{"id":"https://openalex.org/W2005498036","doi":"https://doi.org/10.1213/01.ane.0000061582.09963.fd","title":"Repetitive Large-Dose Infusion of the Novel Hydroxyethyl Starch 130/0.4 in Patients with Severe Head Injury","display_name":"Repetitive Large-Dose Infusion of the Novel Hydroxyethyl Starch 130/0.4 in Patients with Severe Head Injury","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W2005498036","doi":"https://doi.org/10.1213/01.ane.0000061582.09963.fd","mag":"2005498036","pmid":"https://pubmed.ncbi.nlm.nih.gov/12707149"},"language":"en","primary_location":{"id":"doi:10.1213/01.ane.0000061582.09963.fd","doi":"https://doi.org/10.1213/01.ane.0000061582.09963.fd","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000061582.09963.fd","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103570075","display_name":"Thomas A. Neff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["CH","DE","US"],"is_corresponding":true,"raw_author_name":"Thomas A. Neff","raw_affiliation_strings":["*Institute of Anesthesiology and \u2020Division of Surgical Intensive Care, University Hospital, Zurich, Switzerland; \u2021Clinical Research Department, Fresenius Kabi, Bad Homburg, Germany","Institute of Anesthesiology and","reprint requests to Thomas A. Neff, MD, University of Michigan Medical School, Department of Pathology, 7526 MSRB 1/0602, 1150 West Medical Center Dr., Ann Arbor, MI 48109. Address e-mail to [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute of Anesthesiology and \u2020Division of Surgical Intensive Care, University Hospital, Zurich, Switzerland; \u2021Clinical Research Department, Fresenius Kabi, Bad Homburg, Germany","institution_ids":["https://openalex.org/I4210100468","https://openalex.org/I4210108778"]},{"raw_affiliation_string":"Institute of Anesthesiology and","institution_ids":[]},{"raw_affiliation_string":"reprint requests to Thomas A. Neff, MD, University of Michigan Medical School, Department of Pathology, 7526 MSRB 1/0602, 1150 West Medical Center Dr., Ann Arbor, MI 48109. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018226650","display_name":"Martin Doelberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Doelberg","raw_affiliation_strings":["Clinical Research Department, Fresenius Kabi, Bad Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Department, Fresenius Kabi, Bad Homburg, Germany","institution_ids":["https://openalex.org/I4210108778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089530737","display_name":"Cornelius Jungheinrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelius Jungheinrich","raw_affiliation_strings":["Clinical Research Department, Fresenius Kabi, Bad Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Department, Fresenius Kabi, Bad Homburg, Germany","institution_ids":["https://openalex.org/I4210108778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033430765","display_name":"Andrea Sauerland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andrea Sauerland","raw_affiliation_strings":["Division of Surgical Intensive Care, University Hospital, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Intensive Care, University Hospital, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109143834","display_name":"Donat R. Spahn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Donat R. Spahn","raw_affiliation_strings":["Institute of Anesthesiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anesthesiology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071698383","display_name":"Reto A. Stocker","orcid":"https://orcid.org/0000-0001-9869-7894","observed_orcids":["https://orcid.org/0000-0001-9869-7894"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Reto Stocker","raw_affiliation_strings":["Division of Surgical Intensive Care, University Hospital, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Intensive Care, University Hospital, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103570075","https://openalex.org/A5109143834"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210100468","https://openalex.org/I4210108778","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":7.0111,"has_fulltext":false,"cited_by_count":175,"citation_normalized_percentile":{"value":0.97503811,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"96","issue":"5","first_page":"1453","last_page":"1459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyethyl-starch-130-0-4","display_name":"hydroxyethyl starch 130/0.4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hydroxyethyl-starch-200-0-5","display_name":"hydroxyethyl starch 200/0.5","score":0.9779999852180481},{"id":"https://openalex.org/keywords/severe-traumatic-brain-injury","display_name":"severe traumatic brain injury","score":0.6869999766349792},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.7730000019073486},{"id":"https://openalex.org/keywords/plasma-volume-expansion","display_name":"plasma expansion","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6949999928474426},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.765999972820282},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":1.0},{"id":"https://openalex.org/keywords/ristocetin-cofactor-activity","display_name":"ristocetin cofactor activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.9179999828338623},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2779412105","wikidata":"https://www.wikidata.org/wiki/Q415775","display_name":"Hydroxyethyl starch","level":2,"score":0.9075013399124146},{"id":"https://openalex.org/C2777975874","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head injury","level":2,"score":0.5634394288063049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.441182017326355},{"id":"https://openalex.org/C2780312720","wikidata":"https://www.wikidata.org/wiki/Q5689100","display_name":"Head (geology)","level":2,"score":0.4357568323612213},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3981865644454956},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22164538502693176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09365159273147583},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006259","descriptor_name":"Craniocerebral Trauma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006895","descriptor_name":"Hydroxyethyl Starch Derivatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006895","descriptor_name":"Hydroxyethyl Starch Derivatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006895","descriptor_name":"Hydroxyethyl Starch Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010952","descriptor_name":"Plasma Substitutes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010952","descriptor_name":"Plasma Substitutes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010952","descriptor_name":"Plasma Substitutes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1213/01.ane.0000061582.09963.fd","doi":"https://doi.org/10.1213/01.ane.0000061582.09963.fd","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000061582.09963.fd","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:12707149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12707149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1491555408","https://openalex.org/W1548753216","https://openalex.org/W1554783366","https://openalex.org/W1605096863","https://openalex.org/W1964919195","https://openalex.org/W1974157302","https://openalex.org/W1979651875","https://openalex.org/W1982644344","https://openalex.org/W1988695805","https://openalex.org/W1996447886","https://openalex.org/W2005138782","https://openalex.org/W2016339989","https://openalex.org/W2030081634","https://openalex.org/W2045041613","https://openalex.org/W2073781360","https://openalex.org/W2076985673","https://openalex.org/W2084962044","https://openalex.org/W2098653011","https://openalex.org/W2105141806","https://openalex.org/W2129198157","https://openalex.org/W2130713902","https://openalex.org/W2143119488","https://openalex.org/W4240454629","https://openalex.org/W4242684752","https://openalex.org/W4285719527","https://openalex.org/W4376595788"],"related_works":["https://openalex.org/W2008573479","https://openalex.org/W2091771620","https://openalex.org/W2028804590","https://openalex.org/W2012477966","https://openalex.org/W4406850708","https://openalex.org/W2038047633","https://openalex.org/W1966395864","https://openalex.org/W2317073113","https://openalex.org/W7203820596","https://openalex.org/W1506980531"],"abstract_inverted_index":{"UNLABELLED:":[0],"In":[1],"this":[2,227],"prospective,":[3],"controlled,":[4],"randomized,":[5],"single-center":[6],"study,":[7],"we":[8],"investigated":[9,207],"the":[10,54,60,63,145,150,208,211,230,234],"safety":[11,209],"of":[12,16,43,76,96,117,175,190,210],"repetitive":[13,41,222],"large-dose":[14],"infusion":[15,189],"a":[17,89],"novel":[18,212],"hydroxyethyl":[19,192],"starch":[20,193],"solution":[21],"(6%":[22],"HES":[23,35,56,65,146,152,158,213,223],"130/0.4)":[24],"in":[25,59,109,126,144,164,215,226,233],"cranio-cerebral":[26,219],"trauma":[27,168],"patients.":[28],"Patients":[29],"were":[30,121,142],"randomized":[31],"to":[32,45,71,88,177],"receive":[33],"either":[34],"130/0.4":[36,147,159,214],"(n":[37,67],"=":[38,68],"16)":[39],"at":[40,130,173],"doses":[42,153,174,224],"up":[44,70,87,176],"70":[46,97,178],"mL":[47,78,98,179],"x":[48,50,79,81,99,101,180,182],"kg(-1)":[49,80,100,181],"d(-1)":[51,82],"(which":[52],"is":[53],"largest":[55,231],"dose":[57,74,91],"reported":[58,232],"literature)":[61],"or":[62],"control":[64],"200/0.5":[66,93],"15)":[69],"its":[72],"approved":[73],"limit":[75],"33":[77],"followed":[83],"by":[84],"human":[85],"albumin":[86],"total":[90],"(HES":[92],"+":[94],"albumin)":[95],"d(-1).":[102,183],"We":[103,155,206],"found":[104],"no":[105,123],"differences":[106,125],"between":[107],"groups":[108],"mortality,":[110],"renal":[111,204],"function,":[112],"bleeding":[113],"complications,":[114],"and":[115,139,203],"use":[116],"blood":[118],"products.":[119],"There":[120,185],"also":[122],"major":[124],"coagulation":[127,202],"variables.":[128],"However,":[129],"some":[131],"time":[132],"points,":[133],"factor":[134],"VIII,":[135],"von":[136],"Willebrand":[137],"factor,":[138],"ristocetin":[140],"cofactor":[141],"higher":[143],"group":[148],"despite":[149],"large":[151],"administered.":[154],"conclude":[156],"that":[157,188],"can":[160],"safely":[161],"be":[162],"used":[163],"critically":[165],"ill":[166],"head":[167],"patients":[169,216],"over":[170],"several":[171],"days":[172],"IMPLICATIONS:":[184],"are":[186,229],"concerns":[187],"certain":[191],"(HES)":[194],"types":[195],"for":[196],"plasma":[197],"volume":[198],"expansion":[199],"may":[200],"influence":[201],"function.":[205],"with":[217],"severe":[218],"trauma.":[220],"The":[221],"administered":[225],"study":[228],"literature.":[235]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}