cartilage-differentiation","display_name":"cartilage differentiation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chick-limb-bud","display_name":"chick limb bud","score":0.7730000019073486},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9300000071525574},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cartilage-matrix","display_name":"cartilage matrix","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.9259239435195923},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.8139230012893677},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5444011688232422},{"id":"https://openalex.org/C25770073","wikidata":"https://www.wikidata.org/wiki/Q6548937","display_name":"Limb bud","level":3,"score":0.5387178063392639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47295066714286804},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41643136739730835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3321949243545532},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.321367472410202},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22678929567337036},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21147724986076355},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.17662417888641357},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.14313772320747375}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011448","descriptor_name":"Prostaglandin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.1041470304","doi":"https://doi.org/10.1002/jcp.1041470304","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041470304","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:1648563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1648563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G549179942","display_name":null,"funder_award_id":"HD19017","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7082991545","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"2s07rr005404-31","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7164365639","display_name":"ROLE OF PROSTAGLANDINS AND CYCLIC AMP IN CHONDROGENESIS","funder_award_id":"5r01hd019017-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7349394847","display_name":null,"funder_award_id":"RR-05404","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1498045834","https://openalex.org/W1775749144","https://openalex.org/W1853539513","https://openalex.org/W1969178798","https://openalex.org/W1971299651","https://openalex.org/W1986654909","https://openalex.org/W1988922507","https://openalex.org/W1996466550","https://openalex.org/W2009291798","https://openalex.org/W2015404135","https://openalex.org/W2017627341","https://openalex.org/W2020457092","https://openalex.org/W2021486524","https://openalex.org/W2027047679","https://openalex.org/W2036663611","https://openalex.org/W2037484179","https://openalex.org/W2042320391","https://openalex.org/W2044717712","https://openalex.org/W2050073570","https://openalex.org/W2053073736","https://openalex.org/W2068108874","https://openalex.org/W2080678890","https://openalex.org/W2081279185","https://openalex.org/W2084398487","https://openalex.org/W2085145054","https://openalex.org/W2088426351","https://openalex.org/W2090693269","https://openalex.org/W2108468484","https://openalex.org/W2119577416","https://openalex.org/W2138094668","https://openalex.org/W2286535834"],"related_works":["https://openalex.org/W2045144326","https://openalex.org/W1498045834","https://openalex.org/W2037484179","https://openalex.org/W214276381","https://openalex.org/W2015404135","https://openalex.org/W2078817264","https://openalex.org/W2108468484","https://openalex.org/W4394060970","https://openalex.org/W2021486524","https://openalex.org/W1976260673"],"abstract_inverted_index":{"In":[0],"the":[1,7,38,102,151,197,212],"present":[2],"study,":[3],"we":[4],"have":[5],"examined":[6],"effects":[8],"of":[9,13,23,28,50,57,61,66,72,86,99,122,129,134,147,186,214],"a":[10,69],"putative":[11],"antagonist":[12,103],"prostaglandin":[14],"E2":[15],"(PGE2),":[16],"AH6809,":[17],"on":[18],"chondrogenesis":[19,67,87,195],"in":[20,34,52,125,171,179,190,203,211],"serum-free":[21],"cultures":[22],"mesenchyme":[24,193,206],"from":[25],"distal":[26],"tips":[27],"stage":[29],"25":[30],"chick":[31],"limb":[32,53,192,205],"buds":[33],"order":[35],"to":[36,81,94,105,154],"test":[37],"hypothesis":[39,198],"that":[40,184,199],"endogenous":[41,200],"PGE2,":[42],"through":[43],"receptor-linked":[44],"adenylate":[45],"cyclase":[46],"(AC),":[47],"initiates":[48],"differentiation":[49,213],"cartilage":[51,82],"mesenchyme.":[54],"Daily":[55],"addition":[56],"10(-4)":[58,126],"M":[59,127],"concentrations":[60,128,202],"AH6809":[62,130],"produced":[63],"marked":[64],"inhibition":[65,146],"over":[68],"5-day":[70],"period":[71],"cell":[73],"culture":[74],"as":[75],"evaluated":[76],"by":[77,88,136,150,161,169,177],"Alcian":[78],"green":[79],"binding":[80],"matrix":[83,116],"components.":[84],"Inhibition":[85],"this":[89],"compound":[90],"was":[91],"further":[92],"shown":[93],"be":[95],"reversible":[96],"and":[97,111,163],"treatment":[98],"cells":[100,124],"with":[101],"limited":[104],"periods":[106],"when":[107],"chondrocytes":[108],"had":[109,118],"differentiated":[110],"were":[112,174],"actively":[113],"secreting":[114],"cartilage-specific":[115],"components":[117],"little":[119],"effect.":[120],"Preincubation":[121],"control":[123,172],"inhibited":[131],"PGE2-induced":[132],"activation":[133],"AC":[135,159,167],"greater":[137,143],"than":[138,144],"80%":[139],"without":[140],"significant":[141],"(P":[142],".05)":[145],"basal":[148],"activity":[149,160,168],"antagonist.":[152],"Responses":[153],"parathyroid":[155],"hormone,":[156],"which":[157,165],"increased":[158,166],"7-fold,":[162],"forskolin":[164],"23-fold":[170],"cells,":[173],"also":[175],"uninhibited":[176],"preincubation":[178],"AH6809.":[180],"The":[181],"results":[182],"demonstrate":[183],"blockade":[185],"PGE2-AC":[187],"linked":[188],"receptors":[189],"prechondrogenic":[191],"inhibits":[194],"supporting":[196],"PGE2":[201],"undifferentiated":[204],"play":[207],"an":[208],"initiating":[209],"role":[210],"cartilage.":[215]},"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
