{"id":"https://openalex.org/W2005673083","doi":"https://doi.org/10.1016/s0924-977x(14)70019-7","title":"P.1.017 Isoflurane anesthesia rapidly activates TrkB receptor signaling and produces antidepressant-like behavioral effects","display_name":"P.1.017 Isoflurane anesthesia rapidly activates TrkB receptor signaling and produces antidepressant-like behavioral effects","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W2005673083","doi":"https://doi.org/10.1016/s0924-977x(14)70019-7","mag":"2005673083"},"language":"en","primary_location":{"id":"doi:10.1016/s0924-977x(14)70019-7","doi":"https://doi.org/10.1016/s0924-977x(14)70019-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-977x(14)70019-7","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049979820","display_name":"Hanna Antila","orcid":"https://orcid.org/0000-0001-8317-4564","observed_orcids":["https://orcid.org/0000-0001-8317-4564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Antila","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082599845","display_name":"Pia Sipil\u00e4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Sipil\u00e4","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103139619","display_name":"Dina Popova","orcid":"https://orcid.org/0000-0002-2954-4277","observed_orcids":["https://orcid.org/0000-0002-2954-4277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Popova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068889075","display_name":"Jesse Lindholm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Lindholm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003642501","display_name":"Ram\u00f3n Guirado","orcid":"https://orcid.org/0000-0003-0259-5709","observed_orcids":["https://orcid.org/0000-0003-0259-5709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Guirado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019744869","display_name":"Eero \u010aastr\u00e9n","orcid":"https://orcid.org/0000-0002-1402-2791","observed_orcids":["https://orcid.org/0000-0002-1402-2791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Castr\u00e9n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040169342","display_name":"Tomi Rantam\u00e4ki","orcid":"https://orcid.org/0000-0002-0052-1434","observed_orcids":["https://orcid.org/0000-0002-0052-1434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Rantam\u00e4ki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11003639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":"S17","last_page":"S17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mglu5-receptor","display_name":"mGlu5 receptor","score":0.5899999737739563},{"id":"https://openalex.org/keywords/amn082","display_name":"AMN082","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mtep","display_name":"MTEP","score":0.996999979019165},{"id":"https://openalex.org/keywords/ly341495","display_name":"LY341495","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/trkb-receptor","display_name":"TrkB receptor","score":0.6389999985694885},{"id":"https://openalex.org/keywords/isoflurane-anesthesia","display_name":"isoflurane anesthesia","score":0.875},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8130000233650208},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.7850000262260437},{"id":"https://openalex.org/keywords/synapsin-i","display_name":"synapsin I","score":0.7269999980926514},{"id":"https://openalex.org/keywords/glur1","display_name":"GluR1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.6320000290870667},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.7200000286102295},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.6136449575424194},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5923449397087097},{"id":"https://openalex.org/C2780076171","wikidata":"https://www.wikidata.org/wiki/Q972076","display_name":"NBQX","level":5,"score":0.5711822509765625},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.545511782169342},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.47038379311561584},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.46103739738464355},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.4419418275356293},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.41941943764686584},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.4065195620059967},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3743496835231781},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.356136292219162},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3129752278327942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3048807978630066},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2602041959762573},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.23733052611351013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22267189621925354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19928580522537231},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.1863384246826172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05517035722732544}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0924-977x(14)70019-7","doi":"https://doi.org/10.1016/s0924-977x(14)70019-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0924-977x(14)70019-7","pdf_url":null,"source":{"id":"https://openalex.org/S168041952","display_name":"European Neuropsychopharmacology","issn_l":"0924-977X","issn":["0924-977X","1873-7862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neuropsychopharmacology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1995048468","https://openalex.org/W2049697739","https://openalex.org/W2105847350","https://openalex.org/W2155646587"],"related_works":["https://openalex.org/W2080326692","https://openalex.org/W2166921819","https://openalex.org/W4308294447","https://openalex.org/W2089351762","https://openalex.org/W2970683278","https://openalex.org/W2091194550","https://openalex.org/W2078280300","https://openalex.org/W1964466640","https://openalex.org/W2145695817","https://openalex.org/W2306738361"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}