{"id":"https://openalex.org/W2005673028","doi":"https://doi.org/10.1371/journal.pone.0075980","title":"Cerulenin Blockade of Fatty Acid Synthase Reverses Hepatic Steatosis in ob/ob Mice","display_name":"Cerulenin Blockade of Fatty Acid Synthase Reverses Hepatic Steatosis in ob/ob Mice","publication_year":2013,"publication_date":"2013-09-27","ids":{"openalex":"https://openalex.org/W2005673028","doi":"https://doi.org/10.1371/journal.pone.0075980","mag":"2005673028","pmid":"https://pubmed.ncbi.nlm.nih.gov/24086674","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785413"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0075980","doi":"https://doi.org/10.1371/journal.pone.0075980","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075980","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075980&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075980&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Gang Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Cheng","raw_affiliation_strings":["Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026416831","display_name":"Arun Prathap Palanisamy","orcid":"https://orcid.org/0000-0002-7793-0682","observed_orcids":["https://orcid.org/0000-0002-7793-0682"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arun P. Palanisamy","raw_affiliation_strings":["Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112471785","display_name":"Zachary P. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary P. Evans","raw_affiliation_strings":["Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064323902","display_name":"Alton G. Sutter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alton G. Sutter","raw_affiliation_strings":["Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085660499","display_name":"Lan Jin","orcid":"https://orcid.org/0000-0003-3040-1270","observed_orcids":["https://orcid.org/0000-0003-3040-1270"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Jin","raw_affiliation_strings":["Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101621533","display_name":"Inderjit Singh","orcid":"https://orcid.org/0000-0003-1013-5569","observed_orcids":["https://orcid.org/0000-0003-1013-5569"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inderjit Singh","raw_affiliation_strings":["Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, United States of America","Department of Pediatrics, Medical Univ. of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Pediatrics, Medical Univ. of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083622115","display_name":"Harold D. May","orcid":"https://orcid.org/0000-0002-1873-0680","observed_orcids":["https://orcid.org/0000-0002-1873-0680"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold May","raw_affiliation_strings":["Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America","Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael G. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Schmidt","raw_affiliation_strings":["Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America","Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078262925","display_name":"Kenneth D. Chavin","orcid":"https://orcid.org/0000-0003-0818-4847","observed_orcids":["https://orcid.org/0000-0003-0818-4847"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. Chavin","raw_affiliation_strings":["Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, United States of America","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026416831"],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2138,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79374009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"e75980","last_page":"e75980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerulenin","display_name":"cerulenin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fatty-acid-synthase-inhibition","display_name":"fatty acid synthase inhibition","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hepatic-energy-metabolism","display_name":"hepatic energy metabolism","score":0.6140000224113464},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.5920000076293945},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":1.0},{"id":"https://openalex.org/keywords/ucp2","display_name":"UCP2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8980000019073486},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.4830000102519989},{"id":"https://openalex.org/keywords/hepatic-apoptosis","display_name":"hepatic apoptosis","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2780683386","wikidata":"https://www.wikidata.org/wiki/Q5065296","display_name":"Cerulenin","level":4,"score":0.9554487466812134},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8899925351142883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8500840067863464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8337632417678833},{"id":"https://openalex.org/C48289651","wikidata":"https://www.wikidata.org/wiki/Q106916817","display_name":"Fatty acid synthase","level":3,"score":0.7109127640724182},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6819402575492859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39644670486450195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3797956705093384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3111242651939392},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.13698944449424744},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09359762072563171}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002569","descriptor_name":"Cerulenin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002569","descriptor_name":"Cerulenin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054890","descriptor_name":"Fatty Acid Synthase, Type I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054890","descriptor_name":"Fatty Acid Synthase, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0075980","doi":"https://doi.org/10.1371/journal.pone.0075980","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075980","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075980&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2781381","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3785413","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3785413","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785413","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24086674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24086674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:229e859089e94eec9ee0ffe47d9596fa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/229e859089e94eec9ee0ffe47d9596fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e75980 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0075980","doi":"https://doi.org/10.1371/journal.pone.0075980","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075980","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075980&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3498264827","display_name":"Protection of Steatotic Livers From Primary Nonfunction","funder_award_id":"R01DK069369","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4176207476","display_name":null,"funder_award_id":"DK069369","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5613361112","display_name":"Fatty Acid Oxidation in X-Linked Adrenoleukodystrophy","funder_award_id":"R01NS022576","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7246069357","display_name":"Fatty Acid Oxidation in X-Linked Adrenoleukodystrophy","funder_award_id":"R37NS022576","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005673028.pdf","grobid_xml":"https://content.openalex.org/works/W2005673028.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W257392107","https://openalex.org/W394964229","https://openalex.org/W588942190","https://openalex.org/W1615180537","https://openalex.org/W1919789442","https://openalex.org/W1967195358","https://openalex.org/W1970446214","https://openalex.org/W1971723316","https://openalex.org/W1972709924","https://openalex.org/W1978729326","https://openalex.org/W1984180526","https://openalex.org/W1986669855","https://openalex.org/W1988764467","https://openalex.org/W1994419666","https://openalex.org/W1995874485","https://openalex.org/W1998938457","https://openalex.org/W1999692416","https://openalex.org/W2002519246","https://openalex.org/W2018739294","https://openalex.org/W2021591676","https://openalex.org/W2025699570","https://openalex.org/W2029228838","https://openalex.org/W2030783465","https://openalex.org/W2037516140","https://openalex.org/W2039731227","https://openalex.org/W2039815077","https://openalex.org/W2040109162","https://openalex.org/W2040318221","https://openalex.org/W2040371828","https://openalex.org/W2040538211","https://openalex.org/W2041977824","https://openalex.org/W2042764090","https://openalex.org/W2047257800","https://openalex.org/W2048297654","https://openalex.org/W2053125897","https://openalex.org/W2056728315","https://openalex.org/W2060678630","https://openalex.org/W2075397916","https://openalex.org/W2078690570","https://openalex.org/W2088869602","https://openalex.org/W2093273210","https://openalex.org/W2096458076","https://openalex.org/W2104085328","https://openalex.org/W2112677957","https://openalex.org/W2113328569","https://openalex.org/W2121699889","https://openalex.org/W2123135341","https://openalex.org/W2124821727","https://openalex.org/W2124941067","https://openalex.org/W2129722153","https://openalex.org/W2130192045","https://openalex.org/W2134567873","https://openalex.org/W2149057413","https://openalex.org/W2151429631","https://openalex.org/W2154412797","https://openalex.org/W2156581424","https://openalex.org/W2158111644","https://openalex.org/W2160617522","https://openalex.org/W2168526937","https://openalex.org/W2170511183","https://openalex.org/W2442282373","https://openalex.org/W4230280576","https://openalex.org/W4244189832","https://openalex.org/W4249568532"],"related_works":["https://openalex.org/W7099308418","https://openalex.org/W2373675158","https://openalex.org/W2090010934","https://openalex.org/W3106636817","https://openalex.org/W2161118079","https://openalex.org/W2136423962","https://openalex.org/W2990950052","https://openalex.org/W4400148399","https://openalex.org/W7024188023","https://openalex.org/W2982993959"],"abstract_inverted_index":{"Fatty":[0],"liver":[1,13],"or":[2],"hepatic":[3,39,64,83,95,175],"steatosis":[4,176],"is":[5],"a":[6,169],"common":[7],"health":[8],"problem":[9],"associated":[10],"with":[11,128,155],"abnormal":[12],"function":[14,40,84],"and":[15,67,94,120,122,131,145],"increased":[16,98,141],"susceptibility":[17],"to":[18,27,52,57,104],"ischemia/reperfusion":[19],"injury.":[20],"The":[21],"objective":[22],"of":[23,31,47,115],"this":[24],"study":[25],"was":[26,152],"investigate":[28],"the":[29,32,112,149],"effect":[30],"fatty":[33,164],"acid":[34,165],"synthase":[35,166],"inhibitor":[36],"cerulenin":[37,48,79,129,156],"on":[38],"in":[41,71,85,99,111,134,142,148,180],"steatotic":[42,150],"ob/ob":[43,53,72,86],"mice.":[44,87],"Different":[45],"dosages":[46],"were":[49,74,91,126,140],"administered":[50],"intraperitoneally":[51],"mice":[54,73,102],"for":[55,173],"2":[56,125],"7":[58],"days.":[59],"Body":[60],"weight,":[61],"serum":[62],"AST/ALT,":[63],"energy":[65],"state,":[66],"gene":[68],"expression":[69],"patterns":[70],"examined.":[75],"We":[76],"found":[77],"that":[78,163],"treatment":[80,130],"markedly":[81],"improved":[82],"Serum":[88],"AST/ALT":[89,135],"levels":[90,97],"significantly":[92],"decreased":[93],"ATP":[96],"treated":[100],"obese":[101,105,181],"compared":[103],"controls,":[106],"accompanied":[107],"by":[108],"fat":[109],"depletion":[110],"hepatocyte.":[113],"Expression":[114],"peroxisome":[116],"proliferator-activated":[117],"receptors":[118],"\u03b1":[119],"\u03b3":[121],"uncoupling":[123],"protein":[124],"suppressed":[127],"paralleled":[132],"changes":[133],"levels.":[136],"Hepatic":[137],"glutathione":[138],"content":[139],"some":[143],"cases":[144],"apoptotic":[146],"activity":[147],"livers":[151],"minimally":[153],"changed":[154],"treatment.":[157],"In":[158],"conclusion,":[159],"these":[160],"results":[161],"demonstrate":[162],"blockade":[167],"constitutes":[168],"novel":[170],"therapeutic":[171],"strategy":[172],"altering":[174],"at":[177],"non-stressed":[178],"states":[179],"livers.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
