{"id":"https://openalex.org/W2005489905","doi":"https://doi.org/10.1002/art.20781","title":"Effects of sevelamer and calcium\u2010based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: A randomized clinical trial","display_name":"Effects of sevelamer and calcium\u2010based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: A randomized clinical trial","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2005489905","doi":"https://doi.org/10.1002/art.20781","mag":"2005489905","pmid":"https://pubmed.ncbi.nlm.nih.gov/15641045"},"language":"en","primary_location":{"id":"doi:10.1002/art.20781","doi":"https://doi.org/10.1002/art.20781","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.20781","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108974192","display_name":"Jay P Garg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay P. Garg","raw_affiliation_strings":["Department of Medicine Research, University of California-San Francisco, UCSF Laurel Heights Suite 430, 3333 California Street, San Francisco, CA 94118-1211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Research, University of California-San Francisco, UCSF Laurel Heights Suite 430, 3333 California Street, San Francisco, CA 94118-1211, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001479828","display_name":"Scott Chasan-Taber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Chasan\u2010Taber","raw_affiliation_strings":["Pioneer Biodiligence, Inc., Amherst, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pioneer Biodiligence, Inc., Amherst, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054502670","display_name":"Andrew T. Blair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Blair","raw_affiliation_strings":["Genzyme, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme, Inc., Cambridge, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023599600","display_name":"Melissa A. Plone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa Plone","raw_affiliation_strings":["Genzyme, Inc., Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme, Inc., Cambridge, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113563098","display_name":"Juergen Bommer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juergen Bommer","raw_affiliation_strings":["Universitatsklinikum Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitatsklinikum Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016072225","display_name":"Paolo Raggi","orcid":"https://orcid.org/0000-0002-5766-1948","observed_orcids":["https://orcid.org/0000-0002-5766-1948"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Raggi","raw_affiliation_strings":["Tulane University, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034939991","display_name":"Glenn Matthew Chertow","orcid":"https://orcid.org/0000-0002-7599-0534","observed_orcids":["https://orcid.org/0000-0002-7599-0534"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn M. Chertow","raw_affiliation_strings":["University of California\u2014San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2014San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.9842,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.97005614,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"52","issue":"1","first_page":"290","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.06610000133514404,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.05609999969601631,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sevelamer","display_name":"sevelamer","score":1.0},{"id":"https://openalex.org/keywords/calcium-based-phosphate-binders","display_name":"calcium-based phosphate binders","score":0.9779999852180481},{"id":"https://openalex.org/keywords/serum-uric-acid","display_name":"serum uric acid","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.8479999899864197},{"id":"https://openalex.org/keywords/phosphorus-binding","display_name":"phosphorus binding","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hypouricemic-agents","display_name":"hypouricemic agents","score":0.6919999718666077},{"id":"https://openalex.org/keywords/organic-anion-transport","display_name":"organic anion transport","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2777425297","wikidata":"https://www.wikidata.org/wiki/Q904153","display_name":"Sevelamer","level":4,"score":0.9724652767181396},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.7899185419082642},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7755535244941711},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.6495664715766907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6435852646827698},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.6192936301231384},{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.6074346303939819},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.5641052722930908},{"id":"https://openalex.org/C2779148903","wikidata":"https://www.wikidata.org/wiki/Q661790","display_name":"Phosphate binder","level":4,"score":0.5202540159225464},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47324639558792114},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.43885213136672974},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4074966609477997},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3697505593299866}],"mesh":[{"descriptor_ui":"D000069603","descriptor_name":"Sevelamer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011095","descriptor_name":"Polyethylenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028044","descriptor_name":"Phosphate-Binding Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D028044","descriptor_name":"Phosphate-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.20781","doi":"https://doi.org/10.1002/art.20781","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.20781","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:15641045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15641045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W48165959","https://openalex.org/W80021077","https://openalex.org/W1977303973","https://openalex.org/W1986354946","https://openalex.org/W1987332523","https://openalex.org/W2013892016","https://openalex.org/W2026420466","https://openalex.org/W2036551040","https://openalex.org/W2037687164","https://openalex.org/W2039195112","https://openalex.org/W2042564199","https://openalex.org/W2045847718","https://openalex.org/W2067241022","https://openalex.org/W2083678197","https://openalex.org/W2085717480","https://openalex.org/W2106362601","https://openalex.org/W2107703251","https://openalex.org/W2110693651","https://openalex.org/W2113162921","https://openalex.org/W2113528337","https://openalex.org/W2123238413","https://openalex.org/W2124187588","https://openalex.org/W2133217116","https://openalex.org/W2138356436","https://openalex.org/W2156442792","https://openalex.org/W2318373131","https://openalex.org/W2323300482","https://openalex.org/W2331027044","https://openalex.org/W4323526278"],"related_works":["https://openalex.org/W1966784678","https://openalex.org/W4400119490","https://openalex.org/W2340205984","https://openalex.org/W2144621269","https://openalex.org/W1567135211","https://openalex.org/W2031594310","https://openalex.org/W7212295658","https://openalex.org/W4403833011","https://openalex.org/W4247895956","https://openalex.org/W2045847718"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Gout":[1],"affects":[2],"a":[3,35,90,260,286,302],"large":[4],"fraction":[5],"of":[6,19,49,61,150,156,192,223,231,256,266,278],"persons":[7],"with":[8,29,97,276,297,301],"advanced":[9],"chronic":[10],"kidney":[11],"disease,":[12],"and":[13,41,51,128,176,235,241,292],"hyperuricemia":[14],"may":[15],"increase":[16],"the":[17,45,59,76,139,148,151,154,190,193,221,264],"risk":[18],"cardiovascular":[20],"disease.":[21,32],"Several":[22],"hypouricemic":[23],"agents":[24],"are":[25],"contraindicated":[26],"in":[27,44,78,89,119,135,141,169,183,198,213,237,263,305],"patients":[28],"end-stage":[30],"renal":[31],"Sevelamer":[33],"is":[34],"nonabsorbed":[36],"hydrogel":[37],"that":[38,55,75],"binds":[39],"phosphorus":[40,117],"bile":[42],"acids":[43],"intestinal":[46],"tract.":[47],"Results":[48],"short-term":[50],"open-label":[52],"studies":[53],"suggest":[54],"sevelamer":[56,85,96,114,175,291,298],"might":[57],"lower":[58],"concentration":[60,82,144,186,216,265],"uric":[62,80,130,142,164,184,214,267,307],"acid,":[63],"another":[64],"organic":[65],"anion.":[66],"We":[67],"undertook":[68],"this":[69],"study":[70,152],"to":[71,111,147,173,189,270],"test":[72],"our":[73],"hypothesis":[74],"reduction":[77,262,304],"serum":[79,306],"acid":[81,131,143,165,185,215,268,308],"induced":[83],"by":[84],"would":[86],"be":[87],"confirmed":[88],"long-term,":[91],"randomized,":[92],"clinical":[93,123,160,288],"trial":[94,289],"comparing":[95,290],"calcium-based":[98,116,177,293],"phosphate":[99,178,294],"binders.":[100,179],"METHODS:":[101],"Two":[102],"hundred":[103],"subjects":[104,137,170,200,258,280],"undergoing":[105],"maintenance":[106],"hemodialysis":[107],"were":[108,133,167,244],"randomly":[109,171],"assigned":[110,172],"receive":[112,174],"either":[113],"or":[115,273],"binders":[118],"an":[120],"international,":[121],"multicenter,":[122],"trial.":[124],"Data":[125],"on":[126],"baseline":[127,146,188],"end-of-study":[129],"concentrations":[132,243],"available":[134],"169":[136],"(85%);":[138],"change":[140,182,212],"from":[145],"end":[149,191],"was":[153,195,217,299],"outcome":[155],"interest.":[157],"RESULTS:":[158],"Baseline":[159],"characteristics,":[161],"including":[162],"mean":[163,181,211],"concentrations,":[166],"similar":[168],"The":[180,209],"(from":[187],"study)":[194],"significantly":[196],"larger":[197],"sevelamer-treated":[199,257],"(-0.64":[201],"mg/dl":[202,247,272],"versus":[203,248],"-0.26":[204],"mg/dl;":[205,250],"P":[206,251],"=":[207,252,282],"0.03).":[208],"adjusted":[210],"more":[218],"pronounced":[219],"when":[220],"effects":[222],"age,":[224],"sex,":[225],"diabetes,":[226],"vintage":[227],"(time":[228],"since":[229],"initiation":[230],"dialysis),":[232],"dialysis":[233],"dose,":[234],"changes":[236],"blood":[238],"urea":[239],"nitrogen":[240],"bicarbonate":[242],"considered":[245],"(-0.72":[246],"-0.15":[249],"0.001).":[253],"Twenty-three":[254],"percent":[255],"experienced":[259],"study-related":[261],"equal":[269],"-1.5":[271],"more,":[274],"compared":[275],"10%":[277],"calcium-treated":[279],"(P":[281],"0.02).":[283],"CONCLUSION:":[284],"In":[285],"randomized":[287],"binders,":[295],"treatment":[296],"associated":[300],"significant":[303],"concentrations.":[309]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
