{"id":"https://openalex.org/W2005492777","doi":"https://doi.org/10.1046/j.1365-2249.1999.00753.x","title":"Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression","display_name":"Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2005492777","doi":"https://doi.org/10.1046/j.1365-2249.1999.00753.x","mag":"2005492777","pmid":"https://pubmed.ncbi.nlm.nih.gov/9933419","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905174"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2249.1999.00753.x","doi":"https://doi.org/10.1046/j.1365-2249.1999.00753.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1999.00753.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1905174/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032480207","display_name":"Markus Friedrich Neurath","orcid":"https://orcid.org/0000-0003-4344-1474","observed_orcids":["https://orcid.org/0000-0003-4344-1474"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"M F NEURATH","raw_affiliation_strings":["Laboratory of Immunology, I Medical Clinic","Laboratory of Immunology I, Medical Clinic, University of Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, I Medical Clinic","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Immunology I, Medical Clinic, University of Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010174329","display_name":"Kai Hildner","orcid":"https://orcid.org/0000-0001-5007-4874","observed_orcids":["https://orcid.org/0000-0001-5007-4874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K HILDNER","raw_affiliation_strings":["Laboratory of Immunology, I Medical Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, I Medical Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001550826","display_name":"Christoph Becker","orcid":"https://orcid.org/0000-0002-1388-1041","observed_orcids":["https://orcid.org/0000-0002-1388-1041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C BECKER","raw_affiliation_strings":["Laboratory of Immunology, I Medical Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, I Medical Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044805858","display_name":"JF Schlaak","orcid":"https://orcid.org/0000-0002-9499-1014","observed_orcids":["https://orcid.org/0000-0002-9499-1014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F SCHLAAK","raw_affiliation_strings":["Laboratory of Immunology, I Medical Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, I Medical Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080089352","display_name":"Karina Barbulescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K BARBULESCU","raw_affiliation_strings":["Laboratory of Immunology, I Medical Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, I Medical Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031335614","display_name":"Tieno Germann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T GERMANN","raw_affiliation_strings":["Institute of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113741190","display_name":"Edgar Schmitt","orcid":"https://orcid.org/0009-0004-9135-1697","observed_orcids":["https://orcid.org/0009-0004-9135-1697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E SCHMITT","raw_affiliation_strings":["Institute of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081978650","display_name":"Peter Schirmacher","orcid":"https://orcid.org/0000-0002-0950-3339","observed_orcids":["https://orcid.org/0000-0002-0950-3339"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P SCHIRMACHER","raw_affiliation_strings":["Institute of Pathology, University of Mainz, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068814189","display_name":"Sylva Haralambous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S HARALAMBOUS","raw_affiliation_strings":["Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079200229","display_name":"Manolis Pasparakis","orcid":"https://orcid.org/0000-0002-9870-0966","observed_orcids":["https://orcid.org/0000-0002-9870-0966"]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"M PASPARAKIS","raw_affiliation_strings":["Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109138140","display_name":"K-H Meyer Zum B\u00fcSchenfelde","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K-H MEYER ZUM B\u00dcSCHENFELDE","raw_affiliation_strings":["Laboratory of Immunology, I Medical Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, I Medical Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062268324","display_name":"George A. Kollias","orcid":"https://orcid.org/0000-0003-1867-3150","observed_orcids":["https://orcid.org/0000-0003-1867-3150"]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G KOLLIAS","raw_affiliation_strings":["Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028835875","display_name":"Elisabeth M\u00e4rker\u2010Hermann","orcid":"https://orcid.org/0000-0001-6446-6246","observed_orcids":["https://orcid.org/0000-0001-6446-6246"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E M\u00c4RKER-HERMANN","raw_affiliation_strings":["Laboratory of Immunology, I Medical Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, I Medical Clinic","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028835875","https://openalex.org/A5032480207"],"corresponding_institution_ids":["https://openalex.org/I197323543"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":2.9104,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.9030221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"115","issue":"1","first_page":"42","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.796999990940094},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7879999876022339},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6240000128746033},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8700000047683716},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/il-15","display_name":"IL-15","score":0.8500000238418579},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8422471880912781},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7176501750946045},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.69469153881073},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6734589338302612},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6203948259353638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5386014580726624},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5345712304115295},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.435860276222229},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019409","descriptor_name":"Interleukin-15","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2249.1999.00753.x","doi":"https://doi.org/10.1046/j.1365-2249.1999.00753.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1999.00753.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmid:9933419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9933419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1905174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1905174/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1905174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1905174/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W28288604","https://openalex.org/W54463464","https://openalex.org/W132781887","https://openalex.org/W1490165777","https://openalex.org/W1968787464","https://openalex.org/W1976195770","https://openalex.org/W1976262436","https://openalex.org/W1976912963","https://openalex.org/W1988580402","https://openalex.org/W1994030928","https://openalex.org/W1998783767","https://openalex.org/W1999855196","https://openalex.org/W2010771259","https://openalex.org/W2019448678","https://openalex.org/W2025818368","https://openalex.org/W2029968450","https://openalex.org/W2032169254","https://openalex.org/W2043287930","https://openalex.org/W2050832468","https://openalex.org/W2056389096","https://openalex.org/W2064604818","https://openalex.org/W2072857434","https://openalex.org/W2076076823","https://openalex.org/W2085853581","https://openalex.org/W2088244043","https://openalex.org/W2089773409","https://openalex.org/W2096304334","https://openalex.org/W2096470225","https://openalex.org/W2113869393","https://openalex.org/W2129202470","https://openalex.org/W2136430968","https://openalex.org/W2141336840","https://openalex.org/W2142273705","https://openalex.org/W2144152742","https://openalex.org/W2150571795","https://openalex.org/W2158778799","https://openalex.org/W2160877509","https://openalex.org/W2174322658","https://openalex.org/W2331320446","https://openalex.org/W2412773523","https://openalex.org/W4313342465"],"related_works":["https://openalex.org/W2188147365","https://openalex.org/W2074614526","https://openalex.org/W2416526487","https://openalex.org/W2351615686","https://openalex.org/W2112861894","https://openalex.org/W2050428662","https://openalex.org/W7171552968","https://openalex.org/W2029968450","https://openalex.org/W198452255","https://openalex.org/W2060233301"],"abstract_inverted_index":{"Immunosuppressive":[0],"therapy":[1],"with":[2,13,114,155,258],"methotrexate":[3],"(MTX)":[4],"has":[5],"been":[6,205],"established":[7],"as":[8,244],"effective":[9],"treatment":[10,110],"for":[11],"patients":[12,257],"rheumatoid":[14],"arthritis.":[15],"To":[16],"analyse":[17,251],"the":[18,49,140,182,201],"therapeutic":[19],"potential":[20],"and":[21,32,39,43,69,102,124,132,147,215,221,241,249],"mechanisms":[22,253],"of":[23,25,51,57,111,136,142,150,159,170,239,254],"action":[24],"MTX,":[26],"we":[27,47],"determined":[28],"serum":[29,122],"cytokine":[30,33,176],"levels":[31,123],"production":[34,75,97,104,127,161,177,189,218,231],"by":[35,61,76,82,128,162,181,207,232],"splenic":[36,77,129],"T":[37,78,130,233],"cells":[38,79,131,164,234],"macrophages":[40,83],"in":[41,53,87,89,116,172,192,197,199,219,256],"untreated":[42],"MTX-treated":[44,166],"mice.":[45,167],"Furthermore,":[46],"assessed":[48],"role":[50,169],"MTX":[52,66,115,137,185,211,240],"a":[54,90,156,245],"murine":[55,224],"model":[56],"experimental":[58,223],"arthritis":[59,143],"induced":[60],"collagen":[62],"type":[63],"II":[64],"(CIA).":[65],"reduced":[67,101,120],"spontaneous":[68,214],"IL-15-induced":[70,216],"tumour":[71],"necrosis":[72],"factor":[73],"(TNF)":[74],"but":[80,195],"not":[81],"from":[84,165],"healthy":[85,112],"mice":[86,113,194,198,220],"vitro":[88],"dose-dependent":[91],"manner.":[92],"In":[93,108],"contrast,":[94],"interferon-gamma":[95],"(IFN-gamma)":[96],"was":[98,105,153,178],"less":[99],"strikingly":[100],"IL-4":[103],"virtually":[106],"unaffected.":[107],"addition,":[109],"vivo":[117],"led":[118],"to":[119,139,247],"TNF":[121,126,160,171,230],"diminished":[125],"macrophages.":[133],"Intraperitoneal":[134],"administration":[135],"prior":[138],"onset":[141],"completely":[144],"prevented":[145],"clinical":[146],"pathological":[148],"signs":[149],"CIA.":[151,225],"This":[152],"associated":[154],"striking":[157],"reduction":[158],"spleen":[163],"The":[168],"MTX-mediated":[173,252],"effects":[174,186],"on":[175,187],"further":[179,250],"underlined":[180],"finding":[183],"that":[184,229],"IFN-gamma":[188],"were":[190],"augmented":[191],"TNF-transgenic":[193],"abrogated":[196],"which":[200],"TNF-alpha":[202,217],"gene":[203],"had":[204],"inactivated":[206],"homologous":[208],"recombination.":[209],"Thus,":[210],"specifically":[212],"modulates":[213],"prevents":[222],"These":[226],"data":[227],"suggest":[228],"is":[235],"an":[236],"important":[237],"target":[238],"may":[242],"serve":[243],"basis":[246],"understand":[248],"immunosuppression":[255],"RA.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}