{"id":"https://openalex.org/W2005661035","doi":"https://doi.org/10.1371/journal.pone.0056770","title":"Telmisartan Inhibits Cell Proliferation by Blocking Nuclear Translocation of ProHB-EGF C-Terminal Fragment in Colon Cancer Cells","display_name":"Telmisartan Inhibits Cell Proliferation by Blocking Nuclear Translocation of ProHB-EGF C-Terminal Fragment in Colon Cancer Cells","publication_year":2013,"publication_date":"2013-02-22","ids":{"openalex":"https://openalex.org/W2005661035","doi":"https://doi.org/10.1371/journal.pone.0056770","mag":"2005661035","pmid":"https://pubmed.ncbi.nlm.nih.gov/23451083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3579940"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0056770","doi":"https://doi.org/10.1371/journal.pone.0056770","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056770","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056770&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056770&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017490136","display_name":"Keiji Ozeki","orcid":"https://orcid.org/0000-0001-8034-9883","observed_orcids":["https://orcid.org/0000-0001-8034-9883"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiji Ozeki","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076408477","display_name":"Satoshi Tanida","orcid":"https://orcid.org/0000-0003-0068-1283","observed_orcids":["https://orcid.org/0000-0003-0068-1283"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Tanida","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088917268","display_name":"Chie Morimoto","orcid":"https://orcid.org/0000-0001-5610-1909","observed_orcids":["https://orcid.org/0000-0001-5610-1909"]},"institutions":[{"id":"https://openalex.org/I4210091945","display_name":"Matsuyama Shinonome College","ror":"https://ror.org/00fqfkm54","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210091945"]},{"id":"https://openalex.org/I4405255444","display_name":"Matsuyama Shinonome Junior College","ror":"https://ror.org/030t15102","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405255444"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chie Morimoto","raw_affiliation_strings":["Department of Living Science Nutrition Course, Matsuyama Shinonome Junior College, Matsuyama, Ehime, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Living Science Nutrition Course, Matsuyama Shinonome Junior College, Matsuyama, Ehime, Japan","institution_ids":["https://openalex.org/I4210091945","https://openalex.org/I4405255444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072652662","display_name":"Yoshimasa Inoue","orcid":"https://orcid.org/0000-0003-0245-5570","observed_orcids":["https://orcid.org/0000-0003-0245-5570"]},"institutions":[{"id":"https://openalex.org/I4405285453","display_name":"Carna Biosciences (Japan)","ror":"https://ror.org/05fw9gc86","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405285453"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa Inoue","raw_affiliation_strings":["Carna Biosciences Incorporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carna Biosciences Incorporation, Kobe, Japan","institution_ids":["https://openalex.org/I4405285453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083451186","display_name":"Tsutomu Mizoshita","orcid":"https://orcid.org/0000-0003-0460-5288","observed_orcids":["https://orcid.org/0000-0003-0460-5288"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Mizoshita","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036528530","display_name":"Hironobu Tsukamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironobu Tsukamoto","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051727905","display_name":"Takaya Shimura","orcid":"https://orcid.org/0000-0002-6048-0021","observed_orcids":["https://orcid.org/0000-0002-6048-0021"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaya Shimura","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047369080","display_name":"Hiromi Kataoka","orcid":"https://orcid.org/0000-0001-9491-0723","observed_orcids":["https://orcid.org/0000-0001-9491-0723"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Kataoka","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takeshi Kamiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Kamiya","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112006754","display_name":"Eiji Nishiwaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285453","display_name":"Carna Biosciences (Japan)","ror":"https://ror.org/05fw9gc86","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405285453"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiji Nishiwaki","raw_affiliation_strings":["Carna Biosciences Incorporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carna Biosciences Incorporation, Kobe, Japan","institution_ids":["https://openalex.org/I4405285453"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Ishiguro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40502580","display_name":"Gifu University of Medical Science","ror":"https://ror.org/04tcj6w24","country_code":"JP","type":"education","lineage":["https://openalex.org/I40502580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Ishiguro","raw_affiliation_strings":["Department of Medical Technology School of Health Sciences, Gifu University of Medical Science, Seki, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Technology School of Health Sciences, Gifu University of Medical Science, Seki, Gifu, Japan","institution_ids":["https://openalex.org/I40502580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102915092","display_name":"Shigeki Higashiyama","orcid":"https://orcid.org/0000-0002-2417-3921","observed_orcids":["https://orcid.org/0000-0002-2417-3921"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeki Higashiyama","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime University, Toon, Ehime, Japan","Department of Cell Growth and Tumor Regulation, Proteo-Medicine Research Center, Ehime University, Toon, Ehime, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime University, Toon, Ehime, Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Department of Cell Growth and Tumor Regulation, Proteo-Medicine Research Center, Ehime University, Toon, Ehime, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008458565","display_name":"Takashi Joh","orcid":"https://orcid.org/0000-0002-3624-0597","observed_orcids":["https://orcid.org/0000-0002-3624-0597"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Joh","raw_affiliation_strings":["Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5076408477","https://openalex.org/A5102915092"],"corresponding_institution_ids":["https://openalex.org/I33858575","https://openalex.org/I43545212"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.9071,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.8495091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"2","first_page":"e56770","last_page":"e56770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telmisartan","display_name":"telmisartan","score":0.9710000157356262},{"id":"https://openalex.org/keywords/candesartan","display_name":"candesartan","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hb-egf","display_name":"HB-EGF","score":0.7829999923706055},{"id":"https://openalex.org/keywords/plzf","display_name":"PLZF","score":0.7979999780654907},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.843999981880188},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.6320000290870667},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.6430000066757202},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6314522624015808},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6267722845077515},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48517853021621704},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4822840988636017},{"id":"https://openalex.org/C2779716603","wikidata":"https://www.wikidata.org/wiki/Q733186","display_name":"Telmisartan","level":3,"score":0.43810543417930603},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4240760803222656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41874682903289795},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4005407392978668},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3940390646457672},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3672492504119873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1600073277950287},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11885669827461243},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077333","descriptor_name":"Telmisartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066257","descriptor_name":"Heparin-binding EGF-like Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0056770","doi":"https://doi.org/10.1371/journal.pone.0056770","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056770","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056770&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2585531","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3579940","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23451083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23451083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3579940","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3579940/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.8673","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.8673","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/6d/39/pone.0056770.PMC3579940.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ba2a0cad1d9b4d3587c2fc7c2d83e23a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba2a0cad1d9b4d3587c2fc7c2d83e23a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 2, p e56770 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0056770","doi":"https://doi.org/10.1371/journal.pone.0056770","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0056770","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056770&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6722929527","display_name":"Development of HB-EGF-CTF related therapy and biomarker for gastrointestinal cancer","funder_award_id":"24590923","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8225438317","display_name":"Potential of new anti-cancer agents targeting the nuclear translocation signaling of HB-EGF C-terminal fragments","funder_award_id":"22590704","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8884367802","display_name":"Angiotensin II type1 receptor blocker(ARB) Inhibits colon cancer cell proliferation","funder_award_id":"23790802","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G903636931","display_name":"Absolute Quantification of Transmembrane Protein Shedding and Its Application to the Monitoring of Chronic Inflammation","funder_award_id":"24659280","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005661035.pdf","grobid_xml":"https://content.openalex.org/works/W2005661035.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W108690756","https://openalex.org/W153228381","https://openalex.org/W1595716544","https://openalex.org/W1973275724","https://openalex.org/W1986856373","https://openalex.org/W1990280364","https://openalex.org/W1994696430","https://openalex.org/W2008463645","https://openalex.org/W2010806829","https://openalex.org/W2022079797","https://openalex.org/W2022508169","https://openalex.org/W2038086562","https://openalex.org/W2044046734","https://openalex.org/W2048748448","https://openalex.org/W2058422032","https://openalex.org/W2071373198","https://openalex.org/W2074511614","https://openalex.org/W2084339088","https://openalex.org/W2084849295","https://openalex.org/W2095201384","https://openalex.org/W2102882082","https://openalex.org/W2106789440","https://openalex.org/W2115825932","https://openalex.org/W2120230655","https://openalex.org/W2134533989","https://openalex.org/W2142564546","https://openalex.org/W2326819167","https://openalex.org/W2335749764"],"related_works":["https://openalex.org/W1997031494","https://openalex.org/W2120230655","https://openalex.org/W2043360122","https://openalex.org/W2074511614","https://openalex.org/W1994661392","https://openalex.org/W2050597768","https://openalex.org/W2056449387","https://openalex.org/W2042062060","https://openalex.org/W2077818154","https://openalex.org/W1486276764"],"abstract_inverted_index":{"BACKGROUND":[0],"AIMS:":[1],"Current":[2],"treatment":[3],"target":[4],"toward":[5],"advanced":[6],"colorectal":[7],"cancers":[8],"is":[9],"mainly":[10],"focused":[11],"on":[12,66,193,197],"the":[13,35,51,59,67,92,125,146,207,240],"epidermal":[14,37],"growth":[15,38,41,165],"factor":[16,39,42],"receptor":[17,211],"(EGFR)":[18],"signaling,":[19],"but":[20,236,266],"its":[21,86],"additive":[22],"effects":[23,189],"with":[24,135,163,179,286],"chemotherapy":[25],"are":[26],"still":[27],"limited.":[28],"A":[29],"disintegrin":[30],"and":[31,63,157,171,175,182,184,196,202,219,245,256,264],"metalloproteinase":[32],"(ADAM)":[33],"cleaves":[34],"proheparin-binding":[36],"like":[40],"(proHB-EGF).":[43],"And":[44],"soluble":[45],"HB-EGF":[46],"activates":[47],"EGFR.":[48],"In":[49],"parallel,":[50],"carboxy-terminal":[52],"fragment":[53],"of":[54,69,94,127,148,190,200,204,243,247,273,277,282],"proHB-EGF":[55],"(HB-EGF-CTF)":[56],"translocates":[57],"into":[58],"inner":[60],"nuclear":[61,74,87,96,198,241,271,284],"membrane,":[62],"subsequently":[64],"exerts":[65],"regulation":[68],"cell":[70,105,230,295],"proliferation":[71,160,231],"by":[72],"binding":[73,126,147,246],"promyelocytic":[75,130],"leukemia":[76,131],"zinc":[77,132],"finger":[78,133],"(PLZF)":[79,134],"protein,":[80],"a":[81,100,164,290],"transcriptional":[82],"repressor,":[83],"thereby":[84],"causing":[85],"export.":[88],"We":[89],"hypothesized":[90],"that":[91],"inhibition":[93,281],"HB-EGF-CTF":[95,128,149,174,201,248,274,283],"translocation":[97,199,242,272,285],"may":[98,288],"be":[99,224,289],"new":[101],"strategy":[102,292],"in":[103,123,152,293],"preventing":[104,294],"proliferation.":[106,296],"METHODS:":[107],"12-O-tetradecanoylphorbor-13-acetate":[108],"(TPA)":[109],"was":[110,161,177],"treated":[111],"to":[112,129,144,150,223,249],"activate":[113],"ADAM.":[114],"Nine-thousand":[115],"chemical":[116],"compounds":[117],"were":[118,141,214,221],"screened":[119],"for":[120],"their":[121],"efficacies":[122],"blocking":[124],"Alphascreen":[136],"system.":[137],"The":[138,168,188,280],"obtained":[139,191],"candidates":[140,192],"then":[142],"used":[143],"block":[145],"PLZF":[151,205],"colon":[153],"cancer":[154],"cells,":[155],"HT29":[156],"HCT116.":[158],"Cell":[159],"investigated":[162],"curve":[166],"assay.":[167],"intracellular":[169],"localization,":[170],"association":[172],"between":[173],"PLZF,":[176,250],"assessed":[178],"immunofluorescent":[180],"staining,":[181],"immunoprecipitation":[183],"Western":[185],"blotting,":[186],"respectively.":[187],"EGFR":[194,262],"phosphorylation":[195],"export":[203],"during":[206,251],"angiotensin":[208],"II":[209],"type1":[210],"(AT1R)":[212],"knockdown":[213,276],"also":[215],"investigated.":[216],"RESULTS:":[217],"Telmisartan":[218,227],"candesartan":[220,238,257],"found":[222],"potential":[225],"candidates.":[226],"inhibited":[228,269],"TPA-induced":[229,261,270],"stronger":[232],"than":[233],"candesartan.":[234],"Telmisartan,":[235],"not":[237,259,267],"blocked":[239],"HB-EGF-CTF,":[244],"TPA":[252],"stimulation.":[253],"Both":[254],"telmisartan":[255,287],"did":[258],"inhibit":[260],"phosphorylation,":[263],"telmisartan,":[265],"candesartan,":[268],"after":[275],"AT1R.":[278],"CONCLUSIONS:":[279],"novel":[291]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
