{"id":"https://openalex.org/W2005507704","doi":"https://doi.org/10.1074/jbc.m114.619320","title":"Interplay between Disulfide Bonding and N-Glycosylation Defines SLC4 Na+-coupled Transporter Extracellular Topography","display_name":"Interplay between Disulfide Bonding and N-Glycosylation Defines SLC4 Na+-coupled Transporter Extracellular Topography","publication_year":2015,"publication_date":"2015-01-08","ids":{"openalex":"https://openalex.org/W2005507704","doi":"https://doi.org/10.1074/jbc.m114.619320","mag":"2005507704","pmid":"https://pubmed.ncbi.nlm.nih.gov/25568315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4342456"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m114.619320","doi":"https://doi.org/10.1074/jbc.m114.619320","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.619320","pdf_url":"http://www.jbc.org/article/S0021925819468178/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819468178/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102746389","display_name":"Quansheng Zhu","orcid":"https://orcid.org/0000-0001-8030-014X","observed_orcids":["https://orcid.org/0000-0001-8030-014X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Quansheng Zhu","raw_affiliation_strings":["From the Department of Medicine and quzhu@mednet.ucla.edu","From the Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and quzhu@mednet.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"From the Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032556810","display_name":"Liyo Kao","orcid":"https://orcid.org/0009-0001-9045-2320","observed_orcids":["https://orcid.org/0009-0001-9045-2320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liyo Kao","raw_affiliation_strings":["From the Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038936045","display_name":"Rustam Azimov","orcid":"https://orcid.org/0000-0003-0223-5172","observed_orcids":["https://orcid.org/0000-0003-0223-5172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rustam Azimov","raw_affiliation_strings":["From the Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024730010","display_name":"Natalia K. Abuladze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Abuladze","raw_affiliation_strings":["From the Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Debra Newman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debra Newman","raw_affiliation_strings":["From the Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048085772","display_name":"Ira Kurtz","orcid":"https://orcid.org/0000-0003-2834-510X","observed_orcids":["https://orcid.org/0000-0003-2834-510X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira Kurtz","raw_affiliation_strings":["From the Department of Medicine and Brain Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095-1689","Brain Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095-1689","From the Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine and Brain Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095-1689","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Brain Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90095-1689","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"From the Department of Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102746389"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1566,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76857262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"290","issue":"9","first_page":"5391","last_page":"5404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10890000313520432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-hco3-cotransporter","display_name":"Na+/HCO3- cotransporter","score":0.8880000114440918},{"id":"https://openalex.org/keywords/extracellular-loop-3","display_name":"extracellular loop 3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.8999999761581421},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.47099998593330383},{"id":"https://openalex.org/keywords/dimer-interface","display_name":"dimer interface","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.6060000061988831},{"id":"https://openalex.org/keywords/protease-accessibility","display_name":"protease accessibility","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7201799750328064},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.7109829187393188},{"id":"https://openalex.org/C5098756","wikidata":"https://www.wikidata.org/wiki/Q1641611","display_name":"Protein disulfide-isomerase","level":3,"score":0.5264416933059692},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4906586706638336},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.44820621609687805},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.4440293312072754},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42973363399505615},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42651474475860596},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.4199327528476715},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3685835003852844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3175932466983795},{"id":"https://openalex.org/C27256138","wikidata":"https://www.wikidata.org/wiki/Q1230226","display_name":"Disulfide bond","level":2,"score":0.31488317251205444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1225651204586029},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027982","descriptor_name":"Sodium-Bicarbonate Symporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027982","descriptor_name":"Sodium-Bicarbonate Symporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027982","descriptor_name":"Sodium-Bicarbonate Symporters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m114.619320","doi":"https://doi.org/10.1074/jbc.m114.619320","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.619320","pdf_url":"http://www.jbc.org/article/S0021925819468178/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3736365","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4342456","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4342456","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4342456","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:25568315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25568315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2zw2v691","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2zw2v691","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, vol 290, iss 9","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m114.619320","doi":"https://doi.org/10.1074/jbc.m114.619320","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m114.619320","pdf_url":"http://www.jbc.org/article/S0021925819468178/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1025741448","display_name":null,"funder_award_id":"DK-077162","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3294528064","display_name":"The Biology of NBCe1 in Health and Disease","funder_award_id":"R01DK077162","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005507704.pdf","grobid_xml":"https://content.openalex.org/works/W2005507704.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1515586503","https://openalex.org/W1524077978","https://openalex.org/W1973803211","https://openalex.org/W1982833218","https://openalex.org/W1988610091","https://openalex.org/W1989643384","https://openalex.org/W2001795948","https://openalex.org/W2009784616","https://openalex.org/W2009788754","https://openalex.org/W2029716532","https://openalex.org/W2031387450","https://openalex.org/W2039132487","https://openalex.org/W2050700756","https://openalex.org/W2054968596","https://openalex.org/W2063886073","https://openalex.org/W2072265501","https://openalex.org/W2075940311","https://openalex.org/W2081104776","https://openalex.org/W2089329607","https://openalex.org/W2102814406","https://openalex.org/W2109192805","https://openalex.org/W2115967049","https://openalex.org/W2123783102","https://openalex.org/W2143843435","https://openalex.org/W2144396509","https://openalex.org/W2146017389","https://openalex.org/W2152828505","https://openalex.org/W2158074474","https://openalex.org/W2326834067"],"related_works":["https://openalex.org/W2285565598","https://openalex.org/W81183149","https://openalex.org/W2124555607","https://openalex.org/W4225392829","https://openalex.org/W2793656824","https://openalex.org/W3202438608","https://openalex.org/W2029716532","https://openalex.org/W2109192805","https://openalex.org/W4211235288","https://openalex.org/W2088075921"],"abstract_inverted_index":{"The":[0,115,289],"extracellular":[1,36,248],"loop":[2,37,249],"3":[3,28,250],"(EL-3)":[4,251],"of":[5,43,52,117,131,140,149,195,221,271],"SLC4":[6,256],"Na":[7,25,257],"+":[8,26,258],"-coupled":[9,259],"transporters":[10],"contains":[11],"4":[12,88],"highly":[13,89,185,253],"conserved":[14,54,90,254],"cysteines":[15,55,91],"and":[16,38,56,73,76,101,124,154,236,264,294],"multiple":[17],"N":[18,58,74,128,158,237,265,295],"-glycosylation":[19,59,75,129,238,266,296],"consensus":[20],"sites.":[21],"In":[22],"the":[23,34,49,53,57,66,87,118,127,134,141,147,150,169,174,219,229,240,269,284],"electrogenic":[24],"-HCO":[27],"\u2212":[29],"cotransporter":[30],"NBCe1-A,":[31],"EL-3":[32,70,80,110,132,161,180,199,280],"is":[33,39,122,155,165,209,225,281],"largest":[35],"predicted":[40],"to":[41,187],"consist":[42],"82":[44],"amino":[45],"acids.":[46],"To":[47],"determine":[48,268],"structural-functional":[50],"importance":[51],"sites":[60],"in":[61,79,111,215,239,247,255,302],"NBCe1-A":[62,170,213,243,272,285],"EL-3,":[63],"we":[64],"analyzed":[65],"potential":[67],"interplay":[68,232,290],"between":[69,233,291],"disulfide":[71,95,120,136,143,152,176,234,292],"bonding":[72,235,263,293],"their":[77],"roles":[78],"topological":[81],"folding.":[82],"Our":[83],"results":[84],"demonstrate":[85],"that":[86,108,208],"form":[92],"two":[93,175,196],"intramolecular":[94],"bonds,":[96],"Cys":[97,102],"583":[98],"-Cys":[99,104],"585":[100],"617":[103],"642":[105],",":[106],"respectively,":[107],"constrain":[109],"a":[112,205],"folded":[113,198],"conformation.":[114],"formation":[116,139,220],"second":[119,151],"bond":[121,144,153],"spontaneous":[123],"unaffected":[125],"by":[126,157,279],"state":[130],"or":[133],"first":[135,142],"bond,":[137],"whereas":[138],"relies":[145],"on":[146,228],"presence":[148],"affected":[156],"-glycosylation.":[159],"Importantly,":[160],"from":[162,201],"each":[163,202],"monomer":[164,203],"adjacently":[166],"located":[167],"at":[168,283],"dimeric":[171,286],"interface.":[172,287],"When":[173],"bonds":[177],"are":[178,252],"missing,":[179],"adopts":[181],"an":[182,299],"extended":[183],"conformation":[184],"accessible":[186],"protease":[188],"digestion.":[189],"This":[190],"unique":[191,223],"adjacent":[192],"parallel":[193],"location":[194],"symmetrically":[197],"loops":[200],"resembles":[204],"domain-like":[206,276],"structure":[207,224,277],"potentially":[210],"important":[211,300],"for":[212],"function":[214],"vivo":[216],".":[217],"Moreover,":[218],"this":[222],"critically":[226],"dependent":[227],"finely":[230],"tuned":[231],"membrane":[241],"processed":[242],"dimer.":[244],"Background":[245],"Cysteines":[246],"transporters.":[260],"Results":[261],"Disulfide":[262],"uniquely":[267],"topography":[270],"EL-3.":[273],"Conclusion":[274],"A":[275],"formed":[278],"present":[282],"Significance":[288],"may":[297],"play":[298],"role":[301],"transmembrane":[303],"protein":[304],"maturation.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}