{"id":"https://openalex.org/W2005646330","doi":"https://doi.org/10.1073/pnas.74.9.3840","title":"Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.","display_name":"Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.","publication_year":1977,"publication_date":"1977-09-01","ids":{"openalex":"https://openalex.org/W2005646330","doi":"https://doi.org/10.1073/pnas.74.9.3840","mag":"2005646330","pmid":"https://pubmed.ncbi.nlm.nih.gov/198809","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/431753"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.74.9.3840","doi":"https://doi.org/10.1073/pnas.74.9.3840","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.74.9.3840","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005646330"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC431753","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111411888","display_name":"Robert P. C. Shiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R P Shiu","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091254505","display_name":"Jacques Pouyss\u00e9gur","orcid":"https://orcid.org/0000-0003-2779-6902","observed_orcids":["https://orcid.org/0000-0003-2779-6902"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Pouyssegur","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056573254","display_name":"Ira H Pastan","orcid":"https://orcid.org/0000-0002-9223-0270","observed_orcids":["https://orcid.org/0000-0002-9223-0270"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Pastan","raw_affiliation_strings":["Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5898,"has_fulltext":false,"cited_by_count":384,"citation_normalized_percentile":{"value":0.89966233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"74","issue":"9","first_page":"3840","last_page":"3844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.4562999904155731,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.4562999904155731,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.22939999401569366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-regulated-proteins","display_name":"glucose-regulated proteins","score":0.8220000267028809},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9490000009536743},{"id":"https://openalex.org/keywords/glucose-depletion","display_name":"glucose depletion","score":0.8109999895095825},{"id":"https://openalex.org/keywords/rous-sarcoma-virus","display_name":"Rous sarcoma virus","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/chicken-embryo-fibroblasts","display_name":"chicken embryo fibroblasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.8899999856948853},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.7160000205039978},{"id":"https://openalex.org/keywords/protein-synthesis-regulation","display_name":"protein synthesis regulation","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2777441520","wikidata":"https://www.wikidata.org/wiki/Q1444330","display_name":"Rous sarcoma virus","level":3,"score":0.9507213830947876},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7004245519638062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5746554136276245},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.5045350790023804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4634074866771698},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33772531151771545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2989484667778015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12507843971252441}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001358","descriptor_name":"Avian Sarcoma Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.74.9.3840","doi":"https://doi.org/10.1073/pnas.74.9.3840","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.74.9.3840","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:66006","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC431753","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:198809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/198809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:431753","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC431753/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:66006","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC431753","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W654251129","https://openalex.org/W1573930536","https://openalex.org/W1775749144","https://openalex.org/W1896524964","https://openalex.org/W1964015820","https://openalex.org/W1967106886","https://openalex.org/W1972963543","https://openalex.org/W1989037748","https://openalex.org/W2004699574","https://openalex.org/W2018241615","https://openalex.org/W2018289835","https://openalex.org/W2029523024","https://openalex.org/W2038570970","https://openalex.org/W2045143594","https://openalex.org/W2077057155","https://openalex.org/W2095255385","https://openalex.org/W2100837269","https://openalex.org/W2329120917"],"related_works":["https://openalex.org/W2002733795","https://openalex.org/W1767953281","https://openalex.org/W2410347669","https://openalex.org/W2029554563","https://openalex.org/W2023162182","https://openalex.org/W2329002877","https://openalex.org/W1967936337","https://openalex.org/W2003630372","https://openalex.org/W2414744013","https://openalex.org/W2267175241"],"abstract_inverted_index":{"Chick":[0],"embryo":[1],"fibroblasts":[2],"transformed":[3,63,77,116],"by":[4,127],"Rous":[5],"sarcoma":[6],"virus":[7],"have":[8,149],"an":[9,42,150],"increased":[10,23],"content":[11,24,35],"of":[12,16,25,36,45,56,62,76,81,89,98,104,115,121,132,157],"two":[13,123],"membrane":[14],"proteins":[15,108,124,147],"molecular":[17],"weights":[18],"78,000":[19],"and":[20,29,87,144],"95,000.":[21],"The":[22],"the":[26,30,34,37,53,59,73,79,82,90,101,119,128,155],"95,000-dalton":[27,83],"protein":[28,39,84,92],"principal":[31],"increase":[32,109],"in":[33,72,153,159],"78,000-dalton":[38,91],"are":[40,50],"not":[41],"early":[43],"consequence":[44],"cell":[46],"transformation":[47],"but":[48],"instead":[49],"secondary":[51],"to":[52,110,113,139],"rapid":[54],"depletion":[55],"glucose":[57,66,99,158],"from":[58,100],"growth":[60,74,102],"medium":[61,75,103],"cells.":[64,117,161],"When":[65],"is":[67,85,93,125],"maintained":[68],"at":[69],"high":[70],"levels":[71,111],"cells,":[78,106],"synthesis":[80],"arrested":[86],"that":[88],"markedly":[94],"suppressed.":[95],"Upon":[96],"removal":[97],"normal":[105],"these":[107,122],"comparable":[112],"those":[114],"Because":[118],"amount":[120],"influenced":[126],"presence":[129],"or":[130],"absence":[131],"glucose,":[133],"we":[134],"suggest":[135],"they":[136],"be":[137],"referred":[138],"as":[140],"\"glucose-regulated":[141],"proteins.\"":[142],"GRP-78":[143],"GRP-95.":[145],"These":[146],"may":[148],"important":[151],"role":[152],"regulating":[154],"utilization":[156],"cultured":[160]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}