{"id":"https://openalex.org/W2005666320","doi":"https://doi.org/10.1128/aac.35.6.1040","title":"Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14","display_name":"Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W2005666320","doi":"https://doi.org/10.1128/aac.35.6.1040","mag":"2005666320","pmid":"https://pubmed.ncbi.nlm.nih.gov/1656851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/284283"},"language":"en","primary_location":{"id":"doi:10.1128/aac.35.6.1040","doi":"https://doi.org/10.1128/aac.35.6.1040","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.35.6.1040","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC284283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113777200","display_name":"Margaret Fox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M P Fox","raw_affiliation_strings":["Department of Virology, Sterling Research Group, Rensselaer, New York 12144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Sterling Research Group, Rensselaer, New York 12144","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109792849","display_name":"M A McKinlay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A McKinlay","raw_affiliation_strings":["Department of Virology, Sterling Research Group, Rensselaer, New York 12144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Sterling Research Group, Rensselaer, New York 12144","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113523438","display_name":"Guy D. Diana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D Diana","raw_affiliation_strings":["Department of Virology, Sterling Research Group, Rensselaer, New York 12144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Sterling Research Group, Rensselaer, New York 12144","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065019304","display_name":"Frank J. Dutko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Dutko","raw_affiliation_strings":["Department of Virology, Sterling Research Group, Rensselaer, New York 12144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Sterling Research Group, Rensselaer, New York 12144","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5035,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.91927268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"35","issue":"6","first_page":"1040","last_page":"1047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.025599999353289604,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dissociation-kinetics","display_name":"dissociation kinetics","score":0.5989999771118164},{"id":"https://openalex.org/keywords/drug-resistant-mutants","display_name":"drug-resistant mutants","score":0.6399999856948853},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8159999847412109},{"id":"https://openalex.org/keywords/saturation-binding","display_name":"saturation binding","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2779278377","wikidata":"https://www.wikidata.org/wiki/Q1351647","display_name":"Rhinovirus","level":3,"score":0.8103294372558594},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5709591507911682},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.5643746852874756},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.5607866644859314},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.49745801091194153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45488500595092773},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.44986677169799805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43301093578338623},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4250243604183197},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41029632091522217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31801649928092957},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.25676101446151733},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.17455697059631348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012229","descriptor_name":"Rhinovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.35.6.1040","doi":"https://doi.org/10.1128/aac.35.6.1040","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.35.6.1040","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:212831","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC284283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:284283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/284283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:1656851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1656851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:212831","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC284283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1566234506","https://openalex.org/W1604233325","https://openalex.org/W1680430286","https://openalex.org/W1963955646","https://openalex.org/W1964268144","https://openalex.org/W1966428196","https://openalex.org/W1972736403","https://openalex.org/W1975257756","https://openalex.org/W2003233962","https://openalex.org/W2015143736","https://openalex.org/W2030744703","https://openalex.org/W2032522793","https://openalex.org/W2033314862","https://openalex.org/W2037263249","https://openalex.org/W2043810798","https://openalex.org/W2043813981","https://openalex.org/W2045610628","https://openalex.org/W2061280553","https://openalex.org/W2062599950","https://openalex.org/W2077328868","https://openalex.org/W2084352383","https://openalex.org/W2085314440","https://openalex.org/W2088534734","https://openalex.org/W2107351598","https://openalex.org/W2161455368"],"related_works":["https://openalex.org/W2028098100","https://openalex.org/W4236421645","https://openalex.org/W2077777819","https://openalex.org/W2062599950","https://openalex.org/W327519078","https://openalex.org/W1964268144","https://openalex.org/W1566234506","https://openalex.org/W2123359392","https://openalex.org/W2048178108","https://openalex.org/W2242626338"],"abstract_inverted_index":{"The":[0,73,183],"binding":[1,45,98,109,166],"affinities":[2],"(Kds)":[3],"and":[4,9,59,69,80,190],"the":[5,33,49,92,108,133,158,162,171,187,191,200],"rates":[6,77],"of":[7,11,13,17,35,43,78,102,104,128,147,164,167,180,203],"association":[8,79],"dissociation":[10,81],"members":[12],"a":[14,39,178],"chemical":[15],"class":[16],"antiviral":[18,134,181,188],"compounds":[19,106,148],"at":[20],"their":[21],"active":[22],"sites":[23],"in":[24,83,89,96,130,137],"human":[25],"rhinovirus":[26],"type":[27],"14":[28],"(HRV-14)":[29],"were":[30,62,88,118,194],"determined.":[31],"On":[32],"basis":[34],"analysis":[36],"by":[37],"LIGAND,":[38],"nonlinear":[40],"curve-fitting":[41],"program,":[42],"saturation":[44,97],"experiments":[46],"with":[47,91,141,157],"HRV-14,":[48],"Kds":[50,192],"for":[51,107,143,199],"Win":[52,54,60,168],"52084,":[53],"56590,":[55],"disoxaril":[56],"(Win":[57],"51711),":[58],"54954":[61,169],"found":[63],"to":[64,115,170,177],"be":[65],"0.02,":[66,67],"0.08,":[68],"0.22":[70],"microM,":[71],"respectively.":[72],"independently":[74],"determined":[75,95,195],"kinetic":[76],"resulted":[82],"calculated":[84],"Kd":[85,93],"values":[86,94],"which":[87],"agreement":[90],"experiments.":[99],"Scatchard":[100],"plots":[101,124],"each":[103],"four":[105],"data":[110],"indicated":[111],"that":[112,193],"approximately":[113],"40":[114],"60":[116],"molecules":[117],"bound":[119],"per":[120],"HRV-14":[121,174],"virion.":[122],"Hill":[123],"showed":[125],"no":[126],"evidence":[127],"cooperativity":[129],"binding.":[131],"Furthermore,":[132],"activities":[135,189],"(MICs":[136],"plaque":[138],"reduction":[139],"assays":[140],"HRV-14)":[142],"this":[144],"limited":[145],"series":[146],"(n":[149],"=":[150,155],"4)":[151],"correlated":[152],"well":[153],"(r":[154],"0.997)":[156],"observed":[159],"Kds.":[160],"Likewise,":[161],"absence":[163],"detectable":[165],"drug-resistant":[172],"mutant":[173],"(Leu-1188)":[175],"corresponded":[176],"lack":[179],"activity.":[182],"positive":[184],"relationship":[185],"between":[186],"may":[196],"have":[197],"implications":[198],"molecular":[201],"design":[202],"capsid-binding":[204],"antirhinovirus":[205],"drugs.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}