{"id":"https://openalex.org/W2005603971","doi":"https://doi.org/10.1016/j.drup.2006.05.002","title":"DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity","display_name":"DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2005603971","doi":"https://doi.org/10.1016/j.drup.2006.05.002","mag":"2005603971","pmid":"https://pubmed.ncbi.nlm.nih.gov/16790363"},"language":"en","primary_location":{"id":"doi:10.1016/j.drup.2006.05.002","doi":"https://doi.org/10.1016/j.drup.2006.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drup.2006.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S47159833","display_name":"Drug Resistance Updates","issn_l":"1368-7646","issn":["1368-7646","1532-2084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resistance Updates","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081885555","display_name":"Viktor Brabec","orcid":"https://orcid.org/0000-0002-8233-1393","observed_orcids":["https://orcid.org/0000-0002-8233-1393"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Viktor Brabec","raw_affiliation_strings":["Institute of Biophysics, Academy of Sciences of the Czech Republic, Kr\u00e1lovopolsk\u00e1 135, CZ-61265 Brno, Czech Republic. brabec@ibp.cz <brabec@ibp.cz>","Institute of Biophysics, Academy of Sciences of the Czech Republic Kr\u00e1lovopolsk\u00e1 135, CZ-61265 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biophysics, Academy of Sciences of the Czech Republic, Kr\u00e1lovopolsk\u00e1 135, CZ-61265 Brno, Czech Republic. brabec@ibp.cz <brabec@ibp.cz>","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]},{"raw_affiliation_string":"Institute of Biophysics, Academy of Sciences of the Czech Republic Kr\u00e1lovopolsk\u00e1 135, CZ-61265 Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001459184","display_name":"Olga Nov\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0001-8653-4836","observed_orcids":["https://orcid.org/0000-0001-8653-4836","https://orcid.org/0009-0000-9950-8127"]},"institutions":[{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Olga Nov\u00e1kov\u00e1","raw_affiliation_strings":["Institute of Biophysics, Academy of Sciences of the Czech Republic, Kr\u00e1lovopolsk\u00e1 135, CZ-61265 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biophysics, Academy of Sciences of the Czech Republic, Kr\u00e1lovopolsk\u00e1 135, CZ-61265 Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081885555"],"corresponding_institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210089928"],"apc_list":{"value":5410,"currency":"USD","value_usd":5410},"apc_paid":null,"fwci":2.3386,"has_fulltext":false,"cited_by_count":393,"citation_normalized_percentile":{"value":0.91021324,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"111","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ruthenium-complexes","display_name":"ruthenium complexes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cisplatin-analogues","display_name":"cisplatin analogues","score":0.8050000071525574},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.6830000281333923},{"id":"https://openalex.org/keywords/antitumor-cytotoxicity","display_name":"tumor cytotoxicity","score":0.5479999780654907},{"id":"https://openalex.org/keywords/dna-conformation","display_name":"DNA conformation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/redox-potential","display_name":"redox potential","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-surface-targets","display_name":"cell surface targets","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C555196967","wikidata":"https://www.wikidata.org/wiki/Q1086","display_name":"Ruthenium","level":3,"score":0.9612613916397095},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6272277235984802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6073727607727051},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.5836103558540344},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.5625405311584473},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5190401673316956},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4570200443267822},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33349668979644775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2624739408493042},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24931085109710693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14932626485824585},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13111171126365662},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09915342926979065},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.09253549575805664},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07456141710281372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004121","descriptor_name":"Dimethyl Sulfoxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017975","descriptor_name":"Ruthenium Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D017975","descriptor_name":"Ruthenium Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017975","descriptor_name":"Ruthenium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.drup.2006.05.002","doi":"https://doi.org/10.1016/j.drup.2006.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drup.2006.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S47159833","display_name":"Drug Resistance Updates","issn_l":"1368-7646","issn":["1368-7646","1532-2084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resistance Updates","raw_type":"journal-article"},{"id":"pmid:16790363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16790363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W26404334","https://openalex.org/W78319162","https://openalex.org/W98290483","https://openalex.org/W107832641","https://openalex.org/W148087801","https://openalex.org/W177251887","https://openalex.org/W560748447","https://openalex.org/W605051786","https://openalex.org/W612414919","https://openalex.org/W646497531","https://openalex.org/W1242125470","https://openalex.org/W1511491270","https://openalex.org/W1586119447","https://openalex.org/W1599558353","https://openalex.org/W1609739373","https://openalex.org/W1741860215","https://openalex.org/W1964314803","https://openalex.org/W1968330562","https://openalex.org/W1970105936","https://openalex.org/W1970824205","https://openalex.org/W1975104632","https://openalex.org/W1980411311","https://openalex.org/W1981582595","https://openalex.org/W1981983703","https://openalex.org/W1987461824","https://openalex.org/W1997453167","https://openalex.org/W2000510569","https://openalex.org/W2005241587","https://openalex.org/W2009344089","https://openalex.org/W2012108057","https://openalex.org/W2014588550","https://openalex.org/W2014966556","https://openalex.org/W2015754709","https://openalex.org/W2016408785","https://openalex.org/W2019756143","https://openalex.org/W2028338260","https://openalex.org/W2039790918","https://openalex.org/W2041770648","https://openalex.org/W2042246520","https://openalex.org/W2042521338","https://openalex.org/W2043610941","https://openalex.org/W2045343949","https://openalex.org/W2048168597","https://openalex.org/W2050428483","https://openalex.org/W2052153483","https://openalex.org/W2053409523","https://openalex.org/W2054607739","https://openalex.org/W2059837825","https://openalex.org/W2061103770","https://openalex.org/W2065402334","https://openalex.org/W2068922188","https://openalex.org/W2068991440","https://openalex.org/W2069148508","https://openalex.org/W2076579315","https://openalex.org/W2077594563","https://openalex.org/W2084361832","https://openalex.org/W2092261416","https://openalex.org/W2092767907","https://openalex.org/W2094012917","https://openalex.org/W2094765988","https://openalex.org/W2096847256","https://openalex.org/W2103459003","https://openalex.org/W2103902036","https://openalex.org/W2105591137","https://openalex.org/W2105790555","https://openalex.org/W2111570380","https://openalex.org/W2116360054","https://openalex.org/W2121649359","https://openalex.org/W2122684723","https://openalex.org/W2129213133","https://openalex.org/W2132797346","https://openalex.org/W2140895245","https://openalex.org/W2149687304","https://openalex.org/W2153616465","https://openalex.org/W2154244708","https://openalex.org/W2155154899","https://openalex.org/W2159190092","https://openalex.org/W2170756410","https://openalex.org/W2177162343","https://openalex.org/W2316889091","https://openalex.org/W2410885003","https://openalex.org/W2411202549","https://openalex.org/W2417861969","https://openalex.org/W2418774605","https://openalex.org/W2435600454","https://openalex.org/W2441819107","https://openalex.org/W2467008862","https://openalex.org/W2507203008","https://openalex.org/W2925225009","https://openalex.org/W4211092410","https://openalex.org/W4285719527","https://openalex.org/W6675536244","https://openalex.org/W6717764538","https://openalex.org/W6719094500"],"related_works":["https://openalex.org/W2913100279","https://openalex.org/W7120498323","https://openalex.org/W2078034063","https://openalex.org/W202825370","https://openalex.org/W1985917582","https://openalex.org/W2612340147","https://openalex.org/W2946115537","https://openalex.org/W2963673788","https://openalex.org/W2344503877","https://openalex.org/W2409255902"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":35},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
