{"id":"https://openalex.org/W2005491955","doi":"https://doi.org/10.1001/archinte.159.9.981","title":"Effect of Moderate Alcohol Consumption on Hypertriglyceridemia","display_name":"Effect of Moderate Alcohol Consumption on Hypertriglyceridemia","publication_year":1999,"publication_date":"1999-05-10","ids":{"openalex":"https://openalex.org/W2005491955","doi":"https://doi.org/10.1001/archinte.159.9.981","mag":"2005491955","pmid":"https://pubmed.ncbi.nlm.nih.gov/10326940"},"language":"en","primary_location":{"id":"doi:10.1001/archinte.159.9.981","doi":"https://doi.org/10.1001/archinte.159.9.981","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.159.9.981","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089801293","display_name":"Henry J. Pownall","orcid":"https://orcid.org/0000-0001-8412-506X","observed_orcids":["https://orcid.org/0000-0001-8412-506X"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry J. Pownall","raw_affiliation_strings":["Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Tex 77030, USA. hpownall@bcm.tmc.edu","Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Tex 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Tex 77030, USA. hpownall@bcm.tmc.edu","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Tex 77030, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052604218","display_name":"Christie Mitchell Ballantyne","orcid":"https://orcid.org/0000-0002-6432-1730","observed_orcids":["https://orcid.org/0000-0002-6432-1730"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christie M. Ballantyne","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110117627","display_name":"Kay T. Kimball","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kay T. Kimball","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073461723","display_name":"Suzanne L. Simpson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne L. Simpson","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110044656","display_name":"Daniel Yeshurun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Yeshurun","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068202304","display_name":"Antonio M. Gotto","orcid":"https://orcid.org/0000-0001-8076-6783","observed_orcids":["https://orcid.org/0000-0001-8076-6783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio M. Gotto","raw_affiliation_strings":["Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1646,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.86440678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"159","issue":"9","first_page":"981","last_page":"981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.7695000171661377,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.2289000004529953,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/moderate-alcohol-consumption","display_name":"moderate drinking","score":0.9549999833106995},{"id":"https://openalex.org/keywords/plasma-triglycerides","display_name":"plasma triglycerides","score":0.8069999814033508},{"id":"https://openalex.org/keywords/triglyceride-response","display_name":"triglyceride response","score":0.7440000176429749},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/acetate","display_name":"acetate","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.9088464975357056},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.9015750288963318},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.767481803894043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6979246139526367},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6496819257736206},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5973010063171387},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.5140742063522339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4895104169845581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46004652976989746},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3238128423690796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2172669768333435}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015228","descriptor_name":"Hypertriglyceridemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archinte.159.9.981","doi":"https://doi.org/10.1001/archinte.159.9.981","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.159.9.981","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:10326940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10326940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W100225553","https://openalex.org/W117951710","https://openalex.org/W170653800","https://openalex.org/W1511393232","https://openalex.org/W1839068802","https://openalex.org/W1901336933","https://openalex.org/W1907966829","https://openalex.org/W1942679893","https://openalex.org/W1964509015","https://openalex.org/W1971398592","https://openalex.org/W1974393820","https://openalex.org/W1979739661","https://openalex.org/W1981756030","https://openalex.org/W1985985411","https://openalex.org/W1987715649","https://openalex.org/W1994181601","https://openalex.org/W1999388462","https://openalex.org/W2004741651","https://openalex.org/W2011128367","https://openalex.org/W2020908663","https://openalex.org/W2022582429","https://openalex.org/W2025184410","https://openalex.org/W2025600842","https://openalex.org/W2033304539","https://openalex.org/W2035416336","https://openalex.org/W2049282259","https://openalex.org/W2053668418","https://openalex.org/W2058054155","https://openalex.org/W2059099293","https://openalex.org/W2061348196","https://openalex.org/W2066820904","https://openalex.org/W2071950299","https://openalex.org/W2079855940","https://openalex.org/W2082858014","https://openalex.org/W2090783391","https://openalex.org/W2092805169","https://openalex.org/W2094036485","https://openalex.org/W2094123220","https://openalex.org/W2098035527","https://openalex.org/W2104235771","https://openalex.org/W2116404316","https://openalex.org/W2120213297","https://openalex.org/W2136213395","https://openalex.org/W2155085535","https://openalex.org/W2162858860","https://openalex.org/W2166677280","https://openalex.org/W2166720000","https://openalex.org/W2167469562","https://openalex.org/W2172692903","https://openalex.org/W2241423959","https://openalex.org/W2269050221","https://openalex.org/W2302332722","https://openalex.org/W2312874913","https://openalex.org/W2316828431","https://openalex.org/W2317500797","https://openalex.org/W2336433331","https://openalex.org/W2344423072","https://openalex.org/W2361044459","https://openalex.org/W2399807565","https://openalex.org/W2409771361","https://openalex.org/W2410256518","https://openalex.org/W2413418142","https://openalex.org/W2466683403","https://openalex.org/W2477685175","https://openalex.org/W4240887262","https://openalex.org/W4249825849"],"related_works":["https://openalex.org/W2322552576","https://openalex.org/W2414988396","https://openalex.org/W2321694069","https://openalex.org/W2108466581","https://openalex.org/W117951710","https://openalex.org/W180158616","https://openalex.org/W2004741651","https://openalex.org/W2979365407","https://openalex.org/W1983739422","https://openalex.org/W1974393820"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1],"with":[2,38,62,161,184,211,244],"hypertriglyceridemia":[3],"(HTG)":[4],"are":[5],"generally":[6],"advised":[7],"to":[8,68,258],"avoid":[9],"alcohol,":[10,256],"even":[11],"though":[12],"moderate":[13],"alcohol":[14,29,57,92,162,230],"consumption":[15,30,252],"is":[16,40,233],"cardioprotective.":[17],"Alcohol":[18],"increases":[19,33],"plasma":[20,51,165,239],"triglyceride":[21,34,48,52,64,139,177,186,240,260],"concentration":[22,49,53,187,241],"transiently":[23],"in":[24,36,103,133,164,176,191,197,242,263],"normolipidemic":[25],"subjects,":[26],"but":[27,195],"whether":[28,45],"per":[31],"se":[32],"concentrations":[35,65,261],"patients":[37],"HTG":[39,153,193],"unclear.":[41],"OBJECTIVE:":[42],"To":[43],"assess":[44],"baseline":[46,114],"fasting":[47,63],"determines":[50],"after":[54],"acute":[55],"oral":[56],"intake.":[58],"METHODS:":[59],"Twelve":[60],"persons":[61,75],"of":[66,87,101,238,253],"2.3":[67],"8.5":[69],"mmol/L":[70,143,148],"(200-750":[71],"mg/dL)":[72,145,150],"and":[73,85,115,146,154,170,255],"12":[74],"as":[76,249],"a":[77,134],"non-HTG":[78,155,199,264],"group":[79,194],"were":[80,94,111,141],"enrolled.":[81],"Obesity,":[82],"current":[83],"smoking,":[84],"history":[86],"hypertension,":[88],"diabetes,":[89],"or":[90],"excessive":[91],"use":[93],"exclusionary.":[95],"Fasted":[96],"subjects":[97,129],"consumed":[98,130],"38":[99],"mL":[100],"ethanol":[102],"water":[104,131,212],"(equivalent,":[105],"2":[106],"alcoholic":[107],"drinks);":[108],"blood":[109],"samples":[110],"collected":[112],"at":[113,116],"intervals":[117],"thereafter":[118],"for":[119,151],"10":[120],"hours.":[121],"No":[122],"less":[123],"than":[124],"1":[125],"week":[126],"later,":[127],"the":[128,152,173,192,198,209,221,250],"alone":[132,213,232],"control":[135],"test.":[136],"RESULTS:":[137],"Mean":[138],"values":[140],"4.04+/-0.41":[142],"(358+/-36.9":[144],"1.00+/-0.11":[147],"(89+/-10.2":[149],"groups,":[156],"respectively.":[157],"Despite":[158],"similar":[159],"changes":[160],"feeding":[163],"ethanol,":[166],"nonesterified":[167],"fatty":[168],"acid,":[169],"acetate":[171],"concentrations,":[172],"groups":[174],"differed":[175],"response.":[178],"At":[179],"6":[180],"hours":[181],"(peak)":[182],"compared":[183],"baseline,":[185],"increased":[188],"only":[189],"3%":[190],"53%":[196],"group.":[200],"The":[201],"former":[202],"change":[203],"was":[204,223],"not":[205,234],"significantly":[206],"different":[207],"from":[208,215],"effect":[210],"(-9.2%":[214],"baseline;":[216],"P":[217,225],"=":[218,226],".43),":[219],"whereas":[220],"latter":[222],"(-8.0%;":[224],".003).":[227],"CONCLUSIONS:":[228],"Acute":[229],"intake":[231],"an":[235],"important":[236],"determinant":[237],"individuals":[243],"HTG.":[245],"Other":[246],"factors,":[247],"such":[248],"contemporaneous":[251],"fat":[254],"known":[257],"increase":[259],"synergistically":[262],"individuals,":[265],"may":[266],"be":[267],"more":[268],"important.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}