{"id":"https://openalex.org/W2005654670","doi":"https://doi.org/10.7326/0003-4819-154-6-201103150-00008","title":"Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement","display_name":"Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement","publication_year":2011,"publication_date":"2011-03-15","ids":{"openalex":"https://openalex.org/W2005654670","doi":"https://doi.org/10.7326/0003-4819-154-6-201103150-00008","mag":"2005654670","pmid":"https://pubmed.ncbi.nlm.nih.gov/21403077"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-154-6-201103150-00008","doi":"https://doi.org/10.7326/0003-4819-154-6-201103150-00008","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-154-6-201103150-00008","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026632683","display_name":"A. Cecile J.W. Janssens","orcid":"https://orcid.org/0000-0002-6153-4976","observed_orcids":["https://orcid.org/0000-0002-6153-4976"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["CA","GR","NL","US"],"is_corresponding":true,"raw_author_name":"A. Cecile J.W. Janssens","raw_affiliation_strings":["From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia","Centers for Disease Control and Prevention, Atlanta, Georgia","From Erasmus University Medical Center, Rotterdam, the Netherlands","Stanford University School of Medicine, Stanford, California","Tufts University School of Medicine, Boston, Massachusetts","University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece","University of Ottawa, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1289490764","https://openalex.org/I153718931","https://openalex.org/I194019607","https://openalex.org/I2801952686","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"From Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Tufts University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]},{"raw_affiliation_string":"University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070446713","display_name":"John P. A. Ioannidis","orcid":"https://orcid.org/0000-0003-3118-6859","observed_orcids":["https://orcid.org/0000-0003-3118-6859"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["CA","GR","NL","US"],"is_corresponding":false,"raw_author_name":"John P.A. Ioannidis","raw_affiliation_strings":["From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1289490764","https://openalex.org/I153718931","https://openalex.org/I194019607","https://openalex.org/I2801952686","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017009749","display_name":"Cornelia M. van Duijn","orcid":"https://orcid.org/0000-0002-2374-9204","observed_orcids":["https://orcid.org/0000-0002-2374-9204","https://orcid.org/0000-0001-8766-6224"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["CA","GR","NL","US"],"is_corresponding":false,"raw_author_name":"Cornelia M. van Duijn","raw_affiliation_strings":["From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1289490764","https://openalex.org/I153718931","https://openalex.org/I194019607","https://openalex.org/I2801952686","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Julian Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["CA","GR","NL","US"],"is_corresponding":false,"raw_author_name":"Julian Little","raw_affiliation_strings":["From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1289490764","https://openalex.org/I153718931","https://openalex.org/I194019607","https://openalex.org/I2801952686","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Muin J. Khoury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["CA","GR","NL","US"],"is_corresponding":false,"raw_author_name":"Muin J. Khoury","raw_affiliation_strings":["From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Erasmus University Medical Center, Rotterdam, the Netherlands; University of Ioannina School of Medicine and Biomedical Research Institute, Ioannina, Greece; Tufts University School of Medicine, Boston, Massachusetts; Stanford University School of Medicine, Stanford, California; University of Ottawa, Ottawa, Ontario, Canada; and Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1289490764","https://openalex.org/I153718931","https://openalex.org/I194019607","https://openalex.org/I2801952686","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the GRIPS Group*","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the GRIPS Group*","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5026632683"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1289490764","https://openalex.org/I153718931","https://openalex.org/I194019607","https://openalex.org/I2801952686","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":3.4052,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.92563904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"154","issue":"6","first_page":"421","last_page":"425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-risk-prediction","display_name":"genetic risk prediction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/reporting-guidelines","display_name":"reporting guidelines","score":0.48399999737739563},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.722000002861023},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.4410000145435333},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2779157386","wikidata":"https://www.wikidata.org/wiki/Q43499","display_name":"Erasmus+","level":3,"score":0.7762696743011475},{"id":"https://openalex.org/C2778037673","wikidata":"https://www.wikidata.org/wiki/Q4034536","display_name":"Atlanta","level":3,"score":0.7368596196174622},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5020098686218262},{"id":"https://openalex.org/C2993838110","wikidata":"https://www.wikidata.org/wiki/Q494230","display_name":"Medical school","level":2,"score":0.48800840973854065},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.46039101481437683},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.43115752935409546},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.25314778089523315},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.14617455005645752},{"id":"https://openalex.org/C158739034","wikidata":"https://www.wikidata.org/wiki/Q1907114","display_name":"Metropolitan area","level":2,"score":0.07432428002357483},{"id":"https://openalex.org/C52119013","wikidata":"https://www.wikidata.org/wiki/Q50637","display_name":"Art history","level":1,"score":0.07302504777908325},{"id":"https://openalex.org/C52069626","wikidata":"https://www.wikidata.org/wiki/Q4692","display_name":"The Renaissance","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036281","descriptor_name":"Genetic Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7326/0003-4819-154-6-201103150-00008","doi":"https://doi.org/10.7326/0003-4819-154-6-201103150-00008","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-154-6-201103150-00008","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:21403077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21403077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.47999998927116394}],"study_designs":[],"awards":[{"id":"https://openalex.org/G593341389","display_name":"Tufts Clinical and Translation Science Institute (UL1)","funder_award_id":"UL1RR025752","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1492309945","https://openalex.org/W2007591654","https://openalex.org/W2046261241","https://openalex.org/W2051411536","https://openalex.org/W2059263105","https://openalex.org/W2067640897","https://openalex.org/W2072026981","https://openalex.org/W2096910745","https://openalex.org/W2104622393","https://openalex.org/W2104813627","https://openalex.org/W2112316706","https://openalex.org/W2116810060","https://openalex.org/W2118510964","https://openalex.org/W2123330610","https://openalex.org/W2129303461","https://openalex.org/W2130383679","https://openalex.org/W2135745406","https://openalex.org/W2142073070","https://openalex.org/W2144274361","https://openalex.org/W2147581820","https://openalex.org/W2147603039","https://openalex.org/W2153709794","https://openalex.org/W2154184032","https://openalex.org/W2157995113","https://openalex.org/W2599076725","https://openalex.org/W2811157820","https://openalex.org/W3022903699"],"related_works":["https://openalex.org/W7101013390","https://openalex.org/W7097286347","https://openalex.org/W7095691133","https://openalex.org/W2412161653","https://openalex.org/W4302342080","https://openalex.org/W2071708073","https://openalex.org/W7095136724","https://openalex.org/W2039677242","https://openalex.org/W7099309140","https://openalex.org/W6963210839"],"abstract_inverted_index":{"Research":[0,62,115,168,219,273,2912,3064,3073],"and":[1,33,60,86,91,113,139,144,166,192,197,217,243,248,252,271,297,302,311,326,348,365,414,420,437,490,501,537,659,668,679,699,719,721,734,787,804,836,858,926,952,1055,1060,1079,1086,1108,1166,1173,1187,1196,1217,1267,1293,1395,1420,1457,1480,1502,1522,1529,1533,1560,1615,1644,1652,1670,1697,1714,1730,1739,1743,1750,1761,1774,1802,1829,1864,1885,1898,1911,1929,1967,1979,1988,2011,2051,2084,2088,2401,2475,2479,2534,2575,2615,2646,2656,2692,2716,2735,2777,2880,2893,2910,2936,2941,2948,2957,2968,2982,2992,3030,3048,3138,3160,3175,3199,3209,3222,3320,3393,3398,3417,3447,3482,3500,3530],"Reporting":[2,7,1630,2316,2395,2564,2601,2684],"Methods15":[3],"March":[4,3517,3537,3542],"2011Strengthening":[5],"the":[6,40,52,105,158,209,263,307,339,356,363,374,388,398,409,418,451,502,511,562,621,624,636,651,655,687,696,729,732,774,777,789,820,831,837,847,872,913,959,980,1063,1069,1076,1126,1136,1140,1161,1193,1213,1227,1271,1287,1291,1337,1357,1365,1388,1400,1430,1451,1462,1475,1483,1491,1536,1572,1588,1592,1606,1623,1628,1689,1695,1701,1720,1748,1756,1759,1766,1769,1799,1805,1815,1831,1839,1860,1936,1940,1943,1957,1986,1991,1994,2009,2041,2089,2105,2181,2243,2315,2352,2359,2369,2409,2683,2721,2738,2761,2772,2816,2902,2955,2961,2964,2973,2979,2995,3000,3016,3023,3026,3031,3035,3056,3086,3094,3100,3129,3154,3225,3239,3252,3271,3297,3305,3433,3501,3505],"of":[8,55,58,69,76,81,108,111,122,129,134,161,164,175,182,187,212,215,226,233,238,266,269,280,287,292,342,353,367,382,390,411,422,450,473,478,482,492,497,504,513,517,570,580,586,596,602,623,626,638,640,653,695,731,737,776,791,833,849,886,900,915,918,944,961,982,1062,1068,1081,1128,1198,1206,1219,1264,1279,1290,1295,1323,1329,1339,1359,1367,1379,1390,1399,1411,1424,1429,1461,1474,1493,1509,1515,1608,1612,1622,1634,1700,1752,1758,1765,1771,1804,1807,1841,1877,1903,1942,1990,2013,2031,2044,2095,2098,2122,2124,2180,2237,2239,2260,2283,2317,2354,2361,2368,2396,2404,2406,2425,2448,2481,2563,2602,2611,2648,2685,2737,2765,2791,2815,2905,2908,2919,2926,2931,2954,2963,2966,2978,2999,3025,3034,3059,3093,3117,3142,3158,3163,3166,3173,3179,3191,3224,3238,3251,3270,3284,3296,3322,3352,3423,3435,3444,3471,3494,3503],"Genetic":[9,391,962,1640,2355,2362,3364,3367,3429,3485],"Risk":[10,967,1001,1635,2086,3317,3325,3354,3365,3422,3430],"Prediction":[11,393,964,968,1636,3301],"Studies:":[12],"The":[13,852,1041,1119,1619,1668,1712,1722,1792,1845,2029,2258,2313,2446,2497,2566,2605,2639,2945,2987,3079],"GRIPS":[14,41,308,452,1064,1070,1284,1299,1385,1401,1403,1642,1648,1793,1817,1944,1958,1995,2817,3298],"StatementFREEA.":[15],"Cecile":[16,43,2819,3112],"J.W.":[17,44,2820,3113],"Janssens,":[18,45,2821,3114,3212,3228,3242,3259,3274],"PhD,":[19,29,32,38,3115,3412,3416],"John":[20,95,2822],"P.A.":[21,96,2823],"Ioannidis,":[22,97,2824,3214,3230,3244,3261,3276],"MD,":[23,37,98,256,3403],"DSc,":[24],"Cornelia":[25,148,2874],"M.":[26,149,2257,2830,2840,2869,2875,3406],"van":[27,150,2420,2876,3139,3216,3232,3246,3263],"Duijn,":[28,151,2877,3217,3233,3247,3264],"Julian":[30,201,2878],"Little,":[31,202,2879,3219,3235,3266,3278],"Muin":[34,253,2881],"J.":[35,254,2856,2859,2882,3218,3234,3265,3277,3414],"Khoury,":[36,255],"for":[39,88,141,194,245,299,306,332,346,386,540,566,766,780,799,822,839,854,860,958,990,1103,1160,1229,1275,1454,1578,1591,1605,1632,1663,1691,1736,1782,1862,1917,1953,2093,2190,2286,2325,2394,2430,2570,2600,2608,2642,2718,2938,2989,3018,3038,3063,3102,3196,3254,3315,3369,3372],"Group*A.":[42],"PhDFrom":[46,152,203,257],"Erasmus":[47,100,153,204,258,2897,3012,3119,3144],"University":[48,54,67,74,80,101,107,120,127,133,154,160,173,180,186,205,211,224,231,237,259,265,278,285,291,2898,2904,2917,2924,2930,3013,3120,3145,3162,3178],"Medical":[49,102,155,206,260,2899,3014,3019,3121,3146],"Center,":[50,103,156,207,261,2900,3015,3122,3147],"Rotterdam,":[51,104,157,208,262,2901,3128,3153],"Netherlands;":[53,106,159,210,264,2903,3130],"Ioannina":[56,109,162,213,267,2906,3164,3168],"School":[57,68,75,110,121,128,163,174,181,214,225,232,268,279,286,2907,2918,2925,3165],"Medicine":[59,112,165,216,270,2909],"Biomedical":[61,114,167,218,272,2911],"Institute,":[63,116,169,220,274,2913,3051],"Ioannina,":[64,117,170,221,275,2914],"Greece;":[65,118,171,222,276,2915],"Tufts":[66,119,172,223,277,2916,2980,3046],"Medicine,":[70,77,123,130,176,183,227,234,281,288,466,487,489,2920,2927,3167,3177],"Boston,":[71,124,177,228,282,2921],"Massachusetts;":[72,125,178,229,283,2922],"Stanford":[73,126,179,230,284,2923],"Stanford,":[78,131,184,235,289,2928],"California;":[79,132,185,236,290,2929],"Ottawa,":[82,83,135,136,188,189,239,240,293,294,2932,2933,3180,3184],"Ontario,":[84,137,190,241,295,2934],"Canada;":[85,138,191,242,296,2935],"Centers":[87,140,193,244,298,1453,2937,2988,3195],"Disease":[89,142,195,246,300,1455,2939,2990,3197],"Control":[90,143,196,247,301,1456,2940,2991,3198],"Prevention,":[92,145,198,249,303,2942,3200],"Atlanta,":[93,146,199,250,304,1440,2943,3204],"Georgia.,":[94,147,200,251,305],"DScFrom":[99],"Group*Author,":[309],"Article,":[310,2892],"Disclosure":[312,2894],"Informationhttps://doi.org/10.7326/0003-4819-154-6-201103150-00008":[313],"SectionsAboutVisual":[314],"AbstractPDF":[315],"ToolsAdd":[316],"to":[317,407,416,447,521,533,550,619,750,760,813,892,908,923,955,1074,1095,1105,1113,1191,1211,1225,1241,1309,1331,1384,1541,1553,1599,1705,1708,1797,1837,1851,1896,1900,1908,1935,2454,2775,2887,3098,3327,3343,3488],"favoritesDownload":[318],"CitationsTrack":[319],"CitationsPermissions":[320],"ShareFacebookTwitterLinkedInRedditEmail":[321],"Key":[322],"Summary":[323],"PointsThe":[324],"rapid":[325],"continuing":[327],"progress":[328],"in":[329,338,430,486,510,574,610,650,928,933,992,1088,1154,1223,1233,1254,1270,1439,1444,1547,1627,1686,1694,1788,1814,1882,2008,2034,2152,2320,2484,2688,2743,3022,3075,3085,3331,3355,3382,3450,3458,3474],"gene":[330],"discovery":[331,2453],"complex":[333,541,1029,3459],"diseases":[334,1614],"is":[335,359,440,456,617,645,701,708,1093,1152,1164,1625,1870,1952,2002,3007,3043,3053],"fueling":[336],"interest":[337,509],"potential":[340,1231],"application":[341,421,1232,2478],"genetic":[343,519,527,547,571,597,604,612,664,674,814,823,834,893,919,1011,1048,1054,1115,1178,1220,1248,1368,1380,1523,1579,1808,1866,2014,3448],"risk":[344,528,548,553,564,572,598,613,671,675,681,815,880,894,945,970,981,1012,1015,1022,1042,1057,1116,1179,1249,1280,1296,1311,1341,1369,1413,1542,1580,1609,1809,1867,1919,2015,2245,2526,2744,2796,3502],"models":[345,554,672,736,977,1003,1043,1370,1527,1869,1920,2483,3462],"clinical":[347,1394,2485],"public":[349,784,1396,3531],"health":[350,522,575,785,1234,1324,1332,1397,1762,1789,2049,2287,2456,2652],"practice.The":[351],"number":[352],"studies":[354,426,500,581,628,733,743,748,769,825,841,856,864,972,1208,1222,1251,1282,1544,1582,1611,1822,1843,2194,2405,2610,2649],"assessing":[355,1865],"predictive":[357,1381,2763,3469],"ability":[358,2764],"steadily":[360],"increasing,":[361],"but":[362,984,1146,1993,3465],"quality":[364,622,1840],"completeness":[366,1080,1803],"reporting":[368,389,403,625,639,772,848,960,1082,1162,1358,1495,1665,1746,1806,2123,2150,2284,2326,2403,2571,2609,2643,3533],"varies.A":[369],"multidisciplinary":[370,1409],"workshop":[371,939,1734,2530,2996],"sponsored":[372,1449,2994],"by":[373,401,464,635,1407,1450,1726,2004,3009,3045,3055],"Human":[375,483,1463,2498,2969,3001,3076],"Genome":[376,488,1464,2433,2499,3002,3077],"Epidemiology":[377,1465,2321,2500,2689,3003,3174],"Network":[378,1466,2501],"developed":[379,1406,1489,1662,1796],"a":[380,545,578,593,937,1089,1155,1276,1340,1408,1436,1471,1727,1778,1962,1970,2101,2529,2766,2800,2803,3071,3323,3356,3362,3380,3510],"checklist":[381,1272,1624],"25":[383,1066,1412],"items":[384,808,829,845,868,878,1067,1559,1563,1593,1702,1856,1941],"recommended":[385],"strengthening":[387],"RIsk":[392,963,3300],"Studies":[394,965,2319,2364,2687],"(GRIPS),":[395],"building":[396],"on":[397,544,556,728,735,741,830,1047,1083,1286,1459,1490,1518,2080,2185,2214,2531,2997,3361,3432],"principles":[399],"established":[400],"prior":[402],"guidelines.These":[404],"recommendations":[405,957,1099,1577,2189],"aim":[406],"enhance":[408,620],"transparency":[410],"study":[412,656,779,850,1131,1141,1520,1963,1971,3087],"reporting,":[413,1687],"thereby":[415],"improve":[417,1798],"synthesis":[419,790,1261],"information":[423,1260],"from":[424,716,1246,2104,2451,2769,3011],"multiple":[425],"that":[427,582,606,644,711,809,906,978,1097,1139,1243,1305,1447,1477,1682,1703,1956,2650],"might":[428,1386],"differ":[429],"design,":[431,1194,1216,3088],"conduct,":[432,1195],"or":[433,549,673,685,783,975,998,1024,1027,1038,1051,1124,1133,1327,1556,1827,1975,2971,2976,3096,3289],"analysis.A":[434],"detailed":[435],"Explanation":[436,1643,1651,1669,1713],"Elaboration":[438,1645,1653,1671,1715],"document":[439,1654,1672,1716,1723],"published":[441,463,749,798,1680],"at":[442,1677,3108],"www.plosmedicine.org.Editor's":[443],"Note:":[444],"In":[445,818,1201,1938,2886],"order":[446,1224],"encourage":[448],"dissemination":[449],"Statement,":[453],"this":[454,514,705,1647,1954,2001],"article":[455,3253],"freely":[457],"accessible":[458],"onwww.annals.organd":[459],"will":[460,1258,1982,1997],"also":[461,724,811,875,987,1239,1427],"be":[462,531,608,633,690,909,1009,1045,1144,1307,1706,1824,1835,1848,1965,1973,1998,3106],"PLoS":[465,2329,2372,2658,2694],"BMJ,":[467],"Circulation:":[468],"Cardiovascular":[469],"Genetics,":[470,484],"European":[471,476,480,3358],"Journal":[472,477,481,491],"Clinical":[474,493,2981,3047,3374],"Investigation,":[475],"Epidemiology,":[479,3118,3143,3161],"Genetics":[485],"Epidemiology.The":[494],"recent":[495],"successes":[496],"genome-wide":[498],"association":[499,824,2129],"promises":[503],"whole":[505],"genome":[506,2046],"sequencing":[507],"fuel":[508],"translation":[512,1389,2032],"new":[515,2006,2767],"wave":[516],"basic":[518,1214],"knowledge":[520],"care":[523,576,1325,1333,1763,1790,2050,2653],"practice.":[524,1791,2486],"Knowledge":[525],"about":[526,846,869,879],"factors":[529,1058,1524],"may":[530,723,1008,1044,1306,1931],"used":[532,609,1836,1849],"target":[534],"diagnostic,":[535],"preventive,":[536],"therapeutic":[538],"interventions":[539],"disorders":[542],"based":[543,555,740,1046],"person's":[546],"complement":[551],"existing":[552,1494],"classical":[557],"nongenetic":[558,1056],"factors,":[559],"such":[560,911,930,1032,1199,1207],"as":[561,765,912,1033,1182,1184,1262,1371],"Framingham":[563,2244],"score":[565],"cardiovascular":[567,1613,2099],"disease.":[568],"Implementation":[569],"prediction":[573,614,712,816,881,895,946,971,1002,1117,1180,1221,1250,1281,1297,1414,1526,1543,1581,1610,1810,1868,2241,2424,2527,2793],"requires":[577],"series":[579],"encompass":[583],"all":[584,1510,1733,1854,2212],"phases":[585],"translational":[587,2449],"research":[588,713,801,1084,1107,1382,1391,2033,2263],"(1,":[589],"2),":[590],"starting":[591],"with":[592,902,940,1583,1602,1676,1732,2130,3428,3476,3509],"comprehensive":[594],"evaluation":[595,1353,1531,1607,1910,2012,2094],"prediction.With":[599],"increasing":[600],"numbers":[601,917,932],"discovered":[603],"markers":[605,2097,2217],"can":[607,2038,3105],"future":[611,1247,2431],"studies,":[615,896,1181,1361,1754],"it":[616,1203,1315,3378],"crucial":[618],"these":[627,722,742,805,887,1098,1346,1360,1930,1946],"since":[629],"valid":[630],"interpretation":[631,1757,3223],"could":[632],"compromised":[634],"lack":[637],"key":[641],"information.":[642,706],"Information":[643],"often":[646,714],"missing":[647],"includes":[648,1167,1204],"details":[649,1699],"description":[652],"how":[654,663,670,680,686,1104,1112,1821,1961,1969,2037],"was":[657,1405,1448,1478,1488,1717,1724],"designed":[658],"conducted":[660,1974],"(for":[661],"example,":[662,1874],"variants":[665,920,1049],"were":[666,677,683,1426,1506,1545,1551,1795,1879,1949],"selected":[667,1507],"coded,":[669],"scores":[676,1013,1023],"constructed,":[678],"categories":[682],"chosen)":[684],"results":[688,730,754,1228],"should":[689,1143,1823,1833,1847,1964,1972],"interpreted.":[691],"An":[692],"appropriate":[693,2042],"assessment":[694,832,1322,1328,1366],"study's":[697],"strengths":[698,1749],"weaknesses":[700,1751],"not":[702,1110,1122,1148,1301,1819,1834,1968,1983,2959],"possible":[703],"without":[704],"There":[707],"ample":[709],"evidence":[710,792,1780],"suffers":[715],"poor":[717,771,2261],"design":[718,1132,1292],"bias,":[720],"have":[725,796,827,843,876,1190,1890,3379],"an":[726,897,941,1650,2366],"impact":[727,1985,2480],"disease":[738,2052],"outcomes":[739],"(3\u20135).":[744],"Although":[745],"most":[746],"prognostic":[747,863,994,2126,2132,2154,2193,2216,2476,2482],"date":[751],"claim":[752],"significant":[753,2220],"(6,":[755],"7),":[756],"very":[757],"few":[758],"translate":[759],"clinically":[761],"useful":[762,3487],"applications.":[763],"Just":[764],"observational":[767,840,1519,2327],"epidemiological":[768,2262],"(8),":[770],"complicates":[773],"use":[775,991,1901],"specific":[778,903],"research,":[781],"clinical,":[782],"purposes":[786],"hampers":[788],"across":[793],"studies.Reporting":[794],"guidelines":[795,821,838,853,874,888,1101,1120,1137,1163,1237,1476,1512,1604,1666,1794,1832,1846,2285,2324,3534],"been":[797,1344,1656,1891],"various":[800],"designs":[802,1521],"(9),":[803],"contain":[806],"many":[807],"are":[810,889,986,1004,1072,1100,1238,1252,1273,1857,1905,1926,2952,3463,3467],"relevant":[812,828,844,867,877,1274],"studies.":[817,1118,1200,1298,1811,2156,2328],"particular,":[819],"(STREGA)":[826],"variants,":[835],"(STROBE)":[842,2322],"design.":[851],"diagnostic":[855,2407,2612],"(STARD)":[857],"those":[859,1661,2953],"tumor":[861,2191],"marker":[862,2127],"(REMARK)":[865],"include":[866,1052],"test":[870,1310,1530],"evaluation;":[871],"REMARK":[873,1500,2714],"(5,":[882],"10\u201312).":[883],"However,":[884,1376],"none":[885],"fully":[890],"suited":[891],"emerging":[898],"field":[899],"investigation":[901],"methodological":[904,1538,1947,1978,2428],"issues":[905,1539],"need":[907,1704],"addressed,":[910],"handling":[914,929],"large":[916,931],"(from":[921],"10s":[922],"10":[924],"000s)":[925],"flexibility":[927],"analyses.":[934],"We":[935],"organized":[936],"2-day":[938,1437],"international":[942],"group":[943],"researchers,":[947,1415],"epidemiologists,":[948,1168,1416],"geneticists,":[949,1169,1417],"methodologists,":[950,1418],"statisticians,":[951,1170,1419],"journal":[953,1185,1421],"editors":[954,1186],"develop":[956,974],"(GRIPS).Genetic":[966],"StudiesGenetic":[969],"typically":[973],"validate":[976],"predict":[979,3489],"disease,":[983],"they":[985],"being":[988,1927],"investigated":[989],"predicting":[993,3383],"outcome,":[995],"treatment":[996,3472],"response,":[997],"treatment-related":[999],"harms.":[1000],"statistical":[1005],"algorithms,":[1006],"which":[1007,1150,1257,1362,3052],"simple":[1010,1923],"(e.g.,":[1014,1020],"allele":[1016],"counts),":[1017],"regression":[1018,1924],"analyses":[1019,1925],"weighted":[1021],"predicted":[1025],"risks),":[1026],"more":[1028],"analytic":[1030],"approaches,":[1031],"support":[1034,1123],"vector":[1035],"machine":[1036],"learning":[1037],"classification":[1039],"trees.":[1040],"only":[1050,1102,1850],"both":[1053],"(13).Aims":[1059],"Use":[1061,2734],"StatementThe":[1065,1402],"statement":[1071,1404,1959,1996,2103,2569,2607,2641],"intended":[1073,1158,1240],"maximize":[1075],"transparency,":[1077,1800],"quality,":[1078,1801],"methodology":[1085,1861],"findings":[1087,1392],"particular":[1090,1130,1156],"study.":[1091],"It":[1092,1951],"important":[1094,3255],"emphasize":[1096],"report":[1106,2218],"do":[1109,1121,1147,2958],"prescribe":[1111,1820],"perform":[1114],"oppose":[1125],"choice":[1127],"any":[1129],"method,":[1134],"e.g.,":[1135],"recommend":[1138],"population":[1142,1151,2455],"described":[1145],"specify":[1149],"preferred":[1153],"study.The":[1157],"audience":[1159],"broad":[1165],"clinician":[1171],"scientists,":[1172],"laboratory-based":[1174],"investigators":[1175],"who":[1176,1189,1209],"undertake":[1177],"well":[1183],"reviewers":[1188],"appraise":[1192],"analysis":[1197,1294],"addition,":[1202],"\"users\"":[1205],"wish":[1210],"understand":[1212],"premise,":[1215],"limitations":[1218],"interpret":[1226],"their":[1230,1516],"care.":[1235],"These":[1236,1505],"ensure":[1242,1709],"essential":[1244,1855,2005],"data":[1245,3089],"presented":[1253,1269,1626],"standardized":[1255],"form,":[1256],"facilitate":[1259,1387],"part":[1263,1428],"systematic":[1265,1772,2644,3456],"reviews":[1266,1773,2645],"meta-analyses.Items":[1268],"wide":[1277],"array":[1278],"because":[1283,1514],"focuses":[1285],"main":[1288],"aspects":[1289],"does":[1300,1314,1818,2720,2799,3377],"address":[1302,1317],"randomized":[1303,2572],"trials":[1304],"performed":[1308],"models,":[1312],"nor":[1313],"specifically":[1316],"decision":[1318,3097],"analyses,":[1319,1321],"cost-effectiveness":[1320],"needs,":[1326],"barriers":[1330],"implementation":[1334,1350],"(14).":[1335],"Once":[1336],"performance":[1338],"model":[1342,3470],"has":[1343,1655],"established,":[1345],"next":[1347],"steps":[1348],"toward":[1349],"require":[1351],"further":[1352],"(10,":[1354],"15).":[1355],"For":[1356,1873,3294],"go":[1363],"beyond":[1364,2242,2794],"such,":[1372],"additional":[1373,1562,1737],"requirements":[1374],"apply.":[1375],"proper":[1377],"documentation":[1378],"according":[1383],"into":[1393,1786,2048],"practice.Development":[1398],"panel":[1410],"editors,":[1422],"7":[1423],"whom":[1425,2719],"STREGA":[1431,1498],"initiative":[1432],"(11).":[1433],"They":[1434],"attended":[1435],"meeting":[1438],"Georgia":[1441],"(United":[1442],"States)":[1443],"December":[1445],"2009":[1446],"U.S.":[1452],"Prevention":[1458,2993],"behalf":[1460,2998],"(HuGENet)":[1467],"(16).":[1468],"Participants":[1469,1566],"discussed":[1470],"draft":[1472,1486],"version":[1473,1487,1621],"prepared":[1479,1725],"distributed":[1481],"before":[1482],"meeting.":[1484,1573,1721],"This":[1485],"basis":[1492],"guidelines,":[1496,1585],"namely":[1497],"(11),":[1499],"(5),":[1501],"STARD":[1503,2410,2606],"(12).":[1504],"out":[1508],"available":[1511],"(www.equator-network.org)":[1513],"focus":[1517],"(STREGA),":[1525],"(REMARK),":[1528],"(REMARK":[1532],"STARD).":[1534],"During":[1535],"meeting,":[1537],"pertinent":[1540],"addressed":[1546,1707],"presentations.":[1548],"Workshop":[1549],"participants":[1550,1735],"asked":[1552],"change,":[1554],"combine,":[1555],"delete":[1557],"proposed":[1558,1892],"add":[1561,1932],"if":[1564],"necessary.":[1565],"had":[1567,3082],"extensive":[1568],"electronic":[1569],"correspondence":[1570],"after":[1571,1660,1719,3345,3515],"To":[1574],"harmonize":[1575],"our":[1576],"previous":[1584,1603],"we":[1586,1597,1683,2039],"chose":[1587],"same":[1589],"wording":[1590],"wherever":[1594],"possible.":[1595],"Finally,":[1596],"tried":[1598],"create":[1600],"consistency":[1601],"cancer":[1616,2125,2153,2215],"(2,":[1617],"17).":[1618],"final":[1620,1740],"Table.Table.":[1629],"Recommendations":[1631],"Evaluations":[1633],"Models":[1637,3431],"That":[1638],"Include":[1639],"VariantsThe":[1641],"ArticleAccompanying":[1646],"statement,":[1649,1945],"written":[1657],"(www.plosmedicine.org),":[1658],"modeled":[1659],"other":[1664,1921],"(18\u201321).":[1667],"illustrates":[1673],"each":[1674],"item":[1675],"least":[1678],"1":[1679],"example":[1681],"consider":[1684],"transparent":[1685,1710],"explains":[1688],"rationale":[1690],"its":[1692],"inclusion":[1693],"checklist,":[1696],"presents":[1698],"reporting.":[1711,1937],"produced":[1718],"small":[1728],"subgroup":[1729],"shared":[1731],"revisions":[1738],"approval.Concluding":[1741],"Remarks":[1742],"Future":[1744],"DirectionsHigh-quality":[1745],"reveals":[1747],"empirical":[1753,1842],"facilitates":[1755],"scientific":[1760,2102,2452],"relevance":[1764,1989],"results\u2014especially":[1767],"within":[1768],"framework":[1770,3024],"meta-analyses\u2014and":[1775],"helps":[1776],"build":[1777],"solid":[1779],"base":[1781],"moving":[1783],"genomic":[1784,2035],"discoveries":[1785,2047],"applications":[1787],"As":[1812],"outlined":[1813],"introduction,":[1816],"designed,":[1825],"conducted,":[1826],"analyzed,":[1828],"therefore,":[1830],"assess":[1838],"(22).":[1844],"check":[1852],"whether":[1853],"adequately":[1858],"reported.Finally,":[1859],"designing":[1863],"still":[1871,1906],"developing.":[1872],"newer":[1875],"measures":[1876,1889,1895,1902],"reclassification":[1878,1888,1904,2776],"first":[1880],"introduced":[1881],"2007":[1883],"(23),":[1884],"several":[1886],"alternative":[1887,1915],"(24).":[1893],"Which":[1894],"apply":[1897],"when":[1899,2000,2798],"subject":[1907],"ongoing":[1909],"discussion":[1912],"(25).":[1913],"Furthermore,":[1914],"strategies":[1916],"constructing":[1918],"than":[1922],"explored,":[1928],"increased":[1933],"complexity":[1934],"formulating":[1939],"advances":[1948],"anticipated.":[1950],"reason":[1955],"recommends":[1960],"reported":[1966,2131],"analyzed.":[1976],"Therefore,":[1977],"analytical":[1980],"developments":[1981,2007],"immediately":[1984],"validity":[1987],"items,":[1992],"updated":[1999],"warranted":[2003],"construction":[2010],"models.References1.":[2016],"Khoury":[2017,2440,2493,2788],"MJ,":[2018,2441,2494,2753],"Gwinn":[2019,2442],"M,":[2020,2175,2304,2443,2552],"Yoon":[2021],"PW,":[2022],"Dowling":[2023],"N,":[2024],"Moore":[2025],"CA,":[2026,2386,2592],"Bradley":[2027],"L.":[2028],"continuum":[2030],"medicine:":[2036],"accelerate":[2040],"integration":[2043],"human":[2045],"prevention?":[2053],"Genet":[2054],"Med.":[2055,2330,2373,2434,2579,2619,2659,2695,2780],"2007;9:665-74.":[2056],"[PMID:":[2057,2111,2139,2162,2201,2226,2249,2267,2294,2332,2375,2414,2436,2462,2489,2507,2541,2581,2621,2661,2697,2728,2748,2782,2810],"18073579]":[2058],"CrossrefMedlineGoogle":[2059,2113,2141,2164,2203,2228,2251,2269,2296,2334,2377,2416,2438,2464,2491,2509,2543,2663,2699,2730,2750,2784,2812],"Scholar2.":[2060],"Hlatky":[2061],"MA,":[2062],"Greenland":[2063],"P,":[2064,2518],"Arnett":[2065],"DK,":[2066],"Ballantyne":[2067],"CM,":[2068],"Criqui":[2069],"MH,":[2070,2516],"Elkind":[2071],"MS,":[2072],"et":[2073,2349,2391,2523,2557,2597,2637,2678],"al;":[2074,2350,2392,2558,2598,2679],"American":[2075,2106],"Heart":[2076,2107],"Association":[2077,2356,2363,3438],"Expert":[2078],"Panel":[2079],"Subclinical":[2081],"Atherosclerotic":[2082],"Diseases":[2083],"Emerging":[2085],"Factors":[2087],"Stroke":[2090],"Council.":[2091],"Criteria":[2092],"novel":[2096,3445],"risk:":[2100],"Association.":[2108],"Circulation.":[2109,2746],"2009;119:2408-16.":[2110],"19364974]":[2112],"Scholar3.":[2114],"Kyzas":[2115,2143,2205],"PA,":[2116,2144,2206],"Denaxa-Kyza":[2117,2207],"D,":[2118,2208,2274,2343,2514,2550,2556],"Ioannidis":[2119,2147,2209,2234,2340,2444,2635,3042],"JP.":[2120,2148,2210,2235,2445,2702],"Quality":[2121],"studies:":[2128],"effect.":[2133],"J":[2134,2157,2223,2290,2459,2504,2536,2724],"Natl":[2135,2158,2537],"Cancer":[2136,2159,2186,2525,2538],"Inst.":[2137,2160,2539],"2007;99:236-43.":[2138],"17284718]":[2140],"Scholar4.":[2142],"Loizou":[2145],"KT,":[2146],"Selective":[2149],"biases":[2151],"factor":[2155,3497],"2005;97:1043-55.":[2161],"16030302]":[2163],"Scholar5.":[2165],"McShane":[2166],"LM,":[2167,2390,2596],"Altman":[2168,2279,2301,2468,2545,2627,2670],"DG,":[2169,2302,2469,2546,2628,2671],"Sauerbrei":[2170],"W,":[2171],"Taube":[2172],"SE,":[2173],"Gion":[2174],"Clark":[2176],"GM;":[2177],"Statistics":[2178],"Subcommittee":[2179],"NCI-EORTC":[2182],"Working":[2183],"Group":[2184],"Diagnostics.":[2187],"REporting":[2188,2353,2360],"MARKer":[2192],"(REMARK).":[2195],"Nat":[2196],"Clin":[2197,2291,2725],"Pract":[2198],"Urol.":[2199],"2005;2:416-22.":[2200],"16482653]":[2202],"Scholar6.":[2204],"Almost":[2211],"articles":[2213],"statistically":[2219],"results.":[2221],"Eur":[2222,2289],"Cancer.":[2224],"2007;43:2559-79.":[2225],"17981458]":[2227],"Scholar7.":[2229],"Tzoulaki":[2230],"I,":[2231,2272],"Liberopoulos":[2232],"G,":[2233],"Assessment":[2236,2790],"claims":[2238],"improved":[2240,2792],"score.":[2246],"JAMA.":[2247],"2009;302:2345-52.":[2248],"19952321]":[2250],"Scholar8.":[2252],"von":[2253,2298,2346,2667,3495],"Elm":[2254,2299,2347,2668],"E,":[2255,2300,2348,2669,3512],"Egger":[2256,2303,2551],"scandal":[2259],"[Editorial].":[2264,2502,2805],"BMJ.":[2265,2412,2487],"2004;329:868-9.":[2266],"15485939]":[2268],"Scholar9.":[2270],"Simera":[2271],"Moher":[2273,2342,2549],"Hoey":[2275],"J,":[2276,2337,2630],"Schulz":[2277,2547],"KF,":[2278,2548],"DG.":[2280],"A":[2281,2889,3348,3395,3440,3455],"catalogue":[2282],"research.":[2288,2432],"Invest.":[2292],"2010;40:35-53.":[2293],"20055895]":[2295],"Scholar10.":[2297],"Pocock":[2305,2676],"SJ,":[2306,2677],"G\u00f8tzsche":[2307,2633,2672],"PC,":[2308,2634,2673],"Vandenbroucke":[2309,2665,2701],"JP;":[2310],"STROBE":[2311,2370,2680],"Initiative.":[2312,2681],"Strengthening":[2314,2682],"Observational":[2318,2686],"statement:":[2323],"2007;4:296.":[2331],"17941714]":[2333],"Scholar11.":[2335],"Little":[2336,3069],"Higgins":[2338],"JP,":[2339,2341,2636,2666],"Gagnon":[2344],"F,":[2345,2554],"STrengthening":[2351,2358],"Studies.":[2357],"(STREGA):":[2365],"extension":[2367],"statement.":[2371],"2009;6:22.":[2374],"19192942]":[2376],"Scholar12.":[2378],"Bossuyt":[2379,2585],"PM,":[2380,2586],"Reitsma":[2381,2587],"JB,":[2382,2588],"Bruns":[2383,2589],"DE,":[2384,2590],"Gatsonis":[2385,2591],"Glasziou":[2387,2593],"PP,":[2388,2594],"Irwig":[2389,2595],"Standards":[2393,2562,2599],"Diagnostic":[2397,2603],"Accuracy.":[2398,2604],"Towards":[2399],"complete":[2400],"accurate":[2402],"accuracy:":[2408,2613],"initiative.":[2411],"2003;326:41-4.":[2413],"12511463]":[2415],"Scholar13.":[2417],"Janssens":[2418,2786,3006,3137],"AC,":[2419,2787],"Duijn":[2421],"CM.":[2422],"Genome-based":[2423],"common":[2426],"diseases:":[2427],"considerations":[2429],"2009;1:20.":[2435],"19341491]":[2437],"Scholar14.":[2439],"emergence":[2447],"epidemiology:":[2450],"impact.":[2457],"Am":[2458,2503],"Epidemiol.":[2460,2505,2726],"2010;172:517-24.":[2461],"20688899]":[2463],"Scholar15.":[2465],"Moons":[2466],"KG,":[2467],"Vergouwe":[2470],"Y,":[2471],"Royston":[2472],"P.":[2473],"Prognosis":[2474],"research:":[2477],"2009;338:b606.":[2488],"19502216]":[2490],"Scholar16.":[2492],"Dorman":[2495],"JS.":[2496],"1998;148:1-3.":[2506],"9663396]":[2508],"Scholar17.":[2510],"Freedman":[2511],"AN,":[2512],"Seminara":[2513],"Gail":[2515],"Hartge":[2517],"Colditz":[2519],"GA,":[2520],"Ballard-Barbash":[2521],"R,":[2522],"al.":[2524,2638],"models:":[2528],"development,":[2532],"evaluation,":[2533],"application.":[2535],"2005;97:715-23.":[2540],"15900041]":[2542],"Scholar18.":[2544],"Davidoff":[2553],"Elbourne":[2555],"CONSORT":[2559,2568],"GROUP":[2560],"(Consolidated":[2561],"Trials).":[2565],"revised":[2567],"trials:":[2573],"explanation":[2574,2614,2655,2691],"elaboration.":[2576,2616,2657,2693],"Ann":[2577,2617],"Intern":[2578,2618],"2001;134:663-94.":[2580],"11304107]":[2582],"LinkGoogle":[2583,2623],"Scholar19.":[2584],"2003;138:W1-12.":[2620],"12513067]":[2622],"Scholar20.":[2624],"Liberati":[2625],"A,":[2626],"Tetzlaff":[2629],"Mulrow":[2631,2674],"C,":[2632],"PRISMA":[2640],"meta-analyses":[2647],"evaluate":[2651],"interventions:":[2654],"2009;6:1000100.":[2660],"19621070]":[2662],"Scholar21.":[2664],"CD,":[2675],"(STROBE):":[2690],"2007;4:297.":[2696],"17941715]":[2698],"Scholar22.":[2700],"STREGA,":[2703],"STROBE,":[2704],"STARD,":[2705],"SQUIRE,":[2706],"MOOSE,":[2707],"PRISMA,":[2708],"GNOSIS,":[2709],"TREND,":[2710],"ORION,":[2711],"COREQ,":[2712],"QUOROM,":[2713],"\u2026":[2715],"CONSORT:":[2717],"guideline":[2722],"toll?":[2723],"2009;62:594-6.":[2727],"19181482]":[2729],"Scholar23.":[2731],"Cook":[2732],"NR.":[2733],"misuse":[2736],"receiver":[2739],"operating":[2740],"characteristic":[2741],"curve":[2742,2774],"prediction.":[2745],"2007;115:928-35.":[2747],"17309939]":[2749],"Scholar24.":[2751],"Pencina":[2752],"D'Agostino":[2754,2756],"RB,":[2755,2757],"Vasan":[2758],"RS.":[2759],"Evaluating":[2760],"added":[2762],"marker:":[2768],"area":[2770],"under":[2771],"ROC":[2773],"beyond.":[2778],"Stat":[2779],"2008;27:157-72.":[2781],"17569110]":[2783],"Scholar25.":[2785],"MJ.":[2789],"traditional":[2795],"factors:":[2797],"difference":[2801],"make":[2802],"difference?":[2804],"Circ":[2806],"Cardiovasc":[2807],"Genet.":[2808],"2010;3:3-5.":[2809],"20160189]":[2811],"ScholarAppendix:":[2813],"Members":[2814],"GroupA.":[2818],"Sara":[2825],"Bedrosian,":[2826],"Paolo":[2827],"Boffetta,":[2828],"Siobhan":[2829],"Dolan,":[2831],"Nicole":[2832],"Dowling,":[2833],"Isabel":[2834],"Fortier,":[2835],"Andrew":[2836],"N.":[2837],"Freedman,":[2838],"Jeremy":[2839],"Grimshaw,":[2841],"Jeffrey":[2842],"Gulcher,":[2843],"Marta":[2844],"Gwinn,":[2845],"Mark":[2846],"A.":[2847,3111],"Hlatky,":[2848],"Holly":[2849],"Janes,":[2850],"Peter":[2851],"Kraft,":[2852],"Stephanie":[2853],"Melillo,":[2854],"Christopher":[2855],"O'Donnell,":[2857],"Michael":[2858,3413],"Pencina,":[2860,3415],"David":[2861],"Ransohoff,":[2862],"Sheri":[2863],"D.":[2864],"Schully,":[2865],"Daniela":[2866],"Seminara,":[2867],"Deborah":[2868],"Winn,":[2870],"Caroline":[2871],"F.":[2872],"Wright,":[2873],"Khoury.":[2883],"Comments0":[2884],"CommentsSign":[2885],"Submit":[2888],"Comment":[2890],"Author,":[2891],"InformationAffiliations:":[2895],"From":[2896],"Georgia.Disclaimer:":[2944],"opinions,":[2946],"findings,":[2947],"conclusions":[2949],"expressed":[2950],"here":[2951],"authors":[2956],"reflect":[2960],"views":[2962],"Department":[2965,3116,3141,3157,3172],"Health":[2967,3193],"Services":[2970],"represent":[2972],"official":[2974],"position":[2975],"policies":[2977],"Translational":[2983,3049],"Science":[2984,3050],"Institute.Grant":[2985],"Support:":[2986],"Network.":[3004],"Dr.":[3005,3041,3068],"supported":[3008,3044,3054],"grants":[3010],"Center":[3017,3062],"Systems":[3020],"Biology":[3021],"Netherlands":[3027,3036],"Genomics":[3028],"Initiative,":[3029],"VIDI":[3032],"grant":[3033],"Organisation":[3037],"Scientific":[3039],"Research.":[3040],"National":[3057,3061],"Institutes":[3058],"Health,":[3060],"Resources":[3065],"(UL1":[3066],"RR025752).":[3067],"holds":[3070],"Canada":[3072],"Chair":[3074],"Epidemiology.":[3078],"funding":[3080],"sources":[3081],"no":[3083],"role":[3084,3381],"collection,":[3090],"analysis,":[3091],"preparation":[3092],"manuscript,":[3095],"submit":[3099],"manuscript":[3101],"publication.Disclosures:":[3103],"Disclosures":[3104],"viewed":[3107],"www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-2517.Corresponding":[3109],"Author:":[3110],"PO":[3123,3148],"Box":[3124,3149],"2040,":[3125,3150],"3000":[3126,3151],"CA":[3127,3152],"e-mail,":[3131],"a.[email":[3132],"protected]nl.Current":[3133],"Author":[3134],"Addresses:":[3135],"Drs.":[3136],"Duijn:":[3140],"Netherlands.Dr.":[3155],"Ioannidis:":[3156],"Hygiene":[3159],"45110,":[3169],"Greece.Dr.":[3170],"Little:":[3171],"Community":[3176],"451":[3181],"Smyth":[3182],"Road,":[3183,3203],"Ontario":[3185],"K1H":[3186],"8M5,":[3187],"Canada.Dr.":[3188],"Khoury:":[3189],"Office":[3190],"Public":[3192],"Genomics,":[3194],"1600":[3201],"Clifton":[3202],"GA":[3205],"30333.Author":[3206],"Contributions:":[3207],"Conception":[3208],"design:":[3210],"A.C.J.W.":[3211,3227,3241,3258,3273],"J.P.A.":[3213,3229,3243,3260,3275,3282],"C.M.":[3215,3231,3245,3262,3410],"M.J.":[3220,3236,3248,3267,3279,3286,3292],"Khoury.Analysis":[3221],"data:":[3226],"Khoury.Drafting":[3237],"article:":[3240,3272],"Khoury.Critical":[3249],"revision":[3250],"intellectual":[3256],"content:":[3257],"Khoury.Final":[3268],"approval":[3269],"Khoury.Statistical":[3280],"expertise:":[3281],"Ioannidis.Obtaining":[3283],"funding:":[3285],"Khoury.Administrative,":[3287],"technical,":[3288],"logistic":[3290],"support:":[3291],"Khoury.*":[3293],"members":[3295],"(Genetic":[3299],"Studies)":[3302],"Group,":[3303],"see":[3304],"Appendix.":[3306],"PreviousarticleNextarticle":[3307],"Advertisement":[3308],"FiguresReferencesRelatedDetails":[3309],"Metrics":[3310],"Cited":[3311],"ByNew":[3312],"Framework":[3313],"Developed":[3314],"Polygenic":[3316],"Score":[3318,3326],"ReportingDevelopment":[3319],"Validation":[3321],"Clinical-Genetic":[3324],"Predict":[3328],"Hepatic":[3329],"Encephalopathy":[3330],"Patients":[3332],"With":[3333],"Liver":[3334],"CirrhosisCerebrospinal":[3335],"Fluid":[3336],"Cortisol":[3337],"Mediates":[3338]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
