{"id":"https://openalex.org/W2005646573","doi":"https://doi.org/10.4161/auto.26534","title":"Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway","display_name":"Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway","publication_year":2013,"publication_date":"2013-11-11","ids":{"openalex":"https://openalex.org/W2005646573","doi":"https://doi.org/10.4161/auto.26534","mag":"2005646573","pmid":"https://pubmed.ncbi.nlm.nih.gov/24262949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4389881"},"language":"en","primary_location":{"id":"doi:10.4161/auto.26534","doi":"https://doi.org/10.4161/auto.26534","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.26534","pdf_url":null,"source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4161/auto.26534","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043517580","display_name":"Gang Wan","orcid":"https://orcid.org/0000-0002-5990-7438","observed_orcids":["https://orcid.org/0000-0002-5990-7438"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Wan","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","School of Life Sciences; Tsinghua University; Beijing, China","Beijing, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"School of Life Sciences; Tsinghua University; Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083235805","display_name":"Weidong Xie","orcid":"https://orcid.org/0000-0001-5561-7663","observed_orcids":["https://orcid.org/0000-0001-5561-7663"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Xie","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhenyan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyan Liu","raw_affiliation_strings":["School of Pharmacy; Shanghai University of Traditional Chinese Medicine; Shanghai, China","School of Pharmacy","Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy; Shanghai University of Traditional Chinese Medicine; Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614422","display_name":"Wei Xu","orcid":"https://orcid.org/0000-0002-8368-7543","observed_orcids":["https://orcid.org/0000-0002-8368-7543"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xu","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","School of Life Sciences; Tsinghua University; Beijing, China","Beijing, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"School of Life Sciences; Tsinghua University; Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041532891","display_name":"Yuanzhi Lao","orcid":"https://orcid.org/0000-0002-0994-8303","observed_orcids":["https://orcid.org/0000-0002-0994-8303"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanzhi Lao","raw_affiliation_strings":["School of Pharmacy; Shanghai University of Traditional Chinese Medicine; Shanghai, China","School of Pharmacy","Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy; Shanghai University of Traditional Chinese Medicine; Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042710438","display_name":"Nunu Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nunu Huang","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","School of Life Sciences; Tsinghua University; Beijing, China","Beijing, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"School of Life Sciences; Tsinghua University; Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046031394","display_name":"Kai Cui","orcid":"https://orcid.org/0000-0001-8406-6549","observed_orcids":["https://orcid.org/0000-0001-8406-6549"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Cui","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","School of Life Sciences; Tsinghua University; Beijing, China","Beijing, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"School of Life Sciences; Tsinghua University; Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051573441","display_name":"Meijian Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meijian Liao","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","School of Life Sciences; Tsinghua University; Beijing, China","Beijing, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"School of Life Sciences; Tsinghua University; Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627337","display_name":"Jie He","orcid":"https://orcid.org/0000-0002-5880-8112","observed_orcids":["https://orcid.org/0000-0002-5880-8112"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie He","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058689861","display_name":"Yuyang Jiang","orcid":"https://orcid.org/0000-0003-3904-4855","observed_orcids":["https://orcid.org/0000-0003-3904-4855","https://orcid.org/0000-0002-0656-8647","https://orcid.org/0009-0004-3753-2614"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyang Jiang","raw_affiliation_strings":["The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028932344","display_name":"Burton B. Yang","orcid":"https://orcid.org/0000-0002-2892-7209","observed_orcids":["https://orcid.org/0000-0002-2892-7209"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Burton B Yang","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology; University of Toronto; Toronto, ON CA","Toronto, ON CA","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology; University of Toronto; Toronto, ON CA","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Toronto, ON CA","institution_ids":[]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034735808","display_name":"Hong\u2010Xi Xu","orcid":"https://orcid.org/0000-0001-6238-4511","observed_orcids":["https://orcid.org/0000-0001-6238-4511","https://orcid.org/0009-0000-7270-2149","https://orcid.org/0000-0002-1772-4844"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxi Xu","raw_affiliation_strings":["School of Pharmacy; Shanghai University of Traditional Chinese Medicine; Shanghai, China","School of Pharmacy","Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy; Shanghai University of Traditional Chinese Medicine; Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]},{"raw_affiliation_string":"School of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102506750","display_name":"Naihan Xu","orcid":"https://orcid.org/0000-0001-5457-6863","observed_orcids":["https://orcid.org/0000-0001-5457-6863"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Naihan Xu","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090827751","display_name":"Yaou Zhang","orcid":"https://orcid.org/0000-0002-2501-8093","observed_orcids":["https://orcid.org/0000-0002-2501-8093","https://orcid.org/0000-0002-4706-8171"]},"institutions":[{"id":"https://openalex.org/I4405263052","display_name":"Tsinghua Shenzhen International Graduate School","ror":"https://ror.org/01vceef04","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yaou Zhang","raw_affiliation_strings":["Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","Division of Life Science","Graduate School at Shenzhen","Shenzhen, China","Tsinghua University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab in Healthy Science and Technology; Division of Life Science; Graduate School at Shenzhen; Tsinghua University; Shenzhen, China","institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"]},{"raw_affiliation_string":"Division of Life Science","institution_ids":[]},{"raw_affiliation_string":"Graduate School at Shenzhen","institution_ids":["https://openalex.org/I4405263052"]},{"raw_affiliation_string":"Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090827751","https://openalex.org/A5102506750"],"corresponding_institution_ids":["https://openalex.org/I4405263052","https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":5.3558,"has_fulltext":true,"cited_by_count":190,"citation_normalized_percentile":{"value":0.9741374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"70","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.3264000117778778,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-155","display_name":"miR-155","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/rheb","display_name":"Rheb","score":0.8379999995231628},{"id":"https://openalex.org/keywords/rictor","display_name":"Rictor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/g1-s-cell-cycle-arrest","display_name":"G1/S cell cycle arrest","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.887114405632019},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7658265829086304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7312507033348083},{"id":"https://openalex.org/C2778937405","wikidata":"https://www.wikidata.org/wiki/Q18031127","display_name":"RHEB","level":5,"score":0.6283975839614868},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.628317654132843},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4849822521209717},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47152408957481384},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4312279224395752},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.4174804389476776},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3653854727745056},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.32258641719818115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2735491991043091},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.14153185486793518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1380944848060608}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4161/auto.26534","doi":"https://doi.org/10.4161/auto.26534","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.26534","pdf_url":null,"source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4389881","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4389881/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4389881/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Text"},{"id":"pmid:24262949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24262949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/auto.26534","doi":"https://doi.org/10.4161/auto.26534","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.26534","pdf_url":null,"source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005646573.pdf","grobid_xml":"https://content.openalex.org/works/W2005646573.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1557023703","https://openalex.org/W1887368958","https://openalex.org/W1900976126","https://openalex.org/W1955837289","https://openalex.org/W1965602034","https://openalex.org/W1967007963","https://openalex.org/W1969978989","https://openalex.org/W1970637701","https://openalex.org/W1980687166","https://openalex.org/W1991944677","https://openalex.org/W1994823455","https://openalex.org/W1996082612","https://openalex.org/W1998277565","https://openalex.org/W2000093333","https://openalex.org/W2005479935","https://openalex.org/W2006559495","https://openalex.org/W2009031481","https://openalex.org/W2013084027","https://openalex.org/W2014946489","https://openalex.org/W2017018900","https://openalex.org/W2019571961","https://openalex.org/W2021012077","https://openalex.org/W2036294319","https://openalex.org/W2036611042","https://openalex.org/W2046250764","https://openalex.org/W2050278645","https://openalex.org/W2056137479","https://openalex.org/W2058167857","https://openalex.org/W2059357290","https://openalex.org/W2060459012","https://openalex.org/W2060691243","https://openalex.org/W2065800209","https://openalex.org/W2065887259","https://openalex.org/W2068193025","https://openalex.org/W2069759108","https://openalex.org/W2074033424","https://openalex.org/W2077418979","https://openalex.org/W2085586604","https://openalex.org/W2088829127","https://openalex.org/W2097127812","https://openalex.org/W2098150383","https://openalex.org/W2102824849","https://openalex.org/W2106125288","https://openalex.org/W2109034822","https://openalex.org/W2109263914","https://openalex.org/W2113432343","https://openalex.org/W2116365126","https://openalex.org/W2117874431","https://openalex.org/W2123285970","https://openalex.org/W2125132932","https://openalex.org/W2127063807","https://openalex.org/W2129585918","https://openalex.org/W2133226725","https://openalex.org/W2135810600","https://openalex.org/W2135836598","https://openalex.org/W2139992910","https://openalex.org/W2142611308","https://openalex.org/W2145720555","https://openalex.org/W2157096314","https://openalex.org/W2160102037","https://openalex.org/W2162674813","https://openalex.org/W2169563577","https://openalex.org/W4238567307"],"related_works":["https://openalex.org/W2162661847","https://openalex.org/W2010703053","https://openalex.org/W2923577979","https://openalex.org/W2043055809","https://openalex.org/W1978621808","https://openalex.org/W2764019302","https://openalex.org/W1955837289","https://openalex.org/W2058526984","https://openalex.org/W1998773336","https://openalex.org/W3123309940"],"abstract_inverted_index":{"Hypoxia":[0,26],"activates":[1],"autophagy,":[2],"an":[3,18],"evolutionarily":[4],"conserved":[5],"cellular":[6],"catabolic":[7],"process.":[8],"Dysfunction":[9],"in":[10,17,36,60,82],"the":[11,105],"autophagy":[12,143],"pathway":[13],"has":[14],"been":[15],"implicated":[16],"increasing":[19],"number":[20],"of":[21,29,33,39,51,55,104,142,146],"human":[22,61],"diseases,":[23],"including":[24,85],"cancer.":[25],"induces":[27,123],"upregulation":[28],"a":[30,37,48,133,139],"specific":[31],"set":[32],"microRNAs":[34],"(miRNAs)":[35],"variety":[38],"cell":[40,120,126],"types.":[41],"Here,":[42],"we":[43],"describe":[44],"hypoxia-induced":[45,73],"MIR155":[46,56,71,78,90,110,117,137],"as":[47,138],"potent":[49],"inducer":[50],"autophagy.":[52,74],"Enforced":[53],"expression":[54,93],"increases":[57],"autophagic":[58],"activity":[59],"nasopharyngeal":[62],"cancer":[63,66],"and":[64,88,122],"cervical":[65],"cells.":[67],"Knocking":[68],"down":[69],"endogenous":[70],"inhibits":[72],"We":[75],"demonstrated":[76],"that":[77],"targets":[79],"multiple":[80],"players":[81],"MTOR":[83,115,147],"signaling,":[84,116],"RHEB,":[86],"RICTOR,":[87],"RPS6KB2.":[89],"suppresses":[91],"target-gene":[92],"by":[94,113],"directly":[95],"interacting":[96],"with":[97],"their":[98,109],"3'":[99],"untranslated":[100],"regions":[101],"(UTRs),":[102],"mutations":[103],"binding":[106],"sites":[107],"abolish":[108],"responsiveness.":[111],"Furthermore,":[112],"downregulating":[114],"also":[118],"attenuates":[119],"proliferation":[121],"G":[124],"1/S":[125],"cycle":[127],"arrest.":[128],"Collectively,":[129],"these":[130],"data":[131],"present":[132],"new":[134],"role":[135],"for":[136],"key":[140],"regulator":[141],"via":[144],"dysregulation":[145],"pathway.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":14}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
