{"id":"https://openalex.org/W2005519969","doi":"https://doi.org/10.1021/ac048693f","title":"Extrinsic Fabry\u2212Perot Interferometry for Noncontact Temperature Control of Nanoliter-Volume Enzymatic Reactions in Glass Microchips","display_name":"Extrinsic Fabry\u2212Perot Interferometry for Noncontact Temperature Control of Nanoliter-Volume Enzymatic Reactions in Glass Microchips","publication_year":2005,"publication_date":"2005-01-15","ids":{"openalex":"https://openalex.org/W2005519969","doi":"https://doi.org/10.1021/ac048693f","mag":"2005519969","pmid":"https://pubmed.ncbi.nlm.nih.gov/15858983"},"language":"en","primary_location":{"id":"doi:10.1021/ac048693f","doi":"https://doi.org/10.1021/ac048693f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac048693f","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017497897","display_name":"Christopher John Easley","orcid":"https://orcid.org/0000-0002-2403-4147","observed_orcids":["https://orcid.org/0000-0002-2403-4147"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Easley","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064729543","display_name":"Lindsay A. Legendre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay A. Legendre","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064958586","display_name":"Michael G. Roper","orcid":"https://orcid.org/0000-0002-0184-1333","observed_orcids":["https://orcid.org/0000-0002-0184-1333"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Roper","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037199329","display_name":"Thomas A. Wavering","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Wavering","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046014884","display_name":"Jerome P. Ferrance","orcid":"https://orcid.org/0000-0003-1020-8289","observed_orcids":["https://orcid.org/0000-0003-1020-8289"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome P. Ferrance","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031563436","display_name":"James P. Landers","orcid":"https://orcid.org/0000-0002-9310-1796","observed_orcids":["https://orcid.org/0000-0002-9310-1796"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James P. Landers","raw_affiliation_strings":["Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Pathology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, and Luna Innovations, Blacksburg, Virginia 24060","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031563436"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.0013,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.92979452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":"4","first_page":"1038","last_page":"1045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10205","display_name":"Advanced Fiber Optic Sensors","score":0.43650001287460327,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10205","display_name":"Advanced Fiber Optic Sensors","score":0.43650001287460327,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.06379999965429306,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temperature-control","display_name":"temperature control","score":0.6000000238418579},{"id":"https://openalex.org/keywords/glass-microchips","display_name":"glass microchips","score":0.9129999876022339},{"id":"https://openalex.org/keywords/fiber-optic-sensors","display_name":"fiber optic sensors","score":0.6399999856948853},{"id":"https://openalex.org/keywords/optical-path-length","display_name":"optical path length","score":0.6819999814033508},{"id":"https://openalex.org/keywords/refractive-index","display_name":"refractive index","score":0.6399999856948853},{"id":"https://openalex.org/keywords/gold-sputtering","display_name":"gold sputtering","score":0.6399999856948853},{"id":"https://openalex.org/keywords/infrared-heating","display_name":"infrared heating","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9361723065376282},{"id":"https://openalex.org/C169268690","wikidata":"https://www.wikidata.org/wiki/Q1359945","display_name":"Fabry\u2013P\u00e9rot interferometer","level":3,"score":0.8785069584846497},{"id":"https://openalex.org/C166689943","wikidata":"https://www.wikidata.org/wiki/Q850283","display_name":"Interferometry","level":2,"score":0.7100824117660522},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.564315140247345},{"id":"https://openalex.org/C536315585","wikidata":"https://www.wikidata.org/wiki/Q7698332","display_name":"Temperature control","level":2,"score":0.4364390969276428},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.35116827487945557},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.17098644375801086},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.05806952714920044},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005336","descriptor_name":"Fiber Optic Technology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007368","descriptor_name":"Interferometry","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D046208","descriptor_name":"Microchip Analytical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055100","descriptor_name":"Optical Fibers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac048693f","doi":"https://doi.org/10.1021/ac048693f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac048693f","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:15858983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15858983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3145544974","display_name":"Non-contact microchip PCR based on infrared Heating","funder_award_id":"5r01hg001832-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G672836307","display_name":null,"funder_award_id":"R01-HG001832","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310536","display_name":"University of Virginia","ror":"https://ror.org/0153tk833"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W657311337","https://openalex.org/W1967544319","https://openalex.org/W1972466773","https://openalex.org/W1974437320","https://openalex.org/W1975622188","https://openalex.org/W1985586370","https://openalex.org/W1989025953","https://openalex.org/W2006081505","https://openalex.org/W2015472150","https://openalex.org/W2017581879","https://openalex.org/W2030788182","https://openalex.org/W2034758188","https://openalex.org/W2052580465","https://openalex.org/W2056645539","https://openalex.org/W2060246168","https://openalex.org/W2071290149","https://openalex.org/W2081998687","https://openalex.org/W2128691519","https://openalex.org/W2144498825","https://openalex.org/W2148927531","https://openalex.org/W2165628349"],"related_works":["https://openalex.org/W4401105163","https://openalex.org/W2045785385","https://openalex.org/W2081976103","https://openalex.org/W2570702651","https://openalex.org/W2191158824","https://openalex.org/W4402190850","https://openalex.org/W1985166427","https://openalex.org/W7166640591","https://openalex.org/W2089566286","https://openalex.org/W3097883447"],"abstract_inverted_index":{"Optical":[0],"fiber":[1],"extrinsic":[2],"Fabry-Perot":[3],"interferometry":[4],"(EFPI)":[5],"was":[6,72,95,135,160],"investigated":[7],"as":[8],"a":[9,53,93,102,121,143,169,230],"noncontact":[10,75,103,123,232],"temperature":[11,18,79,113,127,158,191,224],"sensor":[12,71,91,159],"and":[13,117,132,152,207,218,223,236,242],"utilized":[14],"for":[15,125,215,239],"regulating":[16],"the":[17,28,42,50,69,84,90,99,155,164,188,205,211],"of":[19,52,74,77,89,111,140,154,210],"small-volume":[20,126],"solutions":[21],"in":[22,41,44,83,101,129,147,177,187,229,245],"microchips.":[23,246],"Interference":[24],"pattern":[25],"analysis":[26],"determined":[27],"optical":[29],"path":[30,86],"lengths":[31],"(OPL)":[32],"associated":[33],"with":[34,105,168],"reflections":[35],"from":[36,46,81,203],"various":[37],"surfaces":[38,209],"on":[39,49,66],"or":[40],"microchip,":[43],"particular,":[45],"gold":[47,167],"sputtered":[48,166],"bottom":[51,206],"microchannel.":[54,212],"Since":[55],"OPL":[56],"is":[57,64],"directly":[58],"proportional":[59],"to":[60],"refractive":[61],"index,":[62],"which":[63],"dependent":[65],"solution":[67,78],"temperature,":[68],"EFPI":[70,112,157],"capable":[73],"monitoring":[76],"simply":[80],"alterations":[82],"measured":[85],"length.":[87],"Calibration":[88],"against":[92],"thermocouple":[94],"performed":[96],"while":[97],"heating":[98],"microchip":[100,130,156],"manner":[104],"an":[106,184,234],"IR":[107],"lamp.":[108],"The":[109,150],"combination":[110],"sensor,":[114],"IR-mediated":[115],"heating,":[116,221],"air":[118],"cooling":[119],"allowed":[120],"fully":[122],"system":[124],"control":[128,225],"structures,":[131],"its":[133],"utility":[134],"illustrated":[136],"by":[137,142,162,200],"optimal":[138],"digestion":[139],"DNA":[141],"temperature-dependent":[144],"restriction":[145],"endonuclease":[146],"320":[148],"nL.":[149],"functionality":[151],"simplicity":[153],"enhanced":[161,201],"replacing":[163],"prebonding":[165],"tunable,":[170],"chemically":[171],"plated":[172],"semireflective":[173],"silver":[174],"coating":[175],"created":[176],"situ":[178],"after":[179],"chip":[180],"fabrication.":[181],"This":[182,213],"provided":[183],"8-fold":[185],"improvement":[186],"lowest":[189],"detectable":[190],"change":[192],"(deltaT":[193],"=":[194],"0.1":[195],"degrees":[196],"C),":[197],"facilitated":[198],"primarily":[199],"reflection":[202],"both":[204],"top":[208],"approach":[214],"controlling":[216],"micro-":[217],"nanoscale":[219],"reactions--with":[220],"cooling,":[222],"being":[226],"carried":[227],"out":[228],"completely":[231],"fashion--provides":[233],"accurate":[235],"sensitive":[237],"method":[238],"executing":[240],"chemical":[241],"biochemical":[243],"reactions":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}