{"id":"https://openalex.org/W2005648670","doi":"https://doi.org/10.1016/0306-4522(91)90159-l","title":"The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration","display_name":"The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2005648670","doi":"https://doi.org/10.1016/0306-4522(91)90159-l","mag":"2005648670","pmid":"https://pubmed.ncbi.nlm.nih.gov/1713656"},"language":"en","primary_location":{"id":"doi:10.1016/0306-4522(91)90159-l","doi":"https://doi.org/10.1016/0306-4522(91)90159-l","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-4522(91)90159-l","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005648670"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113693749","display_name":"P.-B. Andersson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"P-B. Andersson","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, U.K","Department of Experimental Psychology, South Parks Road, University of Oxford, U.K","Sir William Dunn School of Pathology, South Parks Road, University of Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Experimental Psychology, South Parks Road, University of Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Sir William Dunn School of Pathology, South Parks Road, University of Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044019815","display_name":"Victor Hugh Perry","orcid":"https://orcid.org/0000-0001-8950-5045","observed_orcids":["https://orcid.org/0000-0001-8950-5045"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"V.H. Perry","raw_affiliation_strings":["Department of Experimental Psychology, South Parks Road, University of Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Psychology, South Parks Road, University of Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060388462","display_name":"Siamon Gordon","orcid":"https://orcid.org/0000-0001-9967-3624","observed_orcids":["https://orcid.org/0000-0001-9967-3624"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Gordon","raw_affiliation_strings":["Sir William Dunn School of Pathology, South Parks Road, University of Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, South Parks Road, University of Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113693749"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":12.7187,"has_fulltext":false,"cited_by_count":248,"citation_normalized_percentile":{"value":0.99312298,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"1","first_page":"201","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7039999961853027},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/kainic-acid","display_name":"kainic acid","score":0.8289999961853027},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8560000061988831},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/f4-80","display_name":"F4/80","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mononuclear-phagocytes","display_name":"mononuclear phagocytes","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.5590000152587891},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8072029948234558},{"id":"https://openalex.org/C2776108384","wikidata":"https://www.wikidata.org/wiki/Q390239","display_name":"Kainic acid","level":4,"score":0.7512133121490479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5490798950195312},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.5470210313796997},{"id":"https://openalex.org/C2777700362","wikidata":"https://www.wikidata.org/wiki/Q107647","display_name":"Phagocyte","level":3,"score":0.5358601212501526},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4965127110481262},{"id":"https://openalex.org/C19702531","wikidata":"https://www.wikidata.org/wiki/Q929966","display_name":"Mononuclear phagocyte system","level":2,"score":0.44078493118286133},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4324273467063904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4249632954597473},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38581910729408264},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36190569400787354},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34741926193237305},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3207521140575409},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.3166870176792145},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1595543920993805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1527688205242157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15044131875038147},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.13808634877204895},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013238","descriptor_name":"Stereotaxic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0306-4522(91)90159-l","doi":"https://doi.org/10.1016/0306-4522(91)90159-l","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0306-4522(91)90159-l","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:1713656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1713656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W191400563","https://openalex.org/W203735546","https://openalex.org/W1482686873","https://openalex.org/W1570544774","https://openalex.org/W1571209082","https://openalex.org/W1758674665","https://openalex.org/W1897632924","https://openalex.org/W1964748039","https://openalex.org/W1966286149","https://openalex.org/W1970841001","https://openalex.org/W1977170192","https://openalex.org/W1977940746","https://openalex.org/W1980168868","https://openalex.org/W1991805788","https://openalex.org/W1992356992","https://openalex.org/W1993470377","https://openalex.org/W1996455766","https://openalex.org/W2001742897","https://openalex.org/W2003958490","https://openalex.org/W2013651799","https://openalex.org/W2014780485","https://openalex.org/W2015825394","https://openalex.org/W2016575029","https://openalex.org/W2017347652","https://openalex.org/W2018168833","https://openalex.org/W2022071328","https://openalex.org/W2024095334","https://openalex.org/W2029515915","https://openalex.org/W2032074018","https://openalex.org/W2033547663","https://openalex.org/W2034592675","https://openalex.org/W2038884088","https://openalex.org/W2044290944","https://openalex.org/W2045680971","https://openalex.org/W2055406505","https://openalex.org/W2056351034","https://openalex.org/W2059230209","https://openalex.org/W2063470625","https://openalex.org/W2065845618","https://openalex.org/W2065871536","https://openalex.org/W2066912376","https://openalex.org/W2084327649","https://openalex.org/W2084455978","https://openalex.org/W2084861237","https://openalex.org/W2088730075","https://openalex.org/W2096428903","https://openalex.org/W2100837269","https://openalex.org/W2110689626","https://openalex.org/W2122305954","https://openalex.org/W2142925815","https://openalex.org/W2144278714","https://openalex.org/W2147311935","https://openalex.org/W2164620775","https://openalex.org/W2165835604","https://openalex.org/W2167548726","https://openalex.org/W2417936308","https://openalex.org/W2606846219","https://openalex.org/W3004013953","https://openalex.org/W4237236725","https://openalex.org/W4289256526","https://openalex.org/W6829695323","https://openalex.org/W7073534731"],"related_works":["https://openalex.org/W1981126619","https://openalex.org/W3004013953","https://openalex.org/W2085310064","https://openalex.org/W2128532986","https://openalex.org/W1964713959","https://openalex.org/W2038743154","https://openalex.org/W2045738785","https://openalex.org/W2000447621","https://openalex.org/W2403047965","https://openalex.org/W1986182580"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}