{"id":"https://openalex.org/W2005605111","doi":"https://doi.org/10.1158/1055-9965.gwas-35","title":"Abstract 35: Within-person reproducibility of urinary bisphenol A and phthalate metabolites among women in the Nurses' Health Studies.","display_name":"Abstract 35: Within-person reproducibility of urinary bisphenol A and phthalate metabolites among women in the Nurses' Health Studies.","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2005605111","doi":"https://doi.org/10.1158/1055-9965.gwas-35","mag":"2005605111"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.gwas-35","doi":"https://doi.org/10.1158/1055-9965.gwas-35","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.gwas-35","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068795567","display_name":"Mary K. Townsend","orcid":"https://orcid.org/0000-0003-2452-4477","observed_orcids":["https://orcid.org/0000-0003-2452-4477","https://orcid.org/0000-0002-9954-4846"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Townsend","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077982482","display_name":"Adrian A. Franke","orcid":"https://orcid.org/0000-0002-1911-1662","observed_orcids":["https://orcid.org/0000-0002-1911-1662"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian Franke","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xingnan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xingnan Li","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056459536","display_name":"Frank B. Hu","orcid":"https://orcid.org/0000-0002-8233-6274","observed_orcids":["https://orcid.org/0000-0002-8233-6274","https://orcid.org/0000-0002-8412-2261"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Hu","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014551852","display_name":"A. Heather Eliassen","orcid":"https://orcid.org/0000-0002-3961-6609","observed_orcids":["https://orcid.org/0000-0002-3961-6609"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Heather Eliassen","raw_affiliation_strings":["1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital, Boston, MA, 2Cancer Research Center of Hawaii, Honolulu, HI","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"11_Supplement","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.9649999737739563},{"id":"https://openalex.org/keywords/phthalate-metabolites","display_name":"phthalate metabolites","score":0.996999979019165},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.8389999866485596},{"id":"https://openalex.org/keywords/long-term-reproducibility","display_name":"long-term reproducibility","score":0.7929999828338623},{"id":"https://openalex.org/keywords/monoethyl-phthalate","display_name":"monoethyl phthalate","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mono-2-ethylhexyl-phthalate","display_name":"mono(2-ethylhexyl) phthalate","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mono-2-ethyl-5-oxohexyl-phthalate","display_name":"MEOHP","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mono-2-ethyl-5-carboxypentyl-phthalate","display_name":"MECPP","score":0.9229999780654907},{"id":"https://openalex.org/keywords/monobenzyl-phthalate","display_name":"monobenzyl phthalate","score":0.796999990940094},{"id":"https://openalex.org/keywords/monobutyl-phthalate","display_name":"mono-n-butyl phthalate","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mono-isobutyl-phthalate","display_name":"mono-isobutyl phthalate","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nurses-health-study","display_name":"Nurses' Health Study","score":0.7670000195503235},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.3709999918937683},{"id":"https://openalex.org/keywords/first-morning-urine","display_name":"first morning urine","score":0.5849999785423279},{"id":"https://openalex.org/keywords/exposure-assessment","display_name":"exposure assessment","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C2781005124","wikidata":"https://www.wikidata.org/wiki/Q84483575","display_name":"Phthalate","level":2,"score":0.9499130845069885},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6026703119277954},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4746834933757782},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.47406643629074097},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4420904815196991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43173789978027344},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.4133973717689514},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3370441198348999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3161073923110962},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2589806616306305},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07600724697113037}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.gwas-35","doi":"https://doi.org/10.1158/1055-9965.gwas-35","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.gwas-35","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2151355547","https://openalex.org/W2910194074","https://openalex.org/W7099719278","https://openalex.org/W4210341838","https://openalex.org/W2021283344","https://openalex.org/W1082132379","https://openalex.org/W2053501212","https://openalex.org/W3089002614","https://openalex.org/W2005531169","https://openalex.org/W2067256255"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"purpose":[2],"of":[3,13,22,44,73,79,117,124,200,251,262,303,322,338,359,366,385,387,405,422],"our":[4],"study":[5],"was":[6,253],"to":[7,68,98,190,197,246,256,289,316,375],"examine":[8],"the":[9,70,105,320,383,415,423,436],"long-term":[10,367],"within-person":[11,45,160,249,279,378],"reproducibility":[12,64,370,404],"bisphenol":[14,407],"A":[15,408],"(BPA)":[16],"and":[17,24,50,88,109,154,168,175,239,260,346,409],"8":[18,89],"phthalate":[19,51,90,121,130,134,137,140,143,146,149,152,156,176,273,324,361,410],"metabolites.":[20],"Associations":[21],"BPA":[23,49,87,174,252,263,304,344],"phthalates":[25],"with":[26],"health":[27],"are":[28,38,66,363],"increasingly":[29],"being":[30],"investigated":[31],"in":[32,47,82,92,104,305,353,382,414,430],"epidemiologic":[33,354],"studies,":[34,355],"although":[35],"existing":[36],"studies":[37,43],"largely":[39],"cross-sectional.":[40],"Most":[41],"previous":[42],"variability":[46,250,258,379],"urinary":[48,323,343,360,406],"metabolite":[52,177],"concentrations":[53,203],"have":[54],"focused":[55],"on":[56,427],"stability":[57,280],"over":[58,281,314,331],"3":[59,99,207,247,317],"months":[60],"or":[61,285],"less.":[62],"Long-term":[63],"data":[65,371],"needed":[67],"assess":[69],"potential":[71],"usefulness":[72],"these":[74],"biomarkers":[75],"for":[76,115,120,172,209,213,217,221,225,229,233,237,242,377],"predicting":[77],"risk":[78,348],"disease":[80,347],"onset":[81],"prospective":[83],"studies.":[84],"We":[85],"measured":[86],"metabolites":[91,131,325,362,411],"spot":[93,306],"urine":[94,192,291,307],"samples":[95,125,292,308],"donated":[96],"1":[97,245,315],"years":[100],"apart":[101],"by":[102],"women":[103,313,330,413],"Nurses'":[106,110,416],"Health":[107,111,417],"Study":[108,112],"II":[113],"(n=80":[114],"analyses":[116,187,288],"BPA;":[118],"n=40":[119],"metabolites);":[122],"86%":[123],"were":[126,132,180,188,267,309],"first-morning":[127,191,290],"urines.":[128],"Specific":[129],"mono-ethyl":[133],"(MEP),":[135],"mono-isobutyl":[136],"(MiBP),":[138],"mono-n-butyl":[139],"(MnBP),":[141],"mono-benzyl":[142],"(MBzP),":[144],"mono-(2-ethylhexyl)":[145],"(MEHP),":[147],"mono-(2-ethyl-5-hydrohexyl)":[148],"(MEHHP),":[150],"mono-(2-ethyl-5-oxohexyl)":[151],"(MEOHP),":[153],"mono-(2-ethyl-5carboxypentyl)":[155],"(MECPP).":[157],"To":[158],"measure":[159],"reproducibility,":[161],"we":[162,298],"calculated":[163],"Spearman":[164],"rank":[165],"correlation":[166,284],"coefficients":[167],"intraclass":[169],"correlations":[170],"(ICCs)":[171],"creatinine-adjusted":[173,201],"concentrations;":[178],"ICCs":[179],"estimated":[181],"using":[182],"natural":[183],"log-transformed":[184],"values.":[185],"Additional":[186],"restricted":[189],"samples.":[193],"Distributions":[194],"(medians":[195],"[5th":[196],"95th":[198],"percentiles])":[199],"analyte":[202],"(ng/mg":[204],"creatinine)":[205],"were:":[206],"(1-6)":[208],"BPA,":[210],"141":[211],"(21-895)":[212],"MEP,":[214],"4":[215],"(1-12)":[216],"MiBP,":[218],"37":[219],"(10-177)":[220],"MnBP,":[222],"14":[223],"(4-97)":[224],"MBzP,":[226],"5":[227],"(2-26)":[228],"MEHP,":[230,276],"32":[231],"(9-163)":[232],"MEHHP,":[234],"26":[235],"(7-136)":[236],"MEOHP,":[238],"43":[240],"(16-215)":[241],"MECPP.":[243],"Over":[244],"years,":[248],"high":[254],"relative":[255,388],"total":[257],"(ICC=0.14)":[259],"rankings":[261],"levels":[264],"between":[265,340],"time-points":[266],"weakly":[268],"correlated":[269],"(Spearman":[270,283],"correlation=0.19).":[271],"All":[272],"metabolites,":[274],"except":[275],"demonstrated":[277],"moderate":[278],"time":[282],"ICC=0.39-0.55).":[286],"Restricting":[287],"did":[293],"not":[294],"alter":[295],"results.":[296],"Overall,":[297],"found":[299],"that":[300,336,380],"single":[301,342,357],"measurements":[302,358],"highly":[310],"variable":[311],"within":[312,329],"years.":[318],"However,":[319],"majority":[321],"appeared":[326],"moderately":[327],"reproducible":[328],"time.":[332],"Our":[333],"results":[334,381],"suggest":[335],"investigation":[337],"associations":[339],"a":[341],"measurement":[345],"likely":[349],"will":[350],"be":[351,373],"challenging":[352],"while":[356],"reasonable":[364],"measures":[365],"exposure.":[368],"Further,":[369],"could":[372],"used":[374],"correct":[376],"attenuation":[384],"estimates":[386],"risk.":[389],"Citation":[390],"Format:":[391],"Mary":[392],"Townsend,":[393],"Adrian":[394],"Franke,":[395],"Xingnan":[396],"Li,":[397],"Frank":[398],"Hu,":[399],"A.":[400],"Heather":[401],"Eliassen.":[402],"Within-person":[403],"among":[412],"Studies.":[418],"[abstract].":[419],"In:":[420],"Proceedings":[421],"AACR":[424],"Special":[425],"Conference":[426],"Post-GWAS":[428],"Horizons":[429],"Molecular":[431],"Epidemiology:":[432],"Digging":[433],"Deeper":[434],"into":[435],"Environment;":[437],"2012":[438],"Nov":[439],"11-14;":[440],"Hollywood,":[441],"FL.":[442],"Philadelphia":[443],"(PA):":[444],"AACR;":[445],"Cancer":[446],"Epidemiol":[447],"Biomarkers":[448],"Prev":[449],"2012;21(11":[450],"Suppl):Abstract":[451],"nr":[452],"35.":[453]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}