{"id":"https://openalex.org/W2005656449","doi":"https://doi.org/10.1101/gad.2018811","title":"The genomic landscapes of inflammation","display_name":"The genomic landscapes of inflammation","publication_year":2011,"publication_date":"2011-01-15","ids":{"openalex":"https://openalex.org/W2005656449","doi":"https://doi.org/10.1101/gad.2018811","mag":"2005656449","pmid":"https://pubmed.ncbi.nlm.nih.gov/21245163","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3022255"},"language":"en","primary_location":{"id":"doi:10.1101/gad.2018811","doi":"https://doi.org/10.1101/gad.2018811","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.2018811","pdf_url":"http://genesdev.cshlp.org/content/25/2/101.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/25/2/101.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076459388","display_name":"Gioacchino Natoli","orcid":"https://orcid.org/0000-0003-0711-2411","observed_orcids":["https://orcid.org/0000-0003-0711-2411"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gioacchino Natoli","raw_affiliation_strings":["Department of Experimental Oncology, European Institute of Oncology (IEO), I-20139 Milan, Italy. gioacchino.natoli@ifom-ieo-campus.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, European Institute of Oncology (IEO), I-20139 Milan, Italy. gioacchino.natoli@ifom-ieo-campus.it","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016215574","display_name":"Serena Ghisletti","orcid":"https://orcid.org/0000-0002-7087-5553","observed_orcids":["https://orcid.org/0000-0002-7087-5553"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Ghisletti","raw_affiliation_strings":["Department of Experimental Oncology, European Institute of Oncology (IEO), I-20139 Milan, Italy","Istituto Europeo di Oncologia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, European Institute of Oncology (IEO), I-20139 Milan, Italy","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Istituto Europeo di Oncologia","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080587435","display_name":"Iros Barozzi","orcid":"https://orcid.org/0000-0003-0690-3473","observed_orcids":["https://orcid.org/0000-0003-0690-3473"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Iros Barozzi","raw_affiliation_strings":["Department of Experimental Oncology, European Institute of Oncology (IEO), I-20139 Milan, Italy","Istituto Europeo di Oncologia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, European Institute of Oncology (IEO), I-20139 Milan, Italy","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Istituto Europeo di Oncologia","institution_ids":["https://openalex.org/I6141010"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I6141010"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":156,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"2","first_page":"101","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.16050000488758087,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transcriptional-programs","display_name":"transcriptional programs","score":0.6050000190734863},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pu-1","display_name":"PU.1","score":0.796999990940094},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interferon-regulatory-factors","display_name":"interferon regulatory factors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-type-specificity","display_name":"cell type specificity","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8765609264373779},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.740767240524292},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6843602061271667},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6338123083114624},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5089590549468994},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4839213490486145},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44650933146476746},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.44545626640319824},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4417489767074585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.429049015045166},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.42239829897880554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39372849464416504},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32956409454345703},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1101/gad.2018811","doi":"https://doi.org/10.1101/gad.2018811","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.2018811","pdf_url":"http://genesdev.cshlp.org/content/25/2/101.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3022255","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3022255","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Dev","raw_type":"Text"},{"id":"pmid:21245163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21245163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/1038556","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1038556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1101/gad.2018811","doi":"https://doi.org/10.1101/gad.2018811","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.2018811","pdf_url":"http://genesdev.cshlp.org/content/25/2/101.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005656449.pdf","grobid_xml":"https://content.openalex.org/works/W2005656449.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1542293701","https://openalex.org/W1590112381","https://openalex.org/W1814665366","https://openalex.org/W1973208496","https://openalex.org/W1974162725","https://openalex.org/W1974612283","https://openalex.org/W1976209715","https://openalex.org/W1978901723","https://openalex.org/W1980779363","https://openalex.org/W1981231088","https://openalex.org/W1989804575","https://openalex.org/W1991311051","https://openalex.org/W1993936200","https://openalex.org/W1995204178","https://openalex.org/W1996760543","https://openalex.org/W2001452221","https://openalex.org/W2002674047","https://openalex.org/W2007222211","https://openalex.org/W2013708530","https://openalex.org/W2014677321","https://openalex.org/W2015415445","https://openalex.org/W2015445169","https://openalex.org/W2017340736","https://openalex.org/W2031084334","https://openalex.org/W2038239151","https://openalex.org/W2042433863","https://openalex.org/W2058205407","https://openalex.org/W2080961105","https://openalex.org/W2089430148","https://openalex.org/W2123564569","https://openalex.org/W2133244972","https://openalex.org/W2134397552","https://openalex.org/W2135018484","https://openalex.org/W2145010689","https://openalex.org/W2614988191","https://openalex.org/W4211217520","https://openalex.org/W7097241356"],"related_works":["https://openalex.org/W2152308094","https://openalex.org/W2140069364","https://openalex.org/W2024791006","https://openalex.org/W57253301","https://openalex.org/W2398004178","https://openalex.org/W4410809634","https://openalex.org/W2090602346","https://openalex.org/W2123856129","https://openalex.org/W163631356","https://openalex.org/W3199014157"],"abstract_inverted_index":{"Inflammation":[0],"involves":[1],"the":[2,15,35,46,51,54],"activation":[3],"of":[4,56,74],"a":[5,21],"highly":[6],"coordinated":[7],"gene":[8],"expression":[9],"program":[10],"that":[11,41],"is":[12],"specific":[13],"for":[14,53],"initial":[16],"stimulus":[17],"and":[18,28,67,76],"occurs":[19],"in":[20,24,86],"different":[22],"manner":[23],"bystander":[25],"parenchymal":[26],"cells":[27,32],"professional":[29],"immune":[30],"system":[31],"recruited":[33],"to":[34],"inflamed":[36],"site.":[37],"Recent":[38],"data":[39],"demonstrate":[40],"developmental":[42],"transcription":[43,58,78],"factors":[44,59,70,79],"like":[45,64],"macrophage":[47],"fate-determining":[48],"Pu.1":[49],"set":[50],"stage":[52],"activity":[55],"ubiquitous":[57],"activated":[60],"by":[61],"inflammatory":[62,87],"stimuli,":[63],"NF-kB,":[65],"AP-1,":[66],"interferon":[68],"regulatory":[69],"(IRFs).":[71],"The":[72],"intersection":[73],"lineage-determining":[75],"stimulus-activated":[77],"at":[80],"enhancers":[81],"explains":[82],"cell":[83],"type":[84],"specificity":[85],"responses.":[88]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}